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A Class of New Large-Update Primal-Dual Interior-Point Algorithms for P＊（k） Nonlinear Complementarity Problems

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Acta Mathematica Sinica,English Series 2011年第10期27卷 1979-1994页

作者： Hua Ping CHEN ming Wang ZHANG College of Science China Three Gorges University Yichang 443002 P. R. China

In this paper we propose a class of new large-update primal-dual interior-point algorithms for P.（k） nonlinear complementarity problem （NCP）, which are based on a class of kernel functions investigated by Bai et al. in their recent work for linear optimization （lo）. The arguments for the algorithms are followed as Peng et al.＇s for P.（n） complementarity problem based on the self-regular functions [Peng, J., Roos, C., Terlaky, T.： Self-Regularity： A New Paradigm for Primal-Dual Interior- Point Algorithms, Princeton University Press, Princeton, 2002]. It is worth mentioning that since this class of kernel functions includes a class of non-self-regular functions as special case, so our algorithms are different from Peng et al.＇s and the corresponding analysis is simpler than theirs. The ultimate goal of the paper is to show that the algorithms based on these functions have favorable polynomial complexity.

关键词： Large-update method interior-point algorithm nonlinear complementarity problem non- self-regular function polynomial complexity

HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

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Cancer Biology & Medicine 2020年第4期17卷 986-1001页

作者： Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina At he nex Hong Kong Irmo vative Limited Hong Kong China Faculty of Medici ne Macao Un iversity of Science and TechnologyMacaoChina Athenex Inc. New York 14203USA

Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic *** aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant ***:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer *** and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse ***:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did *** study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this ***-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(Plodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans.

关键词： HM30181A glioma pharmacokinetics paclitaxel P-glycoprotein

Malignant lymphoma of spleen presenting as acute pancreatitis: A case report

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World Journal of Gastroenterology 2007年第27期13卷 3773-3775页

作者： Chao-ming Wu Lung-Chih Cheng Gin-Ho lo Kwok-Hung Lai Chia-Ling Cheng Wen-Cheng Pan Department of Gastroenterology Tian-Sheng Memorial Hospital Taiwan 813 China Division of Gastroenterology Department of Medicine.Kaohsiung Veterans General Hospital Taiwan 813 China Deputy Superintedent Kaohsiung Veterans General Hospital Taiwan 813 China

This is a case report of a patient who presented with acute pancreatitis without the common causes. A pancreatic biopsy revealed large B cell lymphoma. Spleen lymphoma with pancreatic involvement inducing acute pancreatitis, which is a rare disorder, was diagnosed. Here we also review the few similar cases reported in the literature.

关键词： Primary lymphoma of spleen Large B cell lymphoma Acute pancreatitis Splenomegaly Idiopathic pancreatitis

Hepatoprotective Effect of Guava (<i>Psidium guajava</i>L.) Leaf Extracts on Ethanol-Induced Injury on Clone 9 Rat Liver Cells

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Food and Nutrition Sciences 2011年第9期2卷 983-988页

作者： Hung-Hui Chen Po-Hua Wu Diana lo Yun-Chieh Pan ming-Chang Wu 不详

Guava (Psidium guajava L.), a tropical fruit, belongs to Myrtaceae family. Leaves and fruits of guava have been reported to have an anti-diarrheal, hypoglycemic, lipid lowering, anti-bacterial in addition to antioxidant activities. The aim of this study was to investigate several guava leaf extract cytotoxic effects on healthy clone 9 liver cells and its hepatoprotective effects on ethanol-induced heap-toxicity. It was discovered that when the clone 9 liver cells were treated with guava (Psidium guajava Linn.) extracts for 24 hours, there was no retardation of growth as well as when ethanol and acetone extracts at low concentrations 100 μg/mL and 50 μg/mL were administered however cytototoxic effects were detected at higher concentrations. Water and hot water extracts in concentrations lower than or equal to 500 μg/mL revealed no cytotoxic effects. Injury induction to healthy clone 9 liver cells using 5% alcohol concentration for 30 minutes revealed the hepatoprotective properties of guava (Psidium guajava Linn.) extracts. This was significant in concentrations of 100 μg/mL or lower for ethanol and all concentrations for hot water extracts. Hot water extracts showed higher hepatoprotective and lower cytotoxic properties than other extracts.

关键词： Guava (Psidium Guajava Linn.) Alcohol-Injured Cell Hepatoprotective Properties Clone 9 Cell Cytotoxicity

Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG Chun Nei TSE Ka ming FOK Tai fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

Letter from Editors-in-Chief

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Neural Regeneration Research 2014年第1期9卷 5-5页

作者： Kwok-fai So Xiao-ming Xu The University of Hong Kong Jinan University Indiana University School of Medicine

Welcome to the first issue of Neural Regeneration Research （NRR） in 2014. Over the past few years, NRR has dedicated its focus *** rapidly growing fieldof neural *** editorial team h＇asmade significant contributions to soliciting higher quality,, papers and many efforts, described below, havebeen or will be made to make NRR one of the leading journals in the field of neural regeneration.

