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Revealing the anti-sintering phenomenon on silica-supported nickel catalysts during CO_(2)hydrogenation

Journal of Environmental Sciences 2024年第6期140卷 270-278页

作者： Liuqingqing Yang Tiancheng Pu Feixiang Tian Yulian He minghui zhu State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The CO_(2)catalytic hydrogenation represents a promising approach for gas-phase CO_(2)utilization in a direct *** to its excellent hydrogenation ability,nickel has been widely studied and has shown good activities in CO_(2)hydrogenation reactions,in addition to its high availability and low ***,Ni-based catalysts are prone to sintering under elevated temperatures,leading to unstable catalytic *** the present study,various characterization techniques were employed to study the structural evolution of Ni/SiO_(2)during CO_(2)*** anti-sintering phenomenon is observed for both 9%Ni/SiO_(2)and 1%Ni/SiO_(2)during CO_(2)hydrogenation at 400℃.Results revealed that Ni species were re-dispersed into smaller-sized nanoparticles and formed Ni^(0)active *** interestingly,this anti-sintering phenomenon leads to distinct outcomes for two catalysts,with a gradual increase in both reactivity and CH_(4)selectivity for 9%Ni/SiO_(2)presumably due to the formation of abundant surface Ni°from redispersion,while an apparent decreasing trend of CH_(4)selectivity for 1%Ni/SiO_(2)sample,presumably due to the formation of ultra-small nanoparticles that diffuse and partially filled the mesoporous pores of the silica support over ***,the redispersion phenomenon was found relevant to the H_(2)gas in the reaction environment and enhanced as the H_(2)concentration *** finding is believed to provide in-depth insights into the structural evolution of Ni-based catalysts and product selectivity control in CO_(2)hydrogenation reactions.

关键词： Carbon dioxide utilization CO_(2)hydrogenation Nickel-based catalysts Anti-sintering Structural evolution

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Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui Cheng Jialiang Wei minghui zhu Xiaodong Dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation Synthetic chemistry

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The emerging roles of lysine-specific demethylase 4A in cancer:Implications in tumorigenesis and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 645-663页

作者： Guanjun Yang Changyun Li Fan Tao Yanjun Liu minghui zhu Yu Du Chenjie Fei Qiusheng She Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China School of Life Science and Engineering Henan University of Urban ConstructionPingdingshanHenan 467044China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo UniversityNingboZhejiang 315211China

Lysine-specific demethylase 4 A(KDM4A,also named JMJD2A,KIA0677,or JHDM3A)is a demethylase that can remove methyl groups from histones H3K9me2/3,H3K36me2/3,and H1.4K26me2/*** evidence suggests that KDM4A is not only involved in body homeostasis(such as cell proliferation,migration and differentiation,and tissue development)but also associated with multiple human diseases,especially ***,an increasing number of studies have shown that pharmacological inhibition of KDM4A significantly attenuates tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid *** there are several reviews on the roles of the KDM4 subfamily in cancer development and therapy,all of them only briefly introduce the roles of KDM4A in cancer without systematically summarizing the specific mechanisms of KDM4A in various physiological and pathological processes,especially in tumorigenesis,which greatly limits advances in the understanding of the roles of KDM4A in a variety of cancers,discovering targeted selective KDM4A inhibitors,and exploring the adaptive profiles of KDM4A ***,we present the structure and functions of KDM4A,simply outline the functions of KDM4A in homeostasis and non-cancer diseases,summarize the role of KDM4A and its distinct target genes in the development of a variety of cancers,systematically classify KDM4A inhibitors,summarize the difficulties encountered in the research of KDM4A and the discovery of related drugs,and provide the corresponding solutions,which would contribute to understanding the recent research trends on KDM4A and advancing the progression of KDM4A as a drug target in cancer therapy.

关键词： Cancer therapy Drug resistance Histone demethylation JmjC domain KDM4A

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Re-usable Cd_(0.9)Zn_(0.1)S-ZnO@C/PVDF piezo-photocatalytic film with exceptional hydrogen evolution capability triggered by the synergetic advantages of piezoelectricity and S-Scheme heterojunction

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Journal of Energy Chemistry 2024年第9期96卷 164-176页

