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Crosst.lk bet.een degradat.on and bioenerget.cs: how aut.phagy and endolysosomal processes regulat. energy product.on

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Neural Regenerat.on Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannat.am Naidu Bhupana ching-On Wong Depart.ent.of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo met.bolic reprogramming t. adapt.t. changes in nut.ient.availabilit., cellular act.vit., and t.ansit.ons in cell st.t.s. t.e balance bet.een glycolysis and mit.chondrial respirat.on is crucial for energy product.on, and met.bolic reprogramming st.pulat.s a shift.in such balance t. opt.mize bot. bioenerget.c efficiency and anabolic requirement.. Failure in swit.2} bioenerget.c dependence can lead t. maladapt.t.on and pat.ogenesis. While cellular degradat.on is known t. recycle precursor molecules for anabolism, it. pot.nt.al role in regulat.ng energy product.on remains less explored. t.e bioenerget.c swit.h bet.een glycolysis and mit.chondrial respirat.on involves t.anscript.on fact.rs and organelle homeost.sis, which are bot. regulat.d by t.e cellular degradat.on pat.ways. A growing body of st.dies has demonst.at.d t.at.bot. st.m cells and different.at.d cells exhibit.bioenerget.c swit.h upon pert.rbat.ons of aut.phagic act.vit. or endolysosomal processes. Here, we highlight.d t.e current.underst.nding of t.e int.rplay bet.een degradat.on processes, specifically aut.phagy and endolysosomes, t.anscript.on fact.rs, endolysosomal signaling, and mit.chondrial homeost.sis in shaping cellular bioenerget.cs. t.is review aims t. summarize t.e relat.onship bet.een degradat.on processes and bioenerget.cs, providing a foundat.on for fut.re research t. unveil deeper mechanist.c insight. int. bioenerget.c regulat.on.

关键词： aut.phagy bioenerget.cs endolysosome energy product.on glycolysis met.bolic reprogramming mit.chondria

t.rbulent.Agglomerat.on of Micropart.cles in a Cylinder Wake Flow Using LES-DEM:Focusing on t.e Effect.of t.e Reynolds Number

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Journal of t.ermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE Jun DONG ming School of Energy and Power Engineering Dalian University of Technology School of Opt.cal Informat.on and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

t.rbulent.agglomerat.on is viewed as a promising t.chnology for enhancing fine part.cle removal *** bet.er underst.nd part.cle t.ansport.agglomerat.on behaviors,and fluid-part.cle int.ract.ons,we numerically explored t.ese phenomena under cylindrical vort.x wake influence using a coupled large eddy simulat.on and discret. element.met.od（LES-DEM） *** validit. of t.e LES approach was verified by comparison wit. available direct.numerical simulat.on（DNS） *** adopt.d t.e Johnson-Kendall-Robert.（JKR） cont.ct.model for part.cle-part.cle *** part.cle dispersion and agglomerat.on charact.rist.cs of part.cles wit. different.diamet.rs（dp=2-20 μm） in t.e laminar and t.ansit.on of shear layer（t.SL） flow regimes were *** part.cles were concent.at.d at.t.e vort.x cent.rs,while larger part.cles accumulat.d around t.e *** agglomerat.on efficiency exhibit.d an M-shaped profile spanwise（y-direct.on）.Wit. increasing Reynolds number,t.e agglomerat.on efficiency and t.rbulence int.nsit. *** part.cle agglomerat.on efficiency peaks at.a cert.in Reynolds ***,at.higher Reynolds numbers,reducing t.e residence t.me of part.cles in t.e flow field decreases t.e agglomerat.on efficiency.

关键词： discret. element.met.od large eddy simulat.on micropart.cle part.cle agglomerat.on

Invest.gat.on of bubbles escape behavior from low basicit. mold flux for high-Mn high-Al st.els using 3D X-ray microscope

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Int.rnat.onal Journal of Minerals,Met.llurgy and Mat.rials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming Zhang St.t. Key Laborat.ry of Advanced Met.llurgy University of Science and Technology BeijingBeijing 100083China

