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球扁钢感应加热温度场模拟与工艺优化

材料热处理学报 2014年第5期35卷 214-218页

作者：原思宇宋华王旭鞍钢股份有限公司技术中心辽宁鞍山114009 辽宁科技大学辽宁鞍山114051

球扁钢采用电磁感应加热技术实现在线淬火热处理。感应加热过程中球头与腹板存在较大温差,导致淬火后性能不均匀。借助数值模拟方法建立感应加热过程有限元模型,获得不同时刻球扁钢断面温度场分布。进一步采用二位控温法进行感应加热工... 详细信息

球扁钢采用电磁感应加热技术实现在线淬火热处理。感应加热过程中球头与腹板存在较大温差,导致淬火后性能不均匀。借助数值模拟方法建立感应加热过程有限元模型,获得不同时刻球扁钢断面温度场分布。进一步采用二位控温法进行感应加热工艺优化,并借助有限元模型进行参数的设计和优化。模拟结果显示腹板与球头温度差由优化前的100℃左右,减少到优化后的少于30℃。采用新工艺进行实验,实验结果与模拟结果比较两者相差较小,验证了模型的准确性和新工艺的可行性。为实现球扁钢感应加热工艺快速选择和优化提供了可靠的数学模型。

关键词：球扁钢电磁感应数值模拟温度场

Constructing Br-Doped Li_(10)SnP_(2)S_(12)-Based All-Solid-State Batteries with Superior Performances

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Energy Material Advances 2023年第1期4卷 500-511页

作者： Qiyue Luo Liang ming Dong Zhang Chaochao Wei Zhongkai Wu Ziling Jiang Chen Liu Shiyu Liu Kecheng Cao Long Zhang Chuang yu Shijie Cheng State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074P.R.China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074P.R.China School of Physical Science and Technology&Shanghai Key Laboratory of High-resolution Electron Microscopy Shanghai Tech UniversityShanghai 201210P.R.China Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074P.R.China College of Physics and Energy Fujian Normal UniversityFuzhou 350117P.R.China

Ionic conductivity and electro/chemical compatibility of Li_(10)SnP_(2)S_(12) electrolytes play crucial roles in achieving superior electrochemical performances of the corresponding solid-state ***,the relatively low Li-ion conductivity and poor stability of Li_(10)SnP_(2)S_(12) toward high-voltage layered oxide cathodes limit its ***,a Br-substituted strategy has been applied to promote Li-ion *** optimal composition of Li_(9.9)SnP_(2)S_(11.9)Br_(0.1) delivers high conductivity up to 6.0 mS cm^(−1).7Li static spin-lattice relaxation(T1)nuclear magnetic resonance(NMR)and density functional theory simulation are combined to unravel the improvement of Li-ion diffusion mechanism for the modified *** mitigate the interfacial stability between the Li_(9.9)SnP_(2)S_(11.9)Br_(0.1) electrolyte and the bare LiNi_(0.7)Co_(0.1)Mn_(0.2)O_(2) cathode,introducing Li_(2)ZrO_(3) coating layer and Li_(3)InCl_(6) isolating layer strategies has been employed to fabricate all-solid-state lithium batteries with excellent electrochemical *** Li_(3)InCl_(6)-LiNi_(0.7)Co_(0.1)Mn_(0.2)O_(2)/Li_(3)InCl_(6)/Li_(9.9)SnP_(2)S_(11.9)Br_(0.1)/Li-In battery delivers much higher discharge capacities and fast capacity degradations at different charge/discharge C rates,while the Li_(2)ZrO_(3)@LiNi_(0.7)Co_(0.1)Mn_(0.2)O_(2)/Li_(9.9)SnP_(2)S_(11.9)Br_(0.1)/Li-In battery shows slightly lower discharge capacities at the same C rates and superior cycling *** characterization methods are conducted to reveal the differences of battery *** poor electrochemical performance of the latter battery configuration is associated with the interfacial instability between the Li_(3)InCl_(6) electrolyte and the Li_(9.9)SnP_(2)S_(11.9)Br_(0.1) *** work offers an effective strategy to constructing Li_(10)SnP_(2)S_(12)-based all-solid-state lithium batteries with high capacities and superior cyclabilities.

