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Pig pangenome graph reveals functional features of non‑reference sequences

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Journal of Animal Science and Biotechnology 2024年第3期15卷 956-970页

作者： jian Miao Xingyu Wei Caiyun cao Jiabao Sun Yuejin Xu Zhe Zhang Qishan Wang Yuchun Pan Zhen Wang College of Animal Sciences Zhejiang UniversityHangzhou 310058ZhejiangChina Yazhou Bay Science and Technology City Hainan Institute of Zhejiang UniversityYazhou DistrictBuilding 11Yongyou Industrial ParkSanya 572025HainanChina

Background The reliance on a solitary linear reference genome has imposed a significant constraint on our compre-hensive understanding of genetic variation in *** constraint is particularly pronounced for non-reference sequences(NRSs),which have not been extensively *** In this study,we constructed a pig pangenome graph using 21 pig assemblies and identified 23,831 NRSs with a total length of 105 *** findings revealed that NRSs were more prevalent in breeds exhibiting greater genetic divergence from the reference ***,we observed that NRSs were rarely found within coding sequences,while NRS insertions were enriched in immune-related Gene Ontology ***,our investigation also unveiled a close association between novel genes and the immune capacity of *** observed substantial differences in terms of frequencies of NRSs between Eastern and Western pigs,and the heat-resistant pigs exhibited a substantial number of NRS insertions in an 11.6 Mb interval on chromosome ***,we discovered a 665 bp insertion in the fourth intron of the TNFRSF19 gene that may be associated with the ability of heat tolerance in South-ern Chinese *** Our findings demonstrate the potential of a graph genome approach to reveal important functional features of NRSs in pig populations.

关键词： Heat tolerance Immune ability Non-reference sequences Pig pangenome

Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： jian-Hu Gong Zheng-ming Zhang Cheng-Liang Zhang Peng-Qiang Hu Chao Zhou Dun-Hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen Lin Tong Li Yi Zhang Wei-Wei Yan Xiao-ming Chen Zhi-Sen Zhang jian-Yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

Computerized cognitive remediation therapy on cognitive impairment and social function in patients with chronic schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 884-893页

作者： jian-Jun Hu Xi-Rong Sun Shuang-ming Ni Yan Kong Department of Psychiatry Shanghai Pudong New Area Mental Health Center(Mental Health Center of Tongji UniversityShanghai Pudong New Area Psychological Counseling Center)Shanghai 200124China

BACKGROUND Patients with schizophrenia may have various disease manifestations,most of which gradually tend toward incurable chronic decline,leading to mental *** basic symptoms of the disease can impair social function,whereas long-term hospitalization produces hospitalization syndrome,causing serious damage to social *** To investigate the effects of Computerized Cognitive Remediation Therapy(CCRT)on cognitive and social functioning in patients with chronic *** A retrospective analysis of 120 patients with chronic schizophrenia in Shanghai Pudong New Area Mental Health Center was *** were divided into an intervention group(60 cases treated with CCRT combined with conventional medication)and a control group(60 cases treated with conventional medication).After treatment,effects on cognitive function and social roles were observed in both *** Positive and Negative Syndrome Scale(PANSS)was used to assess the patients'psychiatric *** Wisconsin Card Sorting Test(WCST)was used to assess the patients'cognitive functioning,and the Social Functioning Scale for Psychiatric Inpatients(SSPI)was used to assess the social functioning of the inpatient psychiatric *** No significant differences were observed in the PANSS,WCST,and SSPI intergroup scores before treatment(P>0.05).After 2,4,and 6 wk of therapy,general psychopathological factors,positive symptoms,negative symptoms,and total PANSS scores of PANSS in the intervention group were lower than in the control group(P<0.05).After 2,4,and 6 wk of treatment,the number of false responses,number of persistent bugs,and total responses in the WCST were significantly lower in the intervention group than in the control group(P<0.05),and the amount of completed classification was significantly higher than in the control group(P<0.05).After 2,4,and 6 wk of therapy,the SSPI scores were significantly greater than those of the controls(P<0.05).After 6 wk of treatm

