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Three-phase Enriched Environment Improves Post-stroke Gait Dysfunction via Facilitating Neuronal Plasticity in the Bilateral Sensorimotor Cortex:A Multimodal MRI/PET Analysis in Rats

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Neuroscience Bulletin 2024年第6期40卷 719-731页

作者： Yun Lu Ziyue lin mingcong li Yuming Zhuang Binbin Nie Jianfeng Lei Yuanyuan Zhao Hui Zhao School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China Beijing Key Lab of TCM Collateral Disease Theory Research Beijing100069China Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Medical Imaging Laboratory of Core Facility Center Capital Medical UniversityBeijing100069China

The three-phase Enriched Environment(EE)paradigm has been shown to promote post-stroke functional improvement,but the neuronal mechanisms are still *** this study,we applied a multimodal neuroimaging protocol combining magnetic resonance imaging(MRI)and positron emission tomography(PET)to examine the effects of post-ischemic EE treatment on structural and functional neuroplasticity in the bilateral sensorimotor *** were subjected to permanent middle cerebral artery *** motor function of the rats was examined using the DigiGait *** was applied to investigate the EE-induced structural modifications of the bilateral sensorimotor cortex.[^(18)F]-fluorodeoxyglucose PET was used to detect glucose *** oxygen level-dependent(BOLD)-functional MRI(fMRI)was used to identify the regional brain activity and functional connectivity(FC).In addition,the expression of neuroplasticity-related signaling pathways including neurotrophic factors(BDNF/CREB),axonal guidance proteins(Robo1/Slit2),and axonal growth-inhibitory proteins(NogoA/NgR)as well as downstream proteins(RhoA/ROCK)in the bilateral sensorimotor cortex were measured by Western *** results showed the three-phase EE improved the walking *** T2 mapping imaging and diffusion tensor imaging demonstrated that EE benefited structure integrity in the bilateral sensorimotor ***-MRI fused images showed improved glucose metabolism in the corresponding regions after EE ***,the BOLD-based amplitude of low-frequency fluctuations showed that EE increased spontaneous activity in the bilateral motor cortex and ipsilateral sensory *** addition,FC results showed increased sensorimotor connectivity in the ipsilateral hemisphere and increased interhemispheric motor cortical connectivity and motor cortical-thalamic connectivity following EE *** addition,a strong correlation was found between increased functional connectivity and improv

关键词： Enriched environment Gait function Neuronal plasticity Structural integrity Glucose metabolism Functional connectivity Microenvironmental molecules Axonogenesis

Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil

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Pedosphere 2022年第4期32卷 637-648页

作者： Weifeng SONG Aiping SHU Jiai liU Wenchong SHI mingcong li Wenxue ZHANG Zuzhang li Guangrong liU Fusheng YUAN Shuxin ZHANG Zengbing liU Zheng GAO State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai'anChina College of life Sciences Shandong Agricultural UniversityTai'anChina Institute of Soil and Fertilizer&Resource and Environment/National Engineering and Technology Research Center for Red Soil Improvement Nanchang330200China

In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and *** chemical fertilizers with organic fertilizers can effectively alleviate these ***,the effects of alternative organic fertilizers remain *** explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,*** results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil *** organic substitution also had positive effects on rice *** findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future.

关键词： bacterial community double-cropping rice organic matter rice yield soil acidification,soil property

微生物菌肥在植物减肥增效中的应用研究进展:以果树为例

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微生物学通报 2024年第11期51卷 4394-4415页

作者：王佳李明聪山东农业大学生命科学学院山东泰安271000 山东农业大学园艺科学与工程学院山东泰安271000

在国内外积极发展绿色农业的背景下,生产绿色优质农产品已成为当今农业绿色发展新趋势。然而,果树栽培中仍存在化肥农药过量施用的问题,造成农田生态环境严重污染,果实品质下降,进而危害人体健康。微生物菌肥是一类能够改良土壤生态、... 详细信息

在国内外积极发展绿色农业的背景下,生产绿色优质农产品已成为当今农业绿色发展新趋势。然而,果树栽培中仍存在化肥农药过量施用的问题,造成农田生态环境严重污染,果实品质下降,进而危害人体健康。微生物菌肥是一类能够改良土壤生态、促进植物生长发育的新型绿色肥料,含有多种有益活性微生物,有助于改善农田生态环境,提高果实产量和品质,实现植物种植减肥增效。以往有关微生物菌肥的研究多局限于少数几种菌或单一植物领域,缺乏对微生物菌肥作用机制及功效的系统探讨。本文综合梳理了微生物菌肥改良土壤生态和提高植物抗病/抗逆的作用机制,并以果树为例,重点阐述微生物菌肥在提高果实产量和品质、改善农业生态环境的应用,同时指出技术瓶颈,提出新的研究思路和方向,为改善农业生态环境、促进现代农业可持续发展提供理论指导。

关键词：微生物菌肥减肥增效机制果树产量和品质应用

无人运输船舶的直线航迹反步自适应滑模控制(英文)

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系统仿真学报 2018年第11期30卷 4448-4453,4461页

作者：李明聪郭晨袁毅大连海事大学、船舶电气工程学院辽宁大连116026

随着无人船技术的发展,智能控制逐渐运用到大型无人运输船舶上。在船舶航行过程中,经常会受到一些非线性因素的干扰。基于船舶运动的Norbbin非线性数学模型和李雅普诺夫稳定性理论在闭环控制系统中的应用,提出一种新型滑模控制方法,并... 详细信息

随着无人船技术的发展,智能控制逐渐运用到大型无人运输船舶上。在船舶航行过程中,经常会受到一些非线性因素的干扰。基于船舶运动的Norbbin非线性数学模型和李雅普诺夫稳定性理论在闭环控制系统中的应用,提出一种新型滑模控制方法,并和反步法相结合,在扰动界已知的前提下设计一种反步滑模控制器,控制船舶的航迹。当扰动界未知时,提出一种自适应反步滑模的控制方法。最后运用Matlab对"大智"智能运输船模型进行仿真,控制方法和PID控制进行对比,结果表明自适应反步滑模控制比PID控制的稳定性更强,响应更快。

关键词：无人运输船舶非线性因素自适应反步滑模直线航迹

Distribution and diversity of bacterioplankton communities in subtropical seawater around Xiamen Island,China

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Distribution and diversity of bacterioplankton communities i...

东亚冬夏季风关系在1970s末的年代际转变

福建省海洋学会2016年学术年会

作者： Dapeng Shan Guangshan Wei mingcong li Wanpeng Wang Xu li Zheng Gao Zongze Shao Key Laboratory of Marine Biogenetic Resources Third Institute of OceanographyState Oceanic Administration State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural University

Marine bacterioplankton communities have profound impact on global biogeochemical cycles and ecological *** have been widely performed in seawater of different latitudes,yet relatively little is known about the diversity of bacterioplankton assemblages and the factors shaping their spatial distribution in subtropical ***,we investigated the bacterial communities in such a subtropical region,Xiamen Island,using quantitative PCR(qPCR) and 454 pyrosequencing *** qPCR results showed that there were higher 16 S rRNA gene abundance in nitrogen and phosphorus-rich *** evidenced that a total of 267 genera of 47 classes in 26 different phyla(or candidate phyla) and some unclassified bacteria were obtained from 52034 high-quality *** most dominant phylum was Proteobacteria,followed by Bacteroidetes,Actinobacteria,Firmicutes,Verrucomicrobia and ***- and Gammaproteobacteria were the most predominant classes,and the most abundant OTU was affiliated with SAR11 clade,followed by Rhodobacteraceae and *** analysis(RDA) revealed that total nitrogen and phosphorus were the critical controlling factors to influence the bacterioplankton communities in Xiamen *** results will provide insights into bacterial abundance,diversity and distribution patterns,as well as their controlling factors,in subtropical marine ecosystems.

关键词： bacterioplankton diversity pyrosequencing subtropical seawater Xiamen Island environmental factors

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气象科学 2017年第3期37卷 329-338页

作者：李明聪李栋梁南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心南京210044

利用NCEP/NCAR和Hadley中心的大气与海洋再分析资料,选取具有代表性的东亚冬、夏季风指数,采用滑动相关和线性回归等方法,主要讨论了受ENSO影响的东亚冬季风分量和后期夏季风之间关系的年代际变化,并分析了二者关系发生变化的原因。结... 详细信息

