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Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury

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World Journal of Clinical Cases 2020年第13期8卷 2738-2748页

作者： Li Lei ming-jun wang Sheng Zhang Da-jun Hu Department of Nephrology the Second People's Hospital of Three Gorges University(Yichang Second People's Hospital)Yichang 443000Hubei ProvinceChina Institute of Nephrology of Integrated Chinese and Western Medicine of Three Gorges University Yichang 443000Hubei ProvinceChina

BACKGROUND The effects of prostaglandin E(PGE)combined with continuous renal replacement therapy(CRRT)on renal function and inflammatory responses in patients with septic acute kidney injury(SAKI)remain *** To investigate the effects of PGE combined with CRRT on urinary augmenter of liver regeneration(ALR),urinary Na+/H+exchanger 3(NHE3),and serum inflammatory cytokines in patients with *** The clinical data of 114 patients with SAKI admitted to Yichang Second People's Hospital from May 2017 to January 2019 were ***-three cases treated by CRRT alone were included in a control group,while the other 61 cases treated with PGE combined with CRRT were included in an experimental *** urinary ALR,urinary NHE3,serum inflammatory cytokines,renal function indices,and immune function indices were *** in disease recovery and the incidence of adverse reactions were *** 28-d survival curve was *** Before treatment,urinary ALR,urinary NHE3,blood urea nitrogen(BUN),serum creatinine(SCr),CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio in the control and experimental groups were approximately the *** treatment,urinary ALR and NHE3 decreased,while BUN,SCr,CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio increased in all *** ALR,urinary NHE3,BUN,and SCr in the experimental group were significantly lower than those in the control group,while CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio were significantly higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-18,and high sensitivity C-reactive protein in the experimental group were significantly lower than those in the control group(P<0.05).The time for urine volume recovery and intensive care unit treatment in the experimental group was significantly shorter than that in the control group(P<0.05),although there was no statistical

关键词： Prostaglandin E Continuous renal replacement therapy Septic acute kidney injury Augmenter of liver regeneration Na+/H+exchanger 3 Serum inflammatory cytokines

Coercivity enhancement of hot-deformed Nd-Fe-B magnets with Pr-Cu alloy addition

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Rare Metals 2023年第4期42卷 1403-1407页

作者： jun-ming wang Zhao-Hui Guo Zheng Jing Xiao Du Neng-jun Yu Meng-Yu Li ming-Gang Zhu Wei Li Division of Functional Materials Central Iron&Steel Research InstituteBeijing100081China

Effects of low-melting Pr-Cu alloy addition on the microstructure and magnetic properties of the hot-deformation Nd-Fe-B magnets were investigated.A small amount of Pr-Cu addition enhances the coercivity of the hot-deformation Nd-Fe-B magnets *** coercivity of the hotdeformation Nd-Fe-B magnets with 4.0 wt%Pr_(85)Cu_(15)addition increases to 1271 kA·m^(-1),75.69%higher than that of Pr-Cu-free magnet(723 kA·m^(-1)),and then decreases with5 wt%Pr_(85)Cu_(15)*** is observed that there a uniform RE-rich phase is formed wrapping the Nd2Fe14B main phase in the sample with 4.0%Pr_(85)Cu_(15)addition by scanning electron microscopy(SEM),which promotes the *** angular dependence of coercivity for the hot-deformation Nd-Fe-B magnets indicates that the coercivity mechanism is nucleation combined with domain wall *** domain wall pinning is weakened,while the nucleation is enhanced after Pr-Cu ***,intrinsic coercivity,and maximum magnetic energy product of the original Nd-Fe-B magnet are 1.45 T,723 kA·m^(-1),and 419.8 kJ·m^(-3),respectively,and those of the sample with 4.0%Pr_(85)Cu_(15)alloy addition are 1.30 T,1271 kA·m^(-1),and 330.0 kJ·m^(-3),respectively.

关键词： Nd-Fe-B Low-melting alloy Hot-deformation Microstructure Coercivity mechanism

EFFECTS OF CONSOLIDATION TIME AND PARTICLE SIZE ON SCOUR RATES OF COHESIVE SEDIMENT

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Journal of Hydrodynamics 2007年第2期19卷 160-164页

作者： TAN Guang-ming wang jun SHU Cai-wen LAI Yong-hui State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan 430072 China

By means of flumes, experiments have been done in order to determine the effects of consolidation time and particle size on scour rates of cohesive sediment. Experimental results shown dry unit weight increased and scour rates decreased during the course of consolidation, the resistance to scour was related to consolidation time, but it presented different consolidation properties that depended on particle size. For the finer particle, the consolidation process was longer, the range of dry unit weight altered was greater, the consolidated sediments moved in chunks. On the other hand, based on analysis of the relationship of dry unit weight change with consolidation time, the simplified analytical expressions of dry unit weight and scour rates were derived, the results were checked with experimental data in the same flow situation and good agreements were achieved. Since the effects of different particle size were considered during the process of consolidation, the variations of consolidation properties were well reflected in these formulas.

关键词： cohesive sediment scour rates,consolidation time dry unit weight

Cooling Efficiency of Laminar Cooling System for Plate Mill

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Journal of Iron and Steel Research International 2008年第5期15卷 24-28页

作者： ZHANG Dian-hua wang Bing-xing ZHOU Na YU ming wang jun State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Heat transfer was researched from a perspective of the industry application. On the basis of the first law of thermodynamics, the cooling efficiency was deduced from the change of enthalpy inside hot plate. The relationship between the cooling efficiency and its influencing parameters was regressed from plenty of data collected from the worksite and discussed in detail. The temperature profiles resulting from the online model and the model modified by regressed formulas were presented and compared. The results indicated that the control accuracy of the modified model was increased obviously.

关键词： hot rolled plate laminar cooling cooling efficiency temperature profile

Consecutive laparoscopic gallbladder and spleen resections in cirrhotic patients

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World Journal of Gastroenterology 2014年第2期20卷 546-554页

作者： ming-jun wang jun-Li Li Jin Zhou Zhong Wu Bing Peng Department of Hepato-Biliary-Pancreatic Surgery West China HospitalSichuan University Laboratory of Cardiovascular Diseases Research Centre of Regeneration MedicineWest China HospitalSichuan University Department of Gastrointestinal Surgery West China HospitalSichuan University

AIM:To evaluate the feasibility,safety,and effectiveness of consecutive laparoscopic cholecystectomy(LC)plus splenectomy(LS)in liver cirrhosis ***:From 2003 to 2013,17(group 1)patients with liver cirrhosis complicated by hypersplenism and symptomatic gallstones were treated with combined LC and LS,while 58(group 2)patients with liver cirrhosis and hypersplenism received LS *** additional 14(group 3)patients who received traditional open procedures during the same period were included as *** were retrospectively collected and reviewed in regard to demographic characteristics and preoperative,intraoperative and postoperative *** between the three groups were assessed by statistical ***:The three groups showed no significant differences in the demographic characteristics or preoperative ***,the patients treated with LC and LS required significantly longer operative time,shorter postoperative stay as well as shorter time of return to the first oral intake,and suffered less intraoperative blood loss as well as fewer postoperative surgical infections than the patients treated with traditional open procedures(group 1 vs group 3,P<0.05 for all).The patients treated with LC and LS showed no significant differences in the intraoperative and postoperative variables from those treated with LS alone(group 1 vs group 2).All patients showed significant improvements in the haematological responses(preoperative period vs postoperative period,P<0.05 for all).None of the patients treated with LC and LS presented with any gallstone-associated symptoms following discharge,while the patients treated with the traditional open procedures expressed complaints of discomfort related to their surgical ***:Consecutive LC and LS is an appropriate treatment option for liver cirrhosis patients with gallstones and hypersplenism,especially for those with Child-Pugh A and B.

关键词： Laparoscopic cholecystectomy Laparoscopic splenectomy Liver cirrhosis Hypersplenism Open surgery

Propagation of shaped beam through uniaxially anisotropic chiral slab

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Chinese Physics B 2020年第11期29卷 380-385页

作者： ming-jun wang Jia-Lin Zhang Hua-Yong Zhang Zi-Han wang School of Automation and Information Engineering Xi’an University of TechnologyXi’an 710048China School of Electronics and Information Engineering Anhui UniversityHefei 230039China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230039China School of Physics and Telecommunications Engineering Shaanxi University of TechnologyHanzhong 723001China

A general solution is obtained to a canonical problem of the reflection and refraction of an arbitrary shaped beam by using a uniaxially anisotropic chiral *** reflected,internal as well as refracted shaped beams are expanded in terms of cylindrical vector wave functions,and the expansion coefficients are determined by using the boundary conditions and method of moments *** two typical examples,the normalized field intensity distributions are evaluated for a fundamental Gaussian beam and Hermite-Gaussian beam,and some propagation properties,especially the negative refraction phenomenon,are discussed briefly.

关键词： shaped beam uniaxially anisotropic chiral slab reflection and refraction negative refraction phenomenon

Early complications after interventions in patients with acute pancreatitis

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World Journal of Gastroenterology 2016年第9期22卷 2828-2836页

作者： Ai-Lin Wei Qiang Guo ming-jun wang Wei-ming Hu Zhao-Da Zhang Department of Pancreatic Surgery West China Hospital

AIM: To identify the possible predictors of early complications after the initial intervention in acute necrotizing ***: We collected the medical records of 334 patients with acute necrotizing pancreatitis who received initial intervention in our center. Complications associated with predictors were ***: The postoperative mortality rate was 16% (53/334). Up to 31% of patients were successfully treated with percutaneous catheter drainage alone. The rates of intra-abdominal bleeding, colonic fistula, and progressive infection were 15% (50/334), 20% (68/334), and 26% (87/334), respectively. Multivariate analysis indicated that Marshall score upon admission, multiple organ failure, preoperative respiratory infection, and sepsis were the predictors of postoperative progressive infection (P < 0.05). Single organ failure, systemic inflammatory response syndrome upon admission, and C-reactive protein level upon admission were the risk factors of postoperative colonic fistula (P < 0.05). Moreover, preoperative Marshall score, organ failure, sepsis, and preoperative systemic inflammatory response syndrome were the risk factors of postoperative intra-abdominal bleeding (P < 0.05).CONCLUSION: Marshall score, organ failures, preoperative respiratory infection, sepsis, preoperative systemic inflammatory response syndrome, and C-reactive protein level upon admission are associated with postoperative complications.

关键词： Acute necrotizing pancreatitis Intervention complications Intra-abdominal bleeding Colonic fistula Progressive infection

Development of LC–MS method for analysis of paclitaxel-inhibited growth and enhanced therapeutic response in human glioblastoma cells

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Chinese Chemical Letters 2015年第10期26卷 1225-1230页

作者： Cai-Hou Lin Xue-Xia Lin Ling Lin jun-ming wang Zhi-Xiong Lin Jin-ming Lin Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of Chemistry Tsinghua University Department of Bioengineering School of Engineering The University of Tokyo

Glioma stem cells are considered responsible for drug resistance and glioma relapse resulting in poor prognosis in glioblastoma multiforme. SU3 glioma cell is a highly invasive glioma stem cell line from the patients with glioblastoma multifrome. It is of great significance to study the efficacy and molecular mechanism for anticancer drug effects on SU3 glioma cells. In this work, we develop a liquid chromatography–mass spectrometry（LC–MS） method for direct analysis of the role of drugs（paclitaxel）on SU3 glioma cells at the molecular level. We use the specific fluorescence dyes to evaluate cell viability,the levels of ROS and GSH when the cells were treated with drugs. In addition, the LC–MS platform was successfully employed to detect the amount of 6-O-methylguanine, demonstrating that it is effective to induce cell apoptosis and enhance the cytotoxic response of SU3 glioma cells. The analytical linear equals are Y = 9.49 ？ 105 X ＋ 2.42 ？ 104 for 6-O-methylguanine（R2= 0.9998） and Y = 4.72 ？ 104 X ＋ 2.21 ？ 103（R2= 0.9996） for 7-methylguanine. Thus, the combination of cell-specific fluorescence dyes and LC–MS method enables us to reveal the molecular mechanism of paclitaxel-inhibited growth and enhanced therapeutic response in the chemotherapy for glioma multiforme.

关键词： LC–MS Drug analysis SU3 glioma cell Paclitaxel Cell cycle arrest ROS assay

Diurnal macular choroidal area fluctuation in normal and primary open angle glaucoma groups

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1233-1238页

作者： Mu Li Jin-Min Guo Xiao-Lan Xu jun-ming wang Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of Ultrasound Tongji Hospital Tongji MedicalCollege Huazhong University of Science and TechnologyWuhan 430030 Hubei Province China

AIM： To assess and compare the diurnal macular choroidal area fluctuation in normal and primary open angle glaucoma （POAG） groups using enhanced depth imaging optical coherence tomography （EDI-OCT）. METHODS： Twenty-eight normal and 27 POAG eyes were enrolled in this study. EDI-OCT was used to measure the macular choroidal area every 3h from 9：00 a.m. to 21：00 p.m. RESULTS： Significant diurnal fluctuations of macular choroidal area were observed in both normal （P=-0.003） and POAG groups （P〈0.001）. But no significant macular choroidal area difference has been found between the two groups at all the five measurement time-points （512778＋166242 vs 455079：1：207278 pm2, P=-0.195 at 9：00 a.m.; 501526168953 vs 447846.：211147 pm2, P=-0.245 at 12：00 a.m.; 501982＋173158 vs 448024#.206653 pm2, P=-0.239 at 15：00 p.m.; 508912＋174589 vs 457783＋-207081 pm2, P=-0.252 at 18：00 p.m.; 503787＋171241 vs 453230＋_205955 pm2, P=-0.274 at 21：00 p.m.; respectively）. Furthermore, neither the fluctuation manners nor the change in macular choroidal area between the two adjacent measurement time points showed significant difference between normal and POAG groups （all P〉0.05）. In the meantime, significant diurnal intraocular pressure fluctuations were also observed in normal and POAG groups （both P〈0.001）. CONCLUSION： In diurnal time, the macular choroidal area in both normal and POAG groups fluctuated significantly; moreover, neither the value of macular choroidal area, nor the fluctuation of macular choroidal area in POAG group is significantly different from that in normal group.

关键词： diurnal fluctuation macular choroidal area primary open angle glaucoma optical coherence tomography