作者： Ping Su Dong Zhang minghui zhu Tengteng Liang Nan Yang Huaihao Zhao Dafeng Zhang Junchang Liu Peiqing Cai Xipeng Pu School of Materials Sciencend Engineering Shandong Provincial Key Laboratory of Chemical Energy Storagend Novel Cell TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina School of Physics Sciencend Information Technology Shandong Key Laboratory of Optical Communication Sciencend TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina College of Opticalnd Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Piezoelectric materials have advantages of fine-tuning photocatalytic performance through harvesting mechanical energy and open a new avenue in facilitating green catalytic ***,polyvinylidene fluoride(PVDF),a flexible piezoelectric material,was introduced to synthesize a novel Cd_(0.9)Zn_(0.1)S-ZnO@C/PVDF(CZS-ZO@C/PVDF)piezo-photocatalytic film by spin coating and immersion phase conversion *** from the piezoelectricity of PVDF and the internal electric field(IEF)of CZS-ZO@C Step-scheme(S-Scheme)heterojunction,CZS-ZO@C/PVDF was able to induce a hydrogen generation rate of 34.9 mmol g^(−1)h^(−1)activated by ultrasound and visible light(U-L),which is∼17.5 times of Cd_(0.9)Zn_(0.1)S/PVDF(CZS/PVDF)and∼7.4 times of the photocatalysis rate activated by visible light only(L).Piezoelectric measurements and COMSOL simulation illustrated the excellent piezoelectricity of CZS-ZO@C/PVDF film,which exhibits a piezoelectric coefficient(d33)of 9.9 pm V−1 and a piezoelectric potential of 874 mV(under 0.5 MPa).The reaction mechanism for the exceptional piezo-photocatalytic performance was finally disclosed through density functional theory(DFT)calculation and electrochemical *** study enriches the application scope of piezoelectric materials in sustainable energy catalysis and provides a new direction to develop efficient piezoelectric photocatalysts.

关键词： Piezo-photocatalysis Heterojunction Cd_(0.9)Zn_(0.1)S Zno@c PVDF

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Rational construction of CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S S-scheme heterojunction photocatalyst for extraordinary photothermal-assisted photocatalytic H_(2) evolution

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Journal of Energy Chemistry 2024年第5期92卷 240-249页

作者： Dong Zhang minghui zhu Ran Qin Peixian Chen Maoye Yin Dafeng Zhang Junchang Liu Hengshuai Li Xipeng Pu Peiqing Cai School of Physics Science and Information Technology Shandong Key Laboratory of Optical Communication Science and TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina School of Materials Science and Engineering Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis *** this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with photothermal effect was synthesized by ultrasonic self-assembly combined with *** dark CFO@C absorbed visible light and partly converted into heat to promote the hydrogen evolution *** presence of heterojunctions inhibited the photogenerated electron-hole *** graphite-carbon layer provided a stable channel for electron transfer,and the presence of magnetic CFO made recycle *** the action of photothermal assistance and heterojunction,the hydrogen evolution rate of the optimal CFO@C/CZS was 80.79 mmol g^(-1) h^(-1),which was 2.55 times and 260.61 times of that of pure CZS and CFO@C,***,the composite samples also exhibit excellent stability and a wide range of environmental *** experimental tests and first-principles simulation calculation methods,the plausible mechanism of photoactivity enhancement was *** work provided a feasible strategy of photothermal assistance for the development of heterojunction photocatalysts with distinctive hydrogen evolution.

关键词： Photothermal effect S-scheme heterojunction Photocatalytic hydrogen evolution First-principles calculations

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一种基于递推最小二乘法的运动平台剩磁差分测量与估计方法

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空间科学学报 2024年第3期44卷 570-584页

作者：朱明慧谷鹏高东中国科学院国家空间科学中心北京100190 中国科学院大学北京100049

地磁导航是通过对地球周围矢量磁场进行测量从而实现导航的一种方法.地磁导航在运动平台上应用的难点之一是平台剩磁对地磁测量的影响,严重污染了磁强计的测量.消除平台剩磁对地磁测量的影响成为地磁导航向应用转化的一项关键技术.为实... 详细信息

地磁导航是通过对地球周围矢量磁场进行测量从而实现导航的一种方法.地磁导航在运动平台上应用的难点之一是平台剩磁对地磁测量的影响,严重污染了磁强计的测量.消除平台剩磁对地磁测量的影响成为地磁导航向应用转化的一项关键技术.为实现运动平台剩磁的有效测量与估计,提出了基于递推最小二乘法的运动平台剩磁差分测量与估计方法.基于载体干扰磁场值只与测量点到磁偶极子的距离和磁偶极子的磁矩有关的结论,根据磁偶极子的磁场分布特性,推导出一种基于内置磁强计阵列的运动平台剩磁差分估计模型,并通过递推最小二乘法求解差分估计模型.大量仿真实验表明,可以通过内置阵列磁强计对平台剩磁进行测量与估计,验证了所提出的平台剩磁估计方法的有效性.

