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Thioredoxin-Interacting Protein(TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes

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Neuroscience Bulletin 2020年第4期36卷 346-358页

作者： Cun-Jin Su Zhu Shen Ru-Xiao Cui Ya Huang De-Lai Xu Feng-Lun Zhao Jie Pan Ai-ming Shi Tong Liu Yun-Li Yu Department of Pharmacy The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Institute of Neuroscience Soochow UniversitySuzhou 215004China Department of Clinical Pharmacology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

Patients with diabetes mellitus have a higher risk of developing Parkinson’s disease(PD). However, the molecular links between PD and diabetes remain *** this study, we investigated the roles of thioredoxininteracting protein(TXNIP) in Parkin/PINK1-mediated mitophagy in dopaminergic(DA) cells under high-glucose(HG) conditions. In streptozotocin-induced diabetic mice,TXNIP was upregulated and autophagy was inhibited in the midbrain, while the loss of DA neurons was accelerated by hyperglycemia. In cultured PC12 cells under HG, TXNIP expression was upregulated and the intracellular reactive oxygen species(ROS) levels increased, leading to cell death. Autophagic flux was further blocked and PINK1 expression was decreased under HG conditions. Parkin expression in the mitochondrial fraction and carbonyl cyanide 3-chlorophenylhydrazone(CCCP)-induced co-localization of COX IV(marker for mitochondria) and LAMP1(marker for lysosomes) were also significantly decreased by HG. Overexpression of TXNIP was sufficient to decrease the expression of both PINK1 and Parkin in PC12 cells, while knockdown of the expression of TXNIP by si RNA decreased intracellular ROS and attenuated cellular injury under HG. Moreover, inhibition of TXNIP improved the CCCP-induced co-localization of COX IV and LAMP1 in PC12 cells under HG. Together, these results suggest that TXNIP regulates Parkin/PINK1-mediated mitophagy under HG conditions, and targeting TXNIP may be a promising therapeutic strategy for reducing the risk of PD under hyperglycemic conditions.

关键词： Diabetes mellitus Parkinson’s disease High glucose TXNIP Mitophagy PC12 cells

基于频谱编码的小波压缩图像在有噪信道中的传输

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山东大学学报（理学版） 2001年第4期36卷 405-409页

作者：郭代飞朱维红高振明张坚强山东大学电子系山东济南250100

研究了利用频谱编码传输技术在有噪信道中传输小波图像压缩数据 .图像压缩采用Said等提出的分层树中的集分割 (SPIHT)小波压缩编码器 .根据图像数据的重要性是从高到低排序的特点 ,在利用基本的双极性线性相位编码的基础上提出了不等错... 详细信息

研究了利用频谱编码传输技术在有噪信道中传输小波图像压缩数据 .图像压缩采用Said等提出的分层树中的集分割 (SPIHT)小波压缩编码器 .根据图像数据的重要性是从高到低排序的特点 ,在利用基本的双极性线性相位编码的基础上提出了不等错误保护的 4ASK编码方案。

关键词：频谱编码 SPIHT 双极性线性相位编码 4ASK

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香港交通噪声问题及其控制政策综述(英文)

声学技术 2009年第6期28卷 778-786页

作者：何德建麦卓明陈汉辉香港声学学会香港理工大学屋宇设备与工程系

不同于世界其他大城市,香港因其特有的噪声问题,有时会被冠以世界最嘈杂的城市的称号。对此,香港政府为改善噪声环境付出了极大的努力,并且取得了一定的成效。然而,主要的噪声问题仍然存在,部分缘于其拥挤的城市结构以及八十年代之前城... 详细信息

不同于世界其他大城市,香港因其特有的噪声问题,有时会被冠以世界最嘈杂的城市的称号。对此,香港政府为改善噪声环境付出了极大的努力,并且取得了一定的成效。然而,主要的噪声问题仍然存在,部分缘于其拥挤的城市结构以及八十年代之前城市规划时对噪声污染问题的忽视,这些都不是一朝一夕之间能解决的问题。香港的噪声问题中,又以交通噪声最为严重,80%的香港人在不同程度上受到道路交通噪声的影响。该文介绍了香港交通噪声问题及其现行的交通噪声政策,并讨论了现行政策所遇到的问题,最后介绍了由香港声学学会提议的进一步的交通噪声控制策略。

关键词：交通噪声噪声控制政策

Peer reviewing of screening mammography in Taiwan： its reliability and the improvement

