检索结果-南通市图书馆

Electrochemical Selective Oxidative Synthesis of Diversified Sulfur Heterocycles fromβ-Ketothioamides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第7期39卷 1831-1837页

作者： Li-Rong Wen Ning-Ning Wang Wu-Bo Du ming-zhe zhu Chao Pan Lin-Bao Zhang ming Li State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdaoShandong266042 China

Main observation and conclusion A general and practical protocol for the construction of diversified sulfur heterocycles has been described through organic electrosynthesis *** undivided cell,dihydrothiophenes,thiazolines and 1,4-dithiines could be easily generated from various availableβ-ketothioamides under metal-free and external oxidant-free conditions.

关键词： Sulfur Synthesis design Annulation Metal-free Electrosynthesis

Integrated miRNA and mRNA Analysis Identified Potential Mechanisms and Targets of Qianggan Extracts in Preventing Nonalcoholic Steatohepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2022年第1期8卷 77-86页

作者： Jie Huang Meng Li Wen-Jun Zhou Ze-Min Yao Guang Ji Li Zhang ming-zhe zhu China-Canada Center of Research for Digestive Diseases Institute of Digestive DiseasesLonghua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Biochemistry Microbiology and ImmunologyOttawa Institute of Systems BiologyUniversity of OttawaOttawaCanada School of Public Health Shanghai University of Traditional Chinese MedicineShanghaiChina

Objective: Qianggan(QG) extract is a patented traditional Chinese medicine that has been widely used for the clinical treatment of nonalcoholic steatohepatitis(NASH). However, its mechanism remains unclear. Methods: The efficacy of QG was evaluated in mice with methionine-and-choline-deficient diet-induced NASH by measuring serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels and by H and E staining of liver sections. Microarray and bioinformatics analyses were performed to obtain hepatic micro RNA(mi RNA) and m RNA expression profiles and to mine potential mechanisms and therapeutic targets. Furthermore, representative mi RNA and m RNA expression levels were validated by quantitative real-time polymerase chain reaction(q RT-PCR). Results: QG extract significantly improved NASH. Twelve differentially expressed mi RNAs and 1124 differentially changed m RNAs were identified as potential targets of QG extract. Integrated analysis detected 976 mi RNA–m RNA regulatory pairs, and networks including 11 mi RNAs and 427 m RNAs were constructed by Cytoscape. Hub nodes including mi R-7050-5p, mi R-212-3p, Bcl2l11, and Kras were filtered out. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that 427 m RNAs were enriched in pathways including apoptotic process, immune response, Fox O signaling pathway, and natural killer cell-mediated cytotoxicity. We also constructed a protein–protein interaction network with 254 nodes, and identified hub genes including Kras, Fasl, and Ncam1. Finally, the results of q RT-PCR were in good accordance with microarray data. Conclusion: This study identified important hub mi RNAs and m RNAs involved in the mechanism of QG extract and which might provide potential therapeutic targets for patients with NASH.

关键词： Fatty liver gene regulatory networks microarray analysis Qianggan extract Traditional Chinese Medicine

An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-Da zhu Yu-zhe Han Xiao-Bi Jing School of Mechanical Engineering Yangzhou University School of Chemistry and Chemical Engineering Yangzhou University

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using H2O2as the green oxidant. It was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb, Cu,Pd, Ag and Hg. Results of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material, which might facilitate its absorption to metals. This work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis, i.e. the Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions, respectively. It discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Adsorption Catalysis Porous materials Rare metal concentration Surfaces

Pressure-induced color change arising from transformation between intra-and inter-band transitions in LuH_(2±x)N_(y)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 161-166页

作者： zhe Liu Yingjie Zhang Shenyang Huang Xue ming Qing Li Chenghao Pan Yaomin Dai Xiaoxiang Zhou Xiyu zhu Hugen Yan Hai-Hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano-Photonic Structures of the Ministry of EducationDepartment of PhysicsFudan UniversityShanghai 200433China

The pressure-induced color change in the nitrogen-doped lutetium hydride has triggered extensive discussions about the underlying physics and potential ***,we study the optical response of LuH_(2±x)N_(y)in a broad frequency range at ambient pressure and its evolution with pressure in the visible spectral *** broad-band optical spectra at ambient pressure reveal a Drude component associated with intra-band electronic transitions and two Lorentz components(L1 and L2)arising from inter-band electronic *** application of pressure causes a spectral weight transfer from L1 to the Drude component,leading to a blue shift of the plasma edge in the reflectivity spectrum alongside a reduction of the high-frequency *** results suggest that the pressure-induced color change in LuH_(2±x)N_(y)is closely related to the transformation between intra-and inter-band electronic transitions,providing new insights into the mechanism of the pressure-induced color change in LuH_(2±x)N_(y).