关键词： battery electrolyte conductivity

Management of intractable epistaxis in patients who received radiation therapy for nasopharyngeal carcinoma

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Management of intractable epistaxis in patients who received...

Alterations of Panicle Antioxidant Metabolism and Carbohydrate Content and Pistil Water Potential Involved in Spikelet Sterility in Rice under Water-Deficit Stress

全国耳鼻咽喉头颈外科中青年学术会议

作者： chengcheng he Yongfeng si lei yu The Guangxi Zhuang Autonomous Region people’s Hospital Department of Otolaryngology Head and neck tumor

OBJECTIVE To report clinical manifestations,bleeding point localization,and outcomes of management in 16 patients with 16 instances of intractable epistaxis after radiation therapy for nasopharyngeal carcinoma. STUDY ...

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Rice science 2010年第4期17卷 303-310页

作者： Fu Guan-fu SONG Jian LI yu-rong yuE ming-kai XIONG Jie TAO Long-xing State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China Agricultural Bureau of Tuanfeng District in Huanggang City of HubeL Huanggang 438813 China

Two rice genotypes with different drought tolerance, namely Jin 23B （drought tolerant） and Zhenshan 97B （drought sensitive）, were used to study the antioxidant enzyme activities, soluble sugar and starch contents in spikelets, pistil water potential and pollen number on a stigma under water-deficit stress at the flowering stage, which were involved in the spikelet sterility. Compared with respective controls, drought stress induced more serious decreases of superoxide dismutase （SOD）, peroxidase （POD） and catalase （CAT） activities and more significant increase of malonaldehyde （MDA） content in spikekets of Zhenshan 97B than in Jin 23B on 9 and 12 days after water stress （DAWS）. The soluble sugar and starch contents increased significantly in spikelets of Jin 23B, but decreased significantly in spikelets of Zhenshan 97B during 9-12 DAWS. The pistil maintained higher water potential in Jin 23B than in Zhenshan 97B during 3-6 DAWS and 9-12 DAWS. In addition, water stress induced more significant decrease in the pollen number on a stigma as well as the percentage of unfilled grains in Zhenshan 97B than in Jin 23B. Thus, it is suggested that water stress induced spikelet sterility by damaging antioxidant enzyme activities, reducing carbohydrate content in spikelets and decreasing pistil water potential at the flowering stage in rice.

关键词： antioxidant enzyme carbohydrate content flowering stage pistil water potential rice water stress spikelet sterility

Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-Hui Kuang Tao Hu Lu-Yong Zhang yu-Feng Yao ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： si-Qi Li Dong-yu Min Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen Qi deficiency syndrome

Flux-to-voltage characteristic simulation of superconducting nanowire interference device

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Chinese Physics B 2020年第9期29卷 553-558页

作者： Xing-yu Zhang Yong-Liang Wang Chao-Lin Lv Li-Xing You Hao Li Zhen Wang Xiao-ming Xie State Key Laboratory of Functional Material for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences(CAS)Shanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Superconducting Electronics Shanghai 200050China

Inspired by recent discoveries of the quasi-Josephson effect in shunted nanowire devices,we propose a superconducting nanowire interference device in this study,which is a combination of parallel ultrathin superconducting nanowires and a shunt resistor.A simple model based on the switching effect of nanowires and fluxoid quantization effect is developed to describe the behavior of the *** current-voltage characteristic and flux-to-voltage conversion curves are simulated and discussed to verify the *** parameters of the shunt resistor and inductor are deduced for fabricating the devices.

