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Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang Chun Li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong ming-yan shao Bing-Hua Tang Dong-Qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

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Circ_0004592:An auxiliary diagnostic biomarker for gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2757-2768页

作者： Shan Kong yan-Hua Xu ming Zheng shao-Qing Ju Heng-Chuan Shi Department of Laboratory Medicine Jiangsu Province Official HospitalNanjing 210000Jiangsu ProvinceChina Department of Laboratory Medicine Northern Jiangsu People’s HospitalYangzhou 225000Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate,and robust diagnostic biomarkers are currently ***,the clinical relevance of circular RNAs(circRNAs)as GC biomarkers remains largely *** To evaluate the potential of novel circRNA circ_0004592 in the early screening and prognosis of *** High-throughput sequencing of circRNAs was performed to screen for potential target ***_0004592 expression was examined in GC tissues,cells,and *** samples were collected from healthy subjects’patients,as well as from patients with benign lesions,precancerous lesions,and GC,whereafter the diagnostic accuracy of circ_0004592 was *** correlation between circ_0004592 levels in plasma and clinicopathological data of patients with GC was further *** Circ_0004592 was upregulated in both the tissue and plasma of patients with ***,circ_0004592 expression was higher in patients with precancerous lesions than in healthy controls while being highest in patients with *** the same patient,the postoperative plasma level of circ_0004592 was lower than that in the preoperative ***,circ_0004592 level was significantly correlated with tumor differentiation,tumor depth,and lymph node *** area under the curve(AUC)of plasma circ_0004592 exhibited high sensitivity and specificity for differentiating patients with GC from healthy *** based on circ_0004592,carcinoembryonic antigen,and cancer antigen 199 achieved a superior AUC and was highly *** Plasma circ_0004592 may represent a potential non-invasive auxiliary diagnostic biomarker for patients with GC.

关键词： Biomarker Circular RNA Diagnosis Gastric cancer Plasma

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Advanced Materials for NH_(3) Capture: Interaction Sites and Transport Pathways

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Nano-Micro Letters 2024年第11期16卷 119-155页

作者： Hai‑yan Jiang Zao‑ming Wang Xue‑Qi Sun shao‑Juan Zeng yang‑yang Guo Lu Bai ming‑Shui Yao Xiang‑Ping Zhang Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China China University of Petroleum Beijing 102249People’s Republic of China Institute for Integrated Cell‑Material Sciences(iCeMS) Kyoto UniversitySakyo‑KuYoshidaKyoto 606‑8501Japan

Ammonia(NH3)is a carbon-free,hydrogen-rich chemical related to global food safety,clean energy,and environmental *** an essential technology for meeting the requirements raised by such issues,NH3 capture has been intensively explored by researchers in both fundamental and applied *** four typical methods used are(1)solvent absorption by ionic liquids and their derivatives,(2)adsorption by porous solids,(3)abadsorption by porous liquids,and(4)membrane *** in the development of advanced materials for NH3 capture,we conducted a coherent review of the design of different materials,mainly in the past 5 years,their interactions with NH3 molecules and construction of transport pathways,as well as the structure–property relationship,with specific examples ***,the challenges in current research and future worthwhile directions for NH3 capture materials are proposed.

关键词： Ammonia capture Solvents Porous solids Porous liquids Membranes

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Tighter sum uncertainty relations via(α,β,γ)weighted Wigner–yanase–Dyson skew information

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Communications in Theoretical Physics 2024年第3期76卷 91-99页

作者： Cong Xu Zhaoqi Wu shao-ming Fei School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Department of Mathematics Nanchang UniversityNanchang 330031China Max-Planck-Institute for Mathematics in the Sciences 04103 LeipzigGermany

We establish tighter uncertainty relations for arbitrary finite observables via(α,β,γ)weighted Wigner–yanase–Dyson((α,β,γ)WWYD)skew *** results are also applicable to the(α,γ)weighted Wigner–yanase–Dyson((α,γ)WWYD)skew information and the weighted Wigner–yanase–Dyson(WWYD)skew *** also present tighter lower bounds for quantum channels and unitary channels via(α,β,γ)modified weighted Wigner–yanase–Dyson((α,β,γ)MWWYD)skew *** examples are provided to illustrate the tightness of our uncertainty relations.

关键词： quantum channels (α,β,γ)WWYD skew information (α,β,γ)MWWYD skew information uncertainty relations

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Signifying quantum uncertainty relations by optimal observable sets and the tightest uncertainty constants

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 47-54页

作者： Xiao-Bin Liang Bo Li shao-ming Fei School of Mathematics and Computer Science Shangrao Normal University Quantum Information Research Center Shangrao Normal University School of Mathematical Sciences Capital Normal University

Quantum uncertainty relations constrain the precision of measurements across multiple non-commuting quantum mechanical observables. Here, we introduce the concept of optimal observable sets and define the tightest uncertainty constants to accurately describe these measurement uncertainties. For any quantum state, we establish optimal sets of three observables for both product and summation forms of uncertainty relations, and analytically derive the corresponding tightest uncertainty constants. We demonstrate that the optimality of these sets remains consistent regardless of the uncertainty relation form. Furthermore, the existence of the tightest constants excludes the validity of standard real quantum mechanics, underscoring the essential role of complex numbers in this field. Additionally, our findings resolve the conjecture posed in [Phys. Rev. Lett. 118, 180402(2017)],offering novel insights and potential applications in understanding preparation uncertainties.

