检索结果-南通市图书馆

The Mystery 40 Hz:Unraveling the Efficacy of Rhythmic Stimulation in Alzheimer's Disease

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第6期40卷 831-834页

作者： Yixuan ku Guangdong Provincial Key Laboratory of Brain Function and Disease Center for Brain and Mental Well-beingDepartment of PsychologySun Yat-sen UniversityGuangzhou510006China Peng Cheng Laboratory Shenzhen518000China

Promises and Challenges of Rhythmic *** advances in research have made significant strides in understanding the potential of 40 Hz rhythmic optogenetic stimulation for the treatment of Alzheimer's disease(AD).A pivotal study conducted by Iaccarino et al.(2016)unveiled that targeted stimulation of interneurons at this specific frequency results in a remarkable reduction ofβ-amyloid levels in a mouse model of AD[1].

关键词： stimulation Alzheimer

Nearly degenerate ground states of a checkerboard antiferromagnet and their bosonic interpretation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 84-89页

作者： Haiyuan Zou Fan Yang Wei ku Key Laboratory of Polar Materials and Devices(MOE) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Department of Physics Beijing Institute of TechnologyBeijing 100081China Tsung-Dao Lee Institute Shanghai 200240China Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) Shanghai 200240China Shanghai Branch Hefei National LaboratoryShanghai 201315China

The spin-1/2 model system with antiferromagnetic(AF) couplings on a J1-J2checkerboard lattice, known as the planar pyrochlore model, is strongly frustrated and associated with a two-to-one dimensional crossover. Using the Projected Entangled Simplex States tensor network ansatz, we identify a large number of nearly degenerate states in the frustrated region(J_(1)

关键词： tensor networks frustrated magnetism dimensional crossover degenerate states

The Sequential Pricing of Ride-Hailing System with Rental Service in the Context of Fleet Electrification

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2024年第1期33卷 77-105页

作者： Yaoyao ku Peng Wu Qiang Ren Yiqing Wang Business School Sichuan UniversityChengdu610065China

Surging demand and reduced capacity in the ride-hailing industry have prompted numerous ride-hailing platforms to build their own car-rental services catering to drivers who do not possess private vehicles. However, the trade-off between the ride-hailing service and the car-rental service is an important issue that is still unclear in theory. Moreover, ride-hailing platforms are transitioning towards all-electric fleets in the context of Carbon Neutrality goals and government regulations. This paper considers a ride-hailing system comprising a monopolist ride-hailing platform, an electric vehicle (EV) rental firm, and a gasoline vehicle (GV) rental firm. Furthermore, we build a stylized model to study the sequential pricing of the system. The equilibrium outcomes show the significant impact of the ride-hailing platform’s decision to continue or withdraw offering EV rental services on EV and GV drivers’ net earnings, rental prices, and wages. The ride-hailing platform providing EV rental services increases EV drivers’ net earnings but decreases the GV driver wages and rental prices. However, the EV rental service offered by the ride-hailing platform does not necessarily lead to an increased total profit for the system. The improved profitability of the system by the ride-hailing platform providing EV rental services is contingent upon lower rider prices and higher fuel costs. The ride-hailing platform’s EV rental services provision also effectively fosters the ride-hailing fleet’s electrification. Furthermore, as the number of riders increases, the ride-hailing platform should reduce the commission rate for EV drivers to maintain competitiveness and profitability.

关键词： Ride-hailing system car rental fleet electrification sequential pricing differential wage scheme

Identification of thermal front dynamics in the northern Malacca Strait using ROMS 3D-model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第1期42卷 41-57页

作者： ku Nor Afiza Asnida ku MANSOR Nur Hidayah ROSELI Poh Heng KOK Fariz Syafiq Mohamad ALI Mohd Fadzil Mohd AKHIR Institute of Oceanography and Environment Universiti Malaysia TerengganuKuala Nerus 21030Malaysia Faculty of Science and Marine Environment Universiti Malaysia TerengganuKuala Nerus 21030Malaysia

The thermal front in the oceanic system is believed to have a significant effect on biological *** an era of climate change,changes in heat regulation between the atmosphere and oceanic interior can alter the characteristics of this important *** the simulation results of the 3D Regional Ocean Modelling System(ROMS),we identified the location of thermal fronts and determined their dynamic variability in the area between the southern Andaman Sea and northern Malacca *** Single Image Edge Detection(SIED)algorithm was used to detect the thermal front from model-derived *** show that a thermal front occurred every year from 2002 to 2012 with the temperature gradient at the location of the front was 0.3°C/*** to the years affected by El Ni?o and negative Indian Ocean Dipole(IOD),the normal years(e.g.,May 2003)show the presence of the thermal front at every selected depth(10,25,50,and 75 m),whereas El Ni?o and negative IOD during 2010 show the presence of the thermal front only at depth of 75 m due to greater warming,leading to the thermocline deepening and enhanced *** May 2003,the thermal front was separated by cooler SST in the southern Andaman Sea and warmer SST in the northern Malacca *** higher SST in the northern Malacca Strait was believed due to the besieged Malacca Strait,which trapped the heat and make it difficult to release while higher chlorophyll a in Malacca Strait is due to the freshwater conduit from nearby rivers(Klang,Langat,Perak,and Selangor).Furthermore,compared to the southern Andaman Sea,the chlorophyll a in the northern Malacca Strait is easier to reach the surface area due to the shallower thermocline,which allows nutrients in the area to reach the surface faster.

关键词： regional ocean modelling system thermal front Andaman Sea Malacca Strait single image edge detection algorithm

Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 406-417页

作者： LIU Shu Yuan ZHANG Li YE Yong Jun DING ku Ke National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Office for Public Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001HunanChina

Objective This study aimed to efficiently reduce the release of radon from water bodies to protect the *** Based on the sizes of the experimental setup and modular float,computational fluid dynamics(CFD)was used to assess the impact of the area coverage rate,immersion depth,diffusion coefficient,and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing *** on the numerical simulation results,an estimation model for the radon retardation rate was *** effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area *** The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value;therefore,an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors:area coverage rate,immersion depth,and diffusion *** deviation between the experimental and simulated results was<4.3%.Conclusion Based on the numerical simulation conditions,an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained,which provides a reference for designing covering floats for radon retardation in radoncontaining water.

关键词： Radon-containing water Radon retardation rate CFD Coverage experiment Optimized design

Review of tribological properties of nanoparticle-based lubricants and their hybrids and composites

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第4期12卷 569-590页

作者： Ye Zar Ni HTWE Aws.S.AL-JANABI Yasmin WADZER Hussin MAMAT ku NOORYASMIN School of Materials&Mineral Resources Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia School of Aerospace Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia Universiti Sains Malaysia

Due to their encouraging results,nanolubricants have been revolutionary in the field of *** degree,to which the new material may improve the tribology,energy savings,and durability,is a crucial consideration for any new additive to a conventional *** results of the earlier research on carbon,metal,metal oxide,and their composites and hybrid nanolubricants as well as their effects on tribology,are summarized in this review *** most popular measuring methodologies,the tribology results for lubricants with an oil base,biodegradable base,and a water base,as well as the reasons that explain these tribological advancements,are all included in this ***,prospects for more study in this area are emphasized.

关键词： nanolubricants tribology carbon metal metal oxide hybrid

Nanocavity enriched CuPd alloy with high selectivity for CO_(2) electroreduction toward C_(2)H_(4)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1513-1523页

作者： Ze-Yu Zhang Hai-Bin Wang Fei-Fei Zhang Jing-Wei Li Xin-Zhuo Hu Si-Wei Yan Yi-ming Bai Xun Zhang Gu-Rong Shen Peng-Fei Yin Jing Yang Cun-ku Dong Jing Mao Hui Liu Xi-Wen Du Institute of New-Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China

Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy barrier of C-C ***,a viable catalyst design strategy to decrease energy barrier of C-C coupling should be put ***,a nanocavity-enriched CuPd single atom alloy(CuPd SAA)catalyst is designed to promote CC coupling *** faradaic efficiency of CuPd SAA for ethylene and C_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RHE),*** on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*CO,thus enhancing the faradaic efficiency for *** functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring Cu atoms to decrease the energy barrier of C-C coupling,further improving the faradaic *** work provides a new idea for designing catalyst with high selectivity for ethylene.

关键词： Adsorption configuration C-C coupling CO_(2) electrocatalysis Ethylene Single atom alloy

Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 270-278页

作者： Tingting ku Jindong Hu Mengmeng Zhou Yuanyuan Xie Yutong Liu Xin Tan Lin Guo Guangke Li Nan Sang College of Environmental Science and Resources Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Tebuconazole exposure has been described as an increasing hazard to human *** increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)***,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are *** the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 *** results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse ***,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent *** investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRα*** findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon.

关键词： Tebuconazole Cardiotoxicity Energy metabolic disorders Energy substrate Mitochondrial damage

Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 443-454页

作者： Zhihua Ren Xiaoxi Yang Tingting ku Qian S.Liu Jiefeng Liang Qunfang Zhou Francesco Faiola Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China College of Sino-Danish University of Chinese Academy of SciencesBeijing 100049China

Investigating the development toxicity of perfuorinated iodine alkanes(PFIs)is critical,given their estrogenic effects through binding with estrogen receptors(ERs).In the present study,two PFIs,including dodecafuoro-1,6-diiodohexane(PFHx DI)and tridecafuorohexyl iodide(PFHx I),with binding preference to ERαand ERβ,respectively,were selected to evaluate their effects on proliferation and differentiation of the mouse embryonic stem cells(m ESCs).The results revealed that,similar to E_(2),50μmol/L PFHx DI accelerated the cell proliferation of the m *** PFI stimulation at the exposure concentrations of 2–50μmol/L promoted the differentiation of the m ESCs as characterized by the upregulation of differentiation-related biomarkers(i.e.,Otx2 and Dnmt3β)and downregulation of pluripotency genes(i.e.,Oct4,Nanog,Sox2,Prdm14 and Rex1).Comparatively,PFHx DI exhibited higher induction effect on the differentiation of the m ESCs than did PFHx *** tests on ER signaling indicated that both PFI compounds induced exposure concentration-dependent expressions of ER signaling-related biomarkers(i.e.,ERα,ERβand Caveolin-1)in the m ESCs,and the downstream ER responsive genes(i.e.,c-fos,c-myc and c-jun)well responded to PFHx I *** role of ER in PFI-induced effects on the m ESCs was further validated by the antagonistic experiments using an ER inhibitor(ICI).The findings demonstrated that PFIs triggered ER signaling,and perturbed the differentiation program of the m ESCs,causing the potential health risk during early stage of development.

关键词： Perfuorinated iodine alkanes(PFIs) Embryonic stem cells(ESCs) Developmental toxicity Cell differentiation Estrogen receptor-related signaling