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扬州综合医院急诊应对新型冠状病毒感染“三级分诊与三级缓冲”模式的构建与实施

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当代医学 2024年第1期30卷 107-110页

作者：赵霞左霞陆明峰谈定玉扬州大学附属苏北人民医院急诊科江苏扬州225000

2021年7月底扬州市区出现新型冠状病毒感染病例,扬州大学附属苏北人民医院作为本地三级综合医院,其急诊科迅速启动“三级分诊、三级缓冲”管理模式,包括合理规划分诊流程,通过三级预检分诊模式对所有急诊患者进行流行病学调查及新型冠... 详细信息

2021年7月底扬州市区出现新型冠状病毒感染病例,扬州大学附属苏北人民医院作为本地三级综合医院,其急诊科迅速启动“三级分诊、三级缓冲”管理模式,包括合理规划分诊流程,通过三级预检分诊模式对所有急诊患者进行流行病学调查及新型冠状病毒感染疑似病例筛查;通过调整科室布局及功能分区,多部门联防联控,将急诊隔离抢救室-缓冲病区-专科单间病房充分联动,形成三级缓冲救治模式。以上管理模式有助于优化管控流程,建立安全屏障,对高效甄别、救治、分流急诊患者起积极作用,减少医院感染风险,为综合医院急诊疫情防控工作提供建议和指导。

关键词：新型冠状病毒感染疫情防控预检分诊缓冲病区急诊扬州

百草枯中毒肺部影像及运动耐力5年随访报道1例

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中华劳动卫生职业病杂志 2022年第2期40卷 142-145页

作者：陆明峰徐继扬范璐扬州大学附属苏北人民医院急诊科扬州225001

我们对1例百草枯中毒患者进行长达5年的随访,胸部CT发现该患者肺间质病变范围随时间推移逐渐缩小并于中毒后6个月不再明显变化,其后病变区密度逐渐降低,并可见缓慢增多的囊性气腔。随时间推移,该患者运动耐力逐渐提高,中毒后第5年检查... 详细信息

我们对1例百草枯中毒患者进行长达5年的随访,胸部CT发现该患者肺间质病变范围随时间推移逐渐缩小并于中毒后6个月不再明显变化,其后病变区密度逐渐降低,并可见缓慢增多的囊性气腔。随时间推移,该患者运动耐力逐渐提高,中毒后第5年检查肺功能已接近正常水平。本例随访报道有助于临床医师对百草枯中毒的远期转归产生更深入的了解。

关键词：百草枯中毒 CT 运动耐力随访

乌药调控p38MAPK/ERK通路对脂多糖诱导ARDS小鼠的肺保护作用

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中华危重病急救医学 2022年第9期34卷 947-951页

作者：陆明峰范璐徐敏嵇玲徐继扬扬州大学临床医学院急诊科江苏扬州225001

目的探讨乌药对脂多糖(LPS)诱导急性呼吸窘迫综合征(ARDS)小鼠的肺保护作用及可能机制。方法将40只C57BL/6小鼠随机分为假手术组、ARDS模型组、乌药低剂量组、乌药高剂量组,每组10只。经气管注射5 mg/kg的LPS制备小鼠ARDS模型;乌药低剂... 详细信息

