检索结果-南通市图书馆

MYJS as potential PTP1B inhibitors showing antihyperglycemic activities

在线全文

学校读者我要写书评

暂无评论

MYJS as potential PTP1B inhibitors showing antihyperglycemic...

从临床标本中分离出的病原性细菌的分布及耐药性分析

中国化学会第十届全国天然有机化学学术会议

作者： Zhi-Qin liu Ting liu Du-Qiang Luo ming-yan li Zi-Yu Wang Gui-Xiang Wei Xiao-Yi Wang Ruo-Song Chen College of Pharmaceutical Sciences Hebei University College of life Sciences Hebei University

＜正＞Diabetes mellitus is an endocrine and metabolic disorder indicated by chronic hyperglycemia that produces biochemical changes and tissue *** insulin resistance is the major abnormality in T2DM,ameliorating insulin resistance has been considered as a principal clinical strategy to mitigate metabolic control in T2DM *** tyrosine phosphatase 1B（PTP1B）

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国现代医学杂志 2015年第10期25卷 40-44页

作者：李虹玲刘文恩张运丽李艳明晏群中南大学湘雅医院检验科湖南长沙410008

目的了解中南大学湘雅医院2012年临床分离病原菌分布及耐药性变迁,为临床合理使用抗菌药物提供依据。方法采用全自动微生物鉴定及药敏系统对临床标本分离的病原性细菌进行鉴定及药敏试验,所有实验数据用WHONET 5.6软件进行分析。结果该... 详细信息

目的了解中南大学湘雅医院2012年临床分离病原菌分布及耐药性变迁,为临床合理使用抗菌药物提供依据。方法采用全自动微生物鉴定及药敏系统对临床标本分离的病原性细菌进行鉴定及药敏试验,所有实验数据用WHONET 5.6软件进行分析。结果该院2012年共分离非重复病原菌7 227株,结果显示革兰阴性菌占63.7%(4 607/7 227),革兰阳性菌占36.3%(2 620/7 227)。革兰阴性菌中分离最多的依次为大肠埃希菌(20.2%)、肺炎克雷伯菌(17.6%)以及鲍曼不动杆菌(16.7%);革兰阳性菌以凝固酶阴性葡萄球菌(30.3%)以及金黄色葡萄球菌(26.1%)的分离为最多。大肠埃希菌和肺炎克雷伯菌ESBLs检出率分别为69.8%和48.6%,肠杆菌科细菌对亚胺培南的耐药率低于4.0%。金黄色葡萄球菌(SA)和凝固酶阴性葡萄球菌(CNS)中耐甲氧西林菌株的检出率分别为45.1%和80.7%,未检出对万古霉素和利奈唑胺耐药株;MRSA中对复方新诺明的敏感率为78.8%,MRCNS中对利福平的敏感率为79.3%。粪肠球菌对所测试抗菌药物的敏感性均显著高于屎肠球菌,两者对万古霉素的耐药率分别为0.9%和1.0%,并均检出少量对VA中介的菌株。铜绿假单胞菌和鲍曼不动杆菌对亚胺培南的耐药率分别为35.9%和68.6%,发现多株泛耐药非发酵菌。结论临床分离病原菌仍以革兰氏阴性杆菌为主,细菌耐药现象十分严重;耐甲氧西林葡萄球菌及产ESBLs的大肠埃希菌和肺炎克雷伯菌的分离率高,泛耐药非发酵革兰阴性杆菌有增加趋势;应加强细菌耐药监测,指导临床合理使用抗菌药物。

关键词：病原菌抗菌药物药敏试验耐药性

Non-coding RNAs in acute ischemic stroke:from brain to periphery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng Jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng li Zhuoran yang Ziming yan Huibin Shi Zhanli liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词：

D-最优混料设计制备复方蜘蛛香凝胶贴膏及初步药效学考察

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中草药 2022年第11期53卷 3329-3337页

作者：梅佳华王涛查丽春林维川颜明丽崔利利马云淑云南中医药大学云南昆明650500 云南省高校外用给药系统与制剂技术研究重点实验室云南省傣医药与彝医药重点实验室云南省南药可持续利用重点实验室云南昆明650500 南京中医药大学江苏南京210023

目的以剂型改造为出发点优选复方蜘蛛香凝胶贴膏(Compound Zhizhuxiang Gel Plaster,CZGP)处方,考察单一促渗剂与二元复合促渗剂的促渗作用,并初步考察CZGP与原处方香果健消片(Xiangguo Jianxiao Tablets,XJT)的镇痛作用。方法以初黏力... 详细信息

