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Emerging role of regulated cell death in intestinal failure-associated liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 228-233页

作者： Si-Yang Cheng Lu Jiang Ying Wang Wei cai Department of Pediatric Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai 200092China Shanghai Institute for Pediatric Research Shanghai 200092China Division of Pediatric Gastroenterology and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and *** is mainly characterized by cholestasis in children and steatohepatitis in ***,there is no effective approach to prevent or reverse the *** cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver *** cell death is reclassified into several types,based on the mechanisms and morphological *** evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver *** studies have shown that different modes of RCD are present in animal models and patients with *** the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in *** this review,we discuss the current knowledge on how RCD may link to the pathogenesis of *** highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.

关键词： Parenteral nutrition Apoptosis Necroptosis Cholestasis Steatosis

Biomimetic Erythrocyte-Like Particles from Microfluidic Electrospray for Tissue Engineering

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Engineering 2024年第9期40卷 78-86页

作者： Zhiqiang Luo Lijun cai Hanxu Chen Guopu Chen Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Microparticles have demonstrated value for regenerative *** in this field tend to focus on the development of intelligent multifunctional microparticles for tissue ***,inspired by erythrocytes-associated self-repairing process in damaged tissue,we present novel biomimetic erythrocyte-like microparticles(ELMPs).These ELMPs,which are composed of extracellular matrix-like hybrid hydrogels and the functional additives of black phosphorus,hemoglobin,and growth factors(GFs),are generated by using a microfluidic *** the resultant ELMPs have the capacity for oxygen delivery and near-infrared-responsive release of both GFs and oxygen,they would have excellent biocompatibility and multifunctional performance when serving as microscaffolds for cell adhesion,stimulating angiogenesis,and adjusting the release profile of *** on these features,we demonstrate that the ELMPs can stably overlap to fill a wound and realize controllable cargo release to achieve the desired curative effect of tissue ***,we consider our biomimetic ELMPs with discoid morphology and cargo-delivery capacity to be ideal for tissue engineering.

关键词： Biomimetics Erythrocyte Tissue engineering Microfluidics Electrospray oxygen delivery

Microstructure and impact behavior of Mg-4Al-5RE-xGd cast magnesium alloys

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Journal of Magnesium and Alloys 2024年第5期12卷 1799-1814页

作者： Jie Wei Qudong Wang Huisheng cai Mahmoud Ebrahimi Chuan Lei National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This work investigated the microstructure and impact behavior of Mg-4Al-5RE-xGd(RE represents La-Ce mischmetal;x=0,0.2,0.7 wt.%)alloys cast by high-pressure die casting(HPDC),permanent mold casting(PMC),and sand casting(SC)*** results indicated that with increasing Gd content,the grain sizes of the HPDC alloy had a slight change,but the grains of the PMC and SC alloys were significantly ***,the acicular Al_(11)RE_(3)phase was modified into the short-rod shape under the three casting *** impact toughness of the studied alloy was mainly dominated by the absorbed energy during the crack *** increasing Gd content,the impact toughness of the studied alloy monotonically increased due to the lower tendency of the modified second phase toward crack *** impact stress was higher than the tensile stress,exhibiting a strain rate sensitivity for the mechanical response;however,the HPDC alloy had an inconsistent strain rate sensitivity during the impact event due to the transformation of the deformation mechanism from twinning to slip with increasing *** dimples covered the fracture surface of the fine-grained HPDC alloys,indicating a typical ductile ***,due to the deficient{1012}twinning activity and the suppressed grain boundary sliding during the impact event,the HPDC alloys showed insufficient plastic deformation capacity.

关键词： Mg-Al-RE alloy Gadolinium Microstructure Impact behavior

Coherence entropy during propagation through complex media

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Advanced Photonics 2024年第4期6卷 25-35页

作者： Xingyuan Lu Zhuoyi Wang Qiwen Zhan Yangjian cai Chengliang Zhao Soochow University School of Physical Science and TechnologyJiangsu Key Laboratory of Frontier Material Physics and DevicesSuzhouChina University of Shanghai for Science and Technology School of Optical-Electrical and Computer EngineeringShanghaiChina Shandong Normal University School of Physics and ElectronicsShandong Provincial Engineering and Technical Center of Light ManipulationsShandong Provincial Key Laboratory of Optics and Photonic DeviceJinanChina East China Normal University Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal UniversityShanghaiChina

