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Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National Science Review 2024年第1期11卷 161-173页

作者： feng Xue Fei li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang mingzhai Sun Pak-ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of life and Health Sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of life Sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern life Sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

Tailoring chaotic motion of microcavity photons in ray and wave dynamics by tuning the curvature of space

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 107-112页

作者： Wei lin Yechun Ding Yongsheng Wang Peng li Yanpeng Zhang feng Yun feng li Key Laboratory for Physical Electronics and Devices of the Ministry of Education Shaanxi Key Lab of Information Photonic TechniqueSchool of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Electrical and Photonics Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark Center for Regenerative and Reconstructive Medicine Med-X InstituteThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Solid-State lighting Engineering Research Center Xi’an Jiaotong UniversityXi’an 710049China

Microcavity photon dynamics in curved space is an emerging interesting area at the crossing point of nanophotonics,chaotic science,and non-Euclidean *** report the sharp difference between the regular and chaotic motions of cavity photons subjected to the varying space *** the island modes of regular motion rise in the phase diagram in the curved space,the chaotic modes show special mechanisms to adapt to the space curvature,including the fast diffusion of ray dynamics,and the localization and hybridization of the Husimi wavepackets among different periodic *** observations are unique effects enabled by the combination of the chaotic trajectory,the wave nature of light,and the non-Euclidean orbital motion,and therefore make the system a versatile optical simulator for chaotic science under quantum mechanics in curved space-time.

关键词： microcavity chaotic motion curved space

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： Ya-Qiong Zhang Jian li Zhe Qin De-ming li Fang-Zhou Ye Song-Hua Bei Xiao-Hong Zhang li feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

Application of super gamma knife in the treatment of cancer of the tongue （a case report）

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中国口腔颌面外科杂志 2008年第B5期6卷 153-154页

作者： Zhang feng Yao Hui ming Zhou feng li Xiao Mi Super Gamma-Knife Center of Shanghai Armed Police Hospital.Shanghai 201103 China

The regulatory mechanism of rapid lignification for timely anther dehiscence

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Journal of Integrative Plant Biology 2024年第8期66卷 1788-1800页

作者： Jing-Shi Xue Yi-feng feng ming-Qi Zhang Qin-lin Xu Ya-Min Xu Jun-Qin Shi li-Fang liu Xiao-feng Wu Shui Wang Zhong-Nan Yang Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China Development Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234China

Anther dehiscence is a crucial event in plant reproduction,tightly regulated and dependent on the lignification of the anther *** this study,we investigated the rapid lignification process that ensures timely anther dehiscence in *** findings reveal that endothecium lignification can be divided into two distinct *** Phase Ⅰ,lignin precursors are synthesized without polymerization,while Phase Ⅱ involves simultaneous synthesis of lignin precursors and *** transcription factors MYB26,NST1/2,and ARF17 specifically regulate the pathway responsible for the synthesis and polymerization of lignin monomers in Phase Ⅱ.MYB26-NST1/2 is the key regulatory pathway responsible for endothecium lignification,while ARF17 facilitates this process by interacting with ***,our results demonstrate that the lignification of the endothecium,which occurs within approximately 26 h,is much faster than that of the vascular *** findings provide valuable insights into the regulation mechanism of rapid lignification in the endothecium,which enables timely anther dehiscence and successful pollen release during plant reproduction.

关键词： anther dehiscence ARF17 endothecium lignin MYB26 NST

Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing Qiu Wei li Thanh Nguyen Shouchun Wang Huaizhang Shi ming Wei feng Wang Di li Hui-Sheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention Department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom *** size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke *** Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre *** AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:*** experimental group will be treated with intra-arterial infusion of TNK during *** control group will be treated with standard *** The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 *** primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial *** The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK

Enrichment of Chemical Element ^(7)li in the Rotating Red Clump Star

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Chinese Physics Letters 2024年第8期41卷 121-125页

作者： Fang-Wen Wu Han-feng Song Qing-li li Yun He Xin-Yue Qu Zhuo Han College of Physics Guizhou UniversityGuiyang 550025China Geneva Observatory University of GenevaCH-1290 SauvernySwitzerland

