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基于Keap1/Nrf2/HO-1信号通路研究当归醇提物对多囊卵巢综合征大鼠的保护作用

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中国药理学通报 2024年第4期40卷 740-747页

作者：莫思懿曹后康张可锋晋玲钟明利韦日明高雅桂林医学院高发病防治药理学重点实验室广西桂林541199 甘肃中医药大学药学院甘肃兰州730000

目的使用来曲唑联合高脂饮食建立多囊卵巢综合征(polycystic ovarian syndrome,PCOS)大鼠模型,探讨当归醇提物(ethanol extract of Angelicae Sinensis Radix,EEA)对PCOS大鼠的保护作用及其作用机制。方法来曲唑联合高脂饮食诱导雌性SD... 详细信息

目的使用来曲唑联合高脂饮食建立多囊卵巢综合征(polycystic ovarian syndrome,PCOS)大鼠模型,探讨当归醇提物(ethanol extract of Angelicae Sinensis Radix,EEA)对PCOS大鼠的保护作用及其作用机制。方法来曲唑联合高脂饮食诱导雌性SD大鼠建立PCOS模型,并用EEA干预。阴道涂片染色、HE染色、酶联免疫吸附法(EliSA)和生化指标检测评价EEA对PCOS大鼠的治疗作用,并通过荧光定量PCR(qRT-PCR)和Western blot检测EEA对Keap1/Nrf2/HO-1信号通路的影响。结果阴道涂片和HE染色结果表明,EEA改善了PCOS大鼠动情周期紊乱和卵巢组织病变,EliSA和生化指标检测结果表明EEA可以调节激素紊乱,改善血脂异常;且在模型组中Keap1蛋白和mRNA表达明显上调,Nrf2和HO-1蛋白和mRNA表达明显下调而经过EEA治疗后Keap1蛋白和mRNA表达明显下调,Nrf2和HO-1蛋白和mRNA表达明显上调(P<0.05或P<0.01)。结论EEA可以减轻大鼠PCOS,其机制可能是通过促进Keap1/Nrf2/HO-1信号通路,从而抑制氧化应激。

关键词：当归醇提物多囊卵巢综合征(PCOS) Keap1/Nrf2/HO-1信号通路氧化应激性激素血脂

附生结晶调控有机高分子半导体材料聚集态结构与性能

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高分子学报 2024年第11期55卷 1441-1462页

作者：闫敬越刘玉敏黄华东高灿董焕丽李忠明中国科学院化学研究所北京分子科学国家重点实验室北京100190 四川大学高分子科学与工程学院四川610065 中国科学院大学北京100049

高质量共轭高分子半导体晶体材料的制备对于其基础物性的研究和高性能有机光电器件的构筑具有至关重要的意义.但是高分子材料存在本征分子量大、呈分散性、链间易于缠结等特征,导致其高度有序共轭高分子聚集体的制备面临巨大挑战.本文... 详细信息

高质量共轭高分子半导体晶体材料的制备对于其基础物性的研究和高性能有机光电器件的构筑具有至关重要的意义.但是高分子材料存在本征分子量大、呈分散性、链间易于缠结等特征,导致其高度有序共轭高分子聚集体的制备面临巨大挑战.本文立足于有机高分子半导体材料聚集态结构与性能调控,在传统溶液组装策略的基础上,介绍了新型取向结晶策略,重点探讨了附生结晶的影响因素以及附生结晶在调控有机高分子半导体材料聚集态结构与性能方面的优势,并对目前附生结晶存在的问题进行了总结与展望.

关键词：有机高分子半导体构效关系结构调控附生结晶

Synthesis and Insecticidal Activities of Novel Analogues of Chlorantraniliprole Containing Nitro Group

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Chemical Research in Chinese Universities 2011年第4期27卷 610-613页

作者： FENG Qi WANG ming-zhong XIONG li-xia liU Zhi-li li Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organie Chemistry Nankai University Tianjin 300071 P. R. China

Twelve novel analogues of chlorantraniliprole containing nitro group were synthesized,and their structures were characterized by 1H NMR and high-resolution mass spectrometry（HRMS）.Their evaluated insecticidal activities against oriental armyworm（Mythimna separata） indicate that the nitro-containing analogues showed favorable insecticidal activities,while the activity of compounds 5g at 0.25mg/L was 40%,but still lower than chlorantraniliprole.

