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Neutron Diffraction Study of Low-Cycle Fatigue Behavior in an Austenitic–Ferritic Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1247-1256页

作者： ming-wei zhu Nan Jia Feng Shi Bjorn Clausen School of Materials Science and Engineering Shenyang Aerospace University Key Laboratory for Anisotropy and Texture of Materials(ATM) Northeastern University School of Science Northeastern University Los Alamos National Laboratory Los Alamos Neutron Science Center

By performing in situ neutron diffraction experiments on an austenitic-ferritic stainless steel subjected to lowcycle fatigue loading, the deformation heterogeneity of the material at microscopic level has been revealed. Based on the in situ neutron diffraction data collected from a single specimen together with the mechanical properties learned from the ex situ micro-hardness, a correlation has been found. The performance versus diffraction-profile correlation agrees with the cyclic-deformation-induced dislocation evolution characterized by ex situ TEM observation. Moreover, based on the refined neutron diffraction-profile data, evident strain anisotropy is found in the austenite. The high anisotropy in this phase is induced by the increase in dislocation density and hence contributes to the hardening of the steel at the first 10 *** 10 fatigue cycles, the annihilation and the rearrangement of the dislocations in both austenitic and ferritic phases softens the plastically deformed specimen. The study suggests that the evolution of strain anisotropy among the differently oriented grains and micro-strain induced by lattice distortion in the respective phases mostly affect the cyclic-deformationinduced mechanical behavior of the steel at different stages of fatigue cycles. The stress discrepancy between phases is not the dominant mechanism for the deformation of the steel.

关键词： Duplex steel Neutron diffraction Fatigue Plastic deformation Microstructure

Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel disease

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World Journal of Gastroenterology 2022年第48期28卷 6888-6899页

作者： Yi-Han Xu wei-ming zhu Zhen Guo Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Treatment strategies for inflammatory bowel disease(IBD)are rapidly evolving with the development of biologics and small molecule drugs(SMDs).However,these drugs are not guaranteed to be effective in all patients,and a“ceiling effect”of biologic monotherapy may *** issue highlights an unmet need for optimizing the use of biologics and predicting therapeutic ***,the development of new drugs with novel mechanisms of action is urgently needed for patients with primary nonresponse and secondary loss of response to conventional biologics and *** addition,combining different biologics or SMDs has been proposed as a novel strategy to enhance treatment efficacy in IBD,which theoretically has multidimensional anti-inflammatory *** on the current evidence available for IBD,dual targeted therapy may be a promising strategy for refractory IBD patients who have failed in multiple biologic treatments or who have extraintestinal ***,identifying the subgroup of IBD patients who are responding to biological combination therapies is also equally important in stable disease *** this review,we summarize the newly developed biologics and SMDs and the current status of biologics/SMDs to highlight the development of individualized treatment in IBD.

关键词： Inflammatory bowel diseases Biologic Dual targeted therapy Therapeutic drug monitoring Bispecific antibodies

Postoperative diarrhea in Crohn's disease:Pathogenesis,diagnosis,and therapy

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World Journal of Clinical Cases 2023年第1期11卷 7-16页

作者： En-Hao Wu Zhen Guo wei-ming zhu Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases(CD),and several different mechanisms likely account for postoperative diarrhea in CD.A targeted strategy based on a comprehensive underst... 详细信息

关键词： Postoperative diarrhea Crohn’s disease Intestinal resection Bile acid malabsorption Treatment

Inhomogeneous Deformation of Multilayered Roll-Bonded Brass/Cu Composites

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 600-607页

作者： Nan Jia ming-wei zhu Yi-Ran Zheng Tong He Xiang Zhao Key Laboratory for Anisotropy and Texture of Materials (ATM) Northeastern University Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Research Institute Northeastern University

The deformation gradients in multilayered hot roll-bonded composite materials incorporating two dissimilar face-centered cubic metals, i.e., brass and Cu, were investigated by characterizing the deformation microstructure, hardness and texture at different thickness positions of the composites. For the constitutive metals, the center part of each metal sheet forms the substructure containing coarse grains, while the ultrafine grains and significant shear banding form in the outer part. As deformation increases, the cross-interface shear occurs in the Cu sheet of the composites. Then, grain fragmentation, shear banding and dynamic recovery become the main factors that influence hardness of the metal. Moreover, in the co-deformed composites, the interface between brass and Cu plays a role in texture developments of the individual metals.

