检索结果-南通市图书馆

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

Frontiers of Medicine 2021年第3期15卷 486-494页

作者： Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang mingfeng han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China Intensive Care Unit the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Drug Clinical Trail Institution the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Department of Respiratory Medicine the Second People’s Hospital of FuyangFuyang 236000China Department of Respiratory Medicine National Key Clinical SpecialtyBranch of National Clinical Research Center for Respiratory DiseaseXiangya HospitalCentral South UniversityXiangya Lung Cancer CenterXiangya HospitalCentral South UniversityHunan Provincial Clinical Research Center for Respiratory DiseasesChangsha 410000China Lu’an People’s Hospital Affiliated to Anhui Medical University Lu’an 237005China Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of Bengbu Medical CollegeClinical Research Center for Respiratory Disease(tumor)in Anhui ProvinceBengbu 233004China Department of Respiratory Medicine Anqing Hospital Affiliated to Anhui Medical UniversityAnqing 246000China The First Affiliated Hospital of Nanjing Medical University Nanjing 210000China Department of Rheumatology and Immunology the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Department of Oncology the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Department of Endocrinology

Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 *** attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this *** conducted a randomized,controlled,open-label multicenter trial among COVID-19 *** patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care *** cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were ***-three patients were randomized to the tocilizumab group,and 32 patients to the control *** cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events *** mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes *** patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome.

关键词： tocilizumab coronavirus disease 2019(COVID-19) cytokine storm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

安徽省阜阳市新型冠状病毒肺炎病例特征分析

引用

中国热带医学 2020年第9期20卷 861-866页

作者：王云韩明锋纪晓倩阜阳市第二人民医院安徽阜阳236000

目的分析安徽省阜阳市新型冠状病毒肺炎病例的流行病学和临床特征,为指导下一步防控措施的制定提供科学依据。方法收集阜阳市截至2020年2月14日的资料完整的新型冠状病毒肺炎病例资料,对其流行病学特征及相关临床症状进行分析。结果共收... 详细信息

目的分析安徽省阜阳市新型冠状病毒肺炎病例的流行病学和临床特征,为指导下一步防控措施的制定提供科学依据。方法收集阜阳市截至2020年2月14日的资料完整的新型冠状病毒肺炎病例资料,对其流行病学特征及相关临床症状进行分析。结果共收集120例新冠肺炎患者资料,轻型23例(19.2%),普通型73例(60.8%),重症20例(16.7%),危重症4例(3.3%),无死亡病例。男性64例(53.3%),女性56例(46.7%)。年龄范围1~82岁,主要在20~59岁之间(77.5%)。1月25日为发病最高峰,发病主要集中在1月24日—2月1日。农民最多,为60例(50.0%),其次为个体户(10.8%)和家务及待业(9.2%),学生占7.5%(9例)。3区5县均有病例发生,前三位分别为临泉县(30.8%)、阜南县(25.0%)和颍州区(14.2%)。53例(44.2%)有武汉相关暴露史。临床症状中,前三位为发热89例(74.2%)、干咳37例(30.8%)和咳痰18例(15.0%)。有4例(3.3%)存在结膜充血症状。患者从发病到首次就诊时间范围为0~13 d,中位时间1 d;发病到住院0~18 d,中位时间3.5 d;发病到确诊0~20 d,中位时间6 d。入院时,白细胞正常81例(67.5%),降低35例(29.2%),淋巴细胞降低59例(49.2%)。CT检查97例(80.8%)患者存在双侧肺炎,25例(20.8%)显示多个斑点和磨玻璃影。结论阜阳市新型冠状病毒肺炎总体特征与全国相似,但具有本地特征,相关部门应根据本地区病例的具体流行特征及相关临床特征,及时调整下一步防控和治疗策略。

关键词：新型冠状病毒肺炎流行病学特征临床特征阜阳市

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

重型/危重型新型冠状病毒肺炎患者的临床特点分析和预警模型构建

引用

中华危重病急救医学 2020年第4期32卷 401-406页

作者：许靖赵凤德韩明锋马蕾张婷阜阳市第二人民医院呼吸与危重症医学科感染病区安徽阜阳236000

目的分析新型冠状病毒肺炎(新冠肺炎)危重症患者的临床特点,构建重型/危重型预警模型,为新冠肺炎重型/危重型的预判提供一定参考。方法回顾性分析2020年1月20日至2月18日安徽省阜阳市第二人民医院收治的新冠肺炎患者临床资料,包括人口... 详细信息

目的分析新型冠状病毒肺炎(新冠肺炎)危重症患者的临床特点,构建重型/危重型预警模型,为新冠肺炎重型/危重型的预判提供一定参考。方法回顾性分析2020年1月20日至2月18日安徽省阜阳市第二人民医院收治的新冠肺炎患者临床资料,包括人口学和流行病史、入院时生命体征及血液学指标等。根据国家卫生健康委员会新冠肺炎诊疗方案的分型标准将患者分为普通型(纳入普通组)和重型/危重型(纳入重症组),比较两组间各指标的差异,并将差异存在统计学意义的变量纳入多因素二分类非条件Logistic回归分析,筛选重型/危重型的危险因素。将危险因素汇总建立预警模型,并用受试者工作特征曲线(ROC)评估预警模型在重型/危重型新冠肺炎预判中的意义。结果共收治155例新冠肺炎患者,普通型125例,重型/危重型30例。①与普通组比较,重症组患者年龄高,合并基础疾病比例高,体重指数(BMI)大,呼吸过速的比例高,并伴有持续高热、脉搏血氧饱和度(SpO2)<0.95的比例高,白细胞计数(WBC)、CD4^+T淋巴细胞、CD8+T淋巴细胞、淋巴细胞计数(LYM)明显降低,白细胞介素-6(IL-6)、C-反应蛋白(CRP)、血清淀粉样蛋白(SAA)水平及CT示肺部多叶病变比例增高;而两组间性别、是否为武汉返乡人员、吸烟史、休克指数(SI)、CD4+/CD8+比值差异均无统计学意义。②多因素Logistic回归分析显示,年龄≥60岁〔优势比(OR)=1.620,P=0.031〕、合并基础疾病(OR=1.521,P=0.044)、持续高热(OR=2.469,P=0.014)、WBC<2.0×10^9/L和(或)LYM<0.4×10^9/L(OR=3.079,P=0.006)、肺部多叶病变(OR=1.367,P=0.047)、IL-6≥30 ng/L(OR=2.426,P=0.010)是发生重型/危重型新冠肺炎的危险因素。③采取四舍五入法对各项危险因素对应的OR值进行记分,以年龄≥60岁记2分、合并基础疾病记2分、持续高热记2分、WBC<2.0×10^9/L和(或)LYM<0.4×10^9/L记3分、肺部多叶病变记1分、IL-6≥30 ng/L记2分,合计为预警模型评分,重症组预警模型评分明显高于普通组(分:9.33±2.79比5.04±2.38,t=9.010,P=0.001)。④ROC曲线分析显示,预警模型对早期筛检新冠肺炎重型/危重型患者的ROC曲线下面积(AUC)为0.944,95%可信区间(95%CI)为0.903~0.985;最佳临界值为6.5分时,敏感度为93.3%,特异度为72.0%。结论重型/危重型与普通型新冠肺炎患者之间存在诸多差异,通过建立预警模型,可以帮助早期筛选重型/危重型患者,对指导治疗有一定意义。

关键词：新型冠状病毒肺炎危险因素预警模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On equivalence of state-based potential games

引用

Science China(Information Sciences) 2024年第6期67卷 313-327页

作者： han WU Jinhuan WANG Institute of Mathematics School of ScienceHebei University of Technology

In this paper, we explore state-based potential games using the semi-tensor product of ***, applying the potential equation, we derive both a necessary and sufficient condition as well as a sufficient condition to verify whether a state-based game qualifies as a potential game. Next, we present two static equivalence conditions of state-based potential games. We then delve into dynamic equivalence. We propose a criterion that allows us to identify state-based games that are dynamically equivalent to state-based potential games and share similar dynamic properties. Ultimately, we introduce the concept of state-based networked evolutionary games. We provide a necessary and sufficient condition to ensure that a state-based networked evolutionary game can be classified as a state-based potential game.

关键词： semi-tensor product of matrices state-based potential game verification equivalence state-based networked evolutionary game

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

深入探讨《Small RTOS51中消息队列的一处隐患》

引用

单片机与嵌入式系统应用 2005年第12期5卷 20-21,28页

作者：韩明峰烟台东方电子信息产业股份有限公司

SmallRTOS51是一款重要的小型实时内核,消息队列是其提供的重要任务间通信的机制。针对其消息队列实现代码中的缺陷以及可能导致的消息丢失这一严重问题,从操作系统等待与唤醒机制理论的角度出发,剖析SmallRTOS51内核在消息队列甚至互... 详细信息

SmallRTOS51是一款重要的小型实时内核,消息队列是其提供的重要任务间通信的机制。针对其消息队列实现代码中的缺陷以及可能导致的消息丢失这一严重问题,从操作系统等待与唤醒机制理论的角度出发,剖析SmallRTOS51内核在消息队列甚至互斥型信号量等实现机制上的漏洞所在;进一步指出原内核实现方式的修改方法,以及《SmallRTOS51中消息队列的一处隐患》作者提出的第2种修改方法的完美实现。

关键词： Small RTOS51 消息队列唤醒模型隐患分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Track-before-detect for bistatic radar based on pseudo-spectrum

引用

Chinese Journal of Aeronautics 2024年第1期37卷 236-246页

作者： Tao han Gongjian ZHOU School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Marine Environmental Monitoring and Information Processing Ministry of Industry and Information TechnologyHarbin 150001China

Track-Before-Detect(TBD) is an efficient method to detect dim targets for radars. Conventional TBD usually follows an approximate motion model of the target, which may cause an inaccurate integration of the target energy. A TBD technique on basis of pseudo-spectrum in mixed coordinates adopting an accurate motion model for bistatic radar system is developed in this *** predicted position in bistatic polar plane is derived according to a nonlinear function that exactly describes the constant Cartesian velocity motion. Then around the predicted position, a pseudo-spectrum is formulated and its samples are accumulated to the integration frame for energy integration. The evolution of the state and the procedure of accumulation of the target energy are derived elaborately. The superior performance of the proposed method is demonstrated by some simulations.