关键词： Chlorantraniliprole Nitro Insecticidal activity Anthranilic diamide

Facile fabrication of highly durable superhydrophobic strain sensors for subtle human motion detection

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Journal of Materials Science & Technology 2022年第15期110卷 35-42页

作者： li-Chuan Jia Chang-Ge Zhou Kun Dai Ding-Xiang Yan zhong-ming li College of Electrical Engineering Sichuan UniversityChengdu 610065China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China College of Materials Science and Engineering The Key Laboratory of Material Processing and Mold of Ministry of EducationZhengzhou UniversityZhengzhou 450001China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China

Endowing strain sensors with superhydrophobicity is of great importance to guarantee their long-term service under harsh environments(such as wet,acid,alkali and salt atmospheres),whereas,the development of superhydrophobic strain sensors remains a great ***,we realized a superhydrophobic and highly sensitive sensor for subtle human motion detection by designing a superhydrophobic and electrically conductive coating on cotton textile,via a facile drop-coating *** resultant strain sensor showed a large water contact angle of 161.3°and a low sliding angle of 3.8°The superhydrophobic characteristics can keep almost unchanged even after undergoing 1000 peeling cycles,1000 stretchingrelease cycles,and 1000 bending-releasing cycles,revealing its excellent mechanical *** sensitivity with the maximum gage factor of 169 was achieved for the strain sensor under a small strain of0–10%,and the sensing performance also showed well ***,our sensor can effectively detect various subtle human physiological signals and body motions even under harsh *** admirable features make the sensor promising applications in wearable electronics,personalized health monitoring,sound recognition,and so on.

关键词： Strain sensors Superhydrophobicity High sensitivity Drop coating Durable

Flexible Polydimethylsiloxane Composite with Multi-Scale Conductive Network for Ultra-Strong Electromagnetic Interference Protection

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Nano-Micro Letters 2023年第1期15卷 293-306页

作者： Jie li He Sun Shuang-Qin Yi Kang-Kang Zou Dan Zhang Gan-Ji zhong Ding-Xiang Yan zhong-ming li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065People’s Republic of China

Highly conductive polymer composites(CPCs) with excellent mechanical flexibility are ideal materials for designing excellent electromagnetic interference(EMI) shielding materials,which can be used for the electromagnetic interference protection of flexible electronic *** is extremely urgent to fabricate ultra-strong EMI shielding CPCs with efficient conductive *** this paper,a novel silver-plated polylactide short fiber(Ag@PL ASF,AAF) was fabricated and was integrated with carbon nanotubes(CNT) to construct a multi-scale conductive network in polydimethylsiloxane(PDMS) *** multi-scale conductive network endowed the flexible PDMS/AAF/CNT composite with excellent electrical conductivity of 440 S m-1and ultra-strong EMI shielding effectiveness(EMI SE) of up to 113 dB,containing only 5.0 vol% of AAF and 3.0 vol% of CNT(11.1wt% conductive filler content).Due to its excellent flexibility,the composite still showed 94% and 90% retention rates of EMI SE even after subjected to a simulated aging strategy(60℃ for 7 days) and 10,000 bending-releasing *** strategy provides an important guidance for designing excellent EMI shielding materials to protect the workspace,environment and sensitive circuits against radiation for flexible electronic devices.

关键词： Flexible conductive polymer composites Silver-plated polylactide short fiber Carbon nanotube Electromagnetic interference shielding Multi-scale conductive network

The Crystallization Behavior of Biodegradable Poly(butylene succinate) in the Presence of Organically Modified Clay with a Wide Range of Loadings

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Chinese Journal of Polymer Science 2015年第4期33卷 576-586页

作者： Jing-bin Chen Jia-zhuang Xu Huan Xu zhong-ming li 钟淦基雷军 College of Polymer Science and Engineering and State Key Laboratory of Polymer Materials Engineering Sichuan University

The crystallization behavior of poly（butylene succinate）（PBS） nanocomposites with a wide range of contents of clays was revealed. It was of interest to find that the crystallization rate of PBS was accelerated obviously at relatively low contents of clays; while a retarded crystallization kinetics and a decreased crystallinity of PBS were found in the nanocomposites with higher clay contents. Two interplaying effects existed in the nanocomposites, i.e., a suppression effect of clays on nucleation and a templating effect of clays on crystal growth, were clarified to contribute to this intriguing crystallization behavior.

关键词： Poly(butylene succinate) Clay Crystallization kinetics Biodegradable.

Towards Efficient Electromagnetic Interference Shielding Performance for Polyethylene Composites by Structuring Segregated Carbon Black/Graphite Networks

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Chinese Journal of Polymer Science 2016年第12期34卷 1490-1499页

作者： Cheng-hua Cui 鄢定祥 Huan Pang li-chuan Jia Yu Bao Xin Jiang zhong-ming li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

