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Treatment-seeking behaviour and barriers to service access for sexually transmitted diseases among men who have sex with men in China:a multicentre cross-sectional survey

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Infectious Diseases of Poverty 2017年第1期6卷 118-127页

作者： Jun-Jie Xu Yan-Qiu Yu Qing-Hai Hu Hong-Jing Yan Zhe Wang Lin Lu ming-Hua Zhuang Xi Chen Ji-Hua Fu wei-ming tang Wen-Qing Geng Yong-Jun Jiang Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouChina Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina Yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina Hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina University of North Carolina Project-China GuangzhouChina

Background:Delayed or inappropriate treatment for sexually transmitted diseases(STDs)increases the risk of HIV acquisition and may cause other harmful ***,studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men(MSM)are *** information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese ***:During 2012-2013,a multicentre cross-sectional study was conducted in 7 Chinese *** completed an interview-questionnaire and gave venous blood samples,which were then tested for antibodies to HIV,syphilis,and herpes simplex virus-2(HSV-2).MSM who tested positive for syphilis/HSV-2 or had obvious STD-related symptoms within the last 12 months were defined as suspected STD-infected ***:Of the 4496 eligible MSM who completed this survey,24.4%(1096/4496)were categorized as suspected STD-infected MSM.35.7%(391/1096)of these MSM with suspected STD infections sought STD treatment in clinics within the last 12 *** MSM who did not attend STD clinics for treatment,the prevalence of syphilis and HSV-2 was significantly higher;the HIV prevalence and incidence within this subpopulation reached as high as 14.5%and 12.2/100 person-years,*** logistic regression analysis indicated that having 7-12 years of education(vs.≤6 years;aOR,2.5;95%CI,1.0-6.1),≥13 years of education(vs.≤6 years:aOR,2.8;95%CI,1.2-7.0),monthly income>500 USD(vs.≤500 USD:aOR,1.5;95%CI,1.1-2.1),obvious STD-related symptoms within last 12 months(aOR,5.3;95%CI,3.7-7.5),being HIV infected(aOR,1.7;95%CI,1.1-2.6),currently syphilis infected(aOR,0.6;95%CI,0.4-0.9)and HSV-2 infected(aOR,0.6;95%CI,0.5-0.9)were independent correlates with seeking STD treatment in clinics among Chinese ***:The high prevalence of STD infection coupled with a low proportion of individuals who exhibit appropriate treatment-seeking behaviour create a high risk of a g

关键词： Sexually transmitted diseases(STDs) Men who have sex with men(MSM) Treatment-seeking behaviour HIV China

High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study

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Infectious Diseases of Poverty 2016年第1期5卷 753-763页

作者： Jun-Jie Xu wei-ming tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu ming-Hua Zhuang Xi Chen Ji-Hua Fu Yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-Xu Han Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyang 110001People’s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouPeople’s Republic of China University of North Carolina at Chapel Hill Project-ChinaNo.2 Lujing RoadGuangzhou 510085People’s Republic of China Guangdong Provincial Center for Skin Diseases and STIs Control Guangzhou 510085People’s Republic of China Kirby Institute the University of New South WalesSydneyNSW 2052Australia Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos Angeles 90095USA Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina Yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina Hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina

Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in *** of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive ***:Mixed methods were used to recruit MSM from seven cities in China between 2012 and *** and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme *** and herpes simplex virus-2(HSV-2)were also ***:A total of 4496 eligible MSM were *** majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 *** prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,*** HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in *** interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour.

