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Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia

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Neural Regeneration Research 2020年第2期15卷 332-341页

作者： Ning-Wei zhu Xiao-Lan Yin Ren Lin Xiao-Lan Fan Shi-Jie Chen yuan-ming zhu Xiao-Zhen Zhao Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Pharmacy Zhejiang Pharmaceutical CollegeNingboZhejiang ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina

Oxidative stress is involved in the pathogenesis of vascular dementia. Studies have shown that lycopene can significantly inhibit oxidative stress;therefore, we hypothesized that lycopene can reduce the level of oxidative stress in vascular dementia. A vascular dementia model was established by permanent bilateral ligation of common carotid arteries. The dosage groups were treated with lycopene(50, 100 and 200 mg/kg) every other day for 2 months. Rats without bilateral carotid artery ligation were prepared as a sham group. To test the ability of learning and memory, the Morris water maze was used to detect the average escape latency and the change of search strategy. Hematoxylin-eosin staining was used to observe changes of hippocampal neurons. The levels of oxidative stress factors, superoxide dismutase and malondialdehyde, were measured in the hippocampus by biochemical detection. The levels of reactive oxygen species in the hippocampus were observed by dihydroethidium staining. The distribution and expression of oxidative stress related protein, neuron-restrictive silencer factor, in hippocampal neurons were detected by immunofluorescence histochemistry and western blot assays. After 2 months of drug administration,(1) in the model group, the average escape latency was longer than that of the sham group, and the proportion of straight and tend tactics was lower than that of the sham group, and the hippocampal neurons were irregularly arranged and the cytoplasm was hyperchromatic.(2) The levels of reactive oxygen species and malondialdehyde in the hippocampus of the model group rats were increased, and the activity of superoxide dismutase was decreased.(3) Lycopene(50, 100 and 200 mg/kg) intervention improved the above changes, and the lycopene 100 mg/kg group showed the most significant improvement effect.(4) Neuron-restrictive silencer factor expression in the hippocampus was lower in the sham group and the lycopene 100 mg/kg group than in the model group.(5) Th

关键词： bilateral carotid artery ligation lycopene hippocampus learning and memory malondialdehyde neuron neuron-restrictive silencer factor reactive oxygen species superoxide dismutase

Structural, ferromagnetic, and optical properties of Fe and Al co-doped ZnO diluted magnetic semiconductor nanoparticles synthesized under high magnetic field

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Advances in Manufacturing 2019年第2期7卷 248-255页

作者： Muhammad Tariq Ying Li Wen-Xian Li Zhong-Rui Yu Jia-Mei Li Ye-Min Hu ming-yuan zhu Hong-ming Jin Yang Liu Yi-Bing Li Katerina Skotnicova School of Materials Science and Engineering/Institute for Sustainable Energy/Institute of Mateirals Shanghai University Shanghai 20072 People's Republic of China School of Chemistry The University of New South Wales Sydney NSW 2052 Australia Faculty of Metallurgy and Materials Engineering VSB-Technical University of Ostrava Ostrava Czech Republic

In this study, 2% Fe and 3% Al co-doped ZnO nanoparticles were synthesized using a hydrothermal method under high magnetic field (HMF). The influences of HMF on the structural, optical, and ferromagnetic properties of Fe and Al co-doped ZnO nanoparticles were characterized and analyzed. The single-phase wurtzite structure of the synthesized samples was confirmed using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), and Raman spectroscopy analysis. The application of HMF decreases the particle size of the spherical nanocrystal as observed by scanning electron microscopy (SEM). Optical analysis indicated that the absoqjtion edge shifted towards a higher wavelength (red shift). The nanoparticles synthesized under the HMF exhibited high room temperature ferromagnetism (RTFM) performance because of the high oxygen vacancy (VO) content as revealed by X-ray photoelectron spectroscopy (XPS), which was in agreement with the prediction of the bound magnetic polarons theory.