The deformation,flicker,and drift of a light field owing to complex media such as a turbulent atmosphere have limited its practical ***,research on invariants in randomly fluctuated light fields has garnered considerable attention in recent *** is a statistical property of light,while its full and quantitative characterization is ***,we successfully realize the orthogonal modal decomposition of partially coherent beams and introduce the application of coherence entropy as a global coherence characteristic of such randomly fluctuated light *** is demonstrated that coherence entropy remains consistent during propagation in a unitary system by unraveling complex *** representative examples,we study the robustness of coherence entropy for partially coherent beams as they propagate through deformed optical systems and turbulent *** entropy is anticipated to serve as a key metric for evaluating the propagation of partially coherent beams in complex *** study paves the way for a broader application scope of a customized low-coherence light field through nonideal optical systems and complex media.

关键词： complex media propagation invariant modal decomposition orbital angular momentum statistical optics coherence

Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol

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Chinese Chemical Letters 2024年第7期35卷 276-280页

作者： Ming Huang Xiuju cai Yan Liu Zhuofeng Ke School of pharmacy School of clinical pharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Materials Science&Engineering PCFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with *** simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary ***,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and *** reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

关键词： Ru complexes Methanol Ketones β-Methylated secondary alcohols Transfer hydrogenation

Low-cycle fatigue behavior of solutionized and aged WE43 magnesium alloys at room temperature

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Journal of Magnesium and Alloys 2024年第6期12卷 2284-2297页

作者： Yong cai Jianxiong Wei Hong Yan Yipeng Chen Rongshi Chen School of Materials Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang 110016China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China

The low-cycle fatigue behavior of solutionized(T4)and aged(T6)WE43 magnesium alloys was studied at room *** total strain amplitudes(△ε_(t)/2)were 0.4%,0.5%,0.6%,0.7%and 1.0%.Detailed microstructure evolution was characterized by scanning electron microscope(SEM),electron backscattered diffraction(EBSD)and transmission electron microscopy(TEM).The results showed that plastic strain amplitude decreased with the increasing cycle number in T4 alloy,which is due to the dense persistent slip bands(PSBs)and dynamic precipitates hinderingdislocation *** contrast,the plastic strain amplitude increases gradually in T6 alloy,which is attributed to the enhanced activation of pyramidal *** low-cycle fatigue life of T6 alloy with larger fatigue ductility coefficient is longer than that of T4 *** Coffin-Manson model can accurately predict the fatigue life of T4 and T6 alloys compared to Jahed-Varvani(JV)energy *** T4 alloy,the fatigue damage mechanism was dominated by basal *** T6 alloy,the enhanced pyramidal slip plays an important role to accommodate plastic deformation.

关键词： Low-cycle fatigue WE43 alloy Cyclic hardening/softening JV model Dislocation

Solving Multi-objective Vehicle Routing Problems with Time Windows: A Decomposition-Based Multiform optimization Approach

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Tsinghua Science and Technology 2024年第2期29卷 305-324页

作者： Yiqiao cai Zifan Lin Meiqin Cheng Peizhong Liu Ying Zhou Xiamen Key Laboratory of Data Security and Blockchain Technology College of Computer Science and TechnologyHuaqiao UniversityXiamen361021China College of Engineering Huaqiao UniversityQuanzhou362000China School of Computer Sciences Shenzhen Institute of Information TechnologyShenzhen518000China

In solving multi-objective vehicle routing problems with time windows (MoVRPTW),most existing algorithms focus on the optimization of a single problem formulation. However,little effort has been devoted to exploiting valuable knowledge from the alternate formulations of MoVRPTW for better optimization performance. Aiming at this insufficiency,this study proposes a decomposition-based multi-objective multiform evolutionary algorithm (MMFEA/D),which performs the evolutionary search on multiple alternate formulations of MoVRPTW simultaneously to complement each other. In particular,the main characteristics of MMFEA/D are three folds. First,a multiform construction (MFC) strategy is adopted to construct multiple alternate formulations,each of which is formulated by grouping several adjacent subproblems based on the decomposition of MoVRPTW. Second,a transfer reproduction (TFR) mechanism is designed to generate offspring for each formulation via transferring promising solutions from other formulations,making that the useful traits captured from different formulations can be shared and leveraged to guide the evolutionary search. Third,an adaptive local search (ALS) strategy is developed to invest search effort on different alternate formulations as per their usefulness for MoVRPTW,thus facilitating the efficient allocation of computational resources. Experimental studies have demonstrated the superior performance of MMFEA/D on the classical Solomon instances and the real-world instances.

关键词： MoVRPTW multiform optimization multiform construction knowledge transfer adaptive local search

The gold-telluride connection:Evidence for multiple fluid pulses in the Jinqingding telluride-rich gold deposit of Jiaodong Peninsula,Eastern China

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Geoscience Frontiers 2024年第3期15卷 146-165页

作者： Wenyan cai mingchun Song M.Santosh Jian Li School of Resources and Environmental Engineering Shandong University of TechnologyZibo 255049China Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China School of Earth Sciences and Resources China University of Geosciences Beijing29 Xueyuan RoadBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA 5005Australia

The mechanism of gold migration,enrichment,and precipitation in forming world-class gold deposits has been a topic of wide interest,particularly where these deposits are abundant in *** Jiaodong Peninsula in eastern China hosts some of the world-class gold deposits among which the Jinqingding deposit is one of the best examples with substantial telluride mineralization and thus provides opportunity to investigate the genetic connection between tellurium and gold *** orebody in this deposit is hosted in the NE-NNE-trending Jiangjunshi-Quhezhuang fault with the Jurassic Kunyushan granitic pluton as wall *** deposit involved three mineralization stages as inferred from assemblages and crosscutting relationships between *** stages are:(I)pre-ore gold-poor quartz-pyrite veins,(II)main ore auriferous quartz-pyrite-Te/Bi-minerals±sphalerite±chalcopyrite±barite±marcasite veins,and(III)post-ore quartz-calcite *** present here the textural,isotopic,and geochemical variations of different stages/generations of pyrite based on scanning electron microscopy-energy dispersive spectroscopy(SEM-EDS),electron probe microanalysis(EPMA),and laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS).Pyrite in the Jinqingding deposit displays distinct ***1a shows a porous and dissolution-reprecipitation texture in the core,whereas Py1b exhibits a smooth and flat *** analysis reveals contrasting elemental compositions,with Py1a characterized by low Au(avg.0.14 ppm),As(avg.15.57 ppm),Ag(avg.17.71 ppm),and Te(avg.19.22 ppm)contents,but elevated Co(avg.1068.10 ppm)and Ni(224.12 ppm)concentrations,and variable sulfur isotopic composition(δ^(34)SV-CDT=9.54‰-12.12‰).Conversely,Py1b displays increased concentrations of these elements and a more concentratedδ^(34)SV-CDT value(11.99‰-12.23‰),possibly associated with weak coupled dissolution-reprecipitation(CDR)*** Stage II,pyrite can be further categorized

关键词： Episodic fluid pulses Sulfur reservoir Gold-Te precipitation Jinqingding deposit Jiaodong Peninsula

Transient Monte Carlo simulation of phonon transport in silicon nanofilms with the local heat source

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Science China(Technological Sciences) 2024年第7期67卷 2087-2098页

作者： LI JiaQi cai JiuQing LI Rui LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China Wuhan Second Ship Design and Research Institute Wuhan 430205China

Accurate prediction of junction temperature is crucial for the efficient thermal design of silicon nano-devices. In nano-scale semiconductor devices, significant ballistic effects occur due to the mean free path of phonons comparable to the heat source size and device scale. We employ a three-dimensional non-gray Monte Carlo simulation to investigate the transient heat conduction of silicon nanofilms with both single and multiple heat sources. The accuracy of the present method is first verified in the ballistic and diffusion limits. When a single local heat source is present, the width of the heat source has a significant impact on heat conduction in the domain. Notably, there is a substantial temperature jump at the boundary when the heat source width is 10 *** increasing heat source width, the boundary temperature jump weakens. Furthermore, we observe that the temperature excitation rate is independent of the heat source width, while the temperature influence range expands simultaneously with the increase in heat source width. Around 500 ps, the temperature and heat flux distribution in the domain stabilize. In the case of dual heat sources, the hot zone is broader than that of a single heat source, and the temperature of the hot spot decreases as the heat source spacing increases. However, the mean heat flux remains unaffected. Upon reaching a spacing of 200 nm between the heat sources, the peak temperature in the domain remains unchanged once a steady state is reached. These findings hold significant implications for the thermal design of silicon nano-devices with local heat sources.

关键词： phonon transport Monte Carlo simulation transient heat conduction silicon nanofilms local heat source