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Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization

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Science China(Life Sciences) 2018年第10期61卷 1178-1188页

作者： Jingyuan yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan yang mingcan yang Tan Ju Wen Zeng Chuhong Zhu Department of Anatomy State Key Laboratory of Trauma Burn and Combined Injury National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University

The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency.

关键词： tissue-engineered blood vessels (TEBVs) icariin β-cyclodextrin sulfate anticoagulation endothelialization

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Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea

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Bioactive Materials 2023年第11期29卷 265-278页

作者： Yansha Hao Jingting Zhou Ju Tan Feng Xiang Zhongliang Qin Jun Yao Gang Li mingcan yang Lingqin Zeng Wen Zeng Chuhong Zhu Department of Anatomy Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqingkey Lab for Biomechanics and Tissue Engineering of ChongqingThird Military Medical UniversityChongqing400038China Engineering Research Center of Tissue and Organ Regeneration and Manufacturing Ministry of EducationChongqing400038China State Key Laboratory of Traum1 Burnand Combined InjuryChongqingChina Department of Cell Biology Third Military Army Medical UniversityChongqing400038China Hong Chang Biotechnology Co. LtdGuangzhou510700China Zhong Zhi Yi Gu Research Institute Chongqing Jiukang Medical Research Institute Co.Ltd..China

Cross-linking agents are frequently used to restore corneal properties after decellularization,and it is especially important to select an appropriate method to avoid excessive *** addition,how to promote wound healing and how to improve scar formation require further *** ensure the safety and efficacy of animal-derived products,we designed bioartificial corneas(BACs)according to the criteria for Class III medical *** BACs do not require cross-linking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid(AHA)and carboxymethyl chitosan(CMC)on the surface of decellularized porcine corneas(DPCs).The results showed that the BACs had good biocompatibility and transparency,and the modification enhanced their antibacterial and anti-inflammatory properties in *** animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a *** 3 months,the BACs were gradually filled with epithelial,stromal,and neuronal cells,and after 6 months,their transparency and histology were almost *** addition,side effects such as corneal neovascularization,conjunctival hyperemia,and ciliary body hyperemia rarely occur in ***,these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time.

关键词： Decellularization Bioartificial cornea Cross-linking Biocompatibility Transparency

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Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

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Bioactive Materials 2021年第12期6卷 4415-4429页

作者： Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan yang mingcan yang Ju Tan Wen Zeng Chuhong Zhu Department of Anatomy State Key Laboratory of TraumaBurn and Combined InjuryKey Lab for Biomechanics and Tissue Engineering of ChongqingArmy Medical University(Third Military Medical University)Chongqing400038China Chongqing Institute of Zhong Zhi Yi Gu Shapingba DistrictChongqing400030China Department of Cell Biology Third Military Army Medical UniversityChongqing400038China

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant *** spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic ***,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction *** vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on *** cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also ***,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and *** conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI.

关键词： Stem cell-laden splenic hydrogel hiPSC differentiation platform Antioxidant stress Myocardial infarction Cardiac repair

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基于深度学习的区域RC框架结构震损评估方法研究

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建筑结构学报 2020年第S2期41卷 27-35页

作者：韩小雷吴梓楠杨明灿季静华南理工大学土木与交通学院广东广州510641 华南理工大学亚热带建筑科学国家重点实验室广东广州510641

为快速评估钢筋混凝土(RC)框架结构在地震作用下的损伤程度,提出基于深度学习和构件变形的区域RC框架结构地震损伤评估方法。以场地类别、抗震设防烈度、结构层数、标准层层高、X向跨度、X向跨数和Y向跨数共7个结构特征参数为变量,设计... 详细信息

为快速评估钢筋混凝土(RC)框架结构在地震作用下的损伤程度,提出基于深度学习和构件变形的区域RC框架结构地震损伤评估方法。以场地类别、抗震设防烈度、结构层数、标准层层高、X向跨度、X向跨数和Y向跨数共7个结构特征参数为变量,设计符合我国现行规范要求的2592个典型框架结构,并进行动力增量弹塑性时程分析(IDA)。将震损指标参数划分为构件震损指标及结构宏观响应两个层次,构件震损指标为梁、柱构件处于7个性能状态的数量占比,结构宏观响应包含最大层间剪力、最大层间位移角、残余层间位移角和最大水平位移,并根据分析结果共提取66208组楼层震损数据。最后引入深度前馈神经网络构建结构特征参数与震损指标参数间的非线性映射关系,建立区域RC框架结构震损评估模型。震损评估结果表明,区域RC框架结构震损评估模型可反映各楼层梁柱构件性能状态的分布规律,并能够较好地预测结构宏观响应,为量化区域建筑群的地震损失奠定基础。

关键词：钢筋混凝土框架结构区域震损评估深度学习构件变形

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Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes

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Bioactive Materials 2022年第1期7卷 466-477页

作者： Yanzhao Li Yeqin Wang Fangchao Xue Xuli Feng Zhaojing Ba Junjie Chen Zhenhua Zhou Yanhong Wang Ge Guan Guanyuan yang Ziwei Xi Hao Tian Yong Liu Ju Tan Gang Li Xiewan Chen mingcan yang Wen Chen Chuhong Zhu Wen Zeng Department of Anatomy National and Regional Engineering Laboratory of Tissue EngineeringState and Local Joint Engineering Laboratory for Vascular ImplantsKey Lab for Biomechanics and Tissue Engineering of ChongqingThird Military Medical UniversityChongqing400038China Department of Cell Biology Third Military Army Medical UniversityChongqing400038China Innovative Drug Research Centre of Chongqing University Chongqing401331China Departments of Neurology Southwest HospitalThird Military Medical UniversityChongqingChina Medical English Department Third Military Medical UniversityChongqing400038China The 8th Medical Center of Chinese PLA General Hospital Beijing100091China Department of Plastic and Aesthetic Surgery Southwest HospitalThird Military Medical UniversityChongqingChina State Key Laboratory of Trauma Burn and Combined InjuryChongqingChina

Small-diameter tissue-engineered vascular grafts(sdTEVGs)with hyperglycemia resistance have not been *** intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of ***,inspired by bionic regulation of nerve on vascular,we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells(VSMCs).The transformation was a prime culprit causing the intimal hyperplasia of *** address this concern,sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin *** external primary Reactive Oxygen Species(ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under ***,the internal secondary ATP-responsive DENND1A(guanine nucleotide exchange factor)system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural *** results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after *** day 90,the abnormal VSMCs phenotype was not detected in the sdTEVGs,which maintained long-time patency without intima *** study provides new insights to construct vascular grafts resisting hyperglycemia damage.

关键词： sdTEVGs On-demand programmed responsive systems Neural exosomes Nerve reconstruction Intimal hyperplasia

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钢筋混凝土框架结构震损预测模型参数敏感性

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哈尔滨工程大学学报 2023年第4期44卷 563-571页

作者：韩小雷蔡燕飞杨明灿季静华南理工大学、亚热带建筑科学国家重点实验室广东广州510640 华南理工大学土木与交通学院广东广州510640

应用机器学习算法进行钢筋混凝土框架结构地震易损性评估时,结构特征参数冗杂且无法便捷选取,针对此问题本文采用基于神经网络的敏感性分析方法,利用2个训练有素的神经网络模型,分别从结构层次和构件层次探究了不同输入参数对结构震损... 详细信息

应用机器学习算法进行钢筋混凝土框架结构地震易损性评估时,结构特征参数冗杂且无法便捷选取,针对此问题本文采用基于神经网络的敏感性分析方法,利用2个训练有素的神经网络模型,分别从结构层次和构件层次探究了不同输入参数对结构震损指标的影响大小。进行敏感性分析的参数包括5个几何参数(结构层数、标准层高度、X向跨度、X向跨数、Y向跨数)、2个设计参数(抗震设防烈度、场地类别)和1个地震动参数(地面峰值加速度)。结果表明:平面尺寸参数对结构及构件层次的震损指标敏感性均较小。剔除敏感性较小的参数后,在重要震损指标的预测上仍然有较高的准确性,为钢筋混凝土框架结构的震损预测提供了更简便的参数输入依据。

关键词：神经网络敏感性分析钢筋混凝土框架结构地震易损性结构特征参数机器学习震损预测震损指标

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Vibration properties of Paulownia wood for Ruan sound quality using machine learning methods

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Journal of Forestry Research 2024年第5期35卷 216-222页

作者： yang yang College of Art and Design Harbin UniversityHarbin 150076People’s Republic of China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin 150040People’s Republic of China

As an important material for manufacturing resonant components of musical instruments,Paulownia has an important influence on the sound quality of *** this paper,a model for evaluating the sound quality of Ruan based on the vibration characteristics of wood is developed using machine learning ***,the selection of materials for Ruan manufacturing relies primarily on manually weighing,observing,striking,and listening by the instrument *** in scientific theory have hindered the quality of the finished *** this study,nine Ruans were manufactured,and a prediction model of Ruan sound quality was proposed based on the raw material information of *** of a total of 180 data sets,145 and 45 sets were chosen for training and validation,*** this paper,typical correlation analysis was used to determine the correlation between two single indicators in two adjacent pairwise combinations of the measured objects in each stage of the production process in *** vibra-tion characteristics of the wood were tested,and a model for predicting the evaluation of Ruan’s acoustic qualities was developed by measuring the vibration characteristics of the resonating plate *** acoustic quality of the Ruan sound board wood was evaluated and predicted using machine learning model generalized regression neural *** results show that the prediction of Ruan sound quality can be achieved using Matlab simulation based on the vibration characteristics of the soundboard *** the model-predicted values were compared with the tradi-tional predicted results,it was found that the generalized regression neural network had good performance,achieving an accuracy of 93.8%which was highly consistent with the experimental *** was concluded that the model can accurately predict the acoustic quality of the Ruan based on the vibration performance of the soundboards.

关键词： Sound quality Wood vibration performance Paulownia wood Machine learning methods

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Overview of radar detection methods for low altitude targets in marine environments

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Journal of Systems Engineering and Electronics 2024年第1期35卷 1-13页

作者： yang Yong yang Boyu School of Electronic Science National University of Defense TechnologyChangsha 410073China

In this paper,a comprehensive overview of radar detection methods for low-altitude targets in maritime environments is presented,focusing on the challenges posed by sea clutter and multipath *** performance of the radar detection methods under sea clutter,multipath,and combined conditions is categorized and summarized,and future research directions are outlined to enhance radar detection performance for low-altitude targets in maritime environments.

关键词： radar sea clutter multipath scattering detection low altitude target

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Fresh-Keeping Decision and Coordination of Fresh Agricultural Product Supply Chain Considering Carbon Cap-and-Trade under Different Dominance

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 30-51页

作者： yang yang Guanxin Yao China Institute for Agricultural Equipment Industrial Development Jiangsu UniversityZhenjiang212013China Jiangsu Modern Logistics Research Base Yangzhou UniversityYangzhou225009China

In the context of low carbon,this paper discussed the impact of the carbon cap-and-trade policy on the fresh-keeping decision-making of two-echelon fresh agricultural product supply chains under different dominance,and designed cost-sharing contracts to coordinate the supply chain of fresh agricultural products dominated by suppliers and retailers *** results showed that:dominance has no effect on the fresh-keeping decision and total revenue of fresh agricultural product supply chain,but it affects the internal income distribution,and dominance does not always bring more benefits;the implementation of carbon cap-and-trade reduces the fresh-keeping decision-making of fresh agricultural products supply chain and reduces the free-rider income of followers;the role of higher carbon trading price is twofold,which not only brings about the speculation of leading enterprises,but also promotes the application of low-carbon technologies;consumers’high preference for freshness,low-cost and high-efficiency low-carbon technology are all conducive to improving the fresh-keeping efforts and benefits of the supply chain;cost-sharing contracts can coordinate the supply chain of fresh agricultural products.

关键词： Dominant power carbon cap-and-trade policy fresh agricultural product supply chain fresh-keeping decision-making

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Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang Ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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