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Acta Metallurgica Sinica(English Letters) 2020年第3期33卷 391-402页

作者： wen-Chao Dong ming-yue wen Hui-Yong Pang Shan-Ping Lu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Wuyang Iron and Steel Co.Ltd. Pingdingshan 462500China

The effects of tempering temperatures on the microstructure and mechanical properties of the simulated coarse-grain heataffected zone(CGHAZ) and inter-critical heat-affected zone(ICHAZ) were investigated for a high-strength-high-toughness combination marine engineering *** results demonstrate that the microstructure of the simulated CGHAZ and ICHAZ after tempering is characterized by tempering sorbites and coarse grain in the simulated *** tempering temperature increases,the tensile strength of the simulated CGHAZ and ICHAZ decreases and the Charpy absorbed energy of the simulated ICHAZ at-50℃increases remarkably,but the impact toughness of the simulated CGHAZ is not *** tempering at 550℃,the coarse flake carbides,which distribute at the prior austenite grain and martensite lath boundaries,deteriorate the impact toughness of the simulated *** the increase in tempering temperature,the morphology and the size of the carbides gradually change from coarse flake to fine granular,which is beneficial to the improvement of impact ***,the coarse-grain size of the simulated CGHAZ and the M23 C6-type carbide precipitated along the grain boundaries weakens the enhancing effect of carbides on impact toughness.

关键词： High-strength-high-toughness combination steel Post-weld heat treatment Heat-affected zones(HAZs) Carbides Impact toughness

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu yue Li Hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Quantitative analysis of hepatic hypoxia-inducible factor-1α and its abnormal gene expression during the formation of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 407-413页

作者： Deng-Fu Yao,Hua Jiang,Min Yao,yue-ming Li,wen-Jing Gu,Yu-Cheng Shen, Li-Wei Qiu,Wei Wu,Xin-Hua Wu and wen-Li Sai Research Center of Clinical Molecular Biology,Department of Laboratory Science,and Department of Oncology,Affiliated Hospital of Nantong University,Nantong 226001, China Third Department of Medicine,Jiaonan People’s Hospital,Jiaonan 266400,China Research Center of Clinical Molecular Biology Affiliated Hospital of Nantong University Nantong 226001 China. yaodf@***

BACKGROUND:Hepatic hypoxia-inducible factor-1(HIF-1) is activated in the progression of hepatocellular carcinoma (HCC).This study aimed to investigate the dynamic alterations of HIF-1αand its gene expression so as to explore the relationship between HIF-1αexpression and hepatocarcinogenesis at the early stage of HCC. METHODS:A hepatoma model was made with 2-fluorenyl- acetamide(2-FAA)in male Sprague-Dawley *** changes of rat hepatocytes were assessed pathologically (HE staining).The dynamic expression of hepatic and circulating HIF-1αwas quantitatively analyzed by ELISA. The gene fragments of hepatic HIF-1αmRNA were amplified by RT-PCR and confirmed by *** cellular distribution of hepatic HIF-1αexpression was confirmed by immunohistochemistry. RESULTS:Histological examination confirmed granulelike degeneration to atypical hyperplasia and HCC development in rat hepatocytes and progressive increases in the levels of hepatic and circulating HIF-1αand its gene expression during the *** levels of HIF-1α expression in the liver and blood of rats with hepatoma were significantly higher than those in normal ratsand those with *** analysis confirmed the positive expression and hepatocyte distribution of HIF-1αin the development of rat hepatoma. A positive relationship was found between HIF-1α expression in the liver and blood(P<0.01). CONCLUSIONS:The above observations support the hypothesis that the overexpression of HIF-1αand its gene are closely associated with the malignant transformation of hepatocytes and play an important role at the stage of hepatocarcinogenesis.

关键词： hepatocellular carcinoma hypoxia inducible factor-1α early expression dynamic alteration

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基于FPGA高效移相全桥变换器的研究

电工电能新技术 2017年第2期36卷 37-42页

作者：安金龙单智尤轶赵明岳文贺河北工业大学天津300132 天津电气科学研究院天津300180

传统的ZVS移相全桥技术应用越来越广泛,但在实际应用中,其效率一般维持在86%左右。为提高电源效率,本文采用非线性饱和电感代替谐振电感;通过采集变压器原边和副边两侧电流来获得磁偏发生的相位和幅值,进而来调整FPGA输出PWM脉冲,从而... 详细信息

传统的ZVS移相全桥技术应用越来越广泛,但在实际应用中,其效率一般维持在86%左右。为提高电源效率,本文采用非线性饱和电感代替谐振电感;通过采集变压器原边和副边两侧电流来获得磁偏发生的相位和幅值,进而来调整FPGA输出PWM脉冲,从而快速地有效地抑制磁偏。最后利用PSIM仿真软件对该设计进行了仿真研究,其结果表明理论设计合理。并制作了一台360V/30k W、20k Hz的单元样机进行验证,实验证明,本实验方案在60%负载时效率已经达到90%以上,满载效率达到94%。