关键词：地磁导航干扰磁场差分模型递推最小二乘法

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基于D-LinkNet与形态学计算的高分遥感图像车流量监测

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电讯技术 2024年第5期64卷 663-669页

作者：刘颖吴凌寻朱明辉南京交通职业技术学院电子信息工程学院南京211119

针对城市交通路面车流量监测实时性和准确性高的需求,设计了一种利用高分遥感图像进行道路网自动提取和车辆自动监测的处理方法。综合利用D-LinkNet和形态学计算实现道路区域的二值化语义分割及连贯性、边缘扩展以及平滑性优化,同时将... 详细信息

针对城市交通路面车流量监测实时性和准确性高的需求,设计了一种利用高分遥感图像进行道路网自动提取和车辆自动监测的处理方法。综合利用D-LinkNet和形态学计算实现道路区域的二值化语义分割及连贯性、边缘扩展以及平滑性优化,同时将道路信息作为掩码并外溢后进行车辆目标检测,有效避免非道路区域车辆目标干扰。提出采用热力图的形式改进车流量监测方法,可以更直观显示道路拥挤程度。综合利用现有数据集对所提方法进行评价,车辆检测的平均精度达91.7%,道路提取平均交并比达85.3%,可以实现道路车流量的有效监测。

关键词：道路网提取车流量监测车辆检测高分遥感影像形态学运算

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基于外周血可溶性T细胞免疫球蛋白黏蛋白3构建重症急性胰腺炎预测模型

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中华危重病急救医学 2024年第1期36卷 67-72页

作者：朱明慧王大明王文龙孟瑶林敏常州市第一人民医院急诊医学科江苏常州213000 常州市第二人民医院消化内科江苏常州213000

目的探讨基于可溶性T细胞免疫球蛋白黏蛋白3(sTIM3)构建的模型对急性胰腺炎(AP)患者进展为重症急性胰腺炎(SAP)的预测价值。方法采用回顾性队列研究方法,选择2020年6月1日至2022年6月30日常州市第一人民医院和常州市第二人民医院收治的A... 详细信息

目的探讨基于可溶性T细胞免疫球蛋白黏蛋白3(sTIM3)构建的模型对急性胰腺炎(AP)患者进展为重症急性胰腺炎(SAP)的预测价值。方法采用回顾性队列研究方法,选择2020年6月1日至2022年6月30日常州市第一人民医院和常州市第二人民医院收治的AP患者作为观察主体。根据AP患者住院期间病情进展情况,将轻症AP(MAP)及中度重症AP(MSAP)患者列为非SAP组,SAP患者列为SAP组。收集患者基本资料,入院48 h内血液生物学指标、外周血sTIM3水平、急性胰腺炎严重程度床旁指数(BISAP)评分、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)、修正CT严重指数(MCTSI)评分,以及预后指标。采用多因素Logistic回归分析筛选AP患者住院期间进展为SAP的独立危险因素,并基于多因素分析结果及最小赤池信息标准(AIC)筛选出的最佳参数,构建基于sTIM3的SAP预测模型;绘制受试者工作特征曲线(ROC曲线),分析模型的预测效能。结果最终纳入99例AP患者,其中非SAP组80例,SAP组19例。与非SAP组比较,SAP组患者体质量指数(BMI)、饮酒史比例、心率(HR)、呼吸频率(RR)、白细胞计数(WBC)、红细胞计数(RBC)、C-反应蛋白(CRP)、丙氨酸转氨酶(ALT)、血肌酐(SCr)、降钙素原(PCT)、白细胞介素-6(IL-6)、sTIM3、BISAP评分、APACHEⅡ评分、MCTSI评分均明显升高,脉搏血氧饱和度(SpO_(2))、直接胆红素(DBil)、IL-10均明显下降;且SAP组患者重症监护病房(ICU)住院时间及总住院时间均较非SAP组明显延长〔ICU住院时间(d):1.0(0,1.5)比0(0,0),总住院时间(d):17.11±9.39比8.40±3.08,均P<0.01〕。多因素Logistic回归分析显示,HR〔优势比(OR)=1.059,95%可信区间(95%CI)为1.010~1.110,P=0.017〕、DBil(OR=0.981,95%CI为0.950~0.997,P=0.043)、sTIM3(OR=1.002,95%CI为1.001~1.003,P=0.027)是AP患者住院期间进展为SAP的独立危险因素;构建基于sTIM3的SAP预测模型:Logit(P)=-14.602+0.187×BMI+0.057×HR+0.006×CRP-0.020×DBil+0.002×sTIM3;ROC曲线分析显示,单因素定量指标中以IL-6预测AP患者住院期间进展为SAP的效能最佳,但基于sTIM3模型的预测效能明显优于IL-6〔ROC曲线下面积(AUC)及95%CI:0.957(0.913~1.000)比0.902(0.845~0.958),P<0.05〕。结论基于sTIM3构建的模型对于AP患者住院期间进展为SAP有较好的预测价值。

