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Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

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Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin Yang hong-Yong Xiang ming Niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao hong-Sheng Ou-Yang Tong-Yu Liu Xiao-Chun Tang Da-Xin Pang hong-ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

Disposal of zinc extraction residues via iron ore sintering process:an innovative resource utilization

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1636-1645页

作者： Chun-long Fan Cheng-yi Ding Tao Yang Yun-fei Luo Yi-fan Wang Qian Li hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Ministry of Education) Anhui University of TechnologyMa'anshan 243002AnhuiChina

Zinc extraction residue,a solid waste generated from the treatment of zinc-containing dust in rotary kilns,is commonly stockpiled in steel companies for extended *** poses significant disposal challenges and environmental pollution *** far,research on the treatment of zinc extraction residues has been slow,inadequate,and *** this gap,a novel approach was proposed to effectively treat the zinc extraction residue via the iron ore sintering *** was feasible to add 1 wt.%of zinc extraction residues to the sintering raw *** more adequate mineralization reaction resulted in higher yield and tumbler indexes,despite a slight decrease in sintering *** this may result in a slight decrease in sintering speed,the more complete mineralization reaction leads to improved sintering yield and tumbler ***,the addition of zinc extraction residues reduced the CO and NO_(x) concentrations in the sintering flue ***,the iron ore sintering process provided a viable solution for resource utilization and environmentally friendly treatment of zinc extraction residues.

关键词： Zinc extraction residue Iron ore sintering Co-processing Waste utilization Gas pollutant reduction

Endoscopic-ultrasound-guided biliary drainage with placement of electrocautery-enhanced lumen-apposing metal stent for palliation of malignant biliary obstruction:Updated meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 907-920页

作者： Zu-Xiang Peng Fang-Fang Chen Wen Tang Xu Zeng hong-Juan Du Ru-Xian Pi hong-ming Liu Xiao-Xiao Lu Department of Hepatobiliary Surgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Oncology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Gastroenterology and Hepatobiliary Surgery People’s Hospital of Fenggang CountyGuizhou 564200Guizhou ProvinceChina Hepatobiliary and Pancreatic Tumor Center Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Endoscopic ultrasound-guided biliary drainage using electrocautery-enhanced(ECE)delivery of lumen-apposing metal stent(LAMS)is gradually being re-cognized as a viable palliative technique for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography(ERCP)***,most of the studies that have assessed its efficacy and safety were small and *** meta-analyses of six or fewer studies that were published 2 years ago were therefore underpowered to yield convincing *** To update the efficacy and safety of ECE-LAMS for treatment of biliary ob-struction after ERCP *** We searched PubMed,EMBASE,and Scopus databases from the inception of the ECE technique to May 13,*** outcome measure was pooled technical success rate,and secondary outcomes were pooled rates of clinical success,re-intervention,and adverse ***-analysis was performed using a random-effects model following Freeman-Tukey double-arcsine transformation in R soft-ware(version 4.1.3).RESULTS Fourteen eligible studies involving 620 participants were ultimately *** pooled rate of technical success was 96.7%,and clinical success was 91.0%.Adverse events were reported in 17.5%of *** reinter-vention rate was 7.3%.Subgroup analyses showed results were generally *** ECE-LAMS has favorable success with acceptable adverse events in relieving biliary obstruction when ERCP is *** consistency of results across most subgroups suggested that this is a generalizable approach.