During t.e cont.nuous cast.ng process of high-Mn high-Al st.els,various t.pes of gases such as Ar need t. escape t.rough t.e t.p of t.e *** which,t.e behavior of bubbles t.aversing t.e liquid slag serves as a rest.ict.ve link,closely associat.d wit. viscosit. and t.e t.ickness of liquid *** cont.ast.t. t.o-dimensional surface observat.on,t.ree-dimensional(3D)analysis met.od can offer a more int.it.ve,accurat.,and comprehensive ***,t.is st.dy employs a 3D X-ray microscope(3D-XRM)t. obt.ined spat.al dist.ibut.on and 3D morphological charact.rist.cs of residual bubbles in mold flux under different.basicit. of liquid slag,different.t.mperat.res,and different.holding *** result. indicat. t.at.as basicit. of slag increases from 0.52 t. 1.03,t.mperat.re increases from 1423 t. 1573 K,t.e viscosit. of slag decreases,t.e float.ng rat. of bubbles *** addit.on,when holding t.me increases from 10 t. 30 s,t.e bubbles float.ng dist.nce increases,and t.e volume fract.on and average equivalent.sphere diamet.r of t.e bubbles solidified in t.e mold flux gradually *** one word,increasing t.e basicit.,t.mperat.re,and holding t.me leading t. an increase in t.e removal rat. of bubbles especially for t.e *** findings of bubbles escape behavior provide valuable insight. int. opt.mizing low basicit. mold flux for high-Mn high-Al st.els.

关键词： mold flux low basicit. bubbles t.ree-dimensional X-ray microscope viscosit.

Cat.lyt.c Performance of Carbon Smoke over Ag-LSCF Composit. Cat.lyst.

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Journal of Wuhan Universit. of t.chnology(Mat.rials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun HAN ming LU Shaomin YU Jing JU Hongling 无 Hubei Key Laborat.ry of Advanced t.chnology for Aut.mot.ve Component.&Hubei Collaborat.ve Innovat.on Cent.r for Aut.mot.ve Component. t.chnology Wuhan University of TechnologyWuhan 430070China College of Mechanical and t.ansport.t.on Southwest Forestry UniversityKunming 650000China

t. improve t.e cat.lyt.c performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)t.wards carbon soot.we ut.lized t.e impregnat.on met.od t. incorporat. Ag int. t.e prepared LSCF *** conduct.d a series of charact.rizat.on t.st. and evaluat.d t.e soot.cat.lyt.c act.vit. of t.e composit. cat.lyst.by comparing it.wit. t.e LaCoO_(3) group,LaFeO_(3) group,and cat.lyst.free *** result. indicat. t.at.t.e Ag-LSCF composit. cat.lyst.exhibit. t.e highest.soot.cat.lyt.c act.vit.,wit. t.e charact.rist.c t.mperat.re values of 376.3,431.1,and 473.9℃at.10%,50%,and 90%carbon soot.conversion,*** values are 24.8,20.2,and 23.1℃lower t.an t.ose of t.e LSCF *** also shows t.at.LSCF can improve t.e cat.lyt.c act.vit. of soot.aft.r compounding wit. Ag,and reflect. t.e necessit. of using cat.lyst. in soot.combust.on *** charact.rizat.on and BEt.t.st.show t.at.Ag-LSCF has more abundant.surface-adsorbed oxygen species,larger specific surface area and pore volume t.an LSCF,which also proves t.at.Ag-LSCF has higher soot.cat.lyt.c act.vit..

关键词： met.llic composit.s carbon smoke oxidat.on perovskit. cat.lyst soot

Dynamic Regulat.on of Hydrogen Bonding Net.orks and Solvat.on St.uct.res for Synergist.c Solar‑t.ermal Desalinat.on of Seawat.r and Cat.lyt.c Degradat.on of Organic Pollut.nt.

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Nano-Micro Let.ers 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laborat.ry of Advanced Funct.onal Polymer Composit.s Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China St.t. Key Laborat.ry of Organic‑Inorganic Composit.s College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Alt.ough solar st.am generat.on st.at.gy is efficient.in desalinat.ng seawat.r,it.is st.ll challenging t. achieve cont.nuous solar-t.ermal desalinat.on of seawat.r and cat.lyt.c degradat.on of organic ***,dynamic regulat.ons of hydrogen bonding net.orks and solvat.on st.uct.res are realized by designing an asymmet.ic bilayer membrane consist.ng of a bact.rial cellulose/carbon nanot.be/Co_(2)(OH)_(2)CO_(3)nanorod t.p layer and a bact.rial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bot.om ***,t.e hydrogen bonding net.orks inside t.e membrane can be t.ned by t.e rich surface–OH groups of t.e bact.rial cellulose and Co_(2)(OH)_(2)CO_(3)as well as t.e ions and radicals in sit. generat.d during t.e cat.lysis ***,bot. SO_(4)^(2−)and HSO_(5)−can regulat. t.e solvat.on st.uct.re of Na^(+)and be adsorbed more preferent.ally on t.e evaporat.on surface t.an Cl^(−),t.us hindering t.e de-solvat.on of t.e solvat.d Na^(+)and subsequent.nucleat.on/growt. of ***,t.e heat.generat.d by t.e solar-t.ermal energy conversion can accelerat. t.e react.on kinet.cs and enhance t.e cat.lyt.c degradat.on *** work provides a flow-bed wat.r purificat.on syst.m wit. an asymmet.ic solar-t.ermal and cat.lyt.c membrane for synergist.c solar t.ermal desalinat.on of seawat.r/brine and cat.lyt.c degradat.on of organic pollut.nt..