An electromagnetic interference （EMI） shielding composite based on ultrahigh molecular weight polyethylene （UHMWPE） loaded with economical graphite-carbon black （CB） hybrid fillers was prepared via a green and facile methodology, i.e., high-speed mechanical mixing combined with hot compression thus avoiding the assistance of the intensive ultrasound dispersion in volatile organic solvents. In this composite, the graphite-CB hybrid fillers were selectively distributed in the interfacial regions of UHMWPE domains resulting a typical segregated structure. Thanks to the specific morphology of segregated conductive networks along with the synergetic effect of large-sized graphite flakes and small-sized CB nanoparticles, a low filler loading of 7.7 vol% （15 wt%） yielded the graphite-CB/UHMWPE composites with a satisfactory electrical conductivity of 33.9 S/m and a superior shielding effectiveness of 40.2 dB, manifesting the comparable value of the pricey large-aspect-ratio carbon nanofillers （e.g., carbon nanotubes and graphene nanosheets） based polymer composites. More interestingly, with the addition of 15 wt% graphite-CB （1/3, W/W） hybrid fillers, the tensile strength and elongation at break of the composite reached 25.3 MPa and 126%, respectively; with a remarkable increase of 58.1% and 2420% over the conventional segregated graphite/UHMWPE composites. The mechanical reinforcement could be attributed to the favor of the small-sized CB particles in the polymer molecular diffusion between UHMWPE domains which in tuna provided a stronger interfacial adhesion. This work provides a facile, green and affordable strategy to obtain the polymer composites with high electrical conductivity, efficient EMI shielding, and balanced mechanical performance.

关键词： Graphite Carbon black Segregated structure Electromagnetic interference Synergistic effect.

How the Aggregates Determine Bound Rubber Models in Silicone Rubber? A Contrast Matching Neutron Scattering Study

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Chinese Journal of Polymer Science 2021年第3期39卷 365-376,I0007页

作者： li-Zhao Huang Yue Shui Wei Chen zhong-ming li Hong-Tao Song Guang-Ai Sun Jia-Zhuang Xu Gan-Ji zhong Dong liu Key Laboratory of Neutron Physics and Institute of Nucear Physics and Chemistry(NPC) China Academy of Engineeing Physict(CAEP)Mcnyang 621999China National Synchrotron Radiation Lab CAS Key Laboratory of soft Mtter Chemisty Anhui Provincial fngineing Laboratory of Advanced funcionad Poymer FilmUniversity of Science and Technology of ChinaHefei 230026China College of Polymer cience and Engineering state Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 61065China

The correlation between aggregates and bound rubber structures in silicone rubbers(S(phr)) with various silica fractions(ΦSi) has been investigated by contrast matching small-angle neutron scattering(SANS), swelling kinetics, and low-field nuclear magnetic resonance(NMR).Mixed solvents with deuterated cyclohexane fractions of 4.9% and 53.7% were chosen to match the scattering length densities of the matrix(SMP(phr)) and the filler(SMS(phr)), respectively. All the data consistently suggest that:(i) There is a critical threshold ΦSic between 10 and 30 phr;below ΦSic, the isolated aggregates are dominant, while beyond ΦSic, some rubber fraction is trapped among the agglomerate;(ii) ΦSiindependent thicknesses around 7.5 nm(NMR) and 8.6 nm(SANS) suggest that the bound rubber formation is determined by inherent properties of the components, and the power-law around 4.2 suggests an exponential changed gradient density of the bound rubber;(iii) SMS(80) presents a bicontinuous bound rubber with three characteristic lengths of 41, 100, and 234 nm. The expanded correlation length, a 20 nm smaller aggregate sizes suggest that such existent bicontinuous network in dry samples with less ΦSi is kind of impacted by swelling. With the obtained bound rubber models, the reinforcing mechanism of filled silicone rubber is elucidated.

关键词： Silicone rubber Bound rubber structures Small-angle neutron scattering(SANS) Nuclear magnetic resonance(NMR)

Vibration Assisted Extrusion of Polypropylene

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Chinese Journal of Polymer Science 2015年第5期33卷 688-696页

作者： Fang-zhen An 高雪芹雷军 Cong Deng zhong-ming li Kai-zhi Shen Department of Polymer Science and Materials State Key Laboratory of Polymer Materials EngineeringSichuan University Analytical and Testing Center Sichuan University

A new homemade apparatus, i.e. vibration assisted extrusion equipment, is employed to extrude polypropylene. Vibration assisted extrusion is based on the application of a specific macroscopic shear vibration field. Reduction of apparent melt viscosity as a function of vibration frequency is measured at different screw speeds and die temperatures. The effect of the process is investigated by performing mechanical tests, differential scanning calorimetry studies, polarized light microscopy and wide-angle X-ray diffraction. It is found that, compared with conventional extrusion, vibration assisted extrusion could effectively improve the rheological properties of PP melt by incorporating an extra shear vibration field. Both the tensile strength and elongation at break increased under the shear vibration field. For vibration assisted extrusion samples, both the melting temperature and crystallinity increased, accompanied by remarkable grain refinement. Vibration assisted extrusion induced a significantly enhanced bimodal orientation with a high fraction of a^＊-oriented α-crystallites, while only a limited improvement in the flow direction orientation. A structural model, i.e. bimodal c-axis and a^＊-axis orientation of PP macromolecular chains, was adopted to explain the experimental results.

关键词： Vibration assisted extrusion Polypropylene Mechanical properties Microstructure