关键词： uncertainty relation the tightest uncertainty constants optimal observable sets

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Experimental Study of Local Scour Around Four Piles Under Different Attack Angles and Gap Ratios

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China Ocean Engineering 2024年第4期38卷 612-624页

作者： LIU ming-ming TANG Guo-qiang JIN Xin GENG shao-yang School of Architecture and Engineering Liaocheng UniversityLiaocheng 252000China Water-Sediment Regulation and Sand Effective Utilization Special Laboratory of Shandong Provincial Education Department Liaocheng UniversityLiaocheng 252000China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China College of Energy Chengdu University of TechnologyChengdu 610059China

In an effort to investigate and quantify the patterns of local scour,researchers embarked on an in-depth study using a systematic experimental *** research focused on the effects of local scour around a set of four piles,each subjected to different hydromechanical *** particular,this study aimed to determine how different attack angles—the angles at which the water flow impinges on the piles,and gap ratios—the ratios of the spacing between the piles to their diameters,influence the extent and nature of scour.A comprehensive series of 35 carefully designed experiments were orchestrated,each designed to dissect the nuances in how the gap ratio and attack angle might contribute to changes in the local scour observed at the base of pile *** these experimental trials,a wealth of local scour data were collected to support the *** data included precise topographic profiles of the sediment bed around the pile groups,as well as detailed scour time histories showing the evolution of scour at strategic feature points throughout the test *** analysis of the experimental data provided interesting *** study revealed that the interplay between the gap ratio and the attack angle had a pronounced influence on the scouring dynamics of the pile *** of the key observations was that the initial phases of scour,particularly within the first hour of water flow exposure,were characterized by a sharp increase in the scour depth occurring immediately in front of the *** this initial rapid development,the scour depth transitioned to a more gradual change *** contrast,the scour topography around the piles continuously *** suggests that sediment displacement and the associated sculpting of the seabed around pile foundations are sustained and progressive processes,altering the underwater landscape over *** results of this empirical investigation have significant implications for the design and constructio

关键词： local scour piles gap ratio attack angle

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Deposition of thin TiO_(2)films on fluorophlogopite particle surface by CVD in fluidized bed reactor to prepare silver pearlescent pigments

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Particuology 2024年第6期89卷 88-98页

作者： ming Liu Guoqiang shao Pengpeng Lv Jun Li Qingshan Zhu State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Two critical parameters:Glossiness and chromaticity space of pearlescent pigments were evaluated based on crystallinity and grain *** the roughness and the vertical distance evolution along the surface of deposited TiO_(2)film are affected by the *** optimal crystallinity of TiO_(2)was deposited at the temperature of 350℃.The TiCl4 concentration effectively changed the grain ***,the high flow rate of fluidizing gas and optimal gas–solid ratio(<0.11 m^(3)/(kg h))restricted the change of TiCl_(4)concentrations in fluidized bed *** this case,the grain size of the deposited TiO_(2)film was about 55 *** on the grain size,the color of pearlescent pigments was adjusted by controlling the film thickness based on TiO_(2)***,the silver pearlescent pigment with high glossiness was prepared by chemical vapor deposition method in a fluidized bed reactor.

关键词： Fluidized bed chemical vapor deposition TiO_(2)film deposition Pearlescent pigment Free powder restrain Crystal growth

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Spin asymmetry and dipole moments inτ-pair production with ultraperipheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 15-21页

作者： Dingyu shao Bin yan Shu-Run Yuan Cheng Zhang Department of Physics Center for Field Theory and Particle PhysicsFudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China(NSFC)and Fudan UniversityShanghai 200438China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics Peking UniversityBeijing 100871China

The anomalous magnetic(MDM)and electric(EDM)dipole moments of theτlepton serve as crucial indicators of new physics beyond the standard *** azimuthal angular asymmetry as a novel tool in ultraperipheral collisions(UPCs),we attain unparalleled precision in the study of these key *** by the highly linear polarization of coherent photons,this method uniquely enables both the MDM and EDM to contribute to the cos 2φangular distribution in similar ***,our approach substantially narrows the parameter space,excluding more than half of it compared to expected UPC-based measurements reliant solely on the total *** method not only provides improved constraints but also minimizes the need for additional theoretical assumptions,and offers a novel avenue to probe the EDM effects.

关键词： ultraperipheral collisions magnetic and electric dipole moments spin asymmetry

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Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1547-1556页

作者： yang yang Xiao-Chuan Duan shao-Hui Guo Xian-ming Zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure

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A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research(International) 2024年第1期31卷 74-91页

作者： yan yan Guang-hao Shang Li-ping Zhang shao-ying Li Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

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