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Chinese Medical Journal 2013年第1期126卷 68-71页

作者： PAN Huay-ben HSU Giu-cheng YANG Tsung-lung HUANG Jer-shyung CHOU Chen-pin LIANG Huei-lung LEE San-kan CHOU Yi-hong LI Hung-ju WONG Kam-fai Department of Radiology Kaohsiung Veterans General HospitalKaohsiung Taiwan China National Yang-ming University Taipei Taiwan China Department of Radiology Tri-Service General Hospital TaipeiTaiwan China Department of Radiology Taichung Veterans General HospitalTaichung Taiwan China Department of Radiology Yaipei Veterans General HospitalTaipei Taiwan China Institute of Statistics National University of KaohsiungKaohsiung Taiwan China

Background Early detection with screening mammography can potentially reduce breast cancer mortality rates. To achieve an efficient screening, a peer review system provides a compensatory double-check reviewing, will hopefully to prevent the omission of detectable lesions and reduce unnecessary recall. Methods In 2009, 4643 initial mammographic screenings reported by 74 screening radiologists had negative results with a recall rate of less than 5%. In the same year, 2538 initial positives screened by 18 screening radiologists had a recall rate higher than 15%. Those 7181 randomized screenings were evenly distributed for reassessment by 39 reviewing radiologists. The disagreement of assessments between the reviewers and screening radiologists was recorded. The differential rate was defined as the number of the disagreements divided by the number of audited films reviewed by a screening radiologist. The equality of the differential rates for each screening radiologists with negative and positive assessments was compared by a Chi-square test. The performance of the 39 auditors was measured by the Kendalrs tau statistic. P values less than 0.05 were considered statistically significant. Results The mean differential rate for screening radiologists of negative assessments was 6.7% （P=0.588）, while 35.0% for positive assessments were significant （P 〈0.001）. The result indicated that most of the initial negative assessments reported by the screening radiologists were generally accepted by the reviewers but not the positive assessments. With respect to the 39 reviewers, there was no significant evidence for the association of the difference rates between negative and positive assessments. Nine reviewers were found to have their differential rate for negative and positive assessments larger than the average of the population. Eleven reviewers were found to have their differential rates smaller than the average for both. Thirteen reviewers had their differential rates smaller

关键词： breast cancer mammography screening peer reviewing

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青梅果冻加工技术研究

中国食品添加剂 2007年第5期18卷 135-139页

作者：董文明吴荣书樊爱萍云南农业大学食品科技学院昆明650201

以青梅为主要原料进行了青梅果冻的研制。运用正交试验设计确定了青梅果冻的最佳配方及工艺参数,结果表明:钾盐0.05%,胶粉0.7%,甜度35%,果汁10%研制出的果冻色泽均一、气味清新、酸甜适口。

关键词：青梅果冻生产工艺

A Potential Model for Detecting Crowding-induced Epithelial Cell and Cancer Cell Extrusion

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Current Medical Science 2019年第3期39卷 391-395页

作者： Ping HAN Dong-xiao LI Yu LEI Jing-mei LIU Xiang-ming DING Han WANG Zhuo-ying LIN Wei YAN De-an TIAN Department of Gastroenterology Tongji HospitalTongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Overcrowding and cell deformation lead to the shedding of apoptotic and live cells to maintain homeostasis in the epithelium. Recent studies have attempted to explain the effect of extrusion on epithelial homeostasis and tumor metastasis, but lack the requisite quantitative models for testing extrusion. Here, we designed a petri dish inversion model to detect the extrusion ability of both normal epithelial cells and epithelial cancer cells. Firstly, we found cell extrusion was observed in both normal epithelial cells (lo2 cells) and cancer cells;in confluent lo2 cell culture, certain cells were surrounded by their neighbors, suffered "collective attack", and were then made round in shape. Green fluorescent protein (GFP)-labeled cancer cells were also found to be squeezed by normal lo2 cells. Using the petri dish inversion model, we quantified the number of extrusion cells, and demonstrated that the ability of cancer cell extrusion was related to the metastatic potential of cancer cell lines. Our findings provide a novel model to detect crowdinginduced epithelial cell and cancer cell extrusion. This novel model provides a quantitative method for research into apoptotic and cancer cell extrusion, particularly in human hepatocellular carcinoma.

