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mRNA vaccines:a new era in vaccine development

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Oncology Research 2024年第10期32卷 1543-1564页

作者： SHuBHRA cHANDRA JENNIFER c.WILSON DAVID GOOD ming Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of cOVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated enc.uraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufac.uring complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufac.uring processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

A transfer learning enhanced physics-informed neural network for parameter identification in soft materials

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1685-1704页

作者： Jing'ang ZHu Yiheng XuE Zishun LIu International center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University

Soft materials, with the sensitivity to various external stimuli, exhibit high flexibility and stretchability. Ac.urate prediction of their mechanical behaviors requires advanced hyperelastic constitutive models incorporating multiple parameters. However,identifying multiple parameters under complex deformations remains a challenge, especially with limited observed data. In this study, we develop a physics-informed neural network(PINN) framework to identify material parameters and predict mechanical fields,focusing on compressible Neo-Hookean materials and hydrogels. To improve ac.uracy, we utilize scaling techniques to normalize network outputs and material parameters. This framework effectively solves forward and inverse problems, extrapolating continuous mechanical fields from sparse boundary data and identifying unknown mechanical *** explore different approaches for imposing boundary conditions(Bcs) to assess their impacts on ac.uracy. To enhance efficiency and generalization, we propose a transfer learning enhanced PINN(TL-PINN), allowing pre-trained networks to quickly adapt to new scenarios. The TL-PINN significantly reduces computational costs while maintaining ac.uracy. This work holds promise in addressing practical challenges in soft material science, and provides insights into soft material mechanics with state-of-the-art experimental methods.

关键词： 35Q74 74A20 74B20 74G75 inverse problem O242 O343 parameter identification physics-informed neural network (PINN) soft material transfer learning

Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An Tao Yang caijuan Shi Shengcheng Mao Lihua Wang ang Li Wei Li Xianmeng Xue ming Sun Yifan Bai Yapeng He Fuzeng Ren Zhouguang Lu ming Yan Yang Ren chain-Tsuan Liu Ze Zhang Xiaodong Han Beijing Key Lab of Microstruc.ure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LcO) is a fundamental sub-nano/nanoscale process that oc.urs in many solid solutions and can be used as a microstruc.ure to optimize strength and ductility. However, the formation of LcO has not been fully elucidated, let alone how to provide efficient routes for designing LcO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LcO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LcO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LcO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LcO can promote dislocation cross-slip, enhancing the interaction between dislocations and their ac.umulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

First record of abnormal body coloration in a rockfish Sebastes koreanus(Scorpaenoidei:Sebastidae)from coastal water of china based on morphological characteristics and DNA barcoding

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Journal of Oceanology and Limnology 2024年第2期42卷 640-646页

作者： ang LI Huan Wang c.angting AN Shufang LIu Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266071China

The first record of abnormal body coloration in Sebastes koreanus Kim and Lee,1994,from the Yellow Sea of china,was documented based on morphological characteristics and DNA *** two rockfish specimens were collected from the coastal waters of Qingdao,china,and the whole body and all fins of them were *** the two red-colored rockfish,there were tiny deep red spots on each fin,2 red radial stripes behind and below the eyes and 1 large deep red blotch on the opercula,while the similar stripe and spot patterns are also present in the *** specimens with normal body *** c.untable characteristics of the two specimens are in the range of the morphometry of *** further clarify the species identity and taxonomic status of the two specimens,DNA barcode analysis was carried *** genetic distance between the red-colored rockfish and *** was 0,and the minimum net genetic distances between the red-colored rockfish and other Sebastes species except for *** were 3.0%,which exceeds the threshold of species *** phylogenetic analysis showed that the DNA barcoding sequences of the two red-colored rockfish c.ustered with the *** *** above results of DNA barcode analysis also support that the two red-colored rockfish c.uld be identified as the species of *** mechanism of color variation in *** is desirable for further research and the species c.uld be an ideal model to study the color-driven speciation of the rockfishes.

关键词： abnormal body coloration Sebastes koreanus coastal water of china Yellow Sea morphological characteristics DNA barcoding

Influence of laser parameters on the microstruc.ures and surface properties in laser surface modification of biomedical magnesium alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： chee Ying Tan cuie Wen Hua Qian ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention bec.use it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstruc.ures inc.uding textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques inc.uding laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstruc.ure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability corrosion Implant applications Laser surface modification Magnesium alloys

Secure state estimation for cyber-physical systems with unknown input sliding mode observer

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control Theory and Technology 2024年第2期22卷 244-253页

作者： Panpan Zhang Yuwei Ren Yixian Fang ang Liu School of Information Science and Engineering Shandong Normal UniversityJinan250358ShandongChina School of Information Engineering Shandong Management UniversityJinan250357ShandongChina

In recent years, cyber attacks have posed great challenges to the development of cyber-physical systems. It is of great significance to study secure state estimation methods to ensure the safe and stable operation of the system. This paper proposes a secure state estimation for multi-input and multi-output continuous-time linear cyber-physical systems with sparse ac.uator and sensor attacks. First, for sparse sensor attacks, we propose an adaptive switching mechanism to mitigate the impact of sparse sensor attacks by filtering out their attack modes. Second, an unknown input sliding mode observer is designed to not only observe the system states, sensor attack signals, and measurement noise present in the system but also c.unteract the effects of sparse ac.uator attacks through an unknown input matrix. Finally, for the design of an unknown input sliding mode state observer, the feasibility of the observing system is demonstrated by means of Lyapunov functions. Additionally, simulation experiments are conducted to show the effectiveness of this method.

关键词： Sparse attacks cyber-physical systems unknown input sliding mode Secure state estimation Adaptive switching mechanism

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science china(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-ang Kang Hua-ming Li Ya-Ting chen Meng-Jie Deng Yan Li Yue-ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHc key Laboratory of Assisted circulation(Sun Yat-sen university) Guangzhou 510080China Guangdong Provincial Engineering and Technology center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(Ecs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,Ec migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in Ec migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited Ec migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,Ec migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to c57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

Recent Advances in In-Memory computing:Exploring Memristor and Memtransistor Arrays with 2D Materials

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Nano-Micro Letters 2024年第7期16卷 1-30页

作者： Hangbo Zhou Sifan Li Kah-Wee ang Yong-Wei Zhang Institute of High Performance computing(IHPc) Agency for ScienceTechnology and Research(A*STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore Department of Electrical and computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Republic of Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WaySingapore 138634Republic of Singapore

The conventional computing architec.ure faces substantial chal-lenges,inc.uding high latency and energy consumption between memory and processing *** response,in-memory computing has emerged as a promising alternative architec.ure,enabling computing operations within memory arrays to overcome these *** devices have gained significant attention as key components for in-memory computing due to their high-density arrays,rapid response times,and ability to emulate biological *** these devices,two-dimensional(2D)material-based memristor and memtransistor arrays have emerged as particularly promising candidates for next-generation in-memory computing,thanks to their exceptional performance driven by the unique properties of 2D materials,such as layered struc.ures,mechanical flexibility,and the capability to form *** review delves into the state-of-the-art research on 2D material-based memristive arrays,encompassing critical aspects such as material selection,device perfor-mance metrics,array struc.ures,and potential ***,it provides a comprehensive overview of the current challenges and limitations associated with these arrays,along with potential *** primary objective of this review is to serve as a significant milestone in realizing next-generation in-memory computing utilizing 2D materials and bridge the gap from single-device characterization to array-level and system-level implementations of neuromorphic computing,leveraging the potential of 2D material-based memristive devices.

关键词： 2D materials Memristors Memtransistors crossbar array In-memory computing

Experimental Study on the Effect of Increased Downstroke Duration for an FWAV with Morphing-c.upled Wing Flapping configuration

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Journal of Bionic Engineering 2024年第1期21卷 192-208页

作者： ang chen Bifeng Song ZhiheWang Kang Liu Dong Xue Xiaojun Yang School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Harbin Institute of Technology Shenzhen 518055China

This paper is based on a previously developed bio-inspired Flapping Wing Aerial Vehicle(FWAV),RoboFalcon,which can fly with a morphing-c.upled flapping *** this paper,a simple flapping stroke control system based on Hall effect sensors is designed and applied,which is capable of assigning different up-and down-stroke speeds for the RoboFalcon platform to achieve an adjustable downstroke *** aerodynamic and power characteristics of the morphing-c.upled flapping pattern and the conventional flapping pattern with varying downstroke ratios are measured through a wind tunnel experiment,and the corresponding aerodynamic models are developed and analyzed by the nonlinear least squares *** relatively low power consumption of the slow-downstroke mode of this vehicle is verified through outdoor flight *** results of wind tunnel experiments and flight tests indicate that increased downstroke duration can improve aerodynamic and power performance for the RoboFalcon platform.

关键词： Flapping wing aerial vehicle(FWAV) Downstroke ratio Bio-inspired design Morphing-c.upled flapping