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长链非编码RNA在糖尿病周围神经病变发病机制中的研究现状

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中国临床药理学杂志 2024年第11期40卷 1679-1683页

作者：陈世婷梅英秀陈明珠杜联成都中医药大学基础医学院四川成都611137

糖尿病周围神经病变(DPN)是一组累及周围神经系统的神经退行性疾病。长链非编码RNA(lncRNA)是机体正常生命活动以及疾病发生发展中重要的调控因子,广泛参与基因表达调控、表观遗传调节、转录及控制等生物学过程。近年来研究发现,lncRNA... 详细信息

糖尿病周围神经病变(DPN)是一组累及周围神经系统的神经退行性疾病。长链非编码RNA(lncRNA)是机体正常生命活动以及疾病发生发展中重要的调控因子,广泛参与基因表达调控、表观遗传调节、转录及控制等生物学过程。近年来研究发现,lncRNA可通过参与DPN的代谢紊乱、氧化应激、神经炎症、血管受损、细胞自噬、细胞凋亡等发病机制,影响DPN的发生发展。本文对lncRNA在DPN发病机制中的调控作用进行阐述,以期为临床研究提供科学参考和新思路。

关键词：长链非编码RNA 糖尿病周围神经病变发病机制代谢紊乱氧化应激

“醒脑开窍”针刺手法治疗神经性耳鸣的临床疗效观察

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安徽医专学报 2024年第2期23卷 24-26页

作者：陈明珠潘小红安徽中医药大学第一临床医学院安徽合肥230012 徐州市中医院江苏徐州221000

目的:探讨“醒脑开窍”针刺法与普通针刺在治疗神经性耳鸣前后的临床疗效,以为该病提供有效的临床治疗思路。方法:将符合诊断标准的60例神经性耳鸣患者采用随机数表法分为治疗组和对照组,每组30例患者,分别予以“醒脑开窍”针刺手法和... 详细信息

目的:探讨“醒脑开窍”针刺法与普通针刺在治疗神经性耳鸣前后的临床疗效,以为该病提供有效的临床治疗思路。方法:将符合诊断标准的60例神经性耳鸣患者采用随机数表法分为治疗组和对照组,每组30例患者,分别予以“醒脑开窍”针刺手法和传统针刺手法进行治疗,两组患者均隔日针灸1次,每周治疗3次,共4周。在治疗前后分别对患者耳鸣严重程度(TEQ)、耳鸣残疾程度(THI)进行评分,并依据耳鸣的严重程度分级进行临床疗效评估。结果:治疗后,两组患者的耳鸣严重程度评分、耳鸣残疾量表评分皆优于治疗前,治疗组优于对照组,差异均具有统计学意义(P<0.05);治疗组患者的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。结论:“醒脑开窍”针刺法与传统针刺治疗在改善神经性耳鸣患者的病情方面均有一定的疗效,但“醒脑开窍”针刺法疗效优于传统针刺。

关键词：醒脑开窍调神神经性耳鸣针刺疗法

Electrochemical Properties of Poly(ethylene oxide)(PEO) Doped TiO_2-PEO Films Prepared by Sol-gel Dip Coating Technique

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Journal of Wuhan University of Technology(Materials Science) 2001年第2期16卷 6-8,12页

作者：袁坚 School of Materials Science and Eng. Wuhan University of Technology Wuhan 430070 China

PEO modified Ti02 -PEO organic-inorganic hybrid thin films were prepared via, sol-gel dipping process on glass substrate pre-coated with ITO. The preparation parameters were studied. Electrochemical and optical properties of the films were characterized by cyclic voltammetric response and visible transmittance. X-ray diffraction (XRD) was used to determined the crystalline structure of the gel. The results show the sols added with PEO have acceptable stable periods for practical use. The PEO modified optical transitivity of the hybrid films has heavy effects on the crystallization of TiO2 during structural evolution because of the interaction between PEO and Ti02 . PEO-TiO2 films have better electrochemical activity than the TiO2 equivalent behaved as higher Li + insertion/extraction current density and cyclic reversibility.

关键词： sol-gel dip-coating films electrochromic materials PEO Ti02

Fe-N_(x) sites coupled with core-shell FeS@C nanoparticles to boost the oxygen catalysis for rechargeable Zn-air batteries

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Journal of Energy Chemistry 2024年第3期90卷 565-577,I0013页

作者： Katam Srinivas zhuo chen Anran chen Fei Ma ming-qiang zhu Yuanfu chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina

The development of efficient single-atom catalysts(SACs) for the oxygen reduction reaction(ORR)remains a formidable challenge,primarily due to the symmetric charge distribution of metal singleatom sites(M-N_(4)).To address such issue,herein,Fe-N_(x) sites coupled synergistic catalysts fabrication strategy is presented to break the uniform electronic distribution,thus enhancing the intrinsic catalytic ***,atomically dispersed Fe-N_(x) sites supported on N/S-doped mesoporous carbon(NSC)coupled with FeS@C core-shell nanoparticles(FAS-NSC@950) is synthesized by a facile hydrothermal reaction and subsequent *** to the presence of an in situ-grown conductive graphitic layer(shell),the FeS nanoparticles(core) effectively adjust the electronic structure of single-atom Fe sites and facilitate the ORR kinetics via short/long-range coupling ***,FAS-NSC@950displays a more positive half-wave potential(E_(1/2)) of 0.871 V with a significantly boosted ORR kinetics(Tafel slope=52.2 mV dec^(-1)),outpacing the commercial Pt/C(E_(1/2)=0.84 V and Tafel slope=54.6 mV dec^(-1)).As a bifunctional electrocatalyst,it displays a smaller bifunctional activity parameter(ΔE) of 0.673 V,surpassing the Pt/C-RuO_(2) combination(ΔE=0.724 V).Besides,the FAS-NSC@950-based zincair battery(ZAB) displays superior power density,specific capacity,and long-term cycling performance to the Pt/C-Ir/C-based *** work significantly contributes to the field by offering a promising strategy to enhance the catalytic activity of SACs for ORR,with potential implications for energy conversion and storage technologies.

关键词： Fe-N_(x)sites Core-shell FeS@C Synergistic interactions Oxygen reduction reaction Zn-air battery

HLA Class I Expressions on Peripheral Blood Mononuclear Cells in Colorectal Cancer Patients

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Chinese Journal of Cancer Research 2012年第1期24卷 77-82页

作者： Zhi-mian Zhang Xiao Guan Ying-jie Li ming-chen zhu Xiao-jing Yang Xiong Zou Department of Health Examination Center Qilu HospitalShandong UniversityJinan 250012China Department of Clinical Laboratory Medicine Qilu HospitalShandong UniversityJinan 250012China

Objective： To investigate the expression change of human leukocyte antigen （HLA） class I on human peripheral blood mononuclear ceils （PBMCs） at both mRNA and protein levels, and to evaluate its roles in the development of colorectal cancer （CRC）. Methods： In the present study, 50 patients with CRC, 35 patients with benign colorectal lesion and 42 healthy volunteers were enrolled. Expression levels of HLA class I mRNA and protein were determined using real-time quantitative reverse transcription PCR （RT-PCR） and flow cytometry analysis, respectively. Results： The expression levels of HLA class I mRNA and proteins were not influenced by age and gender. The relative ratios of HLA class I mRNA were 0.99±0.27 in healthy controls, 0.76±0.19 in benign patients, and 0.48±0.21 in CRC patients. Mean fluorescence intensities of HLA class I were 145.58±38.14 in healthy controls, 102.05±35.98 in benign patients and 87.44±34.01 in CRC patients. HLA class I on PBMCs was significantly down-regulated at both mRNA and protein levels in patients with stage III and IV CRC. CRC patients with lymph node metastasis also showed a decreased HLA class I expression at protein level. Conclusion： HLA class I expressions on PBMCs are associated with staging of CRC and lymph node metastasis. Monitoring the expression of HLA class I on PBMCs may provide useful information for diagnosis and metastasis judgement of CRC.

