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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang meng-Chao Xiao Xia-Lu Hong ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-Lu Cui Bai-Nan Zheng Jin Ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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平台与密度的互补:本地即时电商如何赋能城市生活服务业?

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中国软科学 2024年第2期 74-84页

作者：黄维晨陆铭王越上海交通大学安泰经济与管理学院上海200030 上海交通大学安泰经济与管理学院中国发展研究院上海200030 饿了么新服务研究中心浙江杭州311100

随着中国经济社会迈入新发展阶段,服务业在经济和就业中“稳定器作用”将愈发凸显,但是经济的负面冲击加速了服务业数字化的进程,使得人们认为城市服务业不再依赖于人口密度。利用饿了么消费大数据,证实本地即时电商等数字平台与人口密... 详细信息

随着中国经济社会迈入新发展阶段,服务业在经济和就业中“稳定器作用”将愈发凸显,但是经济的负面冲击加速了服务业数字化的进程,使得人们认为城市服务业不再依赖于人口密度。利用饿了么消费大数据,证实本地即时电商等数字平台与人口密度存在互补作用,城市生活服务业能够借助于平台实现规模性、多样性、便利性以及适配性。具体而言:平台经济扩大城市内人口密度对于生活服务业的集聚效应,在本地市场上实现规模化;生活服务业在平台上供给内容的拓展,提高低密度地区居民的消费选择,缩小城市内消费选择的差异,带来福利的改进;生活服务业数字化给予消费者更合意的消费选择,提升了居民的生活便利度;更加精准的投放服务带来消费适配性的提高,同时人口密度能放大消费服务生产与需求的匹配效率,降低了消费的距离和出行成本。通过以上4个机制,线上平台经济赋能于生活服务业,推动城市实现高品质生活。

关键词：平台经济人口密度生活服务业线上消费

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menstrual blood-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 961-972页

作者： Xiao-zhou MOU Jian LIN Jin-yang CHEN Yi-fei LI Xiao-xing WU Bing-yu xiang Cai-yun LI Ju-ming MA Charlie xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated HospitalSchool of MedicineZhejiang University Institute for Cell-Based Drug Development of Zhejiang Province People's Hospital of Tongling S-Evans Biosciences The 117th Hospital of PLA Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

Orthotopic liver transplantation(OLT)is the only proven effective treatment for both end-stage and metabolic liver *** transplantation is a promising alternative for OLT,but the lack of available donor livers has hampered its clinical ***-like cells(HLCs)differentiated from many multi-potential stem cells can help repair damaged liver *** almost suitable cells currently identified for human use are difficult to harvest and involve invasive ***,a novel mesenchymal stem cell derived from human menstrual blood(menSC)has been discovered and obtained easily and *** this study,we examined whether the menSCs are able to differentiate into functional HLCs in *** three weeks of incubation in hepatogenic differentiation medium containing hepatocyte growth factor(HGF),fibroblast growth factor-4(FGF-4),and oncostain M(OSM),cuboidal HLCs were observed,and cells also expressed hepatocyte-specific marker genes including albumin(ALB),α-fetoprotein(AFP),cytokeratin 18/19(CK18/19),and cytochrome P450 1A1/3A4(CYP1A1/3A4).Differentiated cells further demonstrated in vitro mature hepatocyte functions such as urea synthesis,glycogen storage,and indocyanine green(ICG)*** intrasplenic transplantation into mice with 2/3 partial hepatectomy,the menSC-derived HLCs were detected in recipient livers and expressed human ALB *** also showed that menSC-derived HLC transplantation could restore the serum ALB level and significantly suppressed transaminase activity of liver injury *** conclusion,menSCs may serve as an ideal,easily accessible source of material for tissue engineering and cell therapy of liver tissues.

