检索结果-南通市图书馆

Novel MIP gene mutation causes autosomal-dominant congenital cataract

International Journal of Ophthalmology(English edition) 2024年第3期17卷 454-465页

作者： Jing-Lan Ni hua-ming wen Xiao-Sheng huang Qian-wen Li Jia-Min Cai Bao-Jian Fan Jun Zhao The Second Clinical Medical College Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Ophthalmology Dongguan Chang’an HospitalDongguan 523843Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Oral&Maxillofacial Surgery Shenzhen Stomatology Hospital Affiliated to Shenzhen UniversityShenzhen 518040Guangdong ProvinceChina Department of Neurosurgery Massachusetts General Hospital and Harvard Medical SchoolBoston 02114MassachusettsUSA Department of Ophthalmology Shenzhen People’s Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina

●AIM:To identify disease-causative mutations in families with congenital cataract.●METHODS:Two Chinese families with autosomaldominant congenital cataract(ADCC)were recruited and underwent comprehensive eye *** panel next-generation sequencing of common pathogenic genes of congenital cataract was performed in the proband of each *** sequencing was used to valid the candidate gene mutations and sequence the other family members for co-segregation *** effect of sequence changes on protein structure and function was predicted through bioinformatics *** intrinsic protein(MIP)-wildtype and MIP-G29R plasmids were constructed and microinjected into zebrafish single-cell stage *** embryonic lens phenotypes were screened using confocal microscopy.●RESULTS:A novel heterozygous mutation(c.85G>A;p.G29R)in the MIP gene was identified in the proband of one family.A known heterozygous mutation(c.97C>T;p.R33C;rs864309693)in MIP was found in the proband of another ***-silico prediction indicated that the novel mutation might affect the MIP protein *** embryonic lens was uniformly transparent in both wild-type PCS2+MIP and mutant PCS2+MIP.●CONCLUSION:Two missense mutations in the MIP gene in Chinese cataract families are identified,and one of which is *** findings expand the genetic spectrum of MIP mutations associated with *** functional studies suggest that the novel MIP mutation might not be a gain-of-function but a loss-of-function mutation.

关键词： congenital cataract major intrinsic protein missense mutation zebrafish model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reinvestigation on the Reaction of Salicylic Chloride with Salicylic Amide and X-ray Crystal Structure of a New Macrocyclic Polyester

引用

Chinese Journal of Structural Chemistry 2003年第5期22卷 512-516页

作者： DU Da-ming② CHEN Xiao hua wen-Ting JIN Xiang-Lin (Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China) College of Chemistry and Molecular Engineering Peking University Key Laboratory of Bioorganic Chemistry and Molecular Engineering Ministry of Education 北京 100871

The reaction of salicylic chloride and salicylic amide at 170 ℃ gave benzoxazine and a new macrocyclic polyester 3, whose crystal structure has been determined by single-crystal X-ray diffraction analysis. Compound 3: C28H16O8, Mr = 480.41, monoclinic, space group P21/n, a = 15.353(3), b = 14.196(3), c = 21.147(4) ? b = 103.32(3), V = 4485(2) ?, Z = 8, F(000) = 1984, Dc = 1.423 g/cm3 and m = 0.106 mm-1. The final R = 0.0535 and wR = 0.1275 for 7903 observed reflections (I ≥ 2(I)). In the asymmetric unit of the compound there exist two independent molecules which are connected by weak aromatic CH…O hydrogen bonding between C(47)?H(47) and atom O(7) of the carbonyl group.

关键词： salicylic chloride salicylic amide polyester macrocycle crystal structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

裂纹面接触对中心裂纹圆盘应力强度因子影响分析

引用

岩土力学 2017年第8期38卷 2395-2401页

作者：李念斌董世明华文四川大学建筑与环境学院四川成都610065

从理论和数值两个方面进行分析,发现受径向集中力和围压作用的中心裂纹圆盘(CCBD)试件裂纹面接触会对II型应力强度因子产生较大的影响。通过理论研究,分析CCBD受集中力和围压作用裂纹面接触时圆盘内部的应力场,采用断裂力学权函数理论,... 详细信息