关键词： HLA class I Peripheral blood mononuclear cells RT-PCR Flow cytometry Colorectal cancer

A Comparative Study of the Power-law Relationship between the Pulse width and Energy of Precursor and Main Burst

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Research in Astronomy and Astrophysics 2024年第3期24卷 144-168页

作者： Hui-Ying Deng Zhao-Yang Peng Jia-ming chen Dan zhu College of Physics and Electronic Information Yunnan Normal UniversityKunming 650500China

In gamma-ray burst prompt emission,there is still no consistent conclusion if the precursor and main burst share the same *** this paper,we try to study this issue based on the relationship between pulse width and energy of the precursor and main *** systematically search the light curve data observed by Swift/BAT and Fermi/GBM,and find 13 long bursts with well-structured precursors and main *** fitting the precursor light curve of each different energy channel with the Norris function,we find that there is not only a power-law relationship between precursor width and energy,but also a power-law relationship between the ratio of the rising width to the decaying width and *** comparing the relationship between the precursors and the main burst pulses,we find that the distribution of the precursors and the relationship between the power-law indices are roughly the same as those of the main *** addition,it is found that the precursor width distribution as well as the upper limit of the pulse width ratio does not exceed 1 and both are asymmetric,which are also consistent with the main *** indicate that the precursor and the main burst are indistinguishable,and the precursor and the main burst may have the same physical origin.

关键词： methods data analysis-(stars) gamma-ray burst general-shock waves

A Stable Copper-based Metal-Azolate Framework for Efficient Electroreduction of CO_(2)to C_(2+)Products

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Chemical Research in Chinese Universities 2024年第4期40卷 664-669页

作者： LIU Yuan-Yuan zhu Hao-Lin LIAO Pei-Qin chen Xiao-ming Key Laboratory of Bioinorganic and Synthetic Chemistry Ministry of EducationGBRCE for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou510275P.R.China Chemistry and Chemical Engineering Guangdong Laboratory Shantou515031P.R.China

Driven by renewable or excess electrical energy,electrochemical CO_(2)reduction reaction(eCO_(2)RR)represents a promising carbon-neutral approach to generating valuable low-carbon fuels by consuming CO_(2)and H_(2)O.C_(2+)products are one of the most economically valuable products among the reduction species of eCO_(2)RR,but there are still some challenges,such as low selectivity or low current *** this work,we showed that a copper-based metal-azolate framework(MAF),denoted as MAF-203,exhibits the high performance of eCO_(2)RR to yield C_(2+)products with the Faradaic efficiency(C_(2+))of 52.5%and a current density of 660 mA/cm^(2)at-1.2 V *** in a flow cell device under alkaline *** experiment,in situ infrared spectroscopy and the density functional theory(DFT)calculations showed that the electron donating effect of methyl substituents on organic ligands of the copper-based MAF could enhance the ligand field and activation of key intermediates(*CO and*CHO species),thus promoting the coupling of*CO and*CHO for yielding C_(2+)products.

关键词： Metal-organic framework Carbon dioxide Electroreduction C_(2+)product Metal-azolate framework

The Application of Solid Waste in Thermal Insulation Materials: A Review

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Journal of Renewable Materials 2024年第2期12卷 329-347页

作者： ming Liu Pinghua zhu Xiancui Yan Haichao Li Xintong chen School of Environmental Science and Engineering Changzhou UniversityChangzhou213164China School of Urban Construction Changzhou UniversityChangzhou213164China

As socioeconomic development continues,the issue of building energy consumption has attracted significant attention,and improving the thermal insulation performance of buildings has become a crucial strategic ***,the application of solid waste in insulation materials has also become a hot *** paper reviews the sources and classifications of solid waste,focusing on research progress in its application as insulation materials in the domains of daily life,agriculture,and *** research shows that incorporating household solid waste materials,such as waste glass,paper,and clothing scraps into cementitious thermal insulation can significantly reduce the thermal conductivity of the materials,leading to excellent thermal insulation *** materials prepared from agricultural solid waste,such as barley straw,corn stalk,chicken feather,and date palm fibers,possess characteristics of lightweight and strong thermal *** solid waste,including waste tires,iron tailings,and coal bottom ash,can also be utilized in the preparation of insulation *** innovative applications not only have positive environmental significance by reducing waste emissions and resource consumption,but also provide efficient and sustainable insulation solutions for the construction ***,to further optimize the mix design and enhance the durability of insulation materials,continuous research is required to investigate the mechanisms through which solid waste impacts the performance of insulation materials.

关键词： Solid waste building energy consumption insulation material sustainability

Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing chen Hai-Shen LYU Robert HORTON Yong-Hua zhu Ren-Sheng chen ming-Yue SUN ming-Wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,p<0.05).Flood frequency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions