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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

The Cymbidium genome reveals the evolution of unique morphological traits

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Horticulture Research 2021年第1期8卷 3449-3463页

作者： Ye Ai Zhen Li Wei-Hong Sun Juan chen Diyang Zhang Liang Ma Qing-Hua Zhang ming-kun chen Qing-Dong Zheng Jiang-Feng Liu Yu-Ting Jiang Bai-Jun Li Xuedie Liu Xin-Yu Xu Xia Yu Yu Zheng Xing-Yu Liao Zhuang Zhou Jie-Yu Wang Zhi-Wen Wang Tai-Xiang Xie Shan-Hu Ma Jie Zhou Yu-Jie Ke Yu-Zhen Zhou Hsiang-Chia Lu Ke-Wei Liu Feng-Xi Yang Gen-Fa Zhu Laiqiang Huang Dong-Hui Peng Shi-Pin chen Siren Lan Yves Van de Peer Zhong-Jian Liu Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhouChina Department of Plant Biotechnology and Bioinfor matics Ghent UniversityGentBelgium VIB Center for Plant Systems Biology GentBelgium College of Forestry Fujian Agriculture and Forestry UniversityFuzhouChina Management Office of Yushan Scenic Area FuzhouChina College of Agriculture and Biotechnology Zhejiang UniversityHangzhouChina Key Laboratory of Plant Resource Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhouChina PubBio-Tech WuhanChina Tsinghua-Berkeley Shenzhen Institute(TBSI) Center for Biotechnology and Biomedicine and Shenzhen Key Laboratory of Gene and Antibody The rapyState Key Laboratory of Chemical OncogenomicsState Key Laboratory of Health Sciences and TechnologyInstitute of Biopha rmaceutical and Health Engineering(iBHE)Shenzhen International Graduate SchoolTsinghua UniversityShenzhenChina Guangdong Key Laboratory of Ornamental Plant Germplasm Innovation and Utilization Environmental Horticulture Research InstituteGuangdong Academy of Agricultural SciencesGuangzhouChina Department of Biochemistry Genetics and MicrobiologyUniversity of PretoriaPretoriaSouth Africa College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjingChina Henry Fok College of Biology and Agriculture Shaoguan UniversityShaoguanChina Institute of Vegetable and Flowers Shandong Academy of Agricultural SciencesJinanChina

The marvelously diverse Orchidaceae constitutes the largest family of *** genus Cymbidium in Orchidaceae is well known for its unique vegetation,floral morphology,and flower scent ***,a chromosomescale assembly of the genome of Cymbidium ensifolium(Jianlan)is *** genomic analysis showed that *** has experienced two whole-genome duplication(WGD)events,the most recent of which was shared by all orchids,while the older event was the t event shared by most *** results of MADS-box genes analysis provided support for establishing a unique gene model of orchid flower development regulation,and flower shape mutations in *** were shown to be associated with the abnormal expression of MADS-box *** most abundant floral scent components identi fied included methyl jasmonate,acacia alcohol and linalool,and the genes involved in the floral scent component network of *** were ***,the decreased expression of photosynthesis-antennae and photosynthesis metabolic pathway genes in leaves was shown to result in colorful striped leaves,while the increased expression of MADS-box genes in leaves led to perianth-like *** results provide fundamental insights into orchid evolution and diversi fication.

关键词： traits evolution establishing

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei ming Longfu chen Tianliang Song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

苦荞FtTCPlike1和FtTCPlike2的克隆及表达分析

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植物生理学报 2018年第2期54卷 247-254页

作者：张嘉丽黄铭坤孙伟陈庆富刘霞武汉理工大学化学化工与生命科学学院武汉430070 中国中医科学院中药研究所北京100700 贵州师范大学荞麦产业技术研究中心贵阳550001

植物TCP转录因子家族是一类调控植物生长、发育的重要转录因子,主要分为class Ⅰ和class Ⅱ两种类型。在本研究中,我们克隆了苦荞(Fagopyrum tataricum)两个TCP转录因子基因并分别命名为FtTCPlike1和FtTCPlike2。蛋白聚类分析表明FtTCPl... 详细信息

植物TCP转录因子家族是一类调控植物生长、发育的重要转录因子,主要分为class Ⅰ和class Ⅱ两种类型。在本研究中,我们克隆了苦荞(Fagopyrum tataricum)两个TCP转录因子基因并分别命名为FtTCPlike1和FtTCPlike2。蛋白聚类分析表明FtTCPlike1属于class Ⅱ而FtTCPlike2属于class Ⅰ,并且均含有TCP转录因子典型的保守结构域。亚细胞定位实验也表明FtTCPlike1和FtTCPlike2与报道的其他物种TCP转录因子类似,都定位在细胞核中。本文同时收集了苦荞芽期的子叶和下胚轴、第1~3片长出的真叶以及5个时期由幼嫩到成熟的种子和花共11种样本进行了实时荧光定量PCR,发现FtTCPlike1和FtTCPlike2在苦荞的各个不同时期和不同组织中均有不同的表达,并且在种子的某个特定时期(FtTCPlike1和FtTCPlike2分别在种子发育第3、第4时期和第1、第3时期)有较高的表达量,表明这两个基因可能参与种子发育。从苦荞芽期来看,FtTCPlike1在子叶中表达量较高但在下胚轴表达较低,而FtTCPlike2则相反,这说明FtTCPlike1和FtTCPlike2在苦荞早期形态建成中的调控方式可能有很大区别。

关键词：苦荞 TCP 基因克隆亚细胞定位基因表达

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao chen Xinfei Wang Shaolei Wang Junyi Yin ming Yang Xuxu chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi chen Zhuyong Wang Huantao Wen ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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硅对小麦生长及其抗氧化酶系统的影响

土壤通报 2003年第1期34卷 55-57页

作者：宫海军陈坤明陈国仓王锁民张承烈兰州大学生命科学学院甘肃兰州730000

本文研究了基施硅营养对小麦分蘖期的生长状况、叶片类脂脂肪酸组成及抗氧化酶系统的影响。结果显示 ,施硅促进了小麦的生长 ;降低了膜脂过氧化程度 ,提高了叶片类脂脂肪酸的不饱和度。但施硅处理对超氧化物歧化酶(SOD)和抗坏血酸过氧... 详细信息

本文研究了基施硅营养对小麦分蘖期的生长状况、叶片类脂脂肪酸组成及抗氧化酶系统的影响。结果显示 ,施硅促进了小麦的生长 ;降低了膜脂过氧化程度 ,提高了叶片类脂脂肪酸的不饱和度。但施硅处理对超氧化物歧化酶(SOD)和抗坏血酸过氧化物酶 (APX)活性没有影响 ,却使过氧化物酶 (POD)与过氧化氢酶 (CAT )活性下降 ,暗示POD和CAT具备在较低活力水平上高效清除H2 O2 等强氧化剂的可能性。

关键词：抗氧化酶系统硅素小麦幼苗生长类脂脂肪酸组成

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Hot spot temperature prediction and operating parameter estimation of racks in data center using machine learning algorithms based on simulation data

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Building Simulation 2023年第11期16卷 2159-2176页

作者： Xianzhong chen Rang Tu ming Li Xu Yang kun Jia School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China China Electronics Engineering Design Institute CO. LTD.Beijing100142China

In this paper,models to predict hot spot temperature and to estimate cooling air’s working parameters of racks in data centers were established using machine learning algorithms based on simulation ***,simulation models of typical racks were established in computational fluid dynamics(CFD).The model was validated with field test results and results in literature,error of which was less than 3%.Then,the CFD model was used to simulate thermal environments of a typical rack considering different factors,such as servers’power,which is from 3.3 kW to 20.1 kW,cooling air’s inlet velocity,which is from 1.0 m/s to 3.0 m/s,and cooling air’s inlet temperature,which is from 16℃ to 26℃ The highest temperature in the rack,also called hot spot temperature,was selected for each ***,a prediction model of hot spot temperature was built using machine learning algorithms,with servers’power,cooling air’s inlet velocity and cooling air’s inlet temperature as inputs,and the hot spot temperatures as ***,based on the prediction model,an operating parameters estimation model was established to recommend cooling air’s inlet temperatures and velocities,which can not only keep the hot spot temperature at the safety value,but are also energy saving.

关键词： data center CFD simulation hot spot temperature machine learning algorithm prediction and estimation models