目的以剂型改造为出发点优选复方蜘蛛香凝胶贴膏(Compound Zhizhuxiang Gel Plaster,CZGP)处方,考察单一促渗剂与二元复合促渗剂的促渗作用,并初步考察CZGP与原处方香果健消片(Xiangguo Jianxiao Tablets,XJT)的镇痛作用。方法以初黏力、持黏力、剥离强度和感官评分为评价指标,采用D-最优混料设计优化凝胶贴膏处方;选择3种常用透皮促渗剂氮酮、丙二醇、薄荷醇,以木香烃内酯、去氢木香内酯、橙皮苷为指标,通过干加热透皮系统评价单一促渗剂和二元复合促渗剂的促渗作用,筛选最优促渗剂;通过小鼠(幼鼠)醋酸扭体实验初步评价CZGP与XJT的镇痛作用。结果CZGP的最佳处方为酒石酸1.000 g、PVP K906.000 g、NP70011.000 g、甘羟铝0.800 g、甘油35.000 g、水21.200 g;不同的一元促渗剂及二元促渗剂中,以3%丙二醇促渗作用最好,木香烃内酯、去氢木香内酯、橙皮苷的渗透速率分别为45.744、49.903、14.898μg/(cm^(2)·h),增渗倍数分别为1.523、1.602、2.636;CZGP对小鼠(幼鼠)醋酸扭体具有镇痛作用,且镇痛率高于XJT。结论CZGP具有良好的体外经皮渗透性及镇痛作用,为中药复方口服制剂改造为经皮给药制剂提供思路。

关键词： D-最优混料设计复方蜘蛛香凝胶贴膏体外透皮醋酸扭体实验香果健消片药效学镇痛初黏力持黏力剥离强度氮酮丙二醇薄荷醇木香烃内酯去氢木香内酯橙皮苷干加热透皮系统

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue li Hua Zhang lian-lian Wang Wen-Wen liu Xin yang ming-Zhao Xiao Hao-ling Zhang Juan li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Plitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

过冷水滴凝固特性的计算与实验研究

工程热物理学报 2017年第10期38卷 2196-2201页

作者：肖光明杜雁霞李伟斌王桥易贤桂业伟中国空气动力研究与发展中心空气动力学国家重点实验室绵阳621000

针对飞机结冰的特殊凝固过程,基于Enthalpy-porosity模型,发展了改进的结冰特性预测模型及数值计算方法,并基于凝固实验开展了所建模型及预测方法的验证。研究表明,相对于传统Enthalpy-porosity方法,所发展的方法可有效表征非平衡凝固过... 详细信息

针对飞机结冰的特殊凝固过程,基于Enthalpy-porosity模型,发展了改进的结冰特性预测模型及数值计算方法,并基于凝固实验开展了所建模型及预测方法的验证。研究表明,相对于传统Enthalpy-porosity方法,所发展的方法可有效表征非平衡凝固过程,因而对冷水滴凝固特性的表征具有较好的改进。基于所建方法,开展了水滴凝固特性的影响因素分析,获得了不同过冷条件下水滴凝固过程的温度分布及相界面变化特征。相关研究可为结冰热力学模型的改进,以及结冰特性的精细化预测提供重要参考。

关键词：过冷水滴飞机结冰凝固相变

植物生长调节剂IAA、GA和6-BA对芥菜型油菜和甘蓝型油菜富集镉的强化

在线全文

学校读者我要写书评

暂无评论

农业现代化研究 2010年第4期31卷 504-508页

作者：向言词官春云黄璜严明理彭秀花湖南科技大学生命科学学院湖南湘潭411201 湖南农业大学油料作物研究所湖南长沙410128

重金属植物提取修复效率受到植物体内重金属含量和植物生物量的影响。利用植物生长调节剂可作为强化植物修复效率的一种调控措施。本实验以芥菜型油菜(Brasscia juncea)和甘蓝型油菜(***)为对象,研究了植物生长调节剂IAA、GA和6-BA单独... 详细信息

重金属植物提取修复效率受到植物体内重金属含量和植物生物量的影响。利用植物生长调节剂可作为强化植物修复效率的一种调控措施。本实验以芥菜型油菜(Brasscia juncea)和甘蓝型油菜(***)为对象,研究了植物生长调节剂IAA、GA和6-BA单独或两两联合作用对这两种油菜富集镉的调控作用。研究结果显示:这3种植物生长调节剂对这两种油菜株高和生物量的影响不同,显著增加芥菜型油菜株高和生物量,却显著降低甘蓝型油菜株高和生物量。同时,这3种植物生长调节剂可显著提高芥菜型油菜和甘蓝型油菜的镉含量和植物积累镉量,这两种类型油菜积累的镉主要集中在茎和叶。植物生长调节剂处理的芥菜型油菜和甘蓝型油菜的镉转运系数和生物富集系数都大于对照,并且可增强油菜吸收镉和促进镉向茎和叶转移。IAA与GA或6-BA联合作用可协同强化油菜提取镉。

关键词： IAA GA 6-BA 镉芥菜型油菜甘蓝型油菜