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A reference-grade genome of the xerophyte Ammopiptanthus mongolicus sheds light on its evolution history in legumes and droughttolerance mechanisms

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Plant Communications 2024年第7期5卷 157-177页

作者： Lei Feng Fei Teng Na Li Jia-Cheng Zhang Bian-Jiang Zhang Sau-Na Tsai Xiu-Le Yue Li-Fei Gu Guang-Hua Meng Tian-Quan Deng Suk-Wah Tong Chun-ming Wang yan Li Wei Shi Yong-Lun Zeng Yue-ming Jiang Weichang Yu Sai-ming Ngai Li-Zhe An Hon-ming Lam Jun-xian He School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongSha TinNew TerritoriesHong KongChina Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China BGI-Shenzhen Tech Co. Ltd.Beishan Industrial ZoneYantian DistrictShenzhen 518083China School of Life Sciences and Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations Lanzhou UniversityLanzhou 730030China State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Applied Botany&Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China

Plants that grow in extreme environments represent unique sources of stress-resistance genes and *** mongolicus(Leguminosae)is a xerophytic evergreen broadleaf shrub native to semi-arid and desert regions;however,its drought-tolerance mechanisms remain poorly ***,we report the assembly of a reference-grade genome for ***,describe its evolutionary history within the legume family,and examine its drought-tolerance *** assembled genome is 843.07 Mb in length,with 98.7%of the sequences successfully anchored to the nine chromosomes of *** genome is predicted to contain 47611 protein-coding genes,and 70.71%of the genome is composed of repetitive sequences;these are dominated by transposable elements,particularly longterminal-repeat *** analyses revealed two whole-genome duplication(WGD)events at 130 and 58 million years ago(mya)that are shared by the genus Ammopiptanthus and other legumes,but no species-specific WGDs were found within this *** genome reconstruction revealed that the *** genome has undergone fewer rearrangements than other genomes in the legume family,confirming its status as a"relict plant".Transcriptomic analyses demonstrated that genes involved in cuticular wax biosynthesis and transport are highly expressed,both under normal conditions and in response to polyethylene glycol-induced *** induction of genes related to ethylene biosynthesis and signaling was also observed in leaves under dehydration stress,suggesting that enhanced ethylene response and formation of thick waxy cuticles are two major mechanisms of drought tolerance in *** expression of AmERF2,an ethylene response factor unique to ***,can markedly increase the drought tolerance of transgenic Arabidopsis thaliana plants,demonstrating the potential for application of *** genes in crop improvement.

关键词： Ammopiptanthus mongolicus genome sequencing genome evolution drought tolerance cuticular wax ethylene

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Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： xian-Shuai Kou Fan-Fan Li Yun Meng Jian-ming Zhao Sheng-Fen Liu Lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus *** prognosis is generally *** case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented *** SUMMARY The patient presented with large HCC complicated by intratumoral *** involved a multidisciplinary approach,providing individualized *** strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody *** months after treatment,the patient achieved complete radiological remission,with significant symptom *** studies showed no lesions or recurrence,and clinical assessments confirmed complete *** report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar *** This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report

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Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

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Journal of Pharmaceutical Analysis 2024年第6期14卷 926-929页

作者： Shiyu Chen Yuxuan Li Yingrui Zhang Hongren Yao Tong Xu Yi Zhang Jin-ming Lin xian-Li Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing100084China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China

Microneurovascular units(mNVUs),comprising neurons,micro-glia,and blood-brain barrier(BBB)endothelial cells,are pivotal to the central nervous system and are associated with cerebral hypoxia and brain *** hypoxia triggers microglial overactivity,causing inflammation,neuronal injury,and disruption of the BBB[1].Salidroside(Sal),a key compound in Tibetan medicine Rhodiola crenulata,mitigates hypoxia-induced metabolic disorders and neuronal damage by preserving mitochondrial function[2].