关键词：移相全桥占空比磁偏 FPGA PSIM

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao wen ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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自力式调压器阀瓣受流体冲击力的仿真研究

煤气与热力 2017年第10期37卷 38-42页

作者：杨文量翟军岳明张文中国市政工程华北设计研究总院有限公司天津300072

通过数值模拟的方法,结合调压器阀瓣受力平衡方程,研究自力式调压器在下游流量变化时,调压器阀瓣受到的流体冲击力、冲击力矩对调压器性能的影响。随着流量增大,阀瓣受流体冲击的合力减小,出口压力减小;增大膜片面积可以减小由阀瓣受到... 详细信息

通过数值模拟的方法,结合调压器阀瓣受力平衡方程,研究自力式调压器在下游流量变化时,调压器阀瓣受到的流体冲击力、冲击力矩对调压器性能的影响。随着流量增大,阀瓣受流体冲击的合力减小,出口压力减小;增大膜片面积可以减小由阀瓣受到的冲击合力带来的出口压力变化,但会增大调压器的体积;流量增大,旋涡减小,流体接触腔体底部后转向的流速增大,对阀瓣下表面的冲击力增加。

关键词：自力式调压器数值模拟阀瓣受力流体冲击

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

后交叉韧带胫骨附着点撕脱骨折:关节镜治疗中的材料、植入物及内固定技术

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中国组织工程研究 2025年第4期29卷 872-880页

作者：余铭王文贵州医科大学贵州省贵阳市550004 暨南大学附属广州市红十字会医院广东省广州市510220

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不... 详细信息

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不同关节镜治疗方法、手术入路、胫骨隧道设计、缝合材料选择以及内固定植入物选择等。方法:通过计算机对中国知网、PubMed、Web of Science及ScienceDirect等数据库中的相关文献进行检索,检索时间为2003年1月至2023年11月,中文检索词为“后交叉韧带,后十字韧带,撕脱骨折,关节镜”;英文检索词为“posterior cruciate ligament,avulsion,fracture,tibia,arthroscopic,operation,fixation,treatment”。共纳入97篇文献进行综述。结果与结论:关节镜技术提供了一种可靠的治疗方式来治疗后交叉韧带胫骨附着点撕脱骨折。根据入路、缝合材料类型以及用于缝合的入路和胫骨隧道数量等不同,关节镜技术可以分为关节镜下缝线固定结合自体移植物增强重建、关节镜下多交叉带缝合桥固定、关节镜下高强度缝线固定以及关节镜下直接前后缝合悬吊固定等几类。在各种研究中,常用的临床结果评估指标包括关节活动度、Lysholm评分、国际膝关节文献委员会评分及KT-2000关节测量仪差等,研究显示关节镜手术后末次随访时上述指标检测结果较术前显著改善,影像学随访结果显示关节镜手术都取得了令人满意的结果。在随访过程中,接受关节镜技术治疗后的各类交叉韧带胫骨附着点撕脱骨折患者都未出现严重并发症,例如创伤性关节炎、神经血管损伤、围手术期伤口感染、血栓形成以及骨折不愈合等。

关键词：后交叉韧带胫骨撕脱骨折关节镜手术缝合材料内固定治疗

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有机酸对低盐腌渍黄瓜品质影响的初步研究

食品研究与开发 2018年第16期39卷 8-11页

作者：沈文凤崔文甲王月明王文亮弓志青贾凤娟王延圣山东省农业科学院农产品研究所山东济南250100 山东省农产品精深加工技术重点实验室山东济南250100 农业部新食品资源加工重点实验室山东济南250100

探究不同有机酸对低盐腌渍黄瓜品质的影响。以黄瓜为原料,在黄瓜的腌渍液中分别加入醋酸、乳酸、柠檬酸、苹果酸4种有机酸,以水分活度、p H值、含盐量以及感官评定结果为指标,筛选适合低盐腌渍黄瓜的有机酸。结果表明:醋酸腌渍的黄瓜的... 详细信息

探究不同有机酸对低盐腌渍黄瓜品质的影响。以黄瓜为原料,在黄瓜的腌渍液中分别加入醋酸、乳酸、柠檬酸、苹果酸4种有机酸,以水分活度、p H值、含盐量以及感官评定结果为指标,筛选适合低盐腌渍黄瓜的有机酸。结果表明:醋酸腌渍的黄瓜的水分活度值较低,p H值较为稳定(p H值为5左右),对含盐量的影响较小,感官评价结果较好,所以最后选择醋酸为黄瓜低盐腌渍的有机酸。

关键词：有机酸低盐腌渍黄瓜

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly