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Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons

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National Science Review 2024年第4期11卷 70-83页

作者： Huiying Zhao Jinrong liu Yujin Shao Xiang Feng Binhan Zhao li Sun Yijun liu linghui Zeng xiao-ming li Hongbin Yang Shumin Duan Yan-qin Yu Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of Medicine Nanhu Brain-Computer Interface Institute liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-Machine Intelligence Zhejiang University NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University

The nucleus of Darkschewitsch(ND), mainly composed of GABAergic neurons, is widely recognized as a component of the eye-movement controlling system. However, the functional contribution of ND GABAergic neurons(NDGABA) in animal behavior is largely unknown. Here, we show that NDGABA neurons were selectively activated by different types of fear stimuli, such as predator odor and foot *** and chemogenetic manipulations revealed that NDGABA neurons mediate freezing ***, using circuit-based optogenetic and neuroanatomical tracing methods, we identified an excitatory pathway from the lateral periaqueductal gray(l PAG) to the ND that induces freezing by exciting ND inhibitory outputs to the motor-related gigantocellular reticular nucleus, ventral part(Gi V). Together,these findings indicate the NDGABA population as a novel hub for controlling defensive response by relaying fearful information from the l PAG to Gi V, a mechanism critical for understanding how the freezing behavior is encoded in the mammalian brain.

关键词： nucleus of Darkschewitsch GABAergic population defensive behavior freezing neural circuitry

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang xiao-ming li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi liu Yang Ren Xun-li Wang xiao-Ya Cui xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru li Qi-Long Gao Jia-ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang ling-Kun Zhang Yi-Ping Lu Xu-Bo li Huai-Jun lin Yan Ma Wei-ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang Wang Qing-Feng liu Fei-Yang Wang Hui liu Hong-Hui Wu li-Qiang Wang Yang Lu Nan Wang Tian-li Wang Wei-Bing liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang li Wei-Di liu Zhi-Gang Chen Xiong-Jun liu Wen Ma liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

MATHEMATICAL MODEliNG OF OIL SPILL ON THE SEA AND APPliCATION OF THE MODEliNG IN DAYA BAY

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Journal of Hydrodynamics 2007年第3期19卷 282-291页

作者： CHEN Hai-zhou li Da-ming li xiao School of Civil Engineering Tianjin University Tianjin 300072

Through the study of the theory of oil spill model, a mathematical modeling of oil spill on the sea is developed which with the consideration of spread, diffusion, drifting and attenuation of oil slick is influenced by evaporation and emulsification factors. A model that under the effect of ocean dynamic condition of tide, wind and wave, using Monte Carlo method to simulate the movement of oil slick is established. The modeling is applied to calculate and predict pollution range of oil spill at oil quay and oil ship in Daya Bay. The prediction results have basically shown the pollution situation by emergency of oil spill on the sea.

关键词： oil spill on the sea spread of oil slick diffusion of oil slick Monte Carlo method bay contamination

Detection of telomerase activity by combination of telomeric repeat amplification protocol and electrochemiluminescence assay

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Chinese Chemical Letters 2008年第6期19卷 699-702页

作者： xiao ming Zhou li Jia MOE Key Laboratory of Laser life Science ＆ Institute of Laser life Science South China Normal University Guangzhou 510631 China

A highly sensitive telomerase detection method that combines telomeric repeat amplification protocol （TRAP） and magnetic beads based electrochemiluminescence （ECL） assay has been developed. Briefly, telomerase recognizes biotinylated telomerase synthesis primer （B-TS） and synthesizes extension products, which then serve as the templates for PCR amplification using B-TS as the forward primer and tris-（2′2′-bipyridyl） ruthenium （TBR） labeled ACX （TBR-ACX） as the reversed primer. The amplified product is captured on streptavidin-coated paramagnetic beads and detected by ECL. Telomerase positive HeLa cells were used to validate the feasibility of the method. The experimental results showed down to 10 cancer cells can be detected easily. The method is a useful tool for telomerase activity analysis due to its sensitivity, rapidity, safety, high throughput, and low cost. It can be used for screening a large amount of clinical samples.

关键词： Telomerase activity TRAP Electrochemiluminescence Cancer diagnosis

Type-Aware Question Answering over Knowledge Base with Attention-Based Tree-Structured Neural Networks

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Journal of Computer Science & Technology 2017年第4期32卷 805-813页

作者： Jun Yin Wayne Xin Zhao xiao-ming li School of Electronic Engineering and Computer Science Peking University Beijing 100871 China School of Information Renmin University of China Beijing 100872 China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou 510006 China

Question answering (QA) over knowledge base (KB) aims to provide a structured answer from a knowledge base to a natural language question. In this task, a key step is how to represent and understand the natural language query. In this paper, we propose to use tree-structured neural networks constructed based on the constituency tree to model natural language queries. We identify an interesting observation in the constituency tree: different constituents have their own semantic characteristics and might be suitable to solve different subtasks in a QA system. Based on this point, we incorporate the type information as an auxiliary supervision signal to improve the QA performance. We call our approach type-aware QA. We jointly characterize both the answer and its answer type in a unified neural network model with the attention mechanism. Instead of simply using the root representation, we represent the query by combining the representations of different constituents using task-specific attention weights. Extensive experiments on public datasets have demonstrated the effectiveness of our proposed model. More specially, the learned attention weights are quite useful in understanding the query. The produced representations for intermediate nodes can be used for analyzing the effectiveness of components in a QA system.

关键词： question answering deep neural network knowledge base

基于塑性屈服体积-应变增量积的特高拱坝整体稳定性评价

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水电能源科学 2024年第3期42卷 101-104,114页

作者：李桂林左金涛张广森肖明砾国家能源集团西藏电力有限公司西藏拉萨850033 四川大学水利水电学院四川成都610065 中国电建集团成都勘测设计研究院有限公司四川成都610072

坝肩岩体的工作性状是评价拱坝整体稳定性的重要依据,也是特高拱坝设计与安全调控的重点与难点。数值模拟分析中,以拉裂及压剪屈服区域发育范围的传统评价方法无法考虑岩体及结构面损伤屈服程度,且难以准确评判断层等对应力状态敏感材... 详细信息

坝肩岩体的工作性状是评价拱坝整体稳定性的重要依据,也是特高拱坝设计与安全调控的重点与难点。数值模拟分析中,以拉裂及压剪屈服区域发育范围的传统评价方法无法考虑岩体及结构面损伤屈服程度,且难以准确评判断层等对应力状态敏感材料的工作性态。为此,提出一种基于应变增量判断建坝蓄水后坝肩结构面是否进入屈服状态,采用塑性单元体积与其应变增量的乘积为指标的拱坝整体稳定性评价方法,并采用该方法对ZY特高拱坝展开研究,揭示了其坝肩岩体及结构面在正常运行工况及超载条件下整体稳定特征演化规律,厘清了显著影响坝肩稳定性的断层及结构面,为特高拱坝整体稳定性评估及加固措施优化调控提供了技术支撑。

关键词：拱坝结构面整体稳定性超载法塑性屈服应变增量

Improved QO-STBC for three and four transmit antennas

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 42-46页

作者： JIA ming-ru xiao li-ping College of Information Science and Engineering Yanshan Universitys Qinhuangdao 066004 China

A new quasi-orthogonal space-time block code （QO-STBC） based on ABBA code with lower decoding complexity and higher bit error statistics （BER） performance was proposed by U. Park recently, which can obtain full transmission rate and full diversity. In this article, the authors proposed an improved U. Park scheme based on rotational ABBA code. For eliminating the interference terms resulting from neighboring signals during signal detection, two different matrixes are used. And independent decoding can be realized when maximum-likelihood decoding at the receiver is used. Simulation results demonstrate that the BER performance is improved dramatically without increasing the decoding complexity compared with U. Park scheme.

关键词： independent decoding multiple antennas QO-STBC

Remotely sensed big data for the oceans and polar regions

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Big Earth Data 2022年第2期6卷 141-143页

作者： xiao-ming li International Research Center of Big Data for Sustainable Development Goals BeijingChina Key Laboratory of Digital Earth ScienceAerospace Information Research InstituteChinese Academy of SciencesBeijingChina

The oceans,which account for 71%of the Earth’s area,and the polar regions,the largest cold source on Earth,jointly play crucial roles in energy exchange and circulation,and in climate change(***,Chapin,Walsh,&Wirth,2006).In particular,against the background of global climate change,both the Arctic and Antarctic are experiencing profound changes(Bracegirdle,Connolley,&Turner,2008;Jeffries,Overland,&Perovich,2013),and the inter-actions between the oceans,polar regions and the atmosphere are closer than *** sensing has become one of the main research tools in ocean and polar studies(Lubin,Ayres,&Hart,2009).At the same time,the amount of acquired data is undergoing explosive growth(Ma et al.,2015),thus leading oceanography into the era of“big data”.

关键词： Earth oceans Arctic

Analysis of energy consumption for lump coal degradation in melting gasifier

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Journal of Iron and Steel Research International 2017年第8期24卷 770-777页

作者： Qi-hang liu xiao-ming li Jun-xue Zhao School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina

The volume hypothesis,a theory about the energy scale of comminution,was adopted to analyze the degradation behavior of lump coal under different heating *** breakage energy of chars was determined by a compression test,and the results show that the ultimate strength of chars decreased at the early stage during the heating process,resulting in a decrease of the char breakage *** the late stage during the heating process,the char breakage energy increased with the increase of heating *** power consumption coefficients CKof different chars were determined by a drum experiment,and then the char degradation behavior under different power consumptions was *** addition,agasification experiment was conducted to determine the gasification activation energy（with CO_2）of lump coal heated for different *** results show that the gasification activation energy increased greatly at the early stage during the heating process,which showed opposite change to the breakage energy of ***,the internal temperature and heat changes of the bonded coal briquette were calculated by using an unsteady heat conduction *** large difference between the surface and the center temperatures of coal and the large amount of heat absorption at the early stage during the heating process may have a negative effect on the breakage energy of chars.

关键词： Melting gasifier Lump coal Degradation Volume hypothesis Heat absorption