About 2 percent of red clump stars are found to be the lithium-rich and thus the surface lithium increases obviously in some red clump *** physical mechanism of the lithium enrichment in these stars has not yet been explained satisfactorily by the evolutionary models of single *** flash induced internal gravity wave mixing(i.e.,IGW)could play a primary role in explaining the red clump star with lithium enrichment and it has a very significant impact on the internal structure and surface compositions of a *** can significantly increase the mixing efficiency of the internal gravity wave because the timescale for the enrichment event has been *** mixing can explain the observed behavior of lithium on red giant stars that are more luminosity than the RGB ***,it has a very small effect on the diffusion of elements because its diffusion coefficient is much smaller than the one of IGW induced mixing after the core helium flash.

关键词： flash stars lithium

Preparation and performance evaluation of the slickwater using novel polymeric drag reducing agent with high temperature and shear resistance ability

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Petroleum Science 2024年第2期21卷 1113-1121页

作者： ming-Wei Zhao Zhen-feng Ma Cai-li Dai WeiWu Yong-Quan Sun Xu-Guang Song Yun-Long Cheng Xiang-Yu Wang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao266580ShandongChina Sinopec Shengli Oilfield Dongying257001ShandongChina Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada East China Petroleum Bureau of Sinopec Nanjing210011JiangsuChina

Slickwater fracturing fluids are widely used in the development of unconventional oil and gas resources due to the advantages of low cost,low formation damage and high drag reduction ***,their performance is severely affected at high *** reducing agent is the key to determine the drag reducing performance of *** this work,in order to further improve the temperature resistance of slickwater,a temperature-resistant polymeric drag reducing agent(PDRA)was synthesized and used as the basis for preparing the temperature-resistant *** slickwater system was prepared with the compositions of 0.2 wt%PDRA,0.05 wt%drainage aid nonylphenol polyoxyethylene ether phosphate(NPEP)and 0.5 wt%anti-expansion agent polyepichlorohydrindimethylamine(PDM).The drag reduction ability,rheology properties,temperature and shear resistance ability,and core damage property of slickwater were systematically studied and *** contrast to on-site drag reducing agent(DRA)and HPAM,the temperature-resistant slickwater demonstrates enhanced drag reduction efficacy at 90℃,exhibiting superior temperature and shear resistance ***,the drag reduction retention rate for the slickwater achieved an impressive 90.52%after a 30-min shearing ***,the core damage is only 5.53%.We expect that this study can broaden the application of slickwater in high-temperature reservoirs and provide a theoretical basis for field applications.

关键词： Unconventional resources Polymeric drag reducing agent Slickwater High drag reduction rate Temperature resistance

Slip distribution inversion of seismic sub-fault dip iteration using gradient based optimizer algorithm

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Geodesy and Geodynamics 2024年第2期15卷 114-121页

作者： Leyang Wang Han li ming Pang Key Laboratory of Mine Environmental Monitoring and Improving Around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

This paper considers setting different dips for different sub-faults to fit the actual rupture situation based on the fault rupture of the 2013 Lushan M_(S)7.0 ***,combined with the coseismic GNSS data of the Lushan earthquake,the source parameters and sliding distribution of the Lushan earthquake fault are ***,we use the gradient based optimizer(GBO)in nonlinear inversion to obtain the source parameters of this seismic *** inversion results indicate that the strike of the fault is 206.52°,the dip is 44.10°,the length is 21.92 km,and the depth is 12.79 *** refine the sliding distribution of the seismic fault,the seismic fault is divided into 3×3 ***,we fix the central sub-fault dip of 44.10°;the dip of other sub-faults is obtained by *** that,the model is further divided into a fault layer model composed of 23×19 sub fault slices,and using the Matlab fitting function is used to fit the dip of the 23×19 sub ***,the Lushan seismic fault plane is established as a shovel structure with steep upper and gentle lower,steep south and gentle *** slip distribution inversion results indicate that the depth of the slip peak is 13 km,the corresponding maximum slip momentum is 0.67 m,the seismic moment is 1.10×10^(19)N·m and the corresponding moment magnitude is *** results above are consistent with the research results of seismology.

关键词： Gradient basedoptimizer(GBO) Lushan earthquake Non-planefault model Slid distribution