关键词： Men who have sex with men(MSM) HIV Incidence BED HIV-1 capture enzyme immunoassay(BED-CEIA)

Improvement of lymphangioleiomyomatosis following successful tofacitinib treatment for refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome

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Chinese Medical Journal 2019年第19期132卷 2378-2379页

作者： Shuang Liu Chen Li ming-wei tang Wen-Shuai Xu Ke-Qi Chen Xin Sui Xin-Lun Tian Kai-Feng Xu School of Clinical Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Traditional Chinese Medicine Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Respiratory and Critical Care Medicine Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China

To the Editor:Lymphangioleiomyomatosis(LAM)is a rare multi-systemic disease that predominantly affects women and is associated with cystic lung destruction,chylous fluid accumulation,and abdominal tumors.[1]The lung function of LAM patients declines at two to four or more times faster rates than the typical age-related *** the mammalian target of rapamycin(mTOR)inhibitor has shown certain benefits for patients with LAM,treatment options remain limited.[2]Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome is a spectrum of heterogeneous diseases characterized by osteoarticular and dermatological *** anti-inflammatory drugs(NSAIDs),disease-modifying anti-rheumatic drugs,bisphosphonates,and intra-articular steroids are frequently prescribed but are often insufficient to control disease progression.

关键词： drugs lung treatment

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian tang Yuan-ming Pan wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Correlates of HIV self-testing among female sex workers in China: implications for expanding HIV screening

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Infectious Diseases of Poverty 2020年第5期9卷 128-128页

作者： Cheng Wang Ya‑Jie Wang Joseph D.Tucker ming‑Zhou Xiong Hong‑Yun Fu M.Kumi Smith wei‑ming tang Jason J.Ong He‑Ping Zheng Bin Yang Dermatology Hospital of Southern Medical University GuangzhouGuangdongChina 不详

Background:Human immunodefciency virus(HIV)self-testing may help improve test uptake among female sex *** has implemented many HIV self-testing programs among men who have sex with men,creating an opportunity for promotion among female sex ***,there is a limited literature on examining HIV selftesting among female sex *** study aimed to examine HIV self-testing experiences and its determinants among female sex workers in ***:A venue-based,cross-sectional study was conducted among Chinese female sex workers in *** completed a survey including social-demographic characteristics,sexual behaviors,and HIV self-testing history,the distribution of which were analyzed using descriptive *** logistic regression was conducted to identify associations with HIV ***:Among 1287 Chinese female sex workers,1072(83.3%,95%confdence interval[CI]81.2-85.3%)had ever tested for HIV,and 103(8.0%,95%CI 6.6-9.6%)had ever used HIV *** than half reported that the selftest was their frst HIV test(59.2%,61/103),around one-ffth reported HIV self-testing results infuenced the price of sex(21.4%,22/103).A minority of individuals reported ever experiencing pressure to undertake HIV self-testing(6.8%,7/103).After adjusting for covariates,HIV self-testing was positively associated with receiving anal sex in the past month(adjusted odds ratio[aOR]=2.2,95%CI 1.4-3.5),using drugs before or during sex(aOR=2.8,95%CI 1.8-4.5),injecting drugs in the past 6 months(aOR=2.6,95%CI 1.2-6.0),being diagnosed with other sexually transmitted infections(aOR=1.6,95%CI 1.0-2.5),tested for other sexually transmitted infections in the past six months(aOR=3.4,95%CI 2.1-5.5),ever tested in the hospital(aOR=3.4,95%CI 2.0-5.6),and ever tested in the community(aOR=1.5,95%CI 1.2-1.9).Conclusions:Our fndings suggest that HIV self-testing could expand overall HIV testing uptake,increase HIV testing frequency,reach sub-groups o

关键词： HIV Self-testing Female sex workers China

肠内营养联合化疗治疗晚期胃癌的临床疗效研究

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肠外与肠内营养 2017年第4期24卷 205-208页

作者：蔡铭泉汤玮玮安汉祥李晓虹厦门大学附属第一医院厦门市肿瘤医院肿瘤内科福建厦门361000

目的:探讨晚期胃癌化疗期间联合肠内营养治疗的价值。方法:本研究为前瞻性随机研究。按NRS 2002营养风险量表筛选具有营养不良风险的62例不可手术的晚期胃癌病人随机分为两组。两组病人均行奥沙利铂联合替吉奥化疗,对照组(n=30)在化疗... 详细信息

目的:探讨晚期胃癌化疗期间联合肠内营养治疗的价值。方法:本研究为前瞻性随机研究。按NRS 2002营养风险量表筛选具有营养不良风险的62例不可手术的晚期胃癌病人随机分为两组。两组病人均行奥沙利铂联合替吉奥化疗,对照组(n=30)在化疗的同时予营养咨询;治疗组(n=32)在化疗的同时予安素肠内营养治疗,所有病人在化疗前和化疗后行NRS 2002量表评估,观察并记录体重、体重指数、血清白蛋白,化疗结束后评价化疗疗效与不良反应。结果:化疗结束后肠内营养组血清白蛋白水平、体重及体重指数明显高于对照组(P<0.05),两组病人化疗后不良反应和化疗疗效差别无统计学意义。结论:肠内营养联合化疗可改善晚期胃癌病人的营养状态,降低营养不良风险。

关键词：晚期胃癌肠内营养化疗营养风险筛查NRS 2002

强啡肽和心钠素可能参与可乐定的降压利尿作用

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生理学报 1989年第3期41卷 249-254页

作者：尹丽艳高晓明谢翠微汤健北京医科大学心肺内分泌研究室

静脉注射可乐定引起大鼠血压降低和心率减慢。此效应可被α受体阻断剂酚妥拉明所对抗。预先腹腔注射大剂量阿片受体阻断剂纳洛酮或静脉注射强啡肽抗体可以部分阻断可乐定的降压效应。静脉注射可乐定可以引起大鼠尿量显著增加,该效应也... 详细信息

静脉注射可乐定引起大鼠血压降低和心率减慢。此效应可被α受体阻断剂酚妥拉明所对抗。预先腹腔注射大剂量阿片受体阻断剂纳洛酮或静脉注射强啡肽抗体可以部分阻断可乐定的降压效应。静脉注射可乐定可以引起大鼠尿量显著增加,该效应也可被大剂量的纳洛酮所阻断。静脉注射可乐定引起明显的心钠素释放,这一作用可被α受体阻断剂所完全对抗,亦可被阿片受体阻断剂所部分阻断。以上结果说明强啡肽与心钠素可能参与可乐定的降压利尿作用。

关键词：强啡肽心钠素降压利尿可乐定

基于有限元分析的笔记本纸浆模制品包装改进设计

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包装工程 2022年第3期43卷 175-182页

作者：张书炜贾代涛黄孟凯韦明堂郭晋婷合肥联宝信息技术有限公司合肥230071

目的在跌落工况下验证笔记本纸浆模制品对产品的保护性,并进行改进设计。方法使用Creo对笔记本电脑及缓冲包装结构进行初步设计,根据实际的物理跌落试验工况建立跌落仿真模型,通过ABAQUS/Explicit进行仿真分析,得到产品跌落加速度曲线... 详细信息

目的在跌落工况下验证笔记本纸浆模制品对产品的保护性,并进行改进设计。方法使用Creo对笔记本电脑及缓冲包装结构进行初步设计,根据实际的物理跌落试验工况建立跌落仿真模型,通过ABAQUS/Explicit进行仿真分析,得到产品跌落加速度曲线和产品应力应变云图。根据仿真结果进行缓冲包装设计改进,对改进后的方案再次进行仿真分析并进行试验验证。结果初步设计方案的正面跌落加速度达到160.1g,超过规定值120g,且键盘面板塑性应变达到4.95%,存在较大变形风险。纸浆模制品缓冲结构改进后,跌落时正面、侧面和底面的跌落加速度分别为118.5g、98.2g、101.2g,均处于规定值范围内。键盘面板塑性应变降低至0.14%,符合要求。此外,仿真数据与实测结果基本吻合,仿真过程能较好地反映包装制品与产品的跌落碰撞过程。结论通过有限元分析法进行跌落仿真分析,相较于传统的试验法,能快速、准确地找到包装方案的风险点,可为产品的缓冲包装结构改进设计奠定良好基础。

关键词：仿真分析纸浆模制品缓冲包装塑性应变跌落试验

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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