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Roles of cyclooxygenase-2 in microvascular endothelial cell proliferation induced by basic fibroblast growth factor

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Chinese Medical Journal 2008年第24期121卷 2599-2603页

作者： QIAN Rui-zhe YUE Fei ZHANG Guo-ping hou Li-kun WANG Xin-hong JIN Hui-ming Department of Physiology and Pathophysiology Shanghai Medical College Fudan University Shanghai 200032 China

Background The level of basic fibroblast growth factor （bFGF） increases rapidly after cerebral ischemia. However, the molecular mechanisms for the effects of bFGF on cerebral microvascular endothelial cells （cMVECs） have not yet been fully elucidated. In this study, a murine cMVEC line, bEnd.3, was employed to study the effects of bFGF on cyclooxygenase （COX） expression and its downstream effects in cMVECs. Methods After treatment with bFGF, RT-PCR and Western blotting analyses were carried out to evaluate the changes in COX-2 mRNA and protein expression, respectively. MTT assays were performed to measure cell proliferation. The prostaglandin E2 （PGE2） and vascular endothelial growth factor （VEGF） concentrations in the culture medium were measured by enzyme-linked immunosorbent assay （ELISA）. Results COX-2 mRNA and protein expressions in bEnd.3 cells were induced by bFGF in time- and dose-dependent manners. The bFGF-induced COX-2 upregulation led to enhanced PGE2 production by bEnd.3 cells, and this effect was abolished by the selective COX-2 inhibitor NS-398. bFGF also increased VEGF production by bEnd.3 cells, and this effect was blocked by NS-398 and the EP1/2 （PGE2 receptors） antagonist AH6809. Furthermore, exogenous PGE2 increased VEGF production in bend.3 cells, and AH6809 blocked this effect. Conclusion bFGF increases VEGF production in an autocrine manner by increasing COX-2-generated PGE2 in cMVECs and subsequently stimulates MVEC proliferation and angiogenesis.

关键词： cerebral ischemia cerebral microvascular endothelial cell basic fibroblast growth factor cyclooxygenase prostaglandin E2 vascular endothelial growth factor

Effect of phosphite and epoxy soybean oil on heat stability of poly （vinylchloride） composite stabilizers

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Journal of Chemistry and Chemical Engineering 2007年第1期1卷 45-49页

作者： JIANG Ping-ping ZHANG Xiao-yan duan Ru-zhe ZHANG Xiao-ming Department of Chemical and Materials Engineering Jiangnan University Wuxi 214122 China Department of Food Science and Technology Jiangnan University Wuxi 214122 China

The influences ofphosphite and epoxy soybean oil in combination with liquid calcium/zinc isocaprylates on the thermal stability of flexible poly （vinyl chloride） were studied. The stabilizing effect of poly （vinyl chloride） was evaluated by Congo red method, thermoaging test and Thermogravimetric-differential Scanning Calorimetry （TG-DSC）. The results showed that the addition of the phosphite or epoxy soybean oil improved the thermal stability of PVC with the calcium/zinc isocaprylates stabilizing system, especially epoxidied soybean oil exhibited a remarkable effect, and the synergism on PVC thermal stability for 3：2 phenyl dioctyl phosphite to epoxidized soybean oil weight ratio was acquired. Accordingly, the rapid mass loss in TG curve occured between 258.9 ℃ and 334.4 ℃, which corresponded to the enthalpy of the pyrogenation of 609.2 J/g. It was also found that the stabilized PVC of the best ratio gave better mechanical and processing properties.

关键词： thermal stability poly (vinyl chloride) Ca/Znstabilizers

Ascending aorta dilation protects against coronary artery disease in aortic valvulopathy patient with tricuspid not bicuspid valve

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中国循环杂志 2016年第Z1期31卷 -页

作者： Xinshuang ren Kun Liu zhe zheng Zhihui hou Yang Gao Weihua Yin zhennan Li Xuejing duan Bin Lv FuwaiHospital NationalCenter for Cardiovascular Diseases Chinese Academy of MedicalSciences and Peking Union MedicalColege Beijing China

Objective The aim of our study is to evaluate risk factors of coronary artery disease (CAD) in aortic valve disease with different valve morphology, and identify relationship between ascending aorta dilation and CAD。... 详细信息

关键词：二尖瓣冠状动脉疾病计算机辅助设计胰岛素主动脉主动脉瓣

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离散线性周期系统的模型匹配

控制与决策 2016年第6期31卷 1148-1152页

作者：吕灵灵岳金明侯明哲华北水利水电大学电力学院郑州450045 哈尔滨工业大学控制理论与制导技术研究中心哈尔滨150001

考虑离散线性周期系统的模型匹配问题,提出一种基于参数化极点配置的模型匹配方法.该方法从时域的角度出发,采用周期状态反馈,使得闭环系统充分接近目标系统.由于所采用的参数化极点配置算法提供了充分的自由度,所提出的方法能够实现零... 详细信息

考虑离散线性周期系统的模型匹配问题,提出一种基于参数化极点配置的模型匹配方法.该方法从时域的角度出发,采用周期状态反馈,使得闭环系统充分接近目标系统.由于所采用的参数化极点配置算法提供了充分的自由度,所提出的方法能够实现零误差匹配.数值算例验证了所提出算法的有效性.

关键词：离散周期系统模型匹配极点配置

Twist2 is a valuable prognostic biomarker for colorectal cancer

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World Journal of Gastroenterology 2013年第15期19卷 2404-2411页

作者： Hao Yu guang-Zhi Jin Kai Liu Hui Dong Hua Yu Ji-Cheng duan zhe Li Wei Dong Wen-ming Cong Jia-He Yang Department of Laparoscopy Eastern Hepatobiliary Surgery Hospitalthe Second Military Medical University Department of Pathology Eastern Hepatobiliary Surgery Hospitalthe Second Military Medical University

AIM: To investigate the significance of Twist2 for colorectal cancer (CRC). METHODS: In this study, 93 CRC patients were included who received curative surgery in Eastern Hepatobiliary Surgery Hospital from January 1999 to December 2010. Records of patients' clinicopathological characteristics and follow up data were reviewed. Formalin-fixed, paraffin-embedded tissue blocks were used to observe the protein expression of Twist2 and E-cadherin by immunohistochemistry. Two independent pathologists who were blinded to the clinical information performed semiquantitative scoring of immunostaining. A total score of 3-6 (sum of extent + intensity) was considered as Twist2-positive expression. The expression of E-cadherin was divided into two levels (preserved and reduced). An exploratory statistical analysis was conducted to determine the association between Twist2 expression and clinicopathological parameters, as well as E-cadherin expression. Furthermore, the variables associated with prognosis were analyzed by Cox's proportional hazards model. Kaplan-Meier analysis was used to plot survival curves according to different expression levels of Twist2. RESULTS: Twist2-positive expression was observed in 66 (71.0%) samples and mainly located in the cytoplasm. Forty-three (46.2%) samples showed reduced expression of E-cadherin. There were no significant correlations between Twist2 expression and any of the clinicopathological parameters. However, Twist2-positive expression was significantly associated with reduced expression of E-cadherin (P=0.040). Multivariate analysis revealed that bad M-stage [hazard ratio (HR)=7.694, 95%CI: 2.927-20.224,P < 0.001] and Twist2-positive (HR=5.744, 95%CI: 1.347-24.298,P=0.018) were the independent risk factors for poor overall survival (OS), while Twist2-positive (HR=3.264, 95%CI: 1.455-7.375, P=0.004), bad N-stage (HR=2.149, 95%CI: 1.226-3.767, P=0.008) and bad M-stage (HR=10.907, 95%CI: 4.937-24.096, P < 0.001) were independently associated

关键词： Colorectal cancer Prognostic biomarker Twist2 Epithelial-mesenchymal transition Immunohistochemstry

Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

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Stroke & Vascular Neurology 2022年第3期7卷 190-199页

作者： Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying duan zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstitutePhoenixArizonaUSA Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina Department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to *** Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct *** primary outcome was 90-day functional *** outcomes were assessed with adjusted OR(aOR)from the multivariable logistic *** addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with *** Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+*** EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),phours of *** meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.

关键词： acute intravenous occlusion

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复合材料内部缺陷微波无损检测技术的研究

现代化工 2014年第2期34卷 167-169页

作者：侯哲李为民段滋华太原理工大学化学化工学院山西太原030024 山西阳煤化工机械有限公司山西太原030001

以内铺金属纤维聚酯材料基体复合材料为检测对象,利用微波扫描的方法检测内部金属纤维的断裂缺陷。通过微波无损检测新技术并采用回波法测量回波损耗、相位等特征参量,实现复合材料内部金属丝断裂缺陷的快速定位与测定。实验结果表明,... 详细信息

以内铺金属纤维聚酯材料基体复合材料为检测对象,利用微波扫描的方法检测内部金属纤维的断裂缺陷。通过微波无损检测新技术并采用回波法测量回波损耗、相位等特征参量,实现复合材料内部金属丝断裂缺陷的快速定位与测定。实验结果表明,通过回波损耗和相位的变化规律,可以定位复合材料内部缺陷;结合回波损耗的大小,可以测定缺陷的断裂尺寸。

关键词：微波技术无损检测复合材料内部缺陷

Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry

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International Journal of Oral Science 2023年第3期15卷 371-376页

作者： Bin Liu Xuedong Zhou Lin Yue Benxiang hou Qing Yu Bing Fan Xi Wei Lihong Qiu zhengwei Huang Wenwei Xia zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang Department of Endodontics and Operative Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghaiChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics and Operative Dentistry Beijing Stomatological HospitalCapital Medical UniversityBeijingChina Department of Operative Dentistry and Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina Department of Endodontics School of StomatologyChina Medical UniversityShenyangChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zheji

The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental ***,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this *** October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative *** objective of this meeting was to establish a standard operation procedure for the dental operative ***,a consensus was reached and officially *** the span of about four years,the content of this consensus has been further developed and improved through practical experience.

关键词： operative surgery primarily

金属间化合物Fe_2B在液态锌中的腐蚀机制

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天津大学学报 2010年第7期43卷 633-638页

作者：杜安马瑞娜温鸣范永哲曹晓明河北工业大学材料科学与工程学院天津300130

利用扫描电镜、电子探针以及X射线研究了Fe2B的微观组织及被液态锌腐蚀后的界面形貌及化学组成,并运用固体与分子经验电子理论(EET)建立了Fe2B的价电子结构,对腐蚀过程中的反应扩散机制进行了合理的分析.结果表明:Fe2B在液态锌中的腐蚀... 详细信息

利用扫描电镜、电子探针以及X射线研究了Fe2B的微观组织及被液态锌腐蚀后的界面形貌及化学组成,并运用固体与分子经验电子理论(EET)建立了Fe2B的价电子结构,对腐蚀过程中的反应扩散机制进行了合理的分析.结果表明:Fe2B在液态锌中的腐蚀机制以反应扩散为主;首先液态Zn原子扩散到Fe2B固体表面,然后沿能量较高的晶界进入Fe2B基体;Zn原子在Fe2B晶格中有限固溶,引起了Fe2B晶格畸变,同时在热应力作用下,Fe2B基体产生大量裂纹,液态锌沿着裂纹扩展方向渗入;当晶格畸变达到极限时,Fe原子周围的化学键全部断裂,Fe成为"自由"原子;"自由"的Fe原子与周围的Zn原子发生反应,生成Fe-Zn化合物;化合物从基体上剥落下来,漂移到液态锌中;Fe原子成为"自由"原子需要的能量越高,材料的耐腐蚀性能越好.

关键词：腐蚀 Fe2B 金属间化合物液态锌键能