关键词： Solar st.am generat.on Seawat.r desalinat.on Cat.lyt.c degradat.on Bact.rial cellulose Cobalt.hydroxycarbonat. nanorods

GPS: graph cont.ast.ve learning via mult.-scale augment.d views from adversarial pooling

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Science China(Informat.on Sciences) 2025年第1期68卷 145-158页

作者： Wei JU Yiyang GU Zhengyang MAO Ziyue QIAO Yifang QIN Xiao LUO Hui XIONG ming ZHANG School of Comput.r Science National Key Laboratory for Multimedia Information ProcessingPeking University Art.ficial Int.lligence t.rust The Hong Kong University of Science and Technology Depart.ent.of Comput.r Science University of California

Self-supervised graph represent.t.on learning has recent.y shown considerable promise in a range of fields, including bioinformat.cs and social net.orks. A large number of graph cont.ast.ve learning approaches have shown promising performance for represent.t.on learning on graphs, which t.ain models by maximizing agreement.bet.een original graphs and t.eir augment.d views(i.e., posit.ve views). Unfort.nat.ly, t.ese met.ods usually involve pre-defined augment.t.on st.at.gies based on t.e knowledge of human expert.. Moreover, t.ese st.at.gies may fail t. generat. challenging posit.ve views t. provide sufficient.supervision signals. In t.is paper, we present.a novel approach named graph pooling cont.ast.GPS) t. address t.ese *** by t.e fact.t.at.graph pooling can adapt.vely coarsen t.e graph wit. t.e removal of redundancy, we ret.ink graph pooling and leverage it.t. aut.mat.cally generat. mult.-scale posit.ve views wit. varying emphasis on providing challenging posit.ves and preserving semant.cs, i.e., st.ongly-augment.d view and weakly-augment.d view. t.en, we incorporat. bot. views int. a joint.cont.ast.ve learning framework wit. similarit. learning and consist.ncy learning, where our pooling module is adversarially t.ained wit. respect.t. t.e encoder for adversarial robust.ess. Experiment. on t.elve dat.set. on bot. graph classificat.on and t.ansfer learning t.sks verify t.e superiorit. of t.e proposed met.od over it. count.rpart..

关键词： graph represent.t.on learning graph neural net.orks graph cont.ast.ve learning graph augment.t.ons graph pooling

High-dense nanocryst.lline W-based alloy prepared by hot.isost.t.c pressing wit. uniform microst.uct.re, ult.ahigh hardness and good t.ermal st.bilit.

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t.ngst.n 2025年第1期7卷 120-136页

作者： Zao-ming Wu Lin He Lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang Hong-Bo Lei Inst.t.t. of Mat.rials China Academy of Engineering Physics

High-densit. uniform microst.uct.re nanocryst.lline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy wit. an average grain size of 85 nm and a relat.ve densit. of 99.8% was successfully prepared.W-Cr-Y alloys wit. different.amount. of second-phase part.cles were prepared by high-energy ball milling and hot.isost.t.c pressing *** effect. of composit.on design,ball milling paramet.rs,and sint.ring paramet.rs on t.e microst.uct.re of W-Cr-Y alloys were st.died.A feasible t.chnology for cont.olling t.e synt.esis of high-densit. nanocryst.lline W-based alloys has been *** microst.uct.re analysis of nanocryst.lline W-10Cr-5Y alloy shows t.at.t.ere are t.o t.pes of doping in t.e second phase:int.rgranular doping and int.agranular *** "uniform dist.ibut.on YOx-rich part.cles" effect.vely suppresses t.e grain growt. of W and leads t. t.e format.on of nanocryst.lline W-10Cr-5Y alloy.W-10Cr-5Y has an ult.a-high hardness,wit. a Vickers hardness of 1312±12 kgf·***-t.mperat.re annealing t.eat.ent.shows t.at.W-10Cr-5Y has good t.ermal st.bilit. at.1000 and1100℃,as demonst.at.d by t.e comparison of Vickers hardness and grain size bet.een annealed and unannealed alloys.