从理论和数值两个方面进行分析,发现受径向集中力和围压作用的中心裂纹圆盘(CCBD)试件裂纹面接触会对II型应力强度因子产生较大的影响。通过理论研究,分析CCBD受集中力和围压作用裂纹面接触时圆盘内部的应力场,采用断裂力学权函数理论,推导得出在集中力和围压共同作用下,考虑裂纹面闭合时应力强度因子的解析解。然后,使用ANSYS软件建立了相应的数值模型计算应力强度因子,并与理论解和相关文献进行对比验证,证明了理论公式的正确性。无论裂纹张合与否,所提出的解析公式都能计算出不同裂纹长度、加载角、围压和摩擦系数的应力强度因子。最后,利用公式分析摩擦系数对应力强度因子的影响,结果表明:随着摩擦系数的增大,I型裂纹的应力强度因子不变,II型裂纹的应力强度因子随之显著减小;当加载角较大时,裂纹面产生更为复杂的二次裂纹,故压剪断裂测试的推荐加载角范围为30°~50°。

关键词：中心裂纹圆盘权函数应力强度因子裂纹面接触围压

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

二维相扫星载降水测量雷达地杂波抑制方法

引用

现代雷达 2009年第7期31卷 23-27页

作者：明文华华东电子工程研究所合肥230031

星载降水测量雷达(SPR),在检测气象目标过程中,最大的困难就是强烈的地杂波和海杂波,而对SPR地杂波的抑制要以抑制其副瓣杂波为主。通过分析SPR副瓣杂波的产生过程发现:综合方向图与地面/海面后向反射系数的乘积对副瓣杂波强度影响较大... 详细信息

星载降水测量雷达(SPR),在检测气象目标过程中,最大的困难就是强烈的地杂波和海杂波,而对SPR地杂波的抑制要以抑制其副瓣杂波为主。通过分析SPR副瓣杂波的产生过程发现:综合方向图与地面/海面后向反射系数的乘积对副瓣杂波强度影响较大。因此,文中提出一种针对二维相扫SPR的波束倾斜法来抑制其地杂波。仿真结果表明:该方法能有效抑制SPR地杂波,并能提高可检测单元的个数。

关键词：星载降水测量雷达杂波抑制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

引用

World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study

引用

Chinese Medical Journal 2019年第18期132卷 2150-2156页

作者： Wei Zhou Tao Wang Ling-Juan Zhu ming-hua wen Li-hua Hu Xiao huang Chun-Jiao You Ju-Xiang Li Yan-Qing Wu Qing-hua Wu Hui-Hui Bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Background: The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. Methods: A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. Results: During 6-month follow-up, 87 participants occurred bleeding events. For every 1×10^9/L increase in leukocyte count, the risk of bleeding increased by 11%(hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99–1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75×10^9/L. For leukocyte counts < 6.75×10^9/L, the HR (95% CI) was 0.88 (0.69–1.13), and for leukocyte counts ≥ 6.75×10^9/L, the HR (95% CI) was 1.28 (1.09–1.51). Conclusion: This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran.

关键词： Peripheral leukocyte count Bleeding Nonvalvular atrial fibrillation Threshold effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

星载降水测量雷达杂波计算与分析

引用

雷达科学与技术 2009年第3期7卷 189-193,204页

作者：明文华中国电子科技集团公司第三十八研究所安徽合肥230031

为了保证最佳距离分辨率,星载降水测量雷达(SPR)的扫描方式通常设计为在垂直于飞行向的方向上扫描,以下视的方式观测大气层内的降水分布,这样降雨回波就会受到强烈的地杂波(包括主瓣杂波和副瓣杂波)干扰。文中详细论述了SPR主/副瓣杂波... 详细信息

为了保证最佳距离分辨率,星载降水测量雷达(SPR)的扫描方式通常设计为在垂直于飞行向的方向上扫描,以下视的方式观测大气层内的降水分布,这样降雨回波就会受到强烈的地杂波(包括主瓣杂波和副瓣杂波)干扰。文中详细论述了SPR主/副瓣杂波的产生原理、星地几何关系以及计算步骤,最后通过仿真总结了SPR杂波的一些特性和对杂波抑制方法的建议。文中所述的主/副瓣杂波的计算方法适用于SPR的设计,对其他机载、星载下视雷达的杂波计算也有参考作用。

关键词：星载雷达降水测量雷达主瓣杂波副瓣杂波杂波计算

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress of the Associated Gamma-ray Research from 14 Mev Neutron Reaction

引用

中国核科技报告 1989年第S1期 19-21页

作者： Zhou Hongyu Fan Guoying Yan Yiming hua ming wen Chenlin Tang Lin (Institute of Low Energy Nuclear Physics, Beijing Normal Univ.)