关键词： menstrual blood-derived mesenchymal stem cell(menSC) Differentiation Hepatocyte Intrasplenic transplantation Partial hepatectomy

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Design of detector to monitor the Bragg peak location of carbon ions by means of prompt γ-ray measurements with Geant4

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Nuclear Science and Techniques 2018年第4期29卷 83-91页

作者： Yan Fan Guang-ming Huang xiang-ming Sun Zhen Wang Shu-Guang Zou Jun Liu Dong Wang Hui-Li Kang Ping Yang Hua Pei Da-ming Sun Zi-Li Li PLAC Key Laboratory of Quark & Lepton Physics (MOE)Department of Physics Science and Technology Central China Normal University Wuhan 430079 Hubei China

Real-time monitoring of the Bragg peak location of carbon ions is urgently required for the quality control of hadron therapy. In this study, we design an annular detector to monitor the Bragg peak location of carbon ions with Geant4 simulation. This 360° surrounding structure has a high detection efficiency for the small-dose situation. The detector consists of a multilayered collimator system and an Na I scintillator for prompt gamma counting. The multilayered collimator includes a lead layer to prevent unwanted gammas and the paraffin and boron carbide layers to moderate and capture fast neutrons. An inclination of the detector further diminishes the background signal caused by neutrons. The detector, with optimized parameters, is applicable to carbon ions of different energies. In addition, the scintillator is replaced by an improved EJ301 organic liquid scintillator to discriminate gammas and neutrons. Inserting thin Fe slices into the liquid scintillator improves the energy deposition efficiency. The Bragg peak location of 200 me V/u carbon ions can be monitored by prompt gamma detection with the improved liquid scintillator.

关键词： Braggpeak Carbonion Promptc-ray Geant4

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改性钙基吸附剂在热解原位捕集CO_(2)中的性能

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中国环境科学 2024年第8期44卷 4455-4461页

作者：顾春晗苏明雪李宁朱兵合肥水泥研究设计院有限公司水泥制造绿色低碳技术安徽省重点实验室安徽合肥230022

鉴于固废热解原位吸附CO_(2)存在温度较高和吸附剂易烧结的挑战,采用了不同矿物掺杂的天然石灰石制备了一系列钙基固体吸附剂.热解原位单次吸附和循环吸附实验表明,10%蒙脱土掺杂的钙基吸附剂表现出较为稳定的循环吸附特性和更大的吸附... 详细信息

鉴于固废热解原位吸附CO_(2)存在温度较高和吸附剂易烧结的挑战,采用了不同矿物掺杂的天然石灰石制备了一系列钙基固体吸附剂.热解原位单次吸附和循环吸附实验表明,10%蒙脱土掺杂的钙基吸附剂表现出较为稳定的循环吸附特性和更大的吸附负荷,其CO_(2)吸附比最高可达71.52%.在经过10次循环后,仍能保持43.77%的吸附量,同时使热解气热值达到14kJ/g.因此,10%蒙脱土掺杂的钙基吸附剂在固废共热解中能够有效捕集CO_(2),提高热解气热值,具有良好的应用前景.

关键词：热解气 CO_(2) 原位捕集钙基吸附剂蒙脱土

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An improved method for RNA extraction from urediniospores of and wheat leaves infected by an obligate fungal pathogen, Puccinia striiformis f. sp. tritici

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Journal of Integrative Agriculture 2016年第6期15卷 1293-1303页

作者： MA Li-Jie QIAO Jia-xing KONG Xin-yu WANG Jun-juan XU xiang-ming HU Xiao-ping State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant Protection Northwest A&F University Yangling 712100 P.R.China Genetics and Crop Improvement East Mailing Research East Mailing ME19 6B J UK Erdos Ecological Environment of Career Academy Ordos 017010 P.R. China