目的探讨乌药对脂多糖(LPS)诱导急性呼吸窘迫综合征(ARDS)小鼠的肺保护作用及可能机制。方法将40只C57BL/6小鼠随机分为假手术组、ARDS模型组、乌药低剂量组、乌药高剂量组,每组10只。经气管注射5 mg/kg的LPS制备小鼠ARDS模型;乌药低剂量组和高剂量组分别给予乌药提取物1 g/kg和5 g/kg每日1次灌胃,ARDS模型组以等量生理盐水灌胃;假手术组不进行任何处理。制模前预给药3 d,制模后继续给药2 d并处死动物,取支气管肺泡灌洗液(BALF)和肺组织。光镜下观察各组小鼠肺组织病理学改变,测肺湿/干质量比值(W/D);采用酶联免疫吸附试验(ELISA)检测小鼠血清及BALF中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)含量;采用流式细胞术检测BALF中巨噬细胞表面分子CD40表达率;采用蛋白质免疫印迹试验(Western blotting)检测肺组织p38和细胞外信号调节激酶1/2(ERK1/2)蛋白磷酸化水平变化。结果肺组织病理学显示,乌药高剂量组光镜下肺泡结构破坏、肺泡间隔增厚、炎症细胞浸润,但病理变化均较ARDS模型组减轻,而乌药低剂量组ARDS病理特征较ARDS模型组无明显改变。与假手术组比较,ARDS模型组肺W/D比值明显升高,血清及BALF中TNF-α和IL-6含量明显升高,BALF中巨噬细胞CD40表达率明显增加,肺组织p38和ERK1/2蛋白磷酸化水平明显升高。用乌药干预后,低剂量组肺组织W/D比值、血清及BALF中TNF-α和IL-6水平、BALF中巨噬细胞CD40表达率、肺组织p38和ERK1/2蛋白磷酸化水平均较ARDS模型组无明显变化;而乌药高剂量组上述指标均明显低于ARDS模型组和乌药低剂量组〔W/D比值:5.70±0.19比6.20±0.31、6.01±0.17;血清TNF-α(ng/L):83.63±15.04比111.75±18.45、108.12±13.98;血清IL-6(ng/L):111.38±8.75比244.13±26.85、227.50±9.37;BALF中TNF-α(ng/L):36.25±2.82比51.13±5.44、47.50±5.78;BALF中IL-6(ng/L):35.63±2.20比49.63±4.90、46.38±3.50;CD40表达率(%):23.28±2.45比30.32±2.40、28.17±1.98;p-p38/p38比值:0.50±0.04比0.74±0.07、0.69±0.04;p-ERK1/2/ERK1/2比值:0.47±0.07比0.72±0.07、0.68±0.05,均P<0.01〕。结论乌药能够抑制LPS诱导的ARDS小鼠肺组织炎症,减轻肺损伤,该作用机制可能与抑制p38丝裂素活化蛋白激酶/ERK(p38 MAPK/ERK)信号通路的活化有关。

关键词：乌药急性呼吸窘迫综合征炎症信号通路 p38丝裂素活化蛋白激酶细胞外信号调节蛋白激酶

Light touch in quantum:an interview with *** Haroche

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Advanced Photonics 2024年第1期6卷 10-16页

作者： Chao-Yang lu CAS Centre for Excellence in Quantum Information and Quantum Physics HefeiChina NYU Shanghai NYU-ECNU Institute of PhysicsShanghaiChina University of Science and Technology of China Department of Modern PhysicsShanghaiChina

lu:Hello,***,nice to see you again!Let us start the *** 2012,you and David Wineland won the Nobel Prize in *** you describe your work in simple terms to a general audience?And can you tell us how you were originally interested in this field and got into this study?Haroche:Maybe I should start with the second part of the question.I got interested in atomic physics when I was a student atÉcole Normale Supérieure(ENS)in Paris in the 1960s.

关键词： quantum interview Serge

Optical grade (Gd_(0.95-x)lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) ceramics with near-zero optical loss: Effects of lu^(3+) doping on structural feature, microstructure evolution, and far-red luminescence

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Journal of Advanced Ceramics 2024年第1期13卷 113-123页

作者： Zhigang Sun Ji-Guang Li Huiyu Qian Yoshio Sakka Tohru SSuzuki Bin lu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Research Center for Electronic and Optical Materials National Institute for Materials ScienceIbaraki 305-0044Japan Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