关键词： hepatocellular carcinoma metastasis epithelial homeostasis crowding extrusion

Expression of soluble vascular endothelial growth factor receptor-1 and placental growth factor in fetal growth restriction cases and intervention effect of tetramethylpyrazine

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 663-667页

作者： Shu-Wei Li Yi Ling Song Jin Ye-Fei Lin Ze-Jun Chen Chun-Xia Hu ming-Hua Wang Mao-Zhong Yao Department of Obstetrics and Gynecology Affiliated Hospital of Hainan Medical University

Objective:To investigate the expression of soluble vascular endothelial growth factor receptor-1(sFlt-1) and placental growth factor(PLGF) in the fetal growth restriction(FGR) cases and the intervention mechanism of ***:A total of 60 fetal growth restriction cases that admitted lo our hospital were randomly divided into ligustrazine intervention group(group A) and nutritional support group(group B).A total of 50 healthy pregnant women were also enrolled as control group(group C).Expression level of maternal serum sFlt1,FLGF and fetal growth parameters including HC,AC,FL,BPD,EFW as well as placenta PLGF,sFlt-1 mRNA expression were recorded and compared among the three groups.A total of 15 SD rats were selected and were divided into lliree *** group,alcohol and tobacco group and blank control *** groups of rats were dissected on the twentieth day of ***:Expression level of sFlt-1 and PLGF in group A was not significantly different from that of group C(P>0.05):but significant difference in SFlt1 and PLGF expression level was observed between group C and group B(Plower than those of group *** after treatment,those parameters in group A were significantly improved(P0.05).There was significant difference in PLGF between FGR group with treatment and FGR group without treatment or control group(P<0.01).Conclusions:PLGF level is decreased and sFlt-1 increased in patients suffered from fetal growth restriction,and FGR rats show increased sFlt-1 and decreased *** they can be indicator of the fetal growth *** can effectively improve sFlt-1,PLGF expression level in fetal growth restriction cases,which can be used as treatment for FGR.

关键词： Ligustrazine Fetal growth restriction sFlt-1 PLGF

高速铁路隧道围岩参数空间变异性的力学响应分析

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岩石力学与工程学报 2017年第7期36卷 1697-1709页

作者：文明张顶立房倩北京交通大学城市地下工程教育部重点实验室北京100044

针对大断面高速铁路隧道围岩的参数变异性及空间相关性等问题,在随机场理论的基本框架下,将非侵入式随机分析、地层结构模型、有限差分法和蒙特卡洛模拟有机结合,提出考虑围岩参数空间变异性的非侵入式随机有限差分分析模型。运用该模... 详细信息

针对大断面高速铁路隧道围岩的参数变异性及空间相关性等问题,在随机场理论的基本框架下,将非侵入式随机分析、地层结构模型、有限差分法和蒙特卡洛模拟有机结合,提出考虑围岩参数空间变异性的非侵入式随机有限差分分析模型。运用该模型对隧道开挖后围岩的力学响应进行分析,得到围岩参数空间变异性的2个基本要素:参数变异性和空间相关性,其特征参数的取值变化会直接影响到围岩变形特性、塑性区发展模式以及地表沉降形态。同时与确定性模型的计算结果进行比较,提炼出隧道开挖后围岩参数空间变异性的4种典型工程效应:(1)围岩结构性低强度荷载占优效应;(2)围岩结构空间相关各向异性效应;(3)功能函数敏感性差异及非线性效应;(4)功能函数转变分布类型效应。研究成果为拓展基于空间变异性的高速铁路隧道工程稳健性设计奠定了一定的基础。

关键词：岩石力学高速铁路隧道围岩力学响应空间变异性非侵入式随机分析 Karhunen-loève级数展开

Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

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Chinese Journal of Natural Medicines 2018年第11期16卷 838-845页

作者： CHEN Juan YUE Jia LIU Jiao LIU Yun JIAO Kai-Lin TENG Meng-Ying HU Chun-Yan ZHEN Jing WU Mao-Xuan ZHOU ming LI Zhong LI Yuan Department of Nutrition and Food Hygiene School of Public Health Nanjing Medical University Department of Nutrition and Food Hygiene School of Public Health Gansu University of Chinese Medicine

Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids(TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid(SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and lo2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy(OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein(SREBP)1, fatty acid synthase(FAS), and stearoyl-CoA desaturase(SCD)1, and decreased the liver triglyceride(TG) and total cholesterol(TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription(STAT)-3 was inhibited by salvianolic acids treatment. In lo2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in lo2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.

关键词： Salvianolic acids Lipid metabolism Weight gain Signal transducer and activator of transcription 3