利用NCEP/NCAR和Hadley中心的大气与海洋再分析资料,选取具有代表性的东亚冬、夏季风指数,采用滑动相关和线性回归等方法,主要讨论了受ENSO影响的东亚冬季风分量和后期夏季风之间关系的年代际变化,并分析了二者关系发生变化的原因。结果表明:在1965—1979年,受ENSO影响的冬季风与后期夏季风强度的对应关系并不明显。在1980—2004年,受ENSO影响的冬季风强,对应后期的夏季风偏弱,弱冬季风对应的后期夏季风偏强。当受ENSO影响的冬季风较强时,冬季在对流层低层西北太平洋出现了异常气旋并可以维持到次年夏季,低纬地区位势高度偏低,削弱了西太平洋副热带高压,异常气旋西部的偏北气流阻碍了西南风的北进,导致夏季风偏弱。海表温度异常在1980年前后春、夏季不同的分布型可以解释环流在不同时段内的差异。

关键词：东亚冬季风东亚夏季风相关关系年代际变化

补阳还五汤对脑缺血大鼠梗死灶周围脑区新生神经细胞增殖、分化及Wnt/β-catenin信号通路的影响

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北京中医药大学学报 2021年第11期44卷 1002-1010页

作者：张琪李慢中冯雪枫李明聪赵晖中国中医科学院中医药信息研究所北京100700 首都医科大学附属北京世纪坛医院首都医科大学中医药学院

目的观察补阳还五汤对脑缺血再灌注大鼠梗死灶周围皮层新生细胞增殖、分化及Wnt/β-连环蛋白(β-catenin)信号通路关键蛋白在新生细胞表达的影响。方法将SD大鼠按随机数字表法分为假手术组、模型组、补阳还五汤组,每组9只。采用线栓法... 详细信息

目的观察补阳还五汤对脑缺血再灌注大鼠梗死灶周围皮层新生细胞增殖、分化及Wnt/β-连环蛋白(β-catenin)信号通路关键蛋白在新生细胞表达的影响。方法将SD大鼠按随机数字表法分为假手术组、模型组、补阳还五汤组,每组9只。采用线栓法制备大脑中动脉缺血再灌注模型。造模后24 h,补阳还五汤组灌胃补阳还五汤水煎液16.1 g/kg,每日1次,连续给药30 d。于造模后第3天开始腹腔注射5-溴脱氧尿嘧啶核苷(BrdU),活体标记梗死灶周围皮层新生细胞。分别于造模后第9、15、30天取材。采用免疫荧光双标结合图像分析技术,检测各组大鼠梗死灶周围皮层BrdU阳性细胞、双标BrdU/胶质纤维酸性蛋白(GFAP)、BrdU/微管相关蛋白2(MAP-2)、BrdU/Wnt、BrdU/β-catenin、BrdU/散乱蛋白(Dishevelled)阳性细胞。结果补阳还五汤组大鼠脑缺血再灌注9、15、30 d,梗死灶周围皮层BrdU+细胞数均较同时点模型组大鼠增加(P<0.01),双标BrdU+/GFAP+细胞数较模型组减少(P<0.01);缺血再灌注9、15 d,补阳还五汤组大鼠梗死灶周围皮层双标BrdU+/MAP-2+细胞数较模型组增加(P<0.01)。与同时点模型组比较,脑缺血再灌注9 d,补阳还五汤组大鼠梗死灶周围皮层双标BrdU+/Wnt+细胞数增加(P<0.05);脑缺血再灌注15 d,补阳还五汤组大鼠梗死灶周围皮层双标BrdU+/Dishevelled+、BrdU+/β-catenin+细胞数增加(P<0.05);脑缺血再灌注30 d,补阳还五汤组大鼠梗死灶周围皮层双标BrdU+/Wnt+、BrdU+/Dishevelled+、BrdU+/β-catenin+细胞数均增加(P<0.05或P<0.01)。结论补阳还五汤可激活脑缺血再灌注大鼠梗死灶周围皮层组织新生细胞增殖,抑制新生细胞向胶质细胞分化,促进新生细胞向神经元分化,并可增强新生细胞Wnt、β-catenin、Dishevelled蛋白的表达。

关键词：补阳还五汤脑缺血神经发生 Wnt/β-catenin信号通路细胞增殖大鼠

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu mingcong Tang Jie Wu Kouer Zhang Wenzhi li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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无人运输船舶及其智能控制综述

船舶工程 2019年第1期41卷 1-5页

作者：李明聪郭晨袁毅大连海事大学船舶电气工程学院辽宁大连116026

讨论无人运输船舶的国内外研究现状、特征和发展的必要性。阐述无人运输船舶的几项关键技术,如智能控制、通信系统架构和岸基支持系统。对无人运输船舶的未来发展进行展望。

关键词：无人运输船舶智能控制通信系统岸基支持系统