关键词：急性胰腺炎白细胞介素-6 预测模型可溶性T细胞免疫球蛋白黏蛋白3

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不同剂量艾司氯胺酮复合舒芬太尼自控静脉镇痛对经腹全子宫切除患者术后睡眠质量的影响

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医学研究与战创伤救治 2024年第3期37卷 272-276页

作者：朱明慧姜莉李莎徐钢南京中医药大学附属医院(江苏省中医院)麻醉科南京210029

目的观察不同剂量艾司氯胺酮复合舒芬太尼在经腹全子宫切除术后患者静脉自控镇痛(PCIA)中对其睡眠质量的影响。方法回顾性分析2022年9月至2023年9月于江苏省中医院收治的62例行经腹全子宫切除术并镇痛泵中放入艾司氯胺酮的患者,选取镇... 详细信息

目的观察不同剂量艾司氯胺酮复合舒芬太尼在经腹全子宫切除术后患者静脉自控镇痛(PCIA)中对其睡眠质量的影响。方法回顾性分析2022年9月至2023年9月于江苏省中医院收治的62例行经腹全子宫切除术并镇痛泵中放入艾司氯胺酮的患者,选取镇痛泵中无艾司氯胺酮的31例,按照艾司氯胺酮有无以及剂量高低分为C组、低剂量组、高剂量组,C组:舒芬太尼2.5μg/kg+托烷司琼6 mg;低剂量(ES1)组:艾司氯胺酮0.5 mg/kg+舒芬太尼2.5μg/kg+托烷司琼6 mg;高剂量(ES2)组:艾司氯胺酮1 mg/kg+舒芬太尼2.5μg/kg+托烷司琼6 mg。分析3组患者术前1 d、手术当天和术后2 d的匹兹堡睡眠指数(PSQI),以及术前1 d、术后第3天晨6时血清皮质醇(Cort)浓度、术后6、12、24、48 h的静息时轻度疼痛人数占比及按压次数、不良反应发生等情况。结果ES1组术后当天及2 d的PSQI评分低于C组(P<0.05)、ES2组术后当天的PSQI的评分低于C组及ES1组(P<0.05)、术后2 d的PSQI评分低于C组(P<0.05),与ES1组差异无统计学意义,ES1组术后的Cort浓度低于C组(P<0.05),ES2组术后的Cort浓度低于C组及ES1组(P<0.05)。术后6 h轻度疼痛的人数占比ES2组最大,其他时间点差异无统计学意义。ES2组术后自控次数明显减少,48 h不良反应发生情况三者差异无统计学意义。结论艾司氯胺酮1 mg/kg复合舒芬太尼2.5μg/kg用于经腹全子宫切除术能够改善术后睡眠质量、术后镇痛效果满意。

关键词：艾司氯胺酮舒芬太尼睡眠质量经腹全子宫切除术

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Deactivation and regeneration of the commercial Cu/ZnO/Al_(2)O_(3) catalyst in low-temperature methanol steam reforming

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Science China Chemistry 2023年第12期66卷 3645-3652页

作者： Didi Li Zhen Wang Shiqing Jin minghui zhu State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Cu-based catalysts with excellent activity at low temperatures are widely used for methanol steam reforming(MSR)but suffer from deactivation *** present work aims to elucidate the deactivation and regeneration mechanisms of the commercial Cu/ZnO/Al_(2)O_(3) catalyst in low temperature *** employing a series of(quasi)in situ characterization methods,it is found that the deactivation of the catalyst at a high weight hourly space velocity(WHSV)and a low reaction temperature is mainly due to the poisoning of Cu species associated with surface-oxygenated species with less Cu sintering,rather than carbon deposition,and strong metal-support interaction(SMSI).An in situ regeneration method was developed for the deactivated commercial Cu/ZnO/Al_(2)O_(3) catalyst via the simultaneous supply of O_(2).It is shown that the addition of O_(2)(≥1 vol%)can reverse the deactivation caused by surface-oxygenated poisoning due to the weak interaction between formed surface copper oxide and surface-oxygenated species,facilitating their desorption,but not deactivation caused by sintering,thereby partially restoring the catalytic activity.

关键词： methanol steam reforming Cu/ZnO/Al_(2)O_(3)catalyst deactivation regeneration

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