关键词： Computerized cognitive correction therapy Schizophrenia Cognitive function Social function Psychopathological factors

Development characteristics and controlling factors of fractures in lacustrine shale and their geological significance for evaluating shale oil sweet spots in the third member of the Shahejie Formation in the Qikou Sag, Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 791-805页

作者： Xu Zeng Tao Yang jian-Wei Feng Cong-Sheng Bian ming Guan Wei Liu Bing-Cheng Guo Jin Dong Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing100083China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China School of Earth Sciences China University of PetroleumQingdao266400ShandongChina

Natural fractures are critical for shale oil and gas enrichment and development. Due to the extremely high heterogeneity of shale, the factors controlling the formation of internal fractures, especially horizontal fractures, remain controversial. In this study, we integrate thin section analysis and microcomputed tomography(CT) data from several lacustrine shale samples from the third member(Es3) of the Shahejie Formation, Qikou Sag, Bohai Bay Basin, to assess the fractures in detail. The goal is to reveal the development characteristics, controlling factors, and geological significance for evaluating sweet spots in a shale oil play. The fractures in the Es3contain high-angle structural and horizontal bed-parallel fractures that are mostly shear and extensional. Various factors influence fracture development,including lithofacies, mineral composition, organic matter content, and the number of laminae. Structural fractures occur predominantly in siltstone, whereas bed-parallel fractures are abundant in laminated shale and layered mudstone. A higher quartz content results in higher shale brittleness, causing fractures, whereas the transformation between clay minerals contributes to the development of bedparallel fractures. Excess pore pressure due to hydrocarbon generation and expulsion during thermal advance can cause the formation of bed-parallel fractures. The density of the bed-parallel and structural fractures increases with the lamina density, and the bed-parallel fractures are more sensitive to the number of laminae. The fractures are critical storage spaces and flow conduits and are indicative of sweet spots. The laminated shale in the Es3with a high organic matter content contains natural fractures and is an organic-rich, liquid-rich, self-sourced shale play. Conversely, the siltstone, massive mudstone, and argillaceous carbonate lithofacies contain lower amounts of organic matter and do not have bed-parallel fractures. However, good reservoirs can form in th

关键词： Fractures Development characteristics Controlling factors Shale oil Sweet spot

Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze Zhang ming-Hao Pang Pei-Pei Yang Lu-ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

Thermal-tectonic history of the Baogutu porphyry Cu deposit,West Junggar as constrained from zircon U-Pb,biotite Ar/Ar and zircon/apatite(U-Th)/He dating

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Thermal-tectonic history of the Baogutu porphyry Cu deposit,...

Preparation of crab-shell-based N,O co-doped graded porous carbon for supercapacitors using the confined nanospace deposition

中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Guang-ming Li ming-jian cao Ke-Zhang Qin Noreen J.Evans Brent LA.McInnes Yong-Sheng Liu Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences CSIRO Earth Science and Resource Engineering John de Laeter Center for Isotope Research Dept. Applied Geology/Applied PhysicsCurtin University State Key Laboratory of Geological Processes and Mineral Resources Faculty of Earth SciencesChina University of Geosciences

Understanding postmineralization tectonic movements in porphyry deposits,is critical to interpreting the complete thermal-tectonic *** study reports new zircon U-Pb ages,hydrothermal biotiteAr/Ar age,and zircon and apatite(U-Th)/He ages from the Baogutu porphyry copper deposit,which,in conjunction with pre-existing geochronology and thermochronology and inverse modeling simulations,constrain the thermal-tectonic history of the *** LA-ICP-MS U-Pb concordia ages indicate a Late Carboniferous age of 320.1 ± 2.2 Ma for the diorite complex and 309.8 ± 2.2 Ma for the mineralized granodiorite *** biotite selected from a quartz-biotite-chalcopyrite vein yields a plateau age of 311.0 ± 1.8 Ma which agrees with the age of the granodiorite porphyry and a previously reported molybdenite Re-Os age,and suggests that hydrothermal fluid circulated about310 *** and granodiorite porphyry yield weighted mean zircon(U-Th)/He ages of200.6±5.7Ma and 241.1 ±8.1 Ma,respectively,with ages ranging from 221.0 Ma to 174.3 Ma and225.9 to 261.6 *** mean diorite and granodiorite porphyry apatite(U-Th)/He ages of87.4 ± 2.3 Ma and 120.0 ± 4.2 Ma were obtained with ages ranging from 68.9 Ma to 100.8 Ma,and from91.0 Ma to 152.0 Ma,*** wide range of zircon(U-Th)/He ages may be due to the combined effects of U and Th zonation and radiation damage,and radiation damage effect may also account for the wide range of apatite(U-Th)/He *** combined effects of depth and cooling due to meteoric water circulation contribute to an older(U-Th)/He age for the granodiorite porphyry,relative to the diorite.A five-episode cooling rate history for the diorite can be deduced by inverse model simulation:fast cooling—moderate fast cooling—relatively slow cooling—fast cooling again—very slow *** thermal and tectonic history of the wall rock indicates that it suffered significant far-field effects from the Qiangtang-Eurasia and Lhasa-Qiangta

关键词： Western Junggar Baogutu porphyry copper deposit Zircon U-Pb dating Ar/Ar dating Zircon(U-Th)/He dating Apatite(U-Th)/He dating Thermal-tectonic history

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Waste Disposal and Sustainable Energy 2024年第2期6卷 173-183页

作者： Yiming Li Zhihao Yu Mengyan Guo ming Zhang jian Xiong Yina Qiao Rui Zhang Xuebin Lu School of Environmental Science and Engineering Tianjin UniversityTianjin 30000China School of Ecology and Environment Tibet UniversityLhasa 850000China School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China School of Environmental and Municipal Engineering Tianjin Chengjian UniversityTianjin 300384China

Biomass-based carbon materials with hierarchical porous structures have attracted attention for their ability to provide more channels and shorten ion transport ***,we developed a simple method based on confined nanospace ***-ing high-temperature treatment,the mesoporous silica layer wrapped around the outside of the crab shells acted as a closed nanospace and effectively suppressed the severe deformation of the crab shell structure by shrinking *** prepared carbon material has a layered porous structure with abundant and stable N and O co-doping(N 7.32%,O 3.69%).The specific capacitance of the three-electrode system was 134.3 F/g at a current density of 0.5 A/g in a 6 mol/L KOH electrolyte,and the assembled aqueous symmetric supercapacitors exhibited an excellent cycling stability of 98.81%even after 5000 cycles.

关键词： Supercapacitor Confined nanospace deposition Biomass-based carbon materials Crab shell

Digital Beamforming Demonstration of a Microstrip Antenna Phased Array Feeds(PAF)at 1.25 GHz

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Research in Astronomy and Astrophysics 2024年第10期24卷 76-80页

作者： Peng Wu Mao-Zheng Chen jian Li Kai Wang Liang cao Han Yu Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China

We introduce the structure of a radio astronomy phased array feeds(PAF)beamforming *** a laboratory environment,we have demonstrated beamforming on a received 1.25 GHz sinusoidal signal and used digital weighting techniques to plot the 2D pattern of the *** radio frequency part of the demonstrator includes a 4×4 linearly polarized microstrip antenna array,all of which is connected in series with a low-noise *** signals from the central 4×2 array elements are injected into a radio frequency system-on-chip digital board,which can receive eight inputs with a bandwidth of 512 *** the principle of undersampling,the beamforming is completed at a frequency of 1.25 GHz for the offline data,and a 2D image of the beam is plotted using beam scanning technology.

关键词： Astronomical Instrumentation Methods and Techniques Astronomical Databases methods:data analysis