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Phylogenomics and integrative taxonomy reveal two new species of Amana(Liliaceae)

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Plant Diversity 2023年第1期45卷 54-68页

作者： Mei-Zhen Wang Xiao-Kai Fan Yong-Hua Zhang Jing Wu Li-Mi Mao Sheng-Lu Zhang Min-Qi Cai ming-Hong Li Zhang-Shi-Chang Zhu ming-shui zhao Lu-Xian Liu Kenneth M.Cameron Pan Li Laboratory of Systematic&Evolutionary Botany and Biodiversity College of Life SciencesZhejiang UniversityHangzhou 310058ZhejiangChina College of Life and Environmental Sciences Wenzhou UniversityWenzhou325035China Nanjing Institute of Geology and Palaeontology Chinese Academy of SciencesNanjing 210008JiangsuChina Shanghai Science and Technology Museum Shanghai200127China Nanyue Hengshan National Nature Reserve Administration Hengyang 421900HunanChina Zhejiang Tianmushan National Nature Reserve Management Bureau Hangzhou311311China Key Laboratory of Plant Stress Biology School of Life SciencesHenan UniversityKaifeng 475001HenanChina Department of Botany University of WisconsinMadisonWI53706USA

Until now the genus Amana(Liliaceae),known as ’East Asian tulips’,has contained just seven *** this study,a phylogenomic and integrative taxonomic approach was used to reveal two new species,Amana nanyueensis from Central China and *** from East *** resembles Amana edulis in possessing a densely villous-woolly bulb tunic and two opposite bracts,but differs in its leaves and *** tianmuensis resembles Amana erythronioides in possessing three verticillate bracts and yellow anthers,but differs in aspects of its leaves and *** four species are clearly separated from each other in principal components analysis based on *** analyses based on plastid CDS further support the species delimitation of *** and *** and suggests they are closely related to *** analysis shows that *** and A tianmuensis are both diploid(2n=2x=24),different from A edulis,which is either diploid(northern populations) or tetraploid(southern populations,2n=4x=48).The pollen morphology of *** is similar to other Amana species(single-groove germination aperture),but *** is quite different because of the presence of a sulcus membrane,which creates the illusion of double *** niche modelling also revealed a niche differentiation between ***,*** and ***.

关键词： Amana edulis Parallel evolution Phylogeny Species concept Taxonomy Tulip

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-Jun Zhang Wen-Wei Wang Jing-shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

A simplified physically-based breach model for a high concrete-faced rockfill dam:A case study

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Water Science and Engineering 2018年第1期11卷 46-52页

作者： Qi-ming Zhong Sheng-shui Chen zhao Deng Department of Geotechnical Engineering Nanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Failure Mechanism and Safety Control Techniques of Earth-rock Dam of the Ministry of Water Resources Nanjing 210024China

A simplified physically-based model was developed to simulate the breaching process of the Gouhou concrete-faced rockfill dam （CFRD）, which is the only breach case of a high CFRD in the world. Considering the dam height, a hydraulic method was chosen to simulate the initial scour position on the downstream slope, with the steepening of the downstream slope taken into account; a headcut erosion formula was adopted to simulate the backward erosion as well. The moment equilibrium method was utilized to calculate the ultimate length of a concrete slab under its self-weight and water loads. The calculated results of the Gouhou CFRD breach case show that the proposed model provides reasonable peak breach flow, final breach width, and failure time, with relative errors less than 15% as compared with the measured data. Sensitivity studies show that the outputs of the proposed model are more or less sensitive to different parameters. Three typical parametric models were compared with the proposed model, and the comparison demonstrates that the proposed physically-based breach model performs better and provides more detailed results than the parametric models.

关键词： Concrete-faced rockfill dam Physically-based breach model Parametric breach model Sensitivity analysis Gouhou CFRD

Numerical model for homogeneous cohesive dam breaching due to overtopping failure

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Journal of Mountain Science 2017年第3期14卷 571-580页

作者： ZHONG Qi-ming CHEN Sheng-shui DENG zhao Department of Geotechnical Engineering Nanjing Hgdraulic Research InstituteNanjing 210024China Nanjing Hgdraulic Research Institute Nanjing 210029China Key Laboratory of Failure Mechanism and Safety Control Techniques of Earth-rock Dam of the Ministry of Water Resources Nanjing 210029China

Based on the large-scale model tests, a simplified dam breach model for homogeneous cohesive dam due to overtopping failure is put forward. The model considers headcut erosion as one of the key homogeneous cohesive dam breaching mechanisms and we calculate the time-averaged headcut migration rate using an energy-based empirical formula. A numerical method is adopted to determine the initial scour position at the downstream slope in terms of the water head and dam height, and the broad-crested weir equation is utilized to simulate the breach flow. The limit equilibrium method is used to analyze the stability of breach slope during the breach process. An iterative method is developed to simulate the coupling process of soil and water at each time step. The calculated results of three dam breach cases testify the reasonability of the model, and the sensitivity studies of soil erodibility show that sensitivity is dependent on each test case's soil conditions. In addition, three typical dam breach models, NWS BREACH, WinDAM B, and HR BREACH, are also chosen to compare with the proposed model. It is found that NWS BREACH may have large errors for cohesive dams, since it uses a noncohesive sediment transport model and does notconsider headcut erosion, WinDAM B and HR BREACH consider headcut erosion as the breaching mechanism and handle well homogeneous cohesive dam overtopping failure, but overall, the proposed model has the best performance.

关键词： KeHomogeneous cohesive dam Overtopping Headcut Initial scour position Sensitivity analysis Models comparison

Gemcitabine-based combination therapy compared with gemcitabine alone for advanced pancreatic cancer： a meta-analysis of nine randomized controlled trials

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 236-244页

作者： shui-Fang Jin zhao-Kun Fan Lei Pan Li-ming Jin Intensive Care Unit First Affiliated Hospital Zhejiang Chinese Medical University Hangzhou 310006 China Department of Oncology First Affiliated Hospital Zhejiang Chinese Medical University Hangzhou 310006 China Department of General Surgery Zhejiang Provincial People's Hospital Hangzhou 310014 China

BACKGROUND： Pancreatic cancer is one of the most aggressive malignancies and chemotherapy is an effective strategy for advanced pancreatic cancer. Gemcitabine （GEM） is one of first-line agents. However, GEM-based combination therapy has shown promising efficacy in patients with advanced pancreatic cancer. This meta-analysis aimed to compare the efficacy and safety of GEM-based combination therapy versus GEM alone in the treatment of advanced pancreatic *** SOURCES： A comprehensive search of literature was performed using PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. A quantitative meta-analysis was performed based on the inclusion criteria from all eligible randomized controlled trials. The outcome indicators included overall survival （OS）, 6-month survival, 1-year survival, progression-free survival/time-to-progression （PFS/TTP）, and toxicities. RESULTS： A total of nine randomized controlled trials involving 1661 patients were included in this meta-analysis. There was significant improvement in the GEM-based combination therapy with regard to the OS （HR=0.85, 95% CI： 0.76-0.95, P=0.003）, PFS （HR=0.76, 95% CI： 0.65-0.90, P-0.002）, 6-month survival （RR=1.09, 95% CI： 1.01-1.17, P=0.03）, and the overall toxicity （RR=l.68, 95% CI： 1.52-1.86, P〈0.01）. However, there was no significant difference in the 1-year ***： GEM-based combination chemotherapy might improve the OS, 6-month survival, and PFS in advanced pancreatic cancer. However, combined therapy also added toxicity.

关键词： gemcitabine pancreatic cancer chemotherapy cisplatin S-1 meta-analysis

Centrifugal model tests and numerical simulations for barrier dam break due to overtopping

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Journal of Mountain Science 2019年第3期16卷 630-640页

作者： zhao Tian-long CHEN Sheng-shui FU Chang-jing ZHONG Qi-ming Key Laboratory for Hydraulic and Waterway Engineering of Ministry of Education Chongqing Jiaotong University Nanjing Hydraulic Research Institute Key Laboratory of Failure Mechanism and Safety Control Techniques of Earthrock Dam of the Ministry of Water Resources Department of Geotechnical Engineering Nanjing Hydraulic Research Institute

The present study focuses on the breaching process and failure of barrier dams due to overtopping. In this work, a series of centrifugal model tests is presented to examine the failure mechanisms of landslide dams. Based on the experimental results, failure process and mechanism of barrier dam due to overtopping are analyzed and further verified by simulating the experimental overtopping failure process. The results indicate that the barrier dam will develop during the entire process of overtopping in the width direction, whereas the breach will cease to develop at an early stage in the depth direction because of the large particles that accumulate on the downstream slope. Moreover, headcut erosion can be clearly observed in the first two stages of overtopping, and coarsening on the downstream slope occurs in the last stage of overtopping. Thus, the bottom part of the barrier dam can survive after dam breaching and full dam failure becomes relatively rare for a barrier dam. Furthermore, the remaining breach would be smaller than that of a homogeneous cohesive dam under the same conditions.

关键词： Barrier dam Overtopping Failure mechanism Centrifugal model test Numerical simulation

Precision spectroscopy of atomic helium

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National Science Review 2020年第12期7卷 1818-1827页

作者： Yu R.Sun shui-ming Hu Hefei National Laboratory for Physical Sciences at Microscale iChem CenterUniversity of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China

Helium is a prototype three-body system and has long been a model system for developing quantum mechanics theory and computational *** fine-structure splitting in the 2;P state of helium is considered to be the most suitable for determining the fine-structure constant α in *** more than 50 years of efforts by many theorists and experimentalists,we are now working toward a determination ofα with an accuracy of a few parts per billion,which can be compared to the results obtained by entirely different methods to verify the self-consistency of quantum ***,the precision spectroscopy of helium allows determination of the nuclear charge radius,and it is expected to help resolve the ’proton radius puzzle’.In this review,we introduce the latest developments in the precision spectroscopy of the helium atom,especially the discrepancies among theoretical and experimental results,and give an outlook on future progress.

关键词： precision spectroscopy helium quantum electrodynamics fine-structure constant nuclear charge radius