关键词： Weak target detection Bistatic radar Track-before-detect Pseudo-spectrum Multiframe integration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

引用

Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： Zi-han Wang Jing Guo han-jie Guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

五彩湾矿区四号露天煤矿剥离开采工艺研究

引用

露天采矿技术 2023年第3期38卷 75-77,81页

作者：韩明峰大地工程开发(集团)有限公司北京100102

针对五彩湾矿区四号露天煤矿大部分剥离物为中硬岩石、剥离物加权平均运距较大的特点,分别提出了单斗-卡车工艺、自移式半连续工艺和半固定式半连续工艺3个工艺方案,并从技术角度对3个方案的适用性和优缺点进行分析,3个开采工艺方案均... 详细信息

针对五彩湾矿区四号露天煤矿大部分剥离物为中硬岩石、剥离物加权平均运距较大的特点,分别提出了单斗-卡车工艺、自移式半连续工艺和半固定式半连续工艺3个工艺方案,并从技术角度对3个方案的适用性和优缺点进行分析,3个开采工艺方案均适用于五彩湾矿区四号露天煤矿;采用差额投资回收期比较法和贴现值比较法分别对3个方案进行经济比较,经济指标显示自移式半连续工艺方案为经济最优方案。

关键词：露天煤矿剥离开采工艺加权平均运距自移式破碎机差额投资回收期贴现值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ probing of electron transfer at the dynamic MoS_(2)/graphene–water interface for modulating boundary slip

引用

Nano Research 2024年第8期17卷 7513-7521页

作者： Yishu han Dameng Liu State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

The boundary slip condition is pivotal for nanoscale fluid *** research has primarily focused on simulating the interaction mechanism between the electronic structure of two-dimensional materials and slip of water at the nanoscale,raising the possibility for ultralow friction flow of water at the ***,experimentally elucidating electronic interactions at the dynamic solid–liquid interface to control boundary slip poses a significant *** this study,the crucial role of electron structures at the dynamic solid–liquid interface in regulating slip length was ***,the slip length of water on the molybdenum disulfide/graphene(MoS_(2)/G)heterostructure(100.9±3.6 nm)significantly exceeded that of either graphene(27.7±2.2 nm)or MoS_(2)(5.7±3.1 nm)*** was also analyzed how electron transfer significantly affected interface *** electrons played a crucial role in determining the type and proportion of excitons at both MoS_(2)–water and MoS_(2)/G–water ***,by applying voltage,distinct photoluminescence(PL)responses at static and dynamic interfaces were discovered,achieving a 5-fold modulation in PL intensity and a 2-fold modulation in the trion to exciton intensity *** electrons transfer from the top graphene to the bottom MoS_(2)at the MoS_(2)/G–water interface,reducing surface charge ***,the reduction of electrostatic interactions between the solid and water leads to an increased slip length of water on the MoS_(2)/G *** process aids in comprehending the origin of frictional resistance at the subatomic *** work establishes a foundation for actively controlling and designing of fluid transport at the nanoscale.

关键词： two-dimensional materials solid-liquid interface photoluminescence excitons electron transfer slip length

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mixed Dead-time Effect Suppression Strategy for Modular Multilevel Converters

引用

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1075-1084页

作者： Zhi Geng Minxiao han School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China IEEE

Dead time is necessary for the coupled power switches to prevent shoot-through,especially in the modular multilevel converters(MMCs)with a large number of power *** paper proposes a dead-time effect suppression strategy for MMCs with nearest level *** operational principles of MMCs are first *** to the operational features of MMCs,the method that removes a switching signal from the coupled switches and the reduced switching frequency voltage balancing algorithms(RSFVBAs)are mixed in the proposed *** the intervals that are furthest away from the zerocrossing points(ZCP)of arm currents,the single switching signal method can completely eliminate the dead-time effect(DTE).Alternatively,the DTE is suppressed by the RSFVBA in intervals that are close to the *** the combination of the two methods,the dependence of the DTE suppression method on currents is reduced and the influences of ZCP are also released without degrading the normal operation performance of ***,the output performance of MMCs is improved and the voltage stress on the arm inductor dramatically ***,the validation of the method is verified by the simulation results with the professional tool Matlab/Simulink.

关键词： Dead-time effect modular multilevel converters switching frequency voltage balancing algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：