关键词： Deformation Multilayers Brass/Cu composites Texture

Two New Isosteroid Alkaloids from Fritillaria monatha Migo（Ⅲ）

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Chinese Chemical Letters 2006年第5期17卷 631-634页

作者： Hong Ning LIU Fei LI Yong ming LUO wei Feng zhu Jiangxi University of Traditional Chinese Medicine Nanchang 330004

Two new isosteroid alkaloids, named pengbeimine A and pengbeimine C, were isolated from the fresh bulbs of FritiUaria monatha Migo. Their structures were determined by spectral methods, and were proved by X-ray diffra... 详细信息

关键词： Fritillaria monatha Migo isosteroid alkaloids pengbeimine A pengbeimine C.

Steroidal alkaloids from the bulbs of Fritillaria monatha

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Chinese Chemical Letters 2008年第5期19卷 544-546页

作者： Hong Ning Liu Fei Li Yong ming Luo wei Feng zhu Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China

Two new Steroidal alkaloids, named pengbeisine A and pengbeisine B, were isolated from the fresh bulbs of Fritillaria monatha Migo. along with a known alkaloid. The structures were characterized as 22,26-imino-17, 23-oxido-5α-jerv-6-oxo-2α,3β-diol and 22, 26-imino-17, 23-oxido-5α-jerv-6-oxo-2β,3α-diol on the basis of spectroscopic methods.

关键词： Fritillaria monatha Migo Steroidal alkaloids Pengbeisine A Pengbeisine B

Role of mesenteric component in Crohn’s disease:A friend or foe?

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1536-1549页

作者： Yi Yin Zhen-Xing zhu zhun Li Yu-Sheng Chen wei-ming zhu Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric *** mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis,and this axis has been proven to be *** abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals,neuropeptides,lymphatic drainage,adipokines,and functional *** hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic *** vascular alteration,including angiogenesis and lymphangiogenesis,is concomitant in the disease course of *** note,the enlarged and obstructed lymphatic vessels,which have been described in CD patients,are likely related to the early onset submucosa edema and being a cause of *** function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and ***,the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured,which can lead to lymph *** lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune *** identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.

关键词： Crohn’s disease Mesenteric nerves Angiogenesis Lymphatic drainage Mesenteric adipose tissue

Perforating and nonperforating indications in repeated surgeries for Crohn's disease

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World Journal of Clinical Cases 2022年第9期10卷 2733-2742页

作者： wei-Song Shen Xiao-Hui Huang Rui-Qing Liu Chen-Yang Li Yi Li wei-ming zhu Department of Gastrointestinal Surgery Peking University People’s HospitalBeijing 100044China Department of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China Department of General Surgery The affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Peking University School of Nursing Peking University School of NursingBeijing 100191China Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND Despite advances in medical therapy for Crohn’s disease(CD),most patients with CD require repeated resection *** To analyze the perforating and nonperforating indications of repeated CD operations and identify the anastomosis characteristics for postoperative *** We retrospectively reviewed 386 patients who underwent at least one resection for CD between 2003 and *** characteristics of each surgery were *** and multivariate analyses were performed to determine risk factors for *** The indication for reoperation in CD tends to be the same as that for primary operation,i.e.,perforating disease tends to represent as perforating disease and nonperforating as *** was found between the first surgery and second surgery in terms of the indication for the operation(P=0.006),and the indication for the third surgery was also correlated with that for the second surgery(P=0.033).Even if the correlation of surgical indications between repeated operations,the rate of perforating indication for the second and third surgeries was significantly higher than that of the first *** addition,the presence of perforating CD was a predictor of recurrence for both the first and second ***,anastomotic lesions were the most common sites of recurrence after the *** on the importance of anastomosis,anastomosis might be a new type of disease location for the classification of postoperative *** CD not only has stable characteristics but also progresses *** is a progressive surgical indication for Crohn’s *** CD after surgery,anastomosis may be a new classification of disease location.

关键词： Crohn’s Disease Anastomosis Perforation Nonperforating

New Diterpenoid Alkaloids from Spiraea japonica var. Ovalifolia

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Chinese Chemical Letters 2001年第2期12卷 147-150页

作者： Guo Ying ZUO Hong Ping HE Xin HONG wei ming zhu Yi ming HU Xiao Sheng YANG Xiao Jiang HAO Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Kunming 43 Hospital PLAKunming 650032 The Key Laboratory of Chemistry for Natural Products ofGuizhou Province and Chinese Academy of Sciences Guiyang 550002

Five new diterpenoid alkaloids. 19-O-deethlyspiramine N (1), deacetylspiramine S (2), spiramidine A (3), spiramidine B (4) and deacetylspiramine F (5) were isolated from the aerial parts of Spirae japonica L. f. var o... 详细信息

关键词： Rosaceae Spireae japonica L. f. var. ovalifolia diterpenoid alkaloids