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International Journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1115-1122页

作者： En-ming Zhang yi-ming zhao Zhong-mou Wang Wen-ya Li State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an710072China

Two dissimilar steel plates,structural steel and mild steel,were joined by explosion welding to form a *** composite was then heat-treated by quenching at 840℃ for 30 min followed by tempering at 200℃ for 3 *** microstructure was investigated under an optical microscope and a scanning electron *** mechanical properties were measured using Vickers microhardness and Charpy impact *** results show a deformed interface with typical wave features at the welding zone,but no defects were ***,the ferrite in the parent plate in the weld zone was elongated due to the strong plastic deformation from the *** heat treatment,the hardness of the flyer plate(structural steel)was over HV0.2800,while that of the parent plate(mild steel)was *** increase in hardness was due to the presence of ***,the average impact energy was increased from 18.5 to 44.0 J following heat treatment;this is because of the formation of recrystallized grains at the weld interface,which is due to the dynamic recovery and local recrystallization,and the strong elemental diffusion that occurred between the two plates.

关键词： explosion welding steel composite plate microstructure mechanical properties

Strategies to improve the emulsification properties of rice proteins as a promising source of plant-based emulsifiers:An updated mini-review

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Food Bioscience 2023年第3期53卷 267-274页

作者： Wenqing Chen Yanhua Ding yi-ming zhao Haile Ma School of Food and Biological Engineering Jiangsu UniversityZhenjiang212013China Institute of Food Physical Processing Jiangsu UniversityZhenjiang212013China School of Mechanical Engineering Jiangsu UniversityZhenjiang212013China

Rice and its by-products are an under-utilized resource of high-quality and sustainable plant *** to their characteristics of hypoallergenic,gluten-free,and balanced amino acid composition,rice proteins(RPs)are considered to be more important than other grain proteins and have great potential to compensate for the defects of animal *** particular,the application of RPs in plant-based emulsifiers has attracted much attention in recent ***,the inappropriate molecular structure and excessive molecular weight challenge their potential industrial value in food *** review summarizes the effective strategies to improve the emulsifiability of RPs by relevant modifications with an emphasis on the current scientific knowledge and future *** modifications could mainly be achieved by enzymatic hydrolysis,combination with polyphenols or ***,some physical processing techniques including microwave,ultrasound,and high pressure and chemical strategies such as pH-shifting,fibrosis,phosphorylation,and alkylation have also started to rise.

关键词： Emulsion Hydrolysate Modification Rice proteins Structure

Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

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Chinese Chemical Letters 2006年第9期17卷 1177-1180页

作者： Fei DENG Fu Jun ZHANG ming zhao yi Ping WANG Jin Sheng ZHANG State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 （IC50 = 3.7 μg/mL）. The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.

关键词： Synthesis sapriparaquinone antioxidant activity.

Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie Yu-long Ma ming-tai Gui Lei Yao Jian-hua Li ming-zhu Wang Xun-jie Zhou yi-fan Wang ming-yi zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (P<0.001) in clinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

Plasmon-enhanced ultra-high photoresponse of single-wall carbon nanotube/copper/silicon near-infrared photodetectors

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Nano Research 2024年第7期17卷 5930-5936页

作者： yi-ming zhao Xian-Gang Hu Chao Chen Zuo-Hua Wang An-Ping Wu Hong-Wang Zhang Peng-Xiang Hou Chang Liu Hui-ming Cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling College of Mechanical EngineeringYanshan UniversityQinhuangdao 066004China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Single wall carbon nanotube(SWCNT)/Si heterojunction photodetectors have the advantages of high photoresponse ability and simple structure,however,their detection wavelength range are usually lower than 1100 nm,which limits their application in the infrared *** report a SWCNT/Cu/Si photodetector with both a high photoresponse and a detection range up to the infrared band by depositing a Cu nanoparticles(NPs)layer between a SWCNT film and a n-Si *** was found that the Cu NPs produce strong surface plasmon resonance(SPR)under laser irradiation,which breaks through the limitation of Si band gap and greatly improves the photoresponse of the SWCNT/Cu/Si photodetector in the near infrared *** responsivity(R)of the photodetector in the wavelength range of 1850–1200 nm reached 2.2–14.15 mA/W,which is the highest value in the reported plasmon enhanced n-Si based photodetectors,and about 20,000 times higher than that of a SWCNT/Si *** R value for 1550 nm wavelength used in optical communications reached~8.2 mA/W,which is 64%higher than the previously reported values of commonly used *** attribute the significant increase to the strong SPR and low Schottky barrier of Cu with n-Si,which facilitates the generation and transfer of the carriers.

关键词： single wall carbon nanotube photodetector silicon surface plasmon resonance copper

A new polyacetylene glycoside from the rhizomes of Atractylodes lancea

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Chinese Chemical Letters 2010年第7期21卷 850-852页

作者： ying Ji Xu Feng Chao Cheng Xiao Yun Fa Dong Qi Zhi Wang ming Wang You yi zhao Jiangsu Center for Research & Development of Medicinal Plants Jiangsu Institute of BotanyChinese Academy of Sciences Nanjing Botanical GardenMem.Sun Yat-SenNanjing 210014China

A new polyacetylene glycoside,（1,3Z,11E）-tridecatriene-7,9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside,was isolated from the rhizomes of Atractylodes lancea（Thunb.） *** structure was elucidated on the basis of spect... 详细信息

关键词： Atractylodes lancea Polyacetylene (1 3Z 11E)-Tridecatriene-7 9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside

Enhanced recovery after surgery program in the patients undergoing hepatectomy for benign liver lesions

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 122-128页

作者： Jia-Min Zhou Xi-Gan He Miao Wang yi-ming zhao Lian Shu Long-Rong Wang Lu Wang An-Rong Mao Department of Hepatic Surgery Shanghai Cancer CenterFudan UniversityShanghai 200032China Education Department Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

Background:Enhanced recovery after surgery(ERAS)has shown effectiveness in terms of reducing the hospital stay and ***,the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still ***:ERAS was implemented in our center since March 1st,*** September 2016 to Febru-ary 2018,109 patients were enrolled into the control group,and from March 2018 to June 2019,124 patients were enrolled into the ERAS *** the indicators related to operation,liver functions,and postoperative outcomes were included in the ***:The clinicopathologic baselines were similar in these two groups.A significantly higher propor-tion of patients underwent laparoscopic surgery in the ERAS *** the whole,intraoperative blood loss(100.00 mL vs.200.00 mL,P<0.001),blood transfusion(3.23%vs.10.09%,P=0.033),total bilirubin(17.10μmol/L vs.21.00μmol/L,P=0.041),D-dimer(2.08μg/mL vs.2.57μg/mL,P=0.031),postoperative hospital stay(5.00 d vs.6.00 d,P<0.001),and postoperative morbidity(16.13%vs.32.11%,P=0.008)were significantly shorter or less in the ERAS group than those in the control *** stratified by operation methods,ERAS group showed significantly shorter postoperative hospital stay in both open and laparoscopic operation(both P<0.001).In patients underwent open surgery,ERAS group demonstrated significantly shorter operative duration(131.76±8.75 min vs.160.73±7.23 min,P=0.016),less intra-operative blood loss(200.00 mL vs.450.00 mL,P=0.008)and less postoperative morbidity(16.00%vs.44.44%,P=0.040).Conclusions:ERAS program may be safe and effective for the patients underwent hepatectomy,especially open surgery,for benign liver lesions.

关键词： Enhanced recovery after surgery Hepatectomy Benign liver lesions Laparoscopy Liver function

Application of an ultra performance liquid chromatography-tandem mass spectrometry method to the pharmacokinetics study of paeoniflorin-6'-O-benzene sulfonate and its active paeoniflorin metabolite in rat plasma

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中国药理学与毒理学杂志 2017年第10期31卷 1009-1010页

作者： ming-yi zhao Jun YU Jian WANG yi-jin WU Feng XIAO Chun WANG Wei WEI Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-inflammatory and Immune MedicineMinistry of EducationAnhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine

OBJECTIVE To establish a rapid,simple,precise and sensitive ultra performance liquid chromatography(UPLC) method for determination of paeoniflorin-6'-O-benzene sulfonate(acylated derivative of Pae,CP-25) and its primary metabolite(Pae,M1) in rat plasma,and to investigate the effects of gender,food and disease status on the pharmacokinetics after oral administration in *** Plasma samples and calibrators were extracted with methanol after addition of the internal standard *** evaporation of the methanol layer,the residue was reconstituted in mobile phase,and a 2 μL of the sample was injected into a Waters ACQUITY UPLC BEH C18(2.1 mm × 50 mm,1.7 μm) column for separation at a flow rate of 0.5 mL·min^(-1) at 40℃.The mobile phase was composed of 0.1% formic acid in water and methanol(68∶32,V/V).RESULTS The developed UPLC-MS/MS method was linear in the concentration range of 2-800 mg·L^(-1).Validation of the method proved that the method′s precision,selectivity and stability were all within the acceptable *** study showed that CP-25 could have more extensive distribution in females than that in males but no differences in *** intake could also increase the extent of absorption and decrease the rate of clearance of CP-25 and M1 after oral administration in *** disease status would decrease the absorption of CP-25 in *** single-and multiple-dosing in adjuvant arthritis(AA) model,absorption of CP-25 and M1 was improved with increasing *** The developed UPLC-MS/MS method is sensitive,specific and was successfully applied to the pharmacokinetics of CP-25 and M1 in *** a significant gender,food intake and disease status differences for CP-25 and M1 were observed in this study.

关键词： paeoniflorin-6’-O-benzene sulfonate paeoniflorin UPLC-MS/MS pharmacokinetics

Novel immunotherapy strategy based on tumor microenvironment

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Tumor Microenvironment Research 2020年第2期2卷 34-41页

作者： Qi-Fan Luo yi-ming zhao Tianjin Medical University Tianjin 300052China Department of General Surgery Tianjin Medical University General HospitalTianjin 300052China

Recent advances in molecular and cellular tumor immunology have demonstrated that immunotherapy might have great potential,which would be another important treatment strategy after surgery,radiotherapy and ***,this review mainly summarizes and discusses the classification of tumor immune microenvironment and the existing main immunotherapies,in order to provide some guidance and suggestions for accurate individualized immunotherapy.

关键词： Tumor microenvironment Immunotherapy Immune checkpoint blockade

Hereditary hemorrhagic telangiectasia involving portal venous system:A case report and review of the literature

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2367-2375页

作者： Jun-Ling Wu Zhi-Zhuang zhao Jun Chen Han-Wen Zhang Zhe Luan Cong-Yong Li yi-ming zhao Yu-Jia Jing Shu-Fang Wang Gang Sun Medical School of Chinese PLA Department of Gastroenterology and HepatologyThe First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Geriatrics Hainan Hospital of PLA General HospitalSanya 572013Hainan ProvinceChina Department of Sixth Health Care Second Medical Center of PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology Hainan Hospital of PLA General HospitalSanya 572013Hainan ProvinceChina Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general *** is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and ***,HHT rarely involves the portal venous system to cause serious clinical *** SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with *** tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was *** a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal *** postoperative symptoms of the patient were quickly ***,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining *** For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.

关键词： Hereditary hemorrhagic telangiectasia Portal system Arteriovenous fistula Arteriovenous malformation Selective artery embolization Case report