关键词： superconducting nanowire switching effect flux-to-voltage conversion interference device

Inhibition of miR-873 provides therapeutic benefit in lipopolysaccharide-induced Parkinson disease animal model

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中国药理学与毒理学杂志 2017年第10期31卷 961-962页

作者： Jin-hua WU Juan WU Xu-ming yu Zhe-qiong YANG Xian-fei XIE Jiang yuE Department of Pharmacology Wuhan University School of Basic Medical Sciences

OBJECTIVE Neuroinflammation plays a critical role in neurodegenerative disorders,although the inflammation may not the initiating *** disease(PD)is characterized pathologically by the accumulation of alpha synuclein(α-syn)and the loss of the dopamine(DA)neurons in the substantia nigra(SN),which has been reported to be induced by the stereotaxic injection of lipopolysaccharide(LPS)to the SN region in *** study is to investigate the therapeutic benefit of the inhibition of miR-873 in *** Rats received the right-unilaterally injection with concentrated LV-sponge or LV-EGFP 3 d before LPS treatment,7 or 14 d after LPS *** animals were tested for rotational behavior with the dopaminergic agonist apomorphine dissolved in sterile saline at 21 d after LPS *** regulation of miR-873 on the genes related with cholesterol transport and inflammation was assayed in SH-SY5Y cells and U251 *** TLR4-My D88 signaling pathway was involved the regulation of miR-873 by *** luciferase assay showed that HMGCR,ABCA1 and A20 were down-stream genes of *** transfection of miR-873 decreased the cholesterol levels in cell membrane,but increased in lysosome in SH-SY5Y *** with the control SH-SY5Y cells,cholesterol levels were higher in lysosome withα-synuclein overexpression or LPS *** transfection of miR-873 increased theα-syn levels in lysosome in cel s withα-synuclein *** loss of dopaminergic neuorns induced by LPS was significantly respectively decreased by 22.8%,35.6%and 57% after the inhibition of miR-873 at 3 d before LPS treatment,7 or14 d after LPS *** with LPS-treated group,the number of the rotation of rats was decreased by 60.4%,33.5%and 13.2%after the inhibition of miR-873 at 3 d before LPS treatment,7or 14 d after LPS *** inhibition of miR-873 significantly decreased accumulation ofα-*** m RNA levels of HMGCR,ABCA1 and A20 in SN were decreased by L

关键词： neuroinflammation Parkinson disease TLR4-MyD88 signaling pathway miR-873

Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

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Chinese Journal of Natural Medicines 2016年第11期14卷 856-864页

作者： FENG Li-Xing SUN Peng MI Tian LIU Miao LIU Wang YAO si CAO Yi-Min yu Xiao-Lu WU Wan-Ying JIANG Bao-Hong YANG Min GUO De-An LIU Xuan Shanghai Institute of Materia Medica Chinese Academy of Sciences

Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis(RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema heterophyllum Blume(AHA) and explore the possible mechanisms in human non-small-cell lung cancer A549 cells. AHA with purity up to 95% was isolated and purified from Arisaema heterophyllum Blume using hydrophobic interaction chromatography. AHA dose-dependently inhibited the proliferation of A549 cells and induced G_1 phase cell cycle arrest. AHA induced apoptosis by up-regulating pro-apoptotic Bax, decreasing anti-apoptotic Bcl-2, and activating caspase-9 and caspase-3. In A549 cells treated with AHA, the PI3K/Akt pathway was inhibited. Furthermore, AHA induced increase in the levels of ER stress markers such as phosphorylated eukaryotic initiation factor 2α(p-eIF2α), C/EBP-homologous protein(CHOP), inositol-requiring enzyme 1α(IRE1α), and phosphorylated c-Jun NH_2-terminal kinase(p-JNK). AHA also induced autophagy in A549 cells. Staining of acidic vesicular organelles(AVOs) and increase in the levels of LC3II and ATG7 were observed in AHA-treated cells. These findings suggested that AHA might be one of the active components with anti-cancer effects in Arisaema heterophyllum Blume. In conclusion, cytotoxicity of AHA on cancer cells might be related to its effects on apoptosis and autophagy through inhibition of PI3K/Akt pathway and induction of ER stress.

关键词： Agglutinin Arisaema heterophyllum Blume Human non-small-cell lung cancer A549 cell line Apoptosis Autophagy