关键词： Hot.isost.t.c pressing Microst.uct.re Nanocryst.lline t.ngst.n t.ermal st.bilit. Vickers hardness

A Mn-porphyrinic met.l–organic framework immobilizing glucose oxidase for combined phot.dynamic/chemodynamic/st.rvat.on t.erapy

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t.ngst.n 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-ming Yuan Guo-Da Zhang Chao Wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laborat.ry of Det.ct.on t.chnology for t.mor Markers School of Chemistry and Chemical Engineering Linyi University

t.e combinat.on of phot.dynamic t.erapy（PDt. and chemodynamic t.erapy（CDt. in t.mor t.eat.ent.has at.ract.d considerable ***,t.mor hypoxia and glut.t.ione（GSH） overproduct.on in t.e t.mor t.ssue rest.ict.d t.e progress of t.eir ***,a Mn-porphyrinic met.l-organic framework（Mn-t.PP） was const.uct.d by t.e one-pot.met.od and furt.er used for immobilizing glucose oxidase（GOx） t. obt.in GOx@*** would rapidly exhaust.endogenous glucose int. hydrogen peroxide（H2O2） and gluconic acid,t.us shut.ing off t.e energy supply of t.mor cells for st.rvat.on ***-t.PP cat.lyzed H2O2t. produce oxygen,regulat.ng t.e hypoxic t.mor microenvironment.and in t.rn improving1O2generat.on under laser ***,Mn-t.PP can reduce react.ve oxygen species consumpt.on owing t. t.e redox react.on bet.een Mn3+and GSH,t.us great.y enhancing ***,benefit.ng from GOx-mediat.d st.rvat.on t.erapy,Mn2+produced by Mn3+reduct.on can react.wit. sufficient.int.acellular H2O2t. generat. ·OH wit. high cyt.t.xicit. t.rough a Fent.n-like *** t.eat.ent.by GOx@Mn-t.PP under laser irradiat.on in vit.o,t.e cell viabilit. of 4t. and A549 t.mor cells reached t. 20%,reflect.ng GOx@Mn-t.PP could give full play t. t.e advant.ges of PDt.CDt.st.rvat.on *** result. in vivo demonst.at.d t.at.GOx@Mn-t.PP mediat.d synergist.c cascade t.erapy could significant.y inhibit.t.mor growt. and improve t.e t.erapeut.c effect.

关键词： Chemodynamic t.erapy Immobilizing enzyme Met.l–organic frameworks Phot.dynamic t.erapy St.rvat.on t.erapy

Progress of research in t.e applicat.on of ult.asound t.chnology for t.e t.eat.ent.of Alzheimer’s disease

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Neural Regenerat.on Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong ming Academy of Medical Engineering and t.anslat.onal Medicine Tianjin UniversityTianjinChina Innovat.on Cent.r for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Comput.r Int.ract.on and Human-Machine Fusion Haihe Laborat.ry Tianjin UniversityTianjinChina t.anjin Key Laborat.ry of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerat.ve disorder defined by decreased reasoning abilit.es,memory loss,and cognit.ve *** presence of t.e blood-brain barrier present. a major obst.cle t. t.e development.of effect.ve drug t.erapies for Alzheimer’s *** use of ult.asound as a novel physical modulat.on approach has garnered widespread at.ent.on in recent.*** a safe and feasible t.erapeut.c and drug-delivery met.od,ult.asound has shown promise in improving cognit.ve *** art.cle provides a summary of t.e applicat.on of ult.asound t.chnology for t.eat.ng Alzheimer’s disease over t.e past.5 years,including st.ndalone ult.asound t.eat.ent.ult.asound combined wit. microbubbles or drug t.erapy,and magnet.c resonance imaging-guided focused ult.asound *** is placed on t.e benefit. of int.oducing t.ese t.eat.ent.met.ods and t.eir pot.nt.al *** found t.at.several ult.asound met.ods can open t.e blood-brain barrier and effect.vely alleviat. amyloid-βplaque *** believe t.at.ult.asound is an effect.ve t.erapy for Alzheimer’s disease,and t.is review provides a t.eoret.cal basis for fut.re ult.asound t.eat.ent.met.ods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnet.c resonance imaging-guided focused ult.asound microbubbles scanning ult.asound ult.asound ult.asound st.mulat.on