关键词： NRR Letter from Editors-in-Chief

变易理论：学生自主学习和教师帮助之间的关系

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教育学报 2009年第3期5卷 22-35页

作者：彭明辉马飞龙香港大学教育学院中国香港特别行政区哥德堡大学教育和教育研究系瑞典

本研究旨在运用变易理论来考察学生自主学习和教师帮助之间的关系问题。使用的教学方法是这样的:教师首先使用具体事例,然后讲授原理。其中在使用具体事例时有两种方法。第一种是,学生学习两方面属性同时不同的事例。第二种是,学生先是... 详细信息

本研究旨在运用变易理论来考察学生自主学习和教师帮助之间的关系问题。使用的教学方法是这样的:教师首先使用具体事例,然后讲授原理。其中在使用具体事例时有两种方法。第一种是,学生学习两方面属性同时不同的事例。第二种是,学生先是学习只有一方面属性不同的事例,接着学习只有另一方面属性不同的事例,最后学习两方面属性同时不同的事例。在这之后的讲授是一样的,教师教学生如何系统地解决这一类问题。在第一种方法中,学生更多地掌控了自身的学习,而在第二种方法中,教师通过教学设计来帮助学生学习。这个研究最重要的启示是在讨论教学中教师和学生各自对学习的贡献时,我们可能需要做出更细致的区分。问题不在于谁应该主动谁应该被动,而在于教师应该做什么(创造学习的必要条件)以及学生应该做什么(使用学习的必要条件)。

关键词：教育学变易理论学生自主学习教师帮助

Neuroprotective effects of Lycium barbarum polysaccharides on acute ischemic stroke injury

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Short-term outcome of patients with robot-assisted versus open radical prostatectomy:Prince of Wales Hospital, Hong Kong experience

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Amy Cheuk-Yin lo Chung-Man YEUNG Suk-Yee LI Raymond Chuen-Chung CHANG Kwok-fai SO David WONG Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong Kong Research Center of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong Kong Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong Kong St Paul’s Eye Unit University of LiverpoolUK

＜正＞Objective The polysaccharides in Lycium barbarum,a well known traditional Chinese medicine,have been demonstrated to display multiple biological effects such as anti-aging,anti-tumor and *** the present study,we aimed to evaluate the effects of Lycium barbarum polysaccharides（LBP） on murine brain injury after induction of acute ischemic stroke by middle cerebral artery occlusion（MCAO）.Methods Mice were orally treated with either vehicle（PBS） or LBP（1 mg/kg or 10 mg/kg） for 1 week before induction of cerebral ischemia by *** 2 h of ischemia followed by 22 h of reperfusion,animals were evaluated for neurological *** after scoring of the neurological deficits,brains were isolated,cut into 6 coronal slices of 2 mm thickness and stained with 2%2,3,5-triphenyltetrazolium chloride（TTC） to detect lesion *** posterior surface of each brain slice was subsequently photographed and analyzed using a digital image analysis *** area,volume,and hemispheric brain swelling were calculated using an indirect method in which the effects of edema and brain swelling have been ***（1） Mice treated with either 1 mg/kg LBP or 10 mg/kg LBP（n=7 for each group） had less neurological deficits than the vehicle-treated mice（n=8）（vehicle=2.0+/-0.3,1 mg/kg LBP=1.4+/-0.2,10 mg/kg LBP=1.1+/-0.1）.（2） TTC staining revealed a significantly smaller infarct area in brain slice number 4 in the LBP-treated mice when compared with the vehicle-treated mice（vehicle=35.4+/- 4.2%,1 mg/kg LBP=17.5+/-5.8%,10 mg/kg LBP=17.6+/-4.9%）.（3） Consistent with the infarct area data,the overall infarct volumes were decreased in the LBP-treated groups（vehicle=25.8+/-3.1%,1 mg/kg LBP=215+/-2.5%,10mg/kg LBP=16.6+/-2.7%）. （4） Mice treated with LBP displayed less hemispheric brain swelling（vehicle=11.1+/-0.9%,1 mg/kg LBP=9.7+/-1.1%,10mg/kg LBP=7.9+/-0.6%）.Conclusions Taken together,these data indicate that treatment with LBP for 1 week could protect the mouse

关键词： neuroprotection animal model oxidative stress

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Short-term outcome of patients with robot-assisted versus op...