关键词： Fe and Al co-doped ZnO nanoparticles Room temperature ferromagnetism (RTFM) High magnetic field Hydrothermal Optical property

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma:A case report and review of literature

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World Journal of Clinical Cases 2022年第27期10卷 9790-9797页

作者： Jing Chen ming-yuan zhu Yan-Hua Huang Zhong-Cheng Zhou Yi-Yu Shen Quan Zhou ming-Jian Fei Fan-Chuang Kong Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Synchronous primary cancers(SPCs) have become increasingly frequent over the past ***,the coexistence of duodenal papillary and gallbladder cancers is rare,and such cases have not been previously reported in the English ***,we describe an SPC case with duodenal papilla and gallbladder cancers and its diagnosis and successful *** SUMMARY A 68-year-old Chinese man was admitted to our hospital with the chief complaint of dyspepsia for the past ***-enhanced computed tomography of the abdomen performed at the local hospital revealed dilatation of the bile and pancreatic ducts and a space-occupying lesion in the duodenal *** revealed a tumor protruding from the duodenal *** findings for the biopsied tissue revealed tubular villous growth with moderate heterogeneous *** treatment was *** examination of this surgical specimen revealed a 2-cm papillary tumor and another tumor protruding by 0.5 cm in the gallbladder neck *** rapid pathology identified adenocarcinoma in the gallbladder neck duct and tubular villous adenoma with high-grade intraepithelial neoplasia and local canceration in the duodenal *** an uneventful postoperative recovery,the patient was discharged without *** It is essential for clinicians and pathologists to maintain a high degree of suspicion while evaluating such synchronous cancers.

关键词： Synchronous primary cancers Gallbladder carcinoma Duodenal papillary adenocarcinoma Surgical treatment Case report

Bladder perforation caused by long-term catheterization misdiagnosed as digestive tract perforation:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4993-4998页

作者： Bin Wu Jing Wang Xu-Jian Chen Zhong-Cheng Zhou ming-yuan zhu Yi-Yu Shen Zheng-Xiang Zhong Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Spontaneous bladder rupture is relatively rare,and common causes of spontaneous bladder rupture include bladder diverticulum,neurogenic bladder dysfunction,gonorrhea infection,pelvic radiotherapy,*** bladder perforation caused by urinary catheterization mostly occurs during the intubation *** SUMMARY Here,we describe an 83-year-old male who was admitted with 26 h of middle and upper abdominal pain and a history of long-term *** examination and computed tomography of the abdomen supported the diagnosis of diffuse peritonitis,most likely from a perforated digestive tract *** exploration revealed a possible digestive tract ***,a perforation of approximately 5 mm in diameter was found in the bladder wall during *** reviewing the patient's previous medical records,we found that 1 year prior the patient underwent an ultrasound examination showing that the end of the catheter was embedded into the mucosal layer of the ***,the bladder perforation in this patient may have been caused by the chronic compression of the urinary catheter against the bladder *** For patients with long-term indwelling catheters,there is a possibility of bladder perforation,which needs to be dealt with quickly.

关键词： Bladder perforation Catheterization Misdiagnosed Case report

Cloning and Identification of Porcine HSPC117 Gene Differentially Expressed in F_(1)Crossbreds and Their Parents

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Agricultural Sciences in China 2007年第5期6卷 613-619页

作者： XIE Hong-tao LEI ming-gang XIONG yuan-zhu DENG Chang-yan JIANG Si-wen LI Feng-e ZUO Bo XU De-quan Key Laboratory of Swine Genetics and Breeding Ministry of Agriculture Huazhong Agricultural University Wuhan 430070 P.R.China