Stripe rust, caused by Puccinia striiformis f. sp. tritici, is an important wheat disease in China, seriously threatening wheat production. Understanding the winter survival of the fungus is a key for predicting the spring epidemics of the disease, which determines the crop loss. Estimation of P. striiformis f. sp. tritici winter survival requires processing a large number of samples for sensitive detection of the pathogen in wheat leaf tissue using real-time quantitative reverse transcription PCR （qRT-PCR）. A bottleneck for the analysis is the acquisition of a good yield of high quality RNA suitable for qRT-PCR to distinguish dead and alive fungal hyphae inside leaves. Although several methods have been described in the literatures and commercial kits are available for RNA extraction, these methods are mostly too complicated, expensive and inefficient. Thus, we modified three previously reported RNA extraction methods with common and low-cost reagents （LiCI, SDS and NaCI） to solve the problems and selected the best to obtain high quality and quantity RNA for use in qRT-PCR. In the three improved methods, the NaCI method was proven to be the best for extracting RNAfrom urediniospores of and wheat leaves infected by P. striiformis f. sp. tritici, although the modified LiCI and SDS methods also increased yield of RNA compared to the previous methods. The improved NaCI method has the following advantages： 1） Complete transfer of urediniospores of P. striiformis f. sp. tritici from the mortar and pestle can ensure the initial amount of RNA for the qRT-PCR analysis; 2） the use of low-cost NaCI to replace more expensive Trizol can reduce the cost; 3） the yield and quality of RNA can be increased; 4） the improved method is more suitable for a large number and high quantity of samples from fields. Using the improved NaCI method, the amount of RNA was increased three times from urediniospores of P. striiformis f. sp. tritici compared from the extraction kit. Approximately, 1

关键词： Puccinia striiformis f. sp. tritici RNA extraction RT-PCR urediniospore mycelium

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新质生产力与碳生产率:效应与机制

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技术经济与管理研究 2024年第10期 91-96页

作者：岳明阳徐政刘穷志中共江苏省委党校经济学教研部江苏南京210009 江苏省习近平新时代中国特色社会主义思想研究中心省委党校基地江苏南京210013 武汉大学经济与管理学院湖北武汉430072

选取2013—2022年中国30个省级面板数据,探究新质生产力对碳生产率的影响。研究发现:第一,新质生产力发展对碳生产率的提升具有显著的正向作用,经过一系列稳健性检验和处理内生性问题后结论仍然成立。第二,新质生产力对碳生产率提升的... 详细信息

选取2013—2022年中国30个省级面板数据,探究新质生产力对碳生产率的影响。研究发现:第一,新质生产力发展对碳生产率的提升具有显著的正向作用,经过一系列稳健性检验和处理内生性问题后结论仍然成立。第二,新质生产力对碳生产率提升的影响存在异质性,分地区来看,中西部地区的碳生产率提高效应相对显著;分维度来看,科技、创新和绿色生产力的碳生产率提高效应存在差异性,具体为绿色生产力>科技生产力>创新生产力。第三,资源错配的降低和产业结构高级化是新质生产力发展引起碳生产率提高的重要机制,经济集聚对新质生产力与碳生产率之间的正向关系存在非线性调节作用。

关键词：新质生产力碳生产率产业结构高级化经济集聚

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废旧锂离子电池回收制备MnO_(2)及其储锌性能

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洁净煤技术 2024年第2期30卷 209-218页

作者：彭雪刘培艳夏铭刘媛媛烟台大学化学化工学院山东烟台264005 南京工业大学化工学院江苏南京211816

随着锂离子电池产业的快速发展,退役锂离子电池的回收利用问题已成为工业和学术界关注的热点。前人对废旧锂离子电池中有价值资源的回收做了大量研究,但将回收的锂离子电池材料直接转化为新型储能体系电极材料的研究鲜有报道。为实现退... 详细信息

随着锂离子电池产业的快速发展,退役锂离子电池的回收利用问题已成为工业和学术界关注的热点。前人对废旧锂离子电池中有价值资源的回收做了大量研究,但将回收的锂离子电池材料直接转化为新型储能体系电极材料的研究鲜有报道。为实现退役电池的资源化再利用,可通过简单的H_(2)SO_(4)浸渍法,将废旧锂离子电池中锰酸锂(LiMn_(2)O_(4))材料转化为MnO_(2),并用做水系锌离子电池正极材料。通过XRD、XPS、BET、SEM、CV、TEM、EIS以及电化学性能测试等表征方法,探究酸浸渍条件如温度、时间等对所制备MnO_(2)形貌、结构和电化学性能的影响规律。结果表明:LiMn2O4材料经酸浸渍会发生歧化反应,使Li^(+)和部分Mn^(2+)从晶格中溶出,而浸渍温度对离子的溶出速度有显著影响。室温下,LiMn_(2)O_(4)晶格中离子的溶出速度较慢,可获得与其晶体结构相近的λ-MnO_(2)材料;而水热条件下,高反应温度会加剧晶格中原子的振动,加快离子溶出速度,形成晶体结构更紧密且热力学更稳定的γ-MnO_(2)和β-MnO_(2)。电化学性能测试结果显示,具有纳米棒状形貌和较大比表面积的γ-MnO_(2)材料,表现出较高的放电比容量和最优的循环稳定性,在0.3和3.0 A/g电流密度下,其放电比容量分别为273.3和127.2 mAh/g。在3.0 A/g电流密度下,γ-MnO_(2)材料经200、500和1 000圈循环后,其容量保持率高达77.1%、65.7%和43.9%。此外,通过ex-XRD表征研究发现,该Zn//MnO2电池的电化学储能机理遵循H^(+)/Zn^(2+)共插入/脱出机制。

关键词：废旧锰酸锂回收二氧化锰水系锌离子电池正极材料

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Released energy formula for proton radioactivity based on the liquid-drop model

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Communications in Theoretical Physics 2021年第7期73卷 89-94页

作者： Xiao Pan You-Tian Zou Hong-ming Liu Biao He Xiao-Hua Li Dong xiang School of Nuclear Science and Technology University of South ChinaHengyang 421001China College of Physics and Electronics Central South UniversityChangsha 410083China National Exemplary Base for International Sci&Tech.Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In this work,based on the liquid-drop model and considering the shell correction,we propose a simple formula to calculate the released energy of proton radioactivity(Q_(p)).The parameters of this formula are obtained by fitting the experimental data of 29 nuclei with proton radioactivity from ground *** standard deviation between the theoretical values and experimental ones is only 0.157 me *** addition,we extend this formula to calculate 51 proton radioactivity candidates in region 51≤Z≤83 taken from the latest evaluated atomic mass table Ame2016 and compared with the Q_(p)calculated by WS4 and *** calculated results indicate that the evaluation ability of this formula for Q_(p)is inferior to WS4 while better than HFB-29.

关键词： the released energy of proton radioactivity liquid-drop model shell correction

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Manipulation of band gap in 1T-TiSe_(2) via rubidium deposition

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Chinese Physics B 2024年第8期33卷 102-106页

作者：欧仪陈磊信子鸣任宇靖袁鹏浩王政国朱玉陈景芝张焱 International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China

The 1T-TiSe_(2) is a two-dimensional charge-density-wave(CDW)material that attracts great interest.A small band gap locates at the Fermi level separating the Ti d-bands and Se p-bands,which makes 1T-TiSe_(2) a promising candidate for realizing excitonic ***,we studied the band gap in 1T-TiSe_(2) using angle-resolved photoemission spectroscopy(ARPES).Instead of only focusing on the in-plane band dispersions,we obtained the detailed band dispersions of both conduction and valance bands along the out-of-plane *** found that the conduction and valance bands split into multiple sub-bands in the CDW state due to band *** a result,the band gap between the Ti d-bands and Se p-bands reduces to~25 meV and becomes a direct gap in the CDW *** intriguingly,such band gap can be further reduced by the rubidium *** band structure becomes semimetallic in the rubidium-doped ***,exotic gapless behaviors were observed at the p-d band *** result characterized the band gap of 1T-TiSe_(2) in three-dimensional Brillouin zone with unpreceded *** also suggests a closing of band gap or a potential band inversion in 1T-TiSe_(2) driven by rubidium deposition.

关键词： angle-resolved photoemission spectroscopy metal–insulator transition transition metal dichalcogenides

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