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两岸三地药理学与临床药理学术会议

作者： WANG Huai-liang ZHANG Xin-hua WANG Han-ming ZHAI feng-guo huang Liang (China Medical University, Shenyang 110001, China)

Objective To investigation on novel pharmacological target against pulmonary *** was recognized in the recent years that pulmonary hypertension(PHT)compromised of four components,i. ***,hyperplasia,micro thrombosis and inflammation of pulmonary *** vascular hyperplasia is a hallmark pathologic feature of pulmonary hypertension,Hyperplasia of rat pul- monary artery smooth muscle cells(PASMCs)was significantly increased,and PASMCs from rats or human beings with PHT grow faster than those from control subjects when stimulated by serotonin or ***- monary hypertension(PHT)is the major cause of right ventricular hypertrophy and eventually right heart failure.5-hydroxytraptamine(5-HT)as mitogen for vascular smooth muscle cells plays an important role in the development of *** is known that selective serotonin re-uptake inhibitors(SSRIs)restrain 5-HT ***,this study was aimed to investigate if SSRIs may have protective effect against monocrotaline(MCT)-induced right ventricular *** induced chronic pulmonary hyper- tension in Wistar rats was established;fluoxetine and sertraline(2,10 mg·kg·dwere administered by garages.3 w after MCT injection,right ventricular index(RVI),pulmonary artery pressure(PAP),heart and lung morphology were measured or investigated.5-HT transporter(SERT)assayed by RT-PCR or Western *** MCT-Results RVI was significantly increased in MCT group(P<0.01 vs control) and reduced to by fluoxetine(10mg·kg·d)and 0.42±0.04 by Sertraline(10mg·kg·d(both P<0.05 vs MCT).PAP increased significantly by MCT(P<0.01 vs control).Fluoxetine(10mg·kg·d),or sertraline(10 mg·kg·d)attenuated MCT-induced increase of PAP,respectively(both P<0.05 vs MCT).MCT raised significantly Pulmonary artery muscularization(P<0.01 vs control),and at- tenuated by fluoxetine or sertraline(P<0.01 vs MCT).MCT increased SERT mRNA and protein expres- sion,and both were significantly attenuated by flu

关键词： pulmonary hypertension serotonin serotonin transporter pulmonary artery remodeling

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降低超高层建筑的局部风压措施

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同济大学学报（自然科学版） 2004年第10期32卷 1285-1288页

作者：顾明叶丰黄鹏周日亘毅同济大学土木工程防灾国家重点实验室上海200092

对一栋位于台风区的超高层建筑的刚体模型进行了风洞试验 ,测量了该建筑物表面的平均风压和脉动风压 .在特定风向角下 ,建筑物的几个位置处出现较大的负压 ,不能满足设计要求 .在对建筑物局部外形进行修改之后 ,有效地减小了最大负压 ,... 详细信息

对一栋位于台风区的超高层建筑的刚体模型进行了风洞试验 ,测量了该建筑物表面的平均风压和脉动风压 .在特定风向角下 ,建筑物的几个位置处出现较大的负压 ,不能满足设计要求 .在对建筑物局部外形进行修改之后 ,有效地减小了最大负压 ,满足了表面石材及玻璃幕墙的设计要求 .

关键词：高层建筑风洞试验风压分布外形修改降低风压

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang Jun Ke feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai huang Shuaige Bai Ting Luo Bin feng Min Liu Fan Zheng Shuang huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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多型电机实时群控系统设计与实现

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湖南工程学院学报（自然科学版） 2017年第1期27卷 21-23页

作者：邓辉明黄峰湖南工程学院电气信息学院湘潭411104 湖南省风电装备与电能变换协同创新中心湘潭411104 风力发电机组及控制湖南省重点实验室湘潭411104

针对传统电机控制技术的不足设计了一套多型电机实时群控系统.系统由4台不同的电机组成,由智能型CPS控制与保护开关电器控制.上位机利用力控组态软件,采用Modbus-TCP通讯协议,实现电机的控制、保护、监测.测试表明,系统实现实时遥信、... 详细信息

针对传统电机控制技术的不足设计了一套多型电机实时群控系统.系统由4台不同的电机组成,由智能型CPS控制与保护开关电器控制.上位机利用力控组态软件,采用Modbus-TCP通讯协议,实现电机的控制、保护、监测.测试表明,系统实现实时遥信、遥测、遥控、遥调等功能,提高了控制效率,简化了操作难度,提高了可靠性,可满足电机分布式控制要求.

关键词：电机力控组态软件 Modbus通讯协议

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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引战配合计算机仿真的静态一致性研究

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系统仿真学报 2002年第4期14卷 451-454页

作者：王晓英张庆明黄风雷北京理工大学爆炸灾害预防与控制国家重点实验室北京100081

给出了引战配合计算机仿真结果与真实试验结果进行静态一致性检验的方法。讨论了检验过程中的关键技术,即检验决策、验前概率、采伪概率的确定以及随机样本与再生子样的产生方法。对所开发的引战配合计算机仿真系统进行了检验并对检验... 详细信息

给出了引战配合计算机仿真结果与真实试验结果进行静态一致性检验的方法。讨论了检验过程中的关键技术,即检验决策、验前概率、采伪概率的确定以及随机样本与再生子样的产生方法。对所开发的引战配合计算机仿真系统进行了检验并对检验结果进行分析,检验结果表明该系统具有良好的置信度。

关键词：引战配合计算机仿真静态一致性置信度

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Investigation on novel pharmacological target against pulmonary hypertension

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沈阳药科大学学报 2008年第S1期25卷 10-10页

作者： WANG Huai-liang,ZHANG Xin-hua,WANG Han-ming,ZHAI feng-guo,huang Liang,WANG Yun(China Medical University,Shenyang 110001,China)

Objective To investigation on novel pharmacological target against pulmonary *** was recognized in the recent years that pulmonary hypertension(PHT)compromised of four components,***,hyperplasia,micro thrombosis and inflammation of pulmonary *** vascular hyperplasia is a hallmark pathologic feature of pulmonary *** of rat pulmonary artery smooth muscle cells(PASMCs)was significantly increased,and PASMCs from rats or human beings with PHT grow faster than those from control subjects when stimulated by serotonin or *** hypertension(PHT)is the major cause of right ventricular hypertrophy and eventually right heart failure.5-hydroxytraptamine(5-HT)as mitogen for vascular smooth muscle cells plays an important role in the development of *** is known that selective serotonin re-uptake inhibitors(SSRIs)restrain 5-HT ***,this study was aimed to investigate if SSRIs may have protective effect against monocrotaline(MCT)-induced right ventricular *** induced chronic pulmonary hypertension in Wistar rats was established;fluoxetine and sertraline(2,10 mg·kg-1·d-1 were administered by gavages.3 w after MCT injection,right ventricular index(RVI),pulmonary artery pressure(PAP),heart and lung morphology were measured or investigated.5-HT transporter(SERT)assayed by RT-PCR or Western *** MCT-Results RVI was significantly increased in MCT group(P<0.01 vs control)and reduced to by fluoxetine(10 mg·kg-1·d-1)and 0.42±0.04 by Sertraline(10 mg·kg-1·d-1)(both P<0.05 vs MCT).PAP increased significantly by MCT(P<0.01 vs control).Fluoxetine(10 mg·kg-1·d-1),or sertraline(10 mg·kg-1·d-1)attenuated MCT-induced increase of PAP,respectively(both P<0.05 vs MCT).MCT raised significantly Pulmonary artery muscularization(P<0.01 vs control),and attenuated by fluoxetine or sertraline(P<0.01 vs MCT).MCT increased SERT mRNA and protein expression,and both were significantly atte

关键词： pulmonary hypertension serotonin serotonin transporter pulmonary artery remodeling

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Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： mingshan Xie Yuchen Wang Haiping huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

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小波变换器的改进及其在红外图像压缩中的应用

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计算机科学 2004年第7期31卷 203-205页

作者：刘晓明黄智勇史剑锋重庆大学通信工程学院重庆400044

本文提出了一种改进型的小波变换器结构,与标准的JPEG2000小波变换器相比,节省1/2的乘法器和1/3的存储器,并介绍了该变换器在红外图像压缩系统中的应用。

关键词：小波变换器离散小波变换图像压缩红外线 JPEG2000 FPGA

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