To investigate the molecular basis of porcine heterosis, suppression subtractive hybridization （SSH） was performed to detect the differences in gene expression between porcine longissimus dorsi of Meishan X Large White （MS × LW） F1 hybrids and their parents Meishan pigs. An expression sequence tag （EST） differentially expressed was found, designated as ML556, which was homologous to a hypothetical protein HSPC117, from human hematopoietic stem/progenitor cells （HSPCs）, and the full-length cDNA of porcine HSPC117 was cloned using rapid amplification of cDNA ends （RACE） method. Translation of the mRNA transcript revealed an open reading frame （ORF） of 505 amino acid residues encoding a peroxisomal targeting signal （PTS） with theoretical molecular weight of 55 kDa. Alignment analysis revealed that the deduced protein sequence exhibit 98, 98, 98, 97, and 97% identity with that of cattle, human, dog, rat, and mouse, respectively. The tissue expression analysis indicated that the porcine HSPC117 gene is highly expressed in muscle, spleen, lung, kidney, uterus, ovary and testis, moderately expressed in fat, heart, and liver, and not expressed in stomach and small intestine. The possible role of porcine HSPC117 and its relationship with porcine heterosis were discussed.

关键词： pig HSPCll7 gene longissimus dorsi suppression subtractive hybridization (SSH) rapid amplification of cDNA ends (RACE)

Three cancers in the renal pelvis,bladder,and colon:A case report

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World Journal of Clinical Cases 2024年第2期12卷 392-398页

作者： Jing Chen Hua-Yan Huang Hui-Chun Zhou Lin-Xiao Liu Chuang-Fan Kong Quan Zhou Jian-ming Fei yuan-ming zhu Hu Liu Ye-Chen Tang Cheng-Zhong Zhou Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Medical Imaging The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Urology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 31400Zhejiang ProvinceChina

BACKGROUND Multiple primary cancers are rare occurrences that can involve either metachronous or synchronous *** is particularly rare for an individual to have more than two primary *** this report,we present a case study of an elderly man who was diagnosed with three heterochronous cancers in the renal pelvis,bladder,and *** SUMMARY On December 30,2014,a 51-year-old Chinese man was admitted to our hospital with complaints of intermittent painless gross hematuria for the preceding week.A computed tomography(CT)scan revealed wall thickening in the left ureter’s upper segment,while a CT urography revealed a left renal pelvis tumor.A successful laparoscopic radical resection of the left renal pelvis tumor was subsequently performed at Shanghai Zhongshan Hospital in January *** pathological findings after the surgery revealed a low-grade papillary urothelial carcinoma of the renal *** final pathological tumor stage was *** surgery,this patient received 6 cycles of intravenous chemotherapy with gemcitabine and carboplatin,as well as bladder infusion therapy with *** December 18,2017,the patient was admitted once again to our hospital with a one-day history of painless gross hematuria.A CT scan showed the presence of a space-occupying lesion on the posterior wall of *** examination revealed multiple tumors in the bladder and right cutaneous ureterostomy was performed under general anesthesia on December 29,*** postoperative pathological findings disclosed multifocal papillary urothelial carcinoma of the bladder(maximum size 3.7 cm×2.6 cm).The bladder cancer was considered a metastasis of the renal pelvis cancer after *** pathological tumor stage was *** patient refused chemotherapy after *** another six years,the patient returned on February 28,2023,complaining of periumbilical pain that had lasted six *** time,a CT scan of the abdomen showed a tumor in the ascen

关键词： Metachronous primary carcinoma Renal pelvis carcinoma Bladder carcinoma Colon carcinoma Case report

治疗消化性溃疡出血患者采取胃镜联合卡络磺钠氯化钠注射液冲洗的临床疗效分析

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世界复合医学 2020年第3期6卷 82-84页

作者：袁明珠甘肃省酒泉市第二人民医院甘肃酒泉735000

目的探讨对消化性溃疡出血患者采取胃镜+卡络磺钠氯化钠注射液冲洗方法进行治疗后获得的临床疗效。方法将该院2016年7月—2019年5月收治的84例消化性溃疡出血患者数字奇偶法分组;治疗组(42例):采用胃镜+卡络磺钠氯化钠注射液冲洗方法完... 详细信息