关键词： Biliary obstruction Biliary drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography failure

Molecular dynamics simulations on the interactions between nucleic acids and a phospholipid bilayer

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Chinese Physics B 2024年第2期33卷 512-521页

作者：徐耀黄舒伟丁泓铭马余强 National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Center for Soft Condensed Matter Physics and Interdisciplinary Research School of Physical Science and TechnologySoochow UniversitySuzhou 215006China

Recently,lipid nanoparticles(LNPs)have been extensively investigated as non-viral carriers of nucleic acid vaccines due to their high transport efficiency,safety,and straightforward production and ***,the molecular mechanism underlying the interactions between nucleic acids and phospholipid bilayers within LNPs remains *** this study,we employed the all-atom molecular dynamics simulation to investigate the interactions between single-stranded nucleic acids and a phospholipid *** findings revealed that hydrophilic bases,specifically G in single-stranded RNA(ssRNA)and single-stranded DNA(ssDNA),displayed a higher propensity to form hydrogen bonds with phospholipid head ***,ssRNA exhibited stronger binding energy than ***,divalent ions,particularly Ca2+,facilitated the binding of ssRNA to phospholipids due to their higher binding energy and lower dissociation rate from ***,our study provides valuable insights into the molecular mechanisms underlying nucleic acidphospholipid interactions,with potential implications for the nucleic acids in biotherapies,particularly in the context of lipid carriers.

关键词： RNA DNA lipid bilayer molecular dynamics interface interaction divalent cation

Theoretical calculations of proton emission half-lives based on a deformed Gamow-like model

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Chinese Physics C 2024年第4期48卷 107-114页

作者：张冬萌胡笑源亓林静刘宏铭李明李小华 School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of Modern Physics Fudan UniversityShanghai 200433China National Exemplary Base for International Sci&Tech.Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In this study,proton emission half-lives were investigated for deformed proton emitters with 53≤Z≤83based on the presented deformed Gamow-like model,where the deformation effect was included in the Coulomb *** experimental half-lives of proton emitters can be reproduced within a factor of *** comparison,the results from the universal decay law and the new Geiger-Nuttall law are also ***,the relevance of the half-lives to the angular momentum l for ^(117)La,^(121)Pr,^(135)Tb,and ^(141)Ho were analyzed,and the corresponding possible values of l were proposed:l=3,3,4,4.

关键词： proton emission half-lives deformed nuclei Gamow-like model

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浅谈智慧城管视域下城市道路监测预警系统

科学与信息化 2024年第9期 184-186页

作者：章红明方利红浙江网新帮德信息服务有限公司浙江杭州 310000

智慧城管帮助城市管理部门有效破解了以往城市管理工作中遭遇的管理效能低、干预措施滞后、信息传递受阻等问题.道路管理养护单位可将智慧城管技术与理念应用到城市道路管理工作中,满足道路问题监测与预警需求,保障道路通行的安全性,降... 详细信息

智慧城管帮助城市管理部门有效破解了以往城市管理工作中遭遇的管理效能低、干预措施滞后、信息传递受阻等问题.道路管理养护单位可将智慧城管技术与理念应用到城市道路管理工作中,满足道路问题监测与预警需求,保障道路通行的安全性,降低道路维护成本.本文立足智慧城管视域,分析了城市道路塌陷问题的主要形成原因,而后依托物联网等技术,设计了道路监测预警系统,旨在提高道路安全风险防范水平.

关键词：智慧城管视域城市道路监测预警系统

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美国里奇大学工作嵌入式教师培养模式探究

沈阳师范大学学报(教育科学版) 2024年第1期3卷 60-67页

作者：洪明程婷婷福建师范大学教育学院

里奇大学（Reach University）是美国教师培养实践取向背景下的创新性成果之一。它创建了独特的工作嵌入式教师培养模式，把教师培养嵌入教学实践工作之中，将先取得学位证书后获得工作的传统逻辑序列进行了颠倒，以教师候选人的工作表... 详细信息

里奇大学（Reach University）是美国教师培养实践取向背景下的创新性成果之一。它创建了独特的工作嵌入式教师培养模式，把教师培养嵌入教学实践工作之中，将先取得学位证书后获得工作的传统逻辑序列进行了颠倒，以教师候选人的工作表现而非课程考试成绩作为是否可以取得学位和证书的衡量标准。里奇大学在以工作嵌入式为核心的实践教学基础之上，建立了具有实践性、体验性和相关性的课程体系，以及多元且异于传统的教学实施和评价体系。基于里奇大学工作嵌入式教师培养模式的经验，我国的教师专业培养应确立清晰的人才培养定位，提供灵活的制度服务，开展高质量的教育实习指导。

