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Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

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World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-Hua Fu Zi-Yue zhao Yao-Bing liang Dong-Yu Cheng Jian-ming Luo Hai-Xing Jiang Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu liang Bin Wen ming-Kun liang Xiao-Fang zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

Nonlinear characteristics of torsional stiffness of a coilable mast with triangular section

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Chinese Journal of Aeronautics 2024年第10期37卷 313-324页

作者： Yu LIU liang SUN Hai HUANG Shenyan CHEN Weipeng LI Xurui zhao School of Astronautics Beihang UniversityBeijing 100191China Institute of Remote Sensing Satellite China Academy of Space TechnologyBeijing 100094China

With numerous applications coilable masts in high-precision astronomical observations,such as X-ray source observations,it is important to investigate mast *** date,there have been many studies on the bending stiffness of coilable masts,but few studies on their torsional stiffness,especially regarding the nonlinear characteristics of torsional stiffness of coilable masts under large torsional *** this paper,a nonlinear analysis method is presented to examine the torsional stiffness of coilable masts with triangular *** on the second-order bending buckling hypothesis of battens under large torsion deformation,the nonlinear relationship between torsional torque and torsional angle is obtained by analyzing torsional deformation and force of coilable *** method is used to analyze the torsional stiffness nonlinearity of a certain type of coilable mast which will be used in a practical application in the future and the results are verified by simulation and *** comparison results show that the error is within the acceptable range,which proves the effectiveness of the proposed method.

关键词： Coilable mast Torsion testing Torsional stiffness nonlinearity Torsional deformation Torsion simulation

Age-specific distribution of oculometric parameters and myopia in children aged 8-12y

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1887-1897页

作者： Tao Tang Si-Tong Chen Heng zhao Kai Wang ming-Wei zhao Department of Ophthalmology&Clinical Centre of Optometry Peking University People’s HospitalBeijing 100044China Institute of Medical Technology Peking University Health Science CenterBeijing 100083China College of Optometry Peking University Health Science CenterBeijing 100083China Eye Disease and Optometry Institute Peking University People’s HospitalBeijing 100044China Beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases Beijing 100044China National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the distribution of ocular biometrics and to evaluate its associations with refractive error and to assess the contribution from ocular parameters to refractive error among Chinese myopic ***:This cross-sectional study evaluated subjects aged ***,ocular biometry,and cycloplegic autorefraction were performed on each *** equivalent refraction(SER)and ocular biometrics were assessed as a function of age and *** Pearson correlation analysis between SER and ocular biometrics was carried *** linear regression was performed to analyze the association between SER and ocular ***:A total of 689 out of 735 participants(321 boys,48.1%)were analyzed,with a mean SER of-2.98±1.47 diopter(D).Axial length(AL),anterior chamber depth(ACD),corneal radius of curvature(CR),horizontal visible iris diameter(HVID),central corneal thickness(CCT)and lens power(LP)showed normal *** AL,AL/CR ratio,ACD and CR increased from 8 to 12y of age,while SER and LP decreased,HVID and CCT remained *** was no difference in *** decreased by 0.929 D for every 1 mm increase in AL and decreased by 1.144 D for every 0.1 increase in AL/CR *** Pearson correlation coefficient between SER and AL was-0.538(P<0.01)and-0.747(P<0.01)between SER and AL/CR *** the SER variance,AL explained 29.0%,AL/CR ratio explained 55.7%,while AL,CR,ACD and LP explained 99.3%after adjusting for age and ***:The AL,CR,ACD and LP are the most important determinants of myopic refractive error during myopia progression.

关键词： myopia ocular biometry refractive error population-based study

Identification of pathological characteristics in pulmonary tuberculosis using polarization-sensitive optical coherence tomography

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 97-106页

作者： Yun Ding Zhuoqun Yuan Xiaojiang zhao Guozheng Gao Xin Li Yanmei liang Clinical School of Thoracic Tianjin Medical University TianjinP.R.China Department of Thoracic Surgery Fujian Provincial Hospital FujianP.R.China Institute of Modern Optics Nankai University Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Tianjin 300350P.R.China School of Medicine Tianjin University TianjinP.R.China Department of Pathology Tianjin Chest Hospital No.261Taierzhuang South Road Jinnan District Tianjin 300222P.R.China Department of Thoracic Surgery Tianjin Chest Hospital TianjinP.R.China

The low detection rate of Mycobacterium tuberculosis in clinical practice leads to a high rate of missed diagnosis for pulmonary tuberculosis(PTB).As a noninvasive,high-resolution,real-time imaging technology,polarization-sensitive optical coherence tomography(PS-OCT)may be feasible for the rapid identification of pathological *** study aimed to explore the feasibility of using PS-OCT to identify pathological features of *** the experiments,PTB samples containing some surrounding lung tissues were imaged using *** is demonstrated that PS-OCT images showed good consistency with the corresponding pathological images and were able to identify PTB-related characteristic pathological *** think PS-OCT can serve as an effective supplement for the diagnosis of PTB,enabling rapid and accurate diagnosis,and aiding in the understanding of the pathological characteristics and pathophysiological processes of PTB.

关键词： Pulmonary tuberculosis PS-OCT pathological features.

Attention-Based CNN Fusion Model for Emotion Recognition During Walking Using Discrete Wavelet Transform on EEG and Inertial Signals

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Big Data Mining and Analytics 2024年第1期7卷 188-204页

作者： Yan zhao ming Guo Xiangyong Chen Jianqiang Sun Jianlong Qiu School of Communication Engineering Hangzhou Dianzi UniversityHangzhou 310018China School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China

Walking as a unique biometric tool conveys important information for emotion *** in different emotional states exhibit distinct walking *** this purpose,this paper proposes a novel approach to recognizing emotion during walking using electroencephalogram(EEG)and inertial *** recognition of emotion is achieved by training in an end-to-end deep learning fashion and taking into account multi-modal *** wear virtual reality head-mounted display(VR-HMD)equipment to immerse in strong emotions during *** environment shows excellent imitation and experience ability,which plays an important role in awakening and changing *** addition,the multi-modal signals acquired from EEG and inertial sensors are separately represented as virtual emotion images by discrete wavelet transform(DWT).These serve as input to the attention-based convolutional neural network(CNN)fusion *** designed network structure is simple and lightweight while integrating the channel attention mechanism to extract and enhance *** effectively improve the performance of the recognition system,the proposed decision fusion algorithm combines Critic method and majority voting strategy to determine the weight values that affect the final decision *** investigation is made on the effect of diverse mother wavelet types and wavelet decomposition levels on model performance which indicates that the 2.2-order reverse biorthogonal(rbio2.2)wavelet with two-level decomposition has the best recognition *** experiment results show that the proposed method outperforms other existing state-of-the-art works with an accuracy of 98.73%.

关键词： walking multi-modal fusion virtual reality emotion recognition discrete wavelet transform attention mechanism

Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions

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Science China Chemistry 2024年第5期67卷 1561-1568页

作者： Peng-Fei Guo Ze-Long liang Yue-E Jiao Hang Xu Bin zhao Key Laboratory of Advanced Energy Material Chemistry Renewable Energy Conversion and Storage CenterDepartment of ChemistryNankai UniversityTianjin 300071China

3,4-Dihydroisoquinoline(DHIQ)is an important precursor used in the production of drugs for treating cancer,HIV,Alzheimer's disease,*** studies on DHIQ synthesis show low catalytic selectivity due to the susceptible over-oxidation feedstock of1,2,3,4-tetrahydroisoquinoline(THIQ),which often requires alkali ***,it is desirable yet challenging to explore a highly selective and efficient oxydehydrogenation capacity for DHIQ synthesis under eco-friendly reaction ***,a novel framework 1 was synthesized,exhibiting 1D channels with the size of 4.6 A×9.6 A and high solvent/p H/thermal stability.A stable framework allows it to encapsulate Cu nanoparticles(NPs)to form Cu NPs@1-x(x=1,2,3,and 4)with varying loading amounts of Cu NPs at 2.0 wt%,3.0 wt%,4.0 wt%,and 6.0 wt%,*** NPs@1-3 could selectively catalyze the reaction from THIQ to DHIQ with a high selectivity of 98%and a recorded turnover frequency(TOF)of 22.1 h-1under eco-friendly mild *** corresponding catalytic activity can maintain at least five recyclings and can be further applied to gram-scale ***,the efficient preparation of DHIQ catalyzed by Cu NPs@1-3 could be realized even under air ***,the anticancer molecule precursor synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline was also selectively catalyzed by Cu NPs@*** investigations revealed that high catalytic performance can be attributed to the stable framework and the synergistic catalytic effect of the loaded Cu NPs and Co metal *** importantly,this work represents the first example of MOF catalysts for selectively thermo-catalytic DHIQ synthesis and demonstrates a simple approach to obtain efficient catalysts for selective oxydehydrogenation in the production of unsaturated compounds.

关键词： metal-organic frameworks Cu NPs@MOFs 3 4-dihydroisoquinoline selective oxydehydrogenation synergistic catalysis

Group-wise co-salient object detection via multi-view self-labeling novel class discovery

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Frontiers of Computer Science 2024年第2期18卷 259-261页

作者： Yang WU Gang DONG Lingyan liang Yaqian zhao Kaihua ZHANG Inspur Electronic Information Industry Co. Ltd.Beijing 100080China Jiangsu Key Laboratory of Big Data Analysis Technology and Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China

1 Introduction Co-salient object detection(CoSOD)aims to extract the salient object(s)that are common across a group of relevant images[1].Group-wise clue plays a crucial role in accurately predicting the co-salient ***,numerous groupwise deep models have been proposed by exploring consistency across images in unsupervised clustering manners[2-4]or the semantic connections guidance information[5].

关键词： consistency Group semantic

Neural Network-Based State Estimation for Nonlinear Systems With Denial-of-Service Attack Under Try-Once-Discard Protocol

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2182-2184页

作者： Xueli Wang Shangwei zhao ming Yang Xin Wang Xiaoming Wu the Key Laboratory of Computing Power Network and Information Security Ministry of EducationShandong Computer Science CenterQilu University of Technology(Shandong Academy of Sciences)Jinan 250014 Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer ScienceJinan 250014China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China

Dear Editor,This letter deals with state estimation issues of discrete-time nonlinear systems subject to denial-of-service(DoS)attacks under the try-once-discard(TOD)*** specifically,to reduce the communication burden,a TOD protocol with novel update rules on protocol weights is designed for scheduling measurement *** addition,unknown nonlinear functions vulnerable to DoS attacks are considered due to the openness and vulnerability of the network.

关键词： Service DoS service