关键词： nitrogen-doped lutetium hydride optical spectroscopy high-pressure technique color change

Three-channel CMOS transimpedance amplifier for LiDAR sensor receiver

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第1期35卷 74-80页

作者： LIU Ruqing zhu Jingguo JIANG Yan LI Feng JIANG Chenghao MENG zhe Photoelectric R&D Center Academy of Opto-ElectronicsChinese Academy of SciencesBeijing 100094China

For time-of-flight(TOF)light detection and ranging(LiDAR),a three-channel high-performance transimpedance amplifier(TIA)with high immunity to input load capacitance is presented.A regulated cascade(RGC)as the input stage is at the core of the complementary metal oxide semiconductor(CMOS)circuit chip,giving it more immunity to input photodiode detectors.A simple smart output interface acting as a feedback structure,which is rarely found in other designs,reduces the chip size and power consumption *** circuit is designed using a 0.5μm CMOS process technology to achieve low *** device delivers a 33.87 dB?transimpedance gain at 350 *** a higher input load capacitance,it shows a-3 dB bandwidth of 461 MHz,indicating a better detector tolerance at the front end of the *** a 3.3 V supply voltage,the device consumes 5.2 mW,and the total chip area with three channels is 402.8×597.0μm2(including the test pads).

关键词： transimpedance amplifier(TIA) three-channel regulated cascade(RGC) light detection and ranging(LiDAR)

Manufacturing task data chain-driven production logistics trajectory analysis and optimization decision making method

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第1期12卷 185-206页

作者： Lin Ling zhe-ming Song Xi Zhang Peng-Zhou Cao Xiao-Qiao Wang Cong-Hu Liu ming-Zhou Liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)

The influences of perforating phase and bedding planes on the fracture deflection in laminated shale

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1221-1230页

作者： ming-zhe Gu Mao Sheng Xiao-Ying zhuang Xin-Yi Li Gen-Sheng Li National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Petroleum Engineering China University of PetroleumBeijing102249China College of Civil Engineering Tongji UniversityShanghai200092China

The perforating phase leads to complex and diverse hydraulic fracture propagation behaviors in laminated shale formations. In this paper, a 2D high-speed imaging scheme which can capture the interaction between perforating phase and natural shale bedding planes was proposed. The phase field method was used to simulate the same conditions as in the experiment for verification and hydraulic fracture propagation mechanism under the competition of perforating phase and bedding planes was *** results indicate that the bedding planes appear to be no influence on fracture propagation while the perforating phase is perpendicular to the bedding planes, and the fracture propagates along the perforating phase without deflection. When the perforating phase algins with the bedding planes, the fracture initiation pressure reserves the lowest value, and no deflection occurs during fracture propagation. When the perforating phase is the angle 45°, 60°and 75°of bedding planes, the bedding planes begin to play a key role on the fracture deflection. The maximum deflection degree is reached at the perforating phase of75°. Numerical simulation provides evidence that the existence of shale bedding planes is not exactly equivalent to anisotropy for fracture propagation and the difference of mechanical properties between different shale layers is the fundamental reason for fracture deflection. The findings help to understand the intrinsic characteristics of shale and provide a theoretical basis for the optimization design of field perforation parameters.

关键词： Shale Propagation Perforating Bedding Structure

Influences of shale microstructure on mechanical properties and bedding fractures distribution

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 1944-1954页

作者： ming-zhe Gu Mao Sheng Shi-Zhong Cheng Fan-Hao Gong Gen-Sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

Construction technology for deep tunnels crossing superhigh-temperature fault zones with high water surges

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第8期18卷 1267-1280页

作者： Yong ZHAO Tingyu zhu Li YU ming LU Sichuan–Xizang Railway Co. Ltd.Linzhi 860000China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610036China

The harsh environment in tunnels with high geothermal temperatures and humidity can adversely impact machinery,personnel,and *** main causes of specific problems are the unknown mechanisms of local geothermal formation,inappropriate temperature control measures,and insufficient systematic *** this study,three work sections relating to a high geothermal tunnel are:the tunnel face,middle-of-tunnel section,and outside-oftunnel section.A cooling strategy is proposed to offer technical support in achieving comprehensive cooling,overall as well as for each of the ***,a comprehensive geological survey explores the mechanism and exact location of the heat ***,grouting and centralized drainage measures are used to control the heat release of hot *** ventilation,ice chillers and other applicable measures are used to control the ambient ***,a monitoring and early warning system is established to prevent *** cooling strategy has been applied in the field with good results.

关键词： high geothermal tunnels cooling strategy comprehensive cooling measures safety and security