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Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 87-95页

作者： Zhenhua Zhang Litao Yang Qian Yue Kejun Kang Yuanjing Li Haipeng An Greeshma C. Jianping Chang Yunhua Chen Jianping Cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong Qiuju Guo Tao Guo Xuyuan Guo Li He Shengming He Jinwei Hu Hanxiong Huang Tuchen Huang Lin Jiang S.Karmakar Haubin Li Hanyu Li Jianmin Li Jin Li Qianyun Li Renmingjie Li Xueqian Li Yulan Li Yifan Liang Bin Liao FongKay Lin ShinTed Lin Jiaxuan Liu Shukui Liu Yandong Liu Yu Liu Yuanyuan Liu Hao Ma Yucai Mao Qiyuan Nie Jinhua Ning Hui Pan Ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang Yang Tian Guangfu Wang Junzheng Wang Li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-King Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu Yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng Bingtao Zhang Fengshou Zhang Lei Zhang Zhenyu Zhang Jizhong zhao Kangkang zhao minggang zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Department of Physics Tsinghua University Institute of Physics Academia Sinica NUCTECH Company YaLong River Hydropower Development Company College of Nuclear Science and Technology Beijing Normal University College of Physics Sichuan University School of Physics Peking University Department of Nuclear Physics China Institute of Atomic Energy Sino-French Institute of Nuclear and Technology Sun Yet-sen University School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University

Dark matter（DM） is a major constituent of the ***,no definite evidence of DM particles（denoted as “χ”） has been found in DM direct detection（DD） experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes（PBHs）.We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×1015to 7×1016g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the China Jinping Underground Laboratory,we exclude the χ-electron（χ-e） elastic-scattering cross section σχe～5×10-29cm2for χ with a mass ■ keV from our *** the higher radiation background but lower energy threshold（160 eV）,CDEX-10 fills a part of the gap in the previous *** (mχ,σχe) can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

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婴儿神经轴索营养不良致病基因PLA2G6突变分析

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空军军医大学学报 2024年第6期45卷 650-656页

作者：常世雪李翠杨溪玲甄帅赵明刚李旭赵乐西安交通大学第一附属医院转化医学中心陕西西安710061 陕西省遗传疾病诊断中心陕西西安710061 空军军医大学基础医学院医学遗传与发育生物学教研室陕西西安710032

目的探讨婴儿神经轴索营养不良(INAD)PLA2G6基因突变的致病特点,丰富INAD的基因突变谱,为INAD相关遗传咨询提供依据。方法收集1例先证者的家系相关临床资料,采用三人家系全外显子组测序对先证者及其父母进行测序分析,筛选可能的致病突... 详细信息

目的探讨婴儿神经轴索营养不良(INAD)PLA2G6基因突变的致病特点,丰富INAD的基因突变谱,为INAD相关遗传咨询提供依据。方法收集1例先证者的家系相关临床资料,采用三人家系全外显子组测序对先证者及其父母进行测序分析,筛选可能的致病突变位点,Sanger测序验证突变位点,结合生物信息学分析对突变位点的致病性进行预测,最后通过羊水穿刺检查为孕妇提供产前诊断。结果全外显子测序结果显示临床表现为精神运动发育倒退的先证者为PLA2G6基因c.1A>G(p.M1?)和c.2242G>A(p.A748T)复合杂合突变,其父亲为c.1A>G(p.M1?)杂合突变携带者,母亲为c.2242G>A(p.A748T)杂合突变携带者。根据美国医学遗传学与基因组学学会变异评级相关指南,c.1A>G(p.M1?)为致病性突变,c.2242G>A(p.A748T)为意义未明突变。产前诊断胎儿为c.1A>G(p.M1?)杂合突变携带者,现该孕妇已足月顺产一男活婴,产后随访7个多月生长状况良好。结论PLA2G6基因c.1A>G(p.M1?)和c.2242G>A(p.A748T)复合杂合突变为该先证者患INAD的遗传病因,其中c.2242G>A(p.A748T)为新发现的变异位点,这扩大了INAD的基因突变图谱,全外显子测序数据为该家系提供了精准的遗传咨询和产前诊断。

关键词：婴儿神经轴索营养不良 PLA2G6基因全外显子测序产前诊断

Cognitive function correlations with apolipoprotein Eε4 single nucleotide polymorphism in 1000 elderly patients following general anesthesia A randomized controlled study

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Neural Regeneration Research 2009年第4期4卷 316-320页

作者： Yingmin Cai Haitao Hu Rongliang Xue Pengbin Liu Gaifeng Feng Weijiang Dong Bin Yu minggang zhao Department of Anesthesia Second Affiliated Hospital Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Neuroanatomy Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Forensic Medicine Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

BACKGROUND： Cognitive dysfunction occurs in elderly patients following general anesthesia, and this might be associated with genetics. Studies have shown that the ε4 allele gene is closely associated with senile dementia. OBJECTIVE： To compare and analyze the correlations between cognitive dysfunction and single nucleotide polymorphism of apolipoprotein E （ApoE） following inhalation or intravenous anesthesia. DESIGN, TIME AND SETTING： A randomized, controlled study was performed. The patients were recruited from the Department of Anesthesia, Second Affiliated Hospital, Medical College, Xi＇an Jiaotong University, China between May 2005 and December 2008. Genetic analyses were conducted at the Departments of Neuroanatomy and Forensic Medicine, Medical Corlege, Xi＇an Jiaotong University, China. PARTICIPANTS： A total of t 000 patients of ASA I-II grade, without genetic connection, were enrolled in this study, comprising 520 males and 480 females, aged （70.1± 4.6） years and weighing （57.3 ± 7.5） kg. No patients suffered from cognitive dysfunction. METHODS： The patients were equally and randomly divided into intravenous anesthesia and gas anesthesia groups. Total intravenous anesthesia and inhaled anesthesia were used. Genomic DNA from whole blood was extracted. The ApoE gene was amplified by PCR. Restriction fragment length polymorphism of ApoE gene was analyzed. Cognitive function was evaluated by Mini-Mental State Examination （MMSE）. Patients scoring 〈 25 points were diagnosed with cognitive dysfunction. MAIN OUTCOME MEASURES： Correlation of ApoE gene frequency and ApoE ε 4 allele to MMSE scores was measured. RESULTS： MMSE scores in patients from the gas anesthesia group significantly decreased 3 days after surgery, compared with the intravenous anesthesia group. The proportion of patients that scored 〈 25 points was significantly greater in the gas anesthesia group compared with the intravenous anesthesia group 3 days after surgery. Reduced MMSE scores closely correla

关键词： general anesthesia cognitive function apolipoprotein E polymorphism elderly

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智力障碍儿童遗传学病因筛查与分析

中国妇幼健康研究 2024年第3期35卷 58-63页

作者：李翠王晓岩刘小刚赵明刚李萍萍李旭薛梅西安交通大学第一附属医院转化医学中心陕西西安710061 西安交通大学第一附属医院检验科陕西西安710061

目的分析智力发育障碍(ID)患儿遗传学病因,为ID疾病临床诊疗及家系遗传咨询提供依据。方法选取2020年1月至2021年1月在西安交通大学第一附属医院诊断为ID的5例患儿为研究对象。通过染色体核型分析对5例ID患儿进行初步分类,染色体分析结... 详细信息

目的分析智力发育障碍(ID)患儿遗传学病因,为ID疾病临床诊疗及家系遗传咨询提供依据。方法选取2020年1月至2021年1月在西安交通大学第一附属医院诊断为ID的5例患儿为研究对象。通过染色体核型分析对5例ID患儿进行初步分类,染色体分析结果正常患儿进行全外显子组测序分析。Sanger测序及生物信息学分析软件等对全外显子组测序筛选出的可能致病性变异位点进行验证及功能分析。结果染色体核型分析发现P1患儿核型为46,XY,del(18)(q22q23),其余4例患儿染色体核型正常。全外显子组测序结果显示两例患儿ATP2C2基因均存在c.2096G>A(***699Asn)和c.2644_2655del(***882_Gly885del)复合杂合变异。家系验证结果显示P2患儿及P3患儿母亲为ATP2C2基因c.2096G>A(***699Asn)杂合变异携带者,父亲为ATP2C2基因c.2644_2655del(***882_Gly885del)杂合变异携带者。ATP2C2基因c.2096G>A(***699Asn)变异位点在神州基因组数据1000 Genome、ExAC和gnomAD等数据库未发现。生物信息学分析变异(c.2096G>A和c.2644_2655del)编码的氨基酸在不同物种中高度保守,且均可导致蛋白质结构发生改变。结论ATP2C2基因c.2096G>A(***699Asn)和c.2644_2655del(***882_Gly885del)为新发现的变异位点,可能是ID的致病原因。

关键词：智力发育障碍全外显子组测序致病基因 ATP2C2基因

Interface of 3D Micro-cellular Structural AlMnCe/Al_2O_3 Composite

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稀有金属材料与工程 2011年第S3期40卷 128-131页

作者： Wang Shuxia, Li Shaolong, Jiang Qiuyue, Shi Lei, Wang minggang, Jia Suqiu, zhao Zhankui Key Laboratory of Advanced Structural Materials, Ministry of Education, Changchun University of Technology, Changchun 130012, China Changchun Univ Technol Key Lab Adv Struct Mat Minist Educ Changchun 130012 Peoples R China

The AlMnCe/Al2O3 metal/ceramic composite with 3D micro-cellular structure is prepared by spark plasma sintering (SPS) at 520 ℃. It consists of consecutive nano-Al2O3 sintering body phase and AlMnCe alloy discrete phase. The microstructure of sample, characteristic of the micro-cellular structure and microstructure of the interface are investigated via scanning electron microscope (SEM) and transmission electron microscope (TEM) method. The results indicate that two kinds of interfaces are formed in the sample during SPS process, one is the micro-nano type metal/ceramic interface between the metal cellular body and the nano-ceramic cellular wall, the other is the nano-nano type ceramic/ceramic interface in the nano-ceramic cellular wall. The fusion transition area with a width 200-300 nm at interface of the AlMnCe alloy and nano-Al2O3 sintering body is formed. The AlMnCe alloy has a sufficient immersional wetting for the Al2O3 cellular wall. The bonding of interface between the nano-Al2O3 sintering body and the AlMnCe alloy particle is powerful, and new phase and crack is not found.

