检索结果-南通市图书馆

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

引用

Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiplicity of Solutions for a Class of Kirchhoff Type Problems

引用

Acta Mathematicae Applicatae Sinica 2010年第3期26卷 387-394页

作者： Xiao-ming He Wen-ming zou School of Science Minzu University of China Beijing 100081 China Department of Mathematical Sciences Tsinghua University Beijing 100084 China

In this paper we apply the （variant） fountain theorems to study the symmetric nonlinear Kirch- hoff nonlocal problems. Under the Ambrosetti-Rabinowitz＇s 4-superlinearity condition, or no Ambrosetti- Rabinowitz＇s 4-superlinearity condition, we present two results of existence of infinitely many large energy solutions, respectively.

关键词： Kirchhoff nonlocal problems Multiple solutions Fountain theorems

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

引用

Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang Liu Shusheng Tao Jieming Cai Biao Zhong Jie Li Wentao Deng Hongshuai Hou Guoqiang zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

引用

Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong zou Qian Lu mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrating machine learning and CALPHAD method for exploring low-modulus near-β-Ti alloys

引用

Rare Metals 2024年第1期43卷 309-323页

作者： Hao zou Yue-Yan Tian Li-Gang Zhang Ren-Hao Xue Zi-Xuan Deng ming-ming Lu Jian-xin Wang Li-Bin Liu School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Traditional theoretical and empirical calculation methods can guide the design of β-and metastable β-alloys for bio-titanium. However, it is still difficult to obtain novel near-β-Ti alloys with low modulus. This study developed a method that combines machine learning with calculation of phase diagrams(CALPHAD) to facilitate the design of near-β-Ti alloys. An elastic modulus database of Ti–Nb–Zr–Mo–Ta–Sn system was constructed first, and then three features(the electron to atom ratio, mean absolute deviation of atom mass, and mean electronegativity) were selected as the key factors of modulus by performing a three-step feature selection. With these features, a highly accurate model was built for predicting the modulus of near-β-Ti alloys. To further ensure the accuracy of modulus prediction, machine learning with the elastic constants calculated was leveraged by CALPHAD database. The root mean square error of the well-trained model can be as low as 6.75 GPa. Guided by the prediction of machine learning and CALPHAD, three novel near-β-Ti alloys with elastic modulus below 50 GPa were successfully designed in this study. The best candidate alloy(Ti–26Nb–4Zr–4Sn–1Mo–Ta) exhibits an ultra-low modulus(36.6 GPa) after cold rolling with a thickness reduction of 20%. Our method can greatly save time and resources in the development of novel Ti alloys, and experimental verifications have demonstrated the reliability of this method.

关键词： Near-β-Ti alloy Machine learning Calculation of phase diagram Low-modulus alloy Feature selection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Active disturbance rejection control for hydraulic width control system for rough mill

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1429-1434页

作者： zou Jun FU xin YANG Hua-yong Institute State Key Laboratoty of Fhtid Power Transmission and Control. Zhejiang University Hangzhou 310027 China

The highly nonlinear behavior of the system limits the performance of classical linear proportional and integral （PI） controllers used for hot rolling. An active disturbance rejection controller is proposed in this paper to deal with the nonlinear problem of hydraulic servo system in order to preserve last response and small overshoot of control system. The active disturbance rejection （ADR） controller is composed of nonlinear tracking differentiator （TD）, extended state observer （ESO） and nonlinear feedback （NF） law. An example of the hydraulic edger system case study is investigated to show the effectiveness and robustness of the proposed nonlinear controller, especially, in the circumstance of foreign disturbance and working condition variation, compared with classic PI controller.

关键词： Active disturbance rejection (ADR) Hydraulic servo system Width control Rough mill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coupled models of heat transfer and phase transformation for the run-out table in hot rolling

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 932-939页

作者： Shui-xuan CHEN Jun zou xin FU State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

Mathematical models are been proposed to simulate the thermal and metallurgical behaviors of the strip occtLrring on the run-out table （ROT） in a hot strip mill. A variational method is utilized for the discretization of the governing transient conduction-convection equation, with heat transfer coefficients adaptively determined by the actual mill data. To consider the thermal effect of phase transformation during cooling, a constitutive equation for describing austenite decomposition kinetics of steel in air and water cooling zones is coupled with the heat transfer model. As the basic required inputs in the numerical simulations, thermal material properties are experimentally measured for three carbon steels and the least squares method is used to statistically derive regression models for the properties, including specific heat and thermal conductivity. The numerical simulation and experimental results show that the setup accuracy of the temperature prediction system of ROT is effectively improved.

