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Using Copula functions to predict climatic change impacts on floods in river source regions

Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing CHEN Hai-Shen LYU Robert HORTON Yong-hua ZHU ren-Sheng CHEN ming-Yue SUN ming-Wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,prence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions

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Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： Juan PAN Xian Kun ren Yun hua ZHOU School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorphism is non-uniformly partially hyperbolic if it preserves an ergodic measure with at least one zero Lyapunov *** prove that a C^(1)-smooth Z^(d)-action has the quasishadowing property if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly partially hyperbolic ergodic measure

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Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： Jia-Qi Peng Yuan-Yuan Wei Dong-ming Liu Yun Li Bin Hu Bin huang Jian-Wen Yang Shun-hua Xiao ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

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Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： ren-Yong Wang Jia-Ling Yang Ning Xu Jia Xu Shao-hua Yang Dao-ming Liang Jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

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Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： Ling-Ling Chen ren-Fei Cao hua Ke Zhi-Min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

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Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-Xin Zhang ming-Fei Jiao Xin-Jun ren Bo-Jie Hu Ai-hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-Zhi Chen Chang-Zhen ren Ke-Yan Sun Hao Liu Shao-hua Song Zhi-ren Fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

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Synthesis of poly(thiourethane-alt-thioester) by alternating ring-opening copolymerization of N-thiocarboxyanhydrides and episulfides

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Science China Chemistry 2024年第9期67卷 3091-3097页

作者： Wei Xiong Tianjun Yue Haiwang Lai Chunyan Lyu Weimin ren hua Lu Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University State Key Laboratory of Fine Chemicals Dalian University of Technology

Polythiourethanes(PTU) and polythioesters(PTE) derived from renewable sources are emerging sustainable polymers for their excellent degradability and recyclability. However, P(TU-alt-TE) copolymers have been rare and challenging to ***, we report the efficient synthesis of novel P(TU-alt-TE) copolymers via the alternating copolymerization of N-thiocarboxyanhydrides(NTA)/episufides(ES) and provide mechanistic insight into the alternating chain propagation process via density functional theory(DFT) calculation. The incorporation of ESs into traditional peptide backbone is capable of adjusting the glass transition temperature below thermal decomposition temperature, which confers better thermal processability by regulating the rigidity of the backbone and the hydrogen bond interaction among the polymer chains. Crosslinked PTUs with tailored properties are accessible by altering the feeding ratio of NTAs and(bifunctional) ESs. Moreover, the thiourethane in the backbone can endow interesting underwater adhesion properties to the materials. Considering the broad scope of NTA and ES monomers, this method is expected to provide a promising and general route to a wide range of P(TU-alt-TE) copolymers with diverse properties.

关键词： poly(thiourethane-alt-thioester) alternating ring-opening copolymerization N-thiocarboxyanhydrides episulfides

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Bioinspired Tactile Sensation Based on Synergistic Microcrack-Bristle Structure Design toward High Mechanical Sensitivity and Direction-Resolving Capability

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Research 2024年第1期2023卷 611-624页

作者： Yiqun Zhang Qi Liu Wenjuan ren Yangyang Song hua Luo Yangyang Han Liang He Xiaodong Wu Zhuqing Wang School of Mechanical Engineering Sichuan UniversityChengdu 610065China Med+X Center for Manufacturing West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

Natural tactile sensation is complex,which involves not only contact force intensity detection but also the perception of the force direction,the surface texture,and other mechanical ***,the vast majority of the developed tactile sensors can only detect the normal force,but usually cannot resolve shear force or even distinguish the directions of the ***,we present a new paradigm of bioinspired tactile sensors for resolving both the intensity and the directions of mechanical stimulations via synergistic microcrack-bristle structure design and cross-shaped configuration *** microcrack sensing structure gives high mechanical sensitivity to the tactile sensors,and the synergistic bristle structure further amplifies the sensitivity of the *** cross-shaped configuration engineering of the synergistic microcrack-bristle structure further endows the tactile sensors with good capability to detect and distinguish the directions of the applied mechanical *** as-fabricated tactile sensors exhibit a high sensitivity(25.76 N^(−1)),low detection limit(5.4 mN),desirable stability(over 2,500 cycles),and good capability to resolve both mechanical intensity and directional *** promising application scenarios,surface texture recognition and biomimetic path explorations are successfully demonstrated with these tactile *** newly proposed tactile sensation strategy and technology have great potential applications in ingenious tactile sensation and construction of various robotic and bionic prostheses with high operational dexterity.

关键词： crack sensation directions

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Roles of Loss of Chromosome 14q Allele in the Prognosis of renal Cell Carcinoma with C-reactive Protein Abnormity

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Chinese Medical Journal 2017年第18期130卷 2176-2182页

作者： Gang Wang Da-ming Zhang Hai-Ying Zhuang Chao Yin Jing Liu Zi-Chun Wang Li-Cheng Cai ming-hua ren Wan-Hai Xu Cheng Zhang Department of Urology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Pharmacology Harbin Medical University Harbin Heilongjiang 150081 China Department of Pharmacy The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Urology The Fourth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background：renal cell carcinoma （RCC） is frequently associated with paraneoplastic inflammatory syndrome （PIS）.This study aimed at exploring the connections between the survival rate and specific gene alterations and the potential ***：We retrospectively studied 69 surgical RCC cases from August 2014 to February 2016,including 18 cases of clear cell RCC （ccRCC） demonstrating elevated pretreatment serum C-reactive protein （CRP,Group A）.Twelve of the 18 cases were symptomized with febrile *** also selected 49 cases ofccRCC with normal pretreatment CRP （Group B）.Using 22 microsatellite markers,we compared the incidence of loss of heterozygosity （LOH） between Group A and Group *** statistical tests are ***：The 3p LOH was common in both Group A （89%） and Group B （92%）.The frequency of 14q LOH in Group A （16 of 18） was higher than Group B （4 of 49,χ^2 =40.97 P 〈 0.0001）.The 3p and 14q LOH were the characteristics of ccRCC with elevated acute phase reactants,including PIS,regardless of the presence of *** the contrary,14q LOH was a rare genomic alternation in advanced-staged ccRCC without *** overall survival of patients with elevated CRP （33.3%） was lower than its counterparts （6.1%,hazard ratio=1.852,P 〈 0.0001） in Kaplan-Meier ***：The results imply that the disruption ofa 14q gene（s） might result in not only the inflammatory manifestations in the tumor host but also the poor survival rate as *** isolation of the gene（s） on 14q might be a vital goal in the treatment of PIS-associated RCC.

关键词： C-reactive Protein Gene Alterations Loss of Chromosome Paraneoplastic Inflammatory Syndrome renal Cell Carcinoma

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