Since 1987 the measurements of angular distribution of discrete gamma-ray spectra for the interactions of 14.9 MeV neutrons with some elements of struc-ture materials of fusion reactor,for example,C,Al,U,Fe,Co and Nb,havebeen completed using a pulsed 400 kV Cockcroft walton accelerator and a gam-ma-ray spectrometer in Beijing Normal University,For every sample gamma-ray spectra at 30°,40°,55°,90°,110°,125°,and 140°relative to the incide-nt neutron direction were measured,and the differential cross sections for everygamma lines were determined,where the results at 90°are new independentmeasurements,The angular distributions of the differential cross sections of

关键词： gamma sections Cockcroft accelerator completed spectrometer struc Associated neutron angular

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

复方樟柳碱颞浅动脉旁皮下注射联合针灸治疗眼睑痉挛的疗效

引用

国际眼科杂志 2013年第5期13卷 1032-1033页

作者：张雷闻华明赵芳张晓鄂中国湖北省英山县人民医院眼科 438799 广州医学院附属西乡人民医院中国广东省深圳市518100 中国湖北省武汉市中心医院 430014 中国湖北省宜昌市阳明眼科医院 443000

目的:观察复方樟柳碱颞浅动脉旁皮下注射联合针灸治疗眼睑痉挛的疗效。方法:眼睑痉挛患者55例67眼,实验组30例,对照组25例,实验组用复方樟柳碱注射液2mL患侧颞浅动脉旁皮下注射联合针灸治疗,对照组25例单纯针灸治疗。结果:两组治疗14d后... 详细信息

目的:观察复方樟柳碱颞浅动脉旁皮下注射联合针灸治疗眼睑痉挛的疗效。方法:眼睑痉挛患者55例67眼,实验组30例,对照组25例,实验组用复方樟柳碱注射液2mL患侧颞浅动脉旁皮下注射联合针灸治疗,对照组25例单纯针灸治疗。结果:两组治疗14d后,实验组22例完全缓解,2例明显缓解,5例部分缓解,1例无效,对照组11例完全缓解,2例明显缓解,7例部分缓解,5例无效,两组差异有统计学意义(Z=-3.516,P=0.000<0.001),实验组治疗效果明显优于对照组。结论:复方樟柳碱注射液患眼颞浅动脉旁皮下注射联合针灸治疗眼睑痉挛,疗效显著,可作为治疗眼睑及面肌痉挛的首选方法之一。

关键词：复方樟柳碱针灸眼睑痉挛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杨文华辨治骨髓纤维化经验

引用

河南中医 2017年第10期37卷 1718-1721页

作者：王鸣杨文华天津中医药大学天津300000 天津中医药大学第一附属医院天津300193

杨文华教授认为骨髓纤维化的病因病机为:气滞血瘀、瘀阻脏腑;湿毒内蕴、毒瘀内结;因虚致瘀、因瘀致虚。杨文华教授认为骨髓纤维化的治疗应遵个体化,分期治疗。根据骨髓纤维化的临床特点,杨文华教授在活血化瘀的同时,注重软坚散结类药物... 详细信息

杨文华教授认为骨髓纤维化的病因病机为:气滞血瘀、瘀阻脏腑;湿毒内蕴、毒瘀内结;因虚致瘀、因瘀致虚。杨文华教授认为骨髓纤维化的治疗应遵个体化,分期治疗。根据骨髓纤维化的临床特点,杨文华教授在活血化瘀的同时,注重软坚散结类药物的使用。杨文华教授在长期临床实践中认识到,骨髓纤维化临床上辨证可分为气滞血瘀、气虚血瘀、气血两虚夹瘀、阴亏血瘀、阳虚血瘀、毒热血瘀。无论哪种证型,总以"血瘀"为其基本病机,治疗上以活血化瘀为基本大法,针对血瘀不同证型,分别应用不同的化瘀法。杨文华教授在中药汤剂内服治疗的基础上,充分发挥中医外治作用,运用中药研末外敷体表直接给药,经皮肤吸收后,药力直达病所,作用迅速有效,且可避免口服经消化道吸收多环节灭活作用及一些药物内服带来的毒副反应。杨文华教授治疗骨髓纤维化强调攻补兼施,扶正祛邪;辨清病位,善辨脏腑;调节免疫,预防转白;专药对药,四气五味。

关键词：骨髓纤维化活血化瘀软坚散结杨文华

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：