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The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期68卷 39-88页

作者： Feimin Huang Weiqiang wang Yong wang Feng Xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

关键词： Boltzmann equation incompressible Euler equations hydrodynamic limit Hilbert expansion specular reflection boundary condition viscous boundary layer Knudsen boundary layer

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu Wenxian wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li xin-Ran Song Qian-Qian Wan Yu-ming wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao wang Qingsong Huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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Improved model for defect detection in photovoltaic cells based on Yolov5

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Optoelectronics Letters 2025年

作者： BAI xinfeng XUE Yuming DAI Hongli wang Luoxin BAI xin HU Xiaofeng Institute of New Energy Intelligence Equipment， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In order to meet the requirements of recognition speed and accuracy for complex photovoltaic (PV) cell defect detection tasks， this paper proposed an improvement strategy based on the Yolov5 network model. First， the model's ability to localize defects was enhanced by adding shallow feature inputs to strengthen the model's fusion of shallow feature information; second， the Squeeze-and-excitation (SE) attention mechanism was introduced to expand the receptive field and strengthen the dependency between feature channels; finally， a smoothing downsampling module was constructed to replace the convolutional sampling， which reduced the loss of information while retaining the important features. The experimental results show that the Yolov5 model based on this improved strategy achieved an average accuracy of 92.06% in the multiclassification defect detection task， and the average recognition speed reached 25.31 frames per second (FPS)， which took into account the requirements of performance and real-time performance， and can satisfy the needs of PV cell defect detection in industrial scenarios.

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Acceptor concentration dependent Fo?rster resonance energy transfer in nanocrystal-molecule complexes revealed by spectral analysis

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Optoelectronics Letters 2025年

作者： Rongxin ZHANG Zixiang ZHOU Lei wang xin ZHANG Ying LIANG Guijie LIANG Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices， Hubei University of Arts and Science

A nanocrystal-molecule complex composed of CdSe donor and Rhodamine B (RhB) acceptor is prepared to investigate the effect of accepter-donor ratio on the Fo?rster resonance energy transfer (FRET) process. To highlight the FRET process， the energy level alignment between CdSe and RhB is purposefully designed and CdSe nanocrystal is coated with a wide band-gap ZnS shell. The carrier dynamics is observed via combined spectral analysis. The results reveal clear FRET process between the CdSe donor and RhB acceptor. The FRET is enhanced by increasing RhB/CdSe ratio and a gradual saturation will be present at high RhB concentration.

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The effects of selenization conditions on the microstructure and optoelectronic properties of CZTSSe absorber layers prepared by the sol-gel method

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Optoelectronics Letters 2025年

作者： BAI xin XUE Yuming DAI Hongli wang Luoxin BAI xinfeng HU Xiaofeng Institute of New Energy Intelligence Equipment， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

Cu2ZnSnSSe4（CZTSSe） thin film solar cells， with adjustable bandgap and rich elemental content， hold promise in next-gen photovoltaics. Crystalline quality is pivotal for efficient light absorption and carrier transport. During the post-selenization process， understanding crystal growth mechanisms， and improving layer quality are essential. We explored the effects of ramp rate and annealing temperature on CZTSSe films， using XRD， Raman， SEM， and UV-Vis. The optimal performance occurred at 25.25 ℃/min ramp rate and 530℃ annealing. This led to smoother surfaces， higher density， and larger grains. This condition produced a single-layer structure with large grains， no secondary phases， and a 1.14 eV bandgap， making it promising for photovoltaic applications. The study has highlighted the effect of selenization conditions on the characteristics of the CZTSSe absorber layer and has provided valuable information for developing CZTSSe thin film solar cells.

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High-quality environmentally friendly photovoltaic CZTSSe thin films prepared by Mg doping

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Optoelectronics Letters 2025年

作者： Zhang Zihe Xue Yuming Dai Hongli wang Luoxin Bai xin Hu Xiaofeng Institute of New Energy Intelligence Equipment， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

CZTSSe thin films were prepared using the sol-gel method， and the crystal morphology of the CZTSSe films were improved by Mg doping. The prepared films were characterized using techniques such as XRD， Raman spectroscopy， SEM， and UV-Vis spectroscopy. The results showed that Mg replaced Zn in the CZTSSe lattice， forming the CMZTSSe phase. As the Mg doping concentration increased， the grain size initially increased and then decreased. After Mg doping， no additional impurities are *** the Mg doping concentration was 0.1， the film exhibited the optimal crystal morphology， narrowest peak width， largest grain size， the best light absorption properties smoothest and most compact surface， which is favorable for use as an absorber layer in solar cells.

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Enhancing the performance of the absorber of Cu2ZnSn（S， Se）4 photovoltaic materials by doping Cd2+

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Optoelectronics Letters 2025年

作者： YANG Shuqi XUE Yuming DAI Hongli wang Luoxin ZHANG Haiwei BAI xin Institute of New Energy Intelligence Equipment， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

Cationic doping is considered to be an effective way to improve the efficiency of Cu2ZnSn（S，Se）4（CZTSSe） photovoltaic materials. To improve the quality of the absorption layer of the crystal film， CZTSSe film was doped with some Cd to change the ratio of Cd and Zn in the precursor solution. XRD， Raman， SEM， UV-Vis spectroscopy， and other results showed that Cd successfully replaced Zn in the crystal lattice during post-selenization. The formation of harmful Zn-related defects was reduced， the grain size and crystallinity of the films were significantly increased， and the photoelectric properties of the films such as crystal quality and structural morphology were improved. As the Cd/（Cd+Zn） ratio increased from 0 to 0.35， the band gap of CZCTSSe decreased to 1.02eV. When Cd/（Cd+Zn）=0.25， the crystallinity and grain size reached the best value， and the film surface was smooth and dense， which inhibited the formation of the second phase on the surface of *** theoretical basis and experimental results showed that proper Cd doping can promote the growth of grain， so that compact CZCTSSe films with larger grain sizes and fewer holes could be prepared.

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