关键词：里奇大学工作嵌入式教师培养模式

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基于基于TOPSIS法对和田地区温室番茄滴灌方案优选研究

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节水灌溉 2024年第1期 115-120,127页

作者：王可谢香文洪明新疆农业大学水利与土木工程学院乌鲁木齐830052 新疆农科院土壤肥料与农业节水研究所乌鲁木齐830091 新疆水利工程安全与水灾害防治重点实验室乌鲁木齐830052

为了确定和田地区日光温室越冬茬番茄适宜的灌溉指标,进而为该地区设施农业的科学灌溉提供理论依据,于2020年10月至次年4月,以番茄“粉保利”为材料,在新疆昆玉市现代农业科技示范园进行了灌溉试验。设置了4种土壤水分下限处理T1、T2、T... 详细信息

为了确定和田地区日光温室越冬茬番茄适宜的灌溉指标,进而为该地区设施农业的科学灌溉提供理论依据,于2020年10月至次年4月,以番茄“粉保利”为材料,在新疆昆玉市现代农业科技示范园进行了灌溉试验。设置了4种土壤水分下限处理T1、T2、T3和CK(分别为田间持水率的45%、60%、70%及80%),利用TOPSIS法对滴灌方案进行综合评价优选。研究表明:T3水分下限处理与CK处理相比可提高番茄产量7.5%,T1处理番茄产量最低。随着番茄水分下限升高,灌水量增加,灌溉水利用效率和水分利用效率显著降低。降低水分下限对番茄可溶性固形物(TSS)、可溶性糖、Vc、可滴定酸含量和果实硬度影响显著(P<0.05)。采用TOPSIS法,对番茄产量、水分利用效率、灌溉水利用效率及品质综合评价,得出适宜本地区越冬茬番茄滴灌水分下限最优处理为T3(70%田持)处理。

关键词：新疆和田滴灌日光温室番茄水分下限产量品质综合评价亏水灌溉

少先队组织教育、自主教育、实践教育意涵及关系探析

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教育学术月刊 2024年第7期 9-17页

作者：洪明石佳欢中国青少年研究中心少年儿童研究所中国青年政治学院北京100089

少先队是少年儿童学习中国特色社会主义和共产主义的学校,与学校教育相比有着独特的规律。少先队育人规律孕育在少先队教育实践之中,组织教育、自主教育和实践教育是长期以来实践总结出来的少先队教育的基本形态,准确理解三种教育形态... 详细信息

少先队是少年儿童学习中国特色社会主义和共产主义的学校,与学校教育相比有着独特的规律。少先队育人规律孕育在少先队教育实践之中,组织教育、自主教育和实践教育是长期以来实践总结出来的少先队教育的基本形态,准确理解三种教育形态的基本内涵并坚持三者的有机统一是做好少先队育人工作的根本保证。少先队组织教育是指少先队组织所固有的、基于少先队组织,并为了少先队组织的教育;少先队自主教育是指以培养少先队员主体性精神和自主性品质为目的,并通过少先队自主活动而开展的教育;少先队实践教育是指少先队的教育途径是各种实践体验活动而非书本知识,其教育目的主要是通过各种活动体验而达成的。组织教育、自主教育和实践教育分别从少先队教育本质、教育主体以及教育途径三个方面回答了少先队教育的内在规律,组织教育是根本、自主教育是关键、实践教育是保障,三者相互支撑、相互渗透、相互影响,统一于“团结、教育、引领广大少年儿童努力成长为能够担当民族复兴大任的时代新人”伟大实践之中。

关键词：少先队组织教育自主教育实践教育