A chemical co-precipitation strategy was employed to synthesize a series of(Gd_(0.95−x)lu_(x)Eu_(0.05))_(3)Al_(5)O_(12)(x=0.1−0.95)powder phosphors,followed by vacuum sintering to achieve transparent garnet ceramic *** density functional theory indicated lu_(3)Al_(5)O_(12) was formed in priority compared with Gd_(3)Al_(5)O_(12) during solid-phase *** high-temperature sintering,the lu^(3+)substitution for Gd^(3+)suppressed point mass diffusion leading to a smaller grain *** in-line transmittances of bulk specimens with x=0.1,0.3,0.5,0.7,and 0.95 nm were~83.5%,80.1%,68.8%,73.7%,and 82.2%at 710 nm(Eu^(3+)emission center),respectively,among which the sample of x=0.1 exhibited the optical grade with near-zero optical loss in agreement with the defect-free single crystal(~100%of the theoretical transmittance).The resulting particle and ceramic materials both presented characteristic Eu^(3+)emission arising from 5D0→7FJ(J=1−4)transition,where the dominant far-red emission at~710 nm arising from ^(5)D_(0)→^(7)F_(4) transition overlapped with the absorption of phytochrome(PFR).The photoluminescence excitation and photoluminescence intensities of(Gd_(0.95−x)lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) powders and ceramics generally increased at a higher Gd^(3+)/lu^(3+)***^(3+)dopants delayed the fluorescence lifetime while the bulk samples had shorter lifetime compared to the particle *** transparent(Gd_(0.85)lu_(0.1)Eu_(0.05))3Al_(5)O_(12) ceramic phosphor exhibited good thermal stability with a high thermal quenching temperature above 533 *** designed ceramic phosphor-converted light-emitting diode had a saturation injection current of 435 mA and a current-dependent color rendering *** importantly,our report marked the developmental stage of transparent ceramic materials towards zero optical loss.

关键词： transparent ceramics garnet phosphors light-emitting diode(LED) optical properties Gibbs free energy

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brown rice

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Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi Kong Shenggao lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human *** our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated *** the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased *** vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction *** showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal *** on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy *** amino acids(AAs)in brown rice were determined by high-performance liquid *** contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of *** structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown *** formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

Engineering applications and technical challenges of active array microsystems

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 342-368页

作者： Jiaguo lu Haoran ZHU East China Research Institute of Electronic Engineering Hefei 230039China School of Electronic and Information Engineering Anhui UniversityHefei 230601China

In the post-Moore era,the development of active phased array antennas will inevitably trend towards active array *** this paper,the characteristics and composition of the active array antenna are briefly *** to the high efficiency,low profile,and light weight of the active array microsystems,the application prospects and advantages in the engineering of multi-functional airborne radar,spaceborne radar,and communication systems are ***,according to the characteristics of the post-Moore era of integrated circuits,scientific and technological problems in the active array microsystems are presented,including multi-scale,multi-signal,and multi-physics field *** challenges are also discussed,such as new architectures and algorithms,miniaturization of passive components,novel materials and processes,ultra-wideband technology,and new interdisciplinary technological *** paper is expected to inspire in-depth research on active array microsystems.

关键词： Microelectronics Heterogeneous integration Packaging materials Antenna array microsystems Multi-functional radar Communication

某基层医疗机构抗肿瘤药物超说明书用药情况调查分析

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中国医药指南 2023年第24期21卷 133-135页

作者：陆明锋古田县医院药学部福建宁德352200

目的回顾性调查某基层医疗机构近5年来抗肿瘤药物的超说明书使用情况,为肿瘤药物临床合理用药和规范化管理提供参考。方法通过医院信息系统(HIS)系统抽取、使用Excel进行数据统计,整理所得用药信息共1492条。根据药品说明书,从适应证、... 详细信息

目的回顾性调查某基层医疗机构近5年来抗肿瘤药物的超说明书使用情况,为肿瘤药物临床合理用药和规范化管理提供参考。方法通过医院信息系统(HIS)系统抽取、使用Excel进行数据统计,整理所得用药信息共1492条。根据药品说明书,从适应证、用法、用量等方面的超说明书用药情况进行评价。结果在1492条用药信息中,超说明书用药信息共111条,占7.44%。结论超说明书用药发生率相对国内其他文献资料报道的结果低,但相关管控措施有限,医疗风险尚存,仍需规范化管理的政策性指导。

关键词：抗肿瘤药物超说明书用药基层医疗机构