目的探讨对消化性溃疡出血患者采取胃镜+卡络磺钠氯化钠注射液冲洗方法进行治疗后获得的临床疗效。方法将该院2016年7月—2019年5月收治的84例消化性溃疡出血患者数字奇偶法分组;治疗组(42例):采用胃镜+卡络磺钠氯化钠注射液冲洗方法完成溃疡出血治疗;对照组(42例):采用肾上腺素完成溃疡出血治疗;就组间止血疗效数据、黑便次数、呕血次数、平均住院时长、平均止血时长展开对比。结果治疗组消化性溃疡患者止血疗效数据(95.24%)高于对照组(66.67%)明显(χ2=11.118,P<0.05);治疗组黑便次数为(2.25±0.53)次;呕血次数为(0.25±0.05)次;对照组黑便次数为(2.79±0.66)次;呕血次数为(0.49±0.02)次;治疗组消化性溃疡出血患者黑便次数以及呕血次数均少于对照组明显(t=4.134,28.883,P<0.05);治疗组平均住院时长为(8.85±2.52)d;平均止血时长为(3.02±0.49)d;对照组平均住院时长为(16.25±3.85)d;平均止血时长为(9.13±0.69)d;治疗组消化性溃疡出血患者平均住院时长、平均止血时长均短于对照组明显(t=10.422,46.790,P<0.05)。结论胃镜+卡络磺钠氯化钠注射液冲洗方法的有效运用,使得消化性溃疡出血患者止血疗效获得显著提升,并且黑便次数以及呕血次数获得有效减少,平均住院时长、平均止血时长获得有效缩短,最终实现消化性溃疡出血患者预后改善。

关键词：消化性溃疡出血胃镜卡络磺钠氯化钠注射液止血疗效黑便次数呕血次数

Molecular Cloning and Functional Analysis of MRLC2 Differential Expressed in Meishan×Yorkshire F1 Crossbreeds and Their Parents,Meishan Pigs

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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 788-794页

作者： Hong-Tao XIE ming-Gang LEI yuan-zhu XIONG* Chang-Yan DENG Si-Wen JIANG Bo ZUO Feng-E LI De-Quan XU Tao WANG Key Laboratory of Swine Genetics and Breeding,Ministry of Agriculture,Huazhong Agricultural University,Wuhan 430070,China Key Laboratory of Swine Genetics and Breeding Ministry of Agriculture Huazhong Agricultural University Wuhan 430070 China

In order to detect the molecular basis of heterosis in pigs,suppression subtractivehybridization was carried out to investigate the difference in gene expression in the Longissimus dorsimuscle tissues between Meishan×Yorkshire F1 crossbreeds and their parents,Meishan *** swinemyosin regulatory light chain 2 (MRLC2) gene differentially expressed between the crossbreeds and thepurebreds was isolated and identified using semi-quantitative reverse transcriptase polymerase chain reactionand its complete cDNA sequence was obtained using the rapid amplification of cDNA ends *** sequence of the gene is not homologous to any of the known porcine *** sequenceprediction analysis reveals that the open reading frame of this gene encodes a protein of 172 amino acidscontaining the putative conserved domain of the EF-hand *** predicted amino acid sequenceof porcine MRLC2 protein exhibits 99%,98%,98%,98% and 97% identity with that of cattle,human,dog,rat and mouse,*** homology analysis revealed that the MRLC2 protein was very muchconserved in *** tissue expression analysis indicated that the swine MRLC2 gene is highlyexpressed in muscle,fat,heart,liver,spleen,lung,kidney,stomach,small intestine,ovary and testis,but notexpressed in pancreas.

关键词： MRLC2 gene pig heterosis Longissimus dorsi suppression subtractive hybridization rapid amplification of cDNA end

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑yuan Yu Jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods