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Observations of abundant structural and electronic phases in potassium-doped single-layer p-quaterphenyl film

Science China(Physics,Mechanics & Astronomy) 2021年第5期64卷 54-62页

作者： Wei Chen mingqiang ren Tong Zhang YaJun Yan DongLai Feng 2 3 Slate Key Laboratory of Surface PhysicsDepartmen1 of PhysicsFudan UniversityShanghai 200433China Hefei National Laboratory for Physical Sciences at the Microscale Department of PhysicsUniversity of Science and Technologv of ChinaHefei 230026China Collaborative Innovation Cener of Advanced Micosructures Nanjing 210093China

Scanning tunneling microscopy/spectroscopy is applied herein to study the pristine and potassium(K)-doped single-layer pquaterphenyl(P4P) films grown on the Au(111) substrate at the molecular level. Abundant complex structural and electronic phases are induced by various K doping. The Fermi-level pinning effect is observed at a low doping level. On the contrary,K3P4P exhibits intriguing versatile phases and properties because charge carriers are effectively doped in. For example, two kinds of molecular vibration modes with energies below 100 meV are observed, indicating a possible strong electron-phonon coupling. The splitting of the lowest unoccupied molecular orbital state in K3P4P illustrates an electronic correlation effect, and its strength varies for four different K3P4P phases with different structures. In addition, the appearance of a Kondo resonance on the molecular vacancy/impurity implies a local molecular magnetic moment. Our results demonstrate that the complex electronic properties of an alkali metal-doped P4P/Au film stem from the existence of many competing interactions, such as electronelectron correlations and electron-vibration coupling, which can be effectively tuned via variable carrier doping and molecular structure. Our work also opens new routes toward engineering novel molecular devices and creating new electronic phases in strongly correlated molecular materials.

关键词： scanning tunneling microscopy phenyl-based molecular film electronic correlation electron-vibration coupling Kondo effect

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Two-impurity Kondo effect in potassium-doped single-layer p-sexiphenyl films

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 78-85页

作者： Wei Chen YaJun Yan mingqiang ren Tong Zhang DongLai Feng State Key Laboratory of Surface Physics Department of PhysicsLaboratory of Advanced MaterialsFudan UniversityShanghai 200433China Hefei National Laboratory for Physical Sciences at the Microscale and School of Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Research Center for Quantum Sciences Shanghai 201315China

Herein, we show that a self-assembled phase of potassium(K)-doped single-layer para-sexiphenyl(PSP) film on a gold substrate is an excellent platform for studying the two-impurity Kondo model. On K-doped PSP molecules well separated from others, we observe a Kondo resonance peak close to EFwith a Kondo temperature of 30 K. The Kondo resonance peak splits when another K-doped PSP molecule is present in the vicinity, and the splitting gradually increases with the decrease in intermolecular distance without signs of phase transition. Our data demonstrate how a Kondo singlet state gradually evolves into an antiferromagnetic singlet state due to the competition between Kondo screening and antiferromagnetic Ruderman-Kittel-Kasuya-Yosida coupling,as described in the two-impurity Kondo model. Intriguingly, the antiferromagnetic singlet is quickly destroyed on increasing temperature and transforms back to a Kondo singlet below the Kondo temperature. Our data provide a comprehensive picture and quantitative constraints on related theories and calculations of the two-impurity Kondo model.

关键词： two-impurity Kondo effect Kondo resonance antiferromagnetic singlet scanning tunneling microscopy

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SKA2:一种通用的肿瘤生物标志物和潜在的治疗靶点

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现代肿瘤医学 2024年第14期32卷 2641-2646页

作者：岑美芝高陆任明强遵义医科大学附属医院血液内科贵州遵义563000

SKA2基因是SKA复合体的成员,对有丝分裂中期赤道板的维持以及纺锤体检测点的适时关闭至关重要。它参与细胞周期的调控,并通过糖皮质激素受体、p53等途径影响细胞的增殖和凋亡,与肿瘤密切相关。研究表明,SKA2是一种癌基因,在多种恶性肿... 详细信息

SKA2基因是SKA复合体的成员,对有丝分裂中期赤道板的维持以及纺锤体检测点的适时关闭至关重要。它参与细胞周期的调控,并通过糖皮质激素受体、p53等途径影响细胞的增殖和凋亡,与肿瘤密切相关。研究表明,SKA2是一种癌基因,在多种恶性肿瘤中显示高表达,促进肿瘤的发生、发展。该文重点综述SKA2在各种癌症中的调控、生物学功能和临床重要性。

关键词： SKA2 SKA复合体肿瘤

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恶性血液病合并血流感染病原菌分布及发生脓毒症休克危险因素分析

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遵义医科大学学报 2024年第3期47卷 254-261页

作者：高陆彭志元任娜娜杨春秀赵凌苇任明强冯永怀遵义医科大学附属医院血液内科贵州遵义563003

目的分析我院恶性血液病患者血流感染(BSI)病原菌分布及发生脓毒症休克的危险因素。方法收集纳入研究的2016年1月至2023年8月在遵义医科大学附属医院血液内科治疗的223例恶性血病患者BSI病例资料,根据血流感染后是否并发脓毒症休克,... 详细信息

目的分析我院恶性血液病患者血流感染(BSI)病原菌分布及发生脓毒症休克的危险因素。方法收集纳入研究的2016年1月至2023年8月在遵义医科大学附属医院血液内科治疗的223例恶性血病患者BSI病例资料,根据血流感染后是否并发脓毒症休克,分为脓毒症休克和非脓毒症休克组。收集病例的原发病类型,临床表现,病原菌及药敏结果、中性粒细胞缺乏持续时间、是否合理使用抗生素、是否为多重耐药、是否有使用广谱抗生素史等相关指标进行相关因素分析。采用Logistic回归对恶性血液病患者BSI并发脓毒症休克相关因素进行单因素和多因素分析。结果 223例血流感染患者血培养出238株病原菌,革兰阴性菌142株(59.70%),其中肺炎克雷伯菌25株、大肠埃希菌75株;革兰阳性菌93株(39%),其中人葡萄球菌28株、表皮葡萄球菌22株、金黄色葡萄球菌9株;真菌3株(1.30%),其中热带念珠菌、近平滑假丝酵母菌、克柔假丝酵母菌各1株。223例血液病合并血流感染病例中,发生脓毒症休克25例,死亡16例(64%)。单因素分析结果显示,脓毒症休克和非脓毒症休克组在粒细胞缺乏期(P<0.001)、合理使用抗生素(P=0.007)、多重耐药(P=0.017)、合并心功能不全(P=0.018)、肾功能不全(P<0.001)中存在差异。多因素分析结果显示粒细胞缺乏时间≥7 d(OR=3.306,P=0.008)、不合理使用抗生素(OR=2.612,P=0.004)、心功能不全(OR=6.291,P=0.008)、急性肾功能不全(OR=8.419,P=0.002)是恶性血液病BSI发生感染性休克的独立危险因素。结论恶性血液病合并BSI病原菌以革兰氏阴性菌为主,降低恶性血液病血流感染患者发生脓毒症休克的措施,包括缩短粒缺期、尽早合理使用抗菌药、纠正心脏及肾功能不全。

关键词：恶性血液病血流感染病原菌分布脓毒症休克危险因素

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柔红霉素结合阿糖胞苷在急性髓系白血病患者中的应用效果

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中国当代医药 2024年第27期31卷 46-49页

作者：彭志元高陆赵凌苇刘水玉石彬任明强遵义医科大学附属医院血液内科贵州遵义563000 遵义医科大学附属医院检验科贵州遵义563000

目的评估柔红霉素(DNR)+阿糖胞苷(Ara-C)应用在急性髓系白血病(AML)患者中的效果。方法选取2020年1月至2023年12月遵义医科大学附属医院收治的80例AML患者作为研究对象,按照随机数字表法将其分为对照组(40例)与观察组(40例)。对照组患... 详细信息

目的评估柔红霉素(DNR)+阿糖胞苷(Ara-C)应用在急性髓系白血病(AML)患者中的效果。方法选取2020年1月至2023年12月遵义医科大学附属医院收治的80例AML患者作为研究对象,按照随机数字表法将其分为对照组(40例)与观察组(40例)。对照组患者采用DNR治疗,观察组患者采用DNR+Ara-C治疗。比较两组患者的临床有效率、免疫功能、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性细胞间黏附分子-1(sICAM-1)、不良反应。结果观察组临床总有效率高于对照组,差异有统计学意义(P0.05)。结论AML患者采用DNR+Ara-C,可以降低VEGF、bFGF、sVCAM-1、sICAM-1,减轻免疫抑制,提高临床有效率,安全性好,有临床借鉴意义。

关键词：柔红霉素阿糖胞苷急性髓系白血病免疫功能不良反应

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A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

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Science China(Information Sciences) 2024年第2期67卷 118-143页

作者： Guang-ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Center for Control Science and Technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems

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A FAS approach for stabilization of generalized chained forms: part 2. Continuous control laws

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Science China(Information Sciences) 2024年第3期67卷 114-135页

作者： Guang-ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and Technology

In this paper, continuous time-varying stabilizing controllers for the type of general nonholonomic systems proposed and treated in part 1 are designed using the fully actuated system(FAS) approach. The key step is to differentiate the first scalar equation, and by control of the obtained second-order scalar system, a proportional plus integral feedback form for the first control variable is obtained. With the solution to this designed second-order scalar system, the rest equations in the nonholonomic system form an independent time-varying subsystem which is then handled by the FAS approach. The overall designed controller contains an almost arbitrarily chosen design parameter, and is proven to guarantee the uniformly and globally exponential stability of the closed-loop system. The proposed approach is simple and effective,and is demonstrated with a practical example of ship control.

关键词： nonholonomic systems feedback stabilization fully actuated systems Lyapunov stability continuous controllers

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Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： Dong ZHAO Wenjing ren School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

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Progress in modeling and control of probe-and-drogue autonomous aerial refueling

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Chinese Journal of Aeronautics 2024年第5期37卷 6-26,I0001页

作者： Jinrui ren Quan QUAN School of Automation Xi’an University of Posts&TelecommunicationsXi'an 710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

By refueling aircraft while they are in flight,aerial refueling is an efficient technique to extend their endurance and *** Aerial Refueling(AAR)is anticipated to be used to complete aerial refueling for unmanned *** are three aerial refueling methods:the Probe-and-Drogue Refueling(PDR)refueling method,the flying-boom refueling method,and the boom-drogue-adapter refueling *** paper considers the PDR approach,the most challenging of the three,because the flexible hose-drogue assembly has fast dynamics and is susceptible to various kinds of winds,which makes the probe docking with the drogue *** is divided into four phases,namely the rendezvous phase,joining phase,refueling phase,and reform phase,with the refueling phase being the most *** controller design faces the greatest challenge during the docking control of the refueling phase since it calls for a high level of safety,precision,and *** a result,the modeling and control issues encountered during the refueling phase are typical and *** fundamental idea of AAR is presented in the paper first,after which the characteristics and requirements of AAR are *** progress in modeling and control techniques for the AAR’s refueling phase is then systematically ***,potential future work for high safety,precision,and efficiency requirements is examined and suggested.

关键词： Aerial refueling Probe-and-drogue refueling Docking Flight controlsystems Unmanned Aerial Vehicles

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分化抑制因子1蛋白和基因在弥漫大B细胞淋巴瘤的表达及意义

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重庆医学 2015年第29期44卷 4039-4041页

作者：任明强袁钟苏俊遵义医学院附属医院血液科贵州遵义563003 遵义医学院附属医院病理科贵州遵义563003

目的观察弥漫大B细胞淋巴瘤(DLBCL)组织中分化抑制因子1(Id1)蛋白以及骨髓细胞中Id1基因的表达水平,探讨Id1在评价DLBCL患者病情及预后的临床意义。方法收集2011年10月至2014年10月该院收治的初治DLBCL患者40例为观察组,同期淋巴结反应... 详细信息

目的观察弥漫大B细胞淋巴瘤(DLBCL)组织中分化抑制因子1(Id1)蛋白以及骨髓细胞中Id1基因的表达水平,探讨Id1在评价DLBCL患者病情及预后的临床意义。方法收集2011年10月至2014年10月该院收治的初治DLBCL患者40例为观察组,同期淋巴结反应性增生(RH)的初治患者25例为对照组。采用免疫组织化学SP法分别检测Id1在DLBCL组织和RH组织中的表达水平;采用RT-PCR法分别检测Id1mRNA在两组患者骨髓细胞中的表达水平。结果观察组DLBCL组织切片Id1蛋白阳性表达率为75.00%(30/40),而对照组RH组织切片中Id1蛋白阳性表达率为32.00%(8/25)。Id1蛋白在观察组中表达水平明显高于对照组(P=0.001),观察组中的Id1蛋白表达与患者性别、年龄无关(P>0.05),与临床分期、乳酸脱氢酶(LDH)高低、结外器官受累情况等影响患者预后的指标有关(P<0.05)。Id1基因在观察组患者的骨髓细胞中表达水平明显高于对照组患者骨髓细胞(Id1mRNA水平2.80±0.87 vs.1.37±0.51,P<0.05),且也与临床分期、LDH高低、结外器官受累情况有关(P<0.05)。结论 Id1蛋白及Id1mRNA在DLBCL组织以及骨髓中的表达较RH组织均明显增高,与DLBCL病情预后有关,可能作为未来DLBCL治疗的靶点。

关键词：淋巴瘤,大B细胞,弥漫性淋巴组织增殖性疾病分化抑制因子1

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