关键词： Run-out table (ROT) Cooling process Heat transfer Phase change Material properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical simulation of Marangoni effect induced by species transfer across iron droplet–molten slag interface

引用

Journal of Iron and Steel Research International 2023年第6期30卷 1109-1116页

作者： ming-ming Li Zhen-qiang Wu Lin Li Zong-shu zou Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgical Engineering Liaoning Institute of Science and TechnologyBenxi 117004LiaoningChina

A mathematical model accounting for unsteady mass transfer across interface of a stationary iron droplet immersed into molten slag was established through the volume of fluid coupled with level set *** Marangoni effect induced by mass transfer was reproduced successfully,and the hydrodynamic instability phenomena at the interface,such as the Marangoni convection flow,the evolution of the interfacial tension during the mass transfer,and the influence of Marangoni effect on the mass transfer rate,were *** results show that the Marangoni convection flow develops quickly and behaves as an ordered structure in the forms of four pairs of the convection cell at the edge of the droplet once the oxygen transfer across the interface *** average convection flow velocity along the interface is high,even more than 0.025 m/s,depending on the droplet diameter,which facilitates the mass *** Marangoni convection flow of the large droplet develops more easily than that of the small droplet,and the larger the droplet diameter is,the higher the convection flow velocity and the mass transfer rate ***,it is shown that the droplet diameter influences the impacting region of the Marangoni convection flow and its duration period.

关键词： Interfacial mass transfer Interfacial tension Marangoni effect Droplet Numerical simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China’s Comprehensive Disaster Reduction

引用

International Journal of Disaster Risk Science 2010年第1期1卷 24-32页

作者： ming zou Yi Yuan Department of Disaster Relief Ministry of Civil AffairsBeijing 100721P.R.China National Disaster Reduction Center of China Ministry of Civil AffairsBeijing 100053P.R.China

China is one of the countries in the world that are most affected by natural disasters. In recent years, with global climate change and rapid socioeconomic development in the country, natural disaster risks have been increasing and economic losses and the population affected have shown a growing trend;catastrophic disasters have repeatedly ravaged China, causing major socioeconomic *** Chinese government attaches great importance to disaster prevention, reduction, and relief. Developments in laws and regulations on natural disaster management in the past three decades have provided an improved legal framework for disaster prevention, reduction, and relief. China’s disaster relief is guided by the principle of people-centered, government-led, multilevel management, mutual support within social networks, and self-rescue of victims. Through the years, the government has been expanding the scope of disaster relief and increasing the level of assistance, strengthening integrated coordination mechanisms, and standardizing procedures for relief work. Disaster prevention, reduction, and relief mechanisms based on China’s situation, and with Chinese characteristics, have been established. Attention has also been given to capacity-building. Much effort has been made to implement disaster reduction projects and to improve early warning systems, emergency response, science and technological support, human resource development, and community disaster relief systems. Future disaster reduction efforts of the Chinese government will focus on alleviating the impact of natural disasters, coping with catastrophic disaster risks, harmonizing the relationship between humans and nature, and attaining sustainable development.

关键词： disaster prevention legal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vernier effect facilitates integrated lithium niobate single-mode lasers

引用

Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 133-134页

作者： xin-Biao Xu Chang-Ling zou Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

A research group from Nankai University in China has demonstrated an integrated whispering gallery mode(WGM)microcavity laser on erbium-doped thin-film lithium niobate with a pump threshold of about 200 μW and a side-mode suppression ratio exceeding 26 d B [1]. The Vernier effect is applied to realize the single-mode lasing in a photonic molecule. The work provides a feasible scheme for on-chip single-mode laser for integrated lithium niobate on insulator(LNOI) photonic circuits, and more active devices in LNOI will be developed inspired by this work.

关键词： pump mode lithium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：