关键词： spark plasma sintering composite microcellular structure interface

论新时代高校思想政治理论课建设的守正与创新

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阿坝师范学院学报 2020年第3期37卷 30-38页

作者：赵明刚南阳师范学院马克思主义学院河南南阳473061

新时代,高校思想政治理论课面临的环境、对象、条件、方式发生了重大变化,但其使命任务、重要方针、重大原则、担当精神不能变。守正是搞好思想政治理论课建设的根本前提,创新是思想政治理论课保持活力的不竭动力。守正和创新是辩证统一... 详细信息

新时代,高校思想政治理论课面临的环境、对象、条件、方式发生了重大变化,但其使命任务、重要方针、重大原则、担当精神不能变。守正是搞好思想政治理论课建设的根本前提,创新是思想政治理论课保持活力的不竭动力。守正和创新是辩证统一的,守正是思想政治理论课创新的基础和前提,创新是思想政治理论课守正的深化与发展。搞好新时代思想政治理论课建设,必须坚持将守正基础上的创新和创新基础上的守正相统一,处理好守正与创新的关系。

关键词：新时代高校思想政治理论课守正创新辩证统一

低取代度两亲性β-环糊精及其水相中纳米球的制备

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应用化学 2013年第3期30卷 260-264页

作者：郭文彦赵明刚郝爱友山西师范大学化学与材料科学学院临汾041004 山西师范大学现代文理学院临汾041000 山东大学化学与化工学院济南250100

将2-O-(2-羟丙基)-β-环糊精与十二烷基、十四烷基、十六烷基和十八烷基缩水甘油醚在吡啶中反应,合成了4个低取代度的两亲性β-环糊精衍生物(平均取代度分别为1.87、1.95、2.14和1.80)。将上述4个化合物分散于水中自组装成可稳定2～3周... 详细信息

将2-O-(2-羟丙基)-β-环糊精与十二烷基、十四烷基、十六烷基和十八烷基缩水甘油醚在吡啶中反应,合成了4个低取代度的两亲性β-环糊精衍生物(平均取代度分别为1.87、1.95、2.14和1.80)。将上述4个化合物分散于水中自组装成可稳定2～3周的纳米球,并且均呈现出较好的分散度和均匀性。

关键词：两亲性 O-(羟丙基)-β-环糊精缩水甘油醚纳米球

颗粒堆积床辐射–导热耦合传热等效导热系数参数化分析

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工程热物理学报 2024年第1期45卷 152-156页

作者：付金余罗明罡赵军明哈尔滨工业大学能源科学与工程学院哈尔滨150001

颗粒堆积床在高温气冷堆等工业生产中有重要应用。对于事故下颗粒床核反应堆被动冷却的安全性分析,热辐射是最重要的传热机制。本文以表征颗粒堆积床辐射–导热耦合传热过程的传热特性的等效导热系数为研究对象,采用反向离散坐标光线追... 详细信息

颗粒堆积床在高温气冷堆等工业生产中有重要应用。对于事故下颗粒床核反应堆被动冷却的安全性分析,热辐射是最重要的传热机制。本文以表征颗粒堆积床辐射–导热耦合传热过程的传热特性的等效导热系数为研究对象,采用反向离散坐标光线追踪法与有限体积法结合求解颗粒床内热辐射–导热耦合传热,获得等效导热系数。与半经验模型进行对比并分析颗粒直径、颗粒导热系数和发射率对等效导热系数的影响。结果表明,长短程模型相比较其它模型,可以更好地预测颗粒床的等效导热系数,并且随着颗粒直径、颗粒导热系数以及发射率增加,颗粒床的等效导热系数显著增加。研究结果有助于理解颗粒堆积床中的辐射传热作用,为颗粒堆积床传热分析提供参考。

关键词：颗粒堆积床热辐射效应辐射换热等效导热系数

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我国医改面临的挑战与思考

中国医疗保险 2013年第6期 30-32页

作者：赵明钢卫生部医政司北京100044

深化医药卫生体制改革自启动实施以来,取得了明显进展和成效,但医疗资源总量不足、结构不合理等问题依然突出,需要继续探索,认真研判,着力推进医药卫生体制改革纵深发展。

关键词：医药卫生体制改革