关键词： injuries preserving Tibetan

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Tetraphenylethylene dicycle helicates: circularly polarized luminescence and chiral recognition based on emission wavelength change

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Science China Chemistry 2024年第11期67卷 3817-3824页

作者： Zhi-Rong Xu Miao-Li Gao ming Hu Wei Yu yan-Song Zheng Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Chiral tetraphenylethylene(TPE) dicycle tetraaldehyde and TPE dicycle tetraacids bearing optically pure groups on the cycles were designed and synthesized. Due to the propeller-like conformation immobilization of TPE unit, this new class of TPE dicycle was resolved into M-and P-enantiomers, which could emit strong circular polarized luminescence(CPL). Interestingly,these TPE helicates displayed exceptional ability of molecule recognition. While the TPE dicycle tetraaldehyde could detect the microscale water in anhydrous tetrahydrofuran, the chiral TPE dicycle tetraacid could display different fluorescent color after interacting with two enantiomers of a wide variety of chiral amines including monoamines, diamines, and aminols, which could be applied to chiral recognition of these chiral amines. Furthermore, the emission wavelength of TPE dicycle tetraacid was found to change linearly with the enantiomer purity of chiral amine from enantiomer excess(ee) percent-100% to +100%, for the first time showing the potential for quantitative chiral analysis of chiral amines based on emission wavelength change. The emission wavelength was affected less by environmental factors than fluorescence intensity, which would enable the chiral analysis based on wavelength change with higher accuracy and repeatability.

关键词： TPE dicycle helicate CPL chiral recognition enantiomer excess analysis emission wavelength change

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Engineering molecular regulation for SiO_(x) with long-term stable cycle and high Coulombic efficiency as lithium-ion battery anodes

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Rare Metals 2024年第2期43卷 588-598页

作者： Fei Wang Han Gao Zhao-Yu Niu Yao-Peng Zheng ming-yan Chuai Jia-Nan Xu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

In the current situation where the practical application of silicon anode materials encounters great challenges,silicon oxide(SiO_(x),0≤x≤2)has attracted the attention of researchers due to its relatively small volume expansion,stable cycling performance,and low cost,which is possible to realize commercial applications earlier than silicon ***,it remains a challenge to prepare SiO_(x)materials with long-term stable cycling performance and high Coulombic efficiency using low-cost *** this work,SiO_(x)anode material with high Coulombic efficiency and good long-term cycling stability was prepared at a low cost by hydrolysis of siloxane and in situ polymerization of phenolic *** hydrolysis of siloxane was further regulated by different silane coupling agents to regulate the size and microstructure of prepared SiO_(x)materials,which displayed the substantially improved electrochemical *** excellent electrochemical performance of SiO_(x)prepared by regulated hydrolysis of siloxane with silane coupling agents is attributed to the effect of silane coupling agent on size and microstructure of SiO_(x),revealing that the strategy of modulating the hydrolysis of siloxane by silane coupling agent is a potential method to prepare high-performance SiO_(x)materials.

关键词： Hydrolysis Silane coupling agent Long cycle SiO_(x) anode Lithium-ion battery(LIB)

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Effect of temperature and reaction path interaction on fluidization reduction kinetics of iron ore powder

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Journal of Iron and Steel Research International 2024年第8期31卷 1840-1849页

作者： Guo-min Zhu ming-wei Hu An-nan Dou Jin-yu Huang Jing Ding Qi-yan Xu School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina

Due to the instability of FeO at temperatures below 843 K,the fuidization reduction pathway of iron ore powder changes with the reduction ***,the effect of temperature and reaction pathway interaction on the kinetics of fuidization reduction of iron ore powder under low-temperature conditions ranging from 783 to 903 K was investigated to describe the fluidization reduction rate of iron ore powder from three aspects:microstructure change,reaction limiting link,and apparent activation energy of the reaction,exploring their internal *** experimental results revealed that in a temperature range of 783-813 K,the formation of a dense iron layer hindered the internal diffusion of reducing gas,resulting in relatively high gas diffusion *** addition,due to the differences in limiting links and reaction pathways in the intermediate stage of reduction,the apparent activation energy of the reaction *** apparent activation energy of the reaction ranged from 23.36 to 89.13 kJ/mol at temperature ranging from 783 to 813 K,while it ranged from 14.30 to 68.34 kJ/mol at temperature ranging from 873 to 903 K.

关键词： Reaction limiting link Gas internal diffusion Interface reaction Apparent activation energy Iron ore powder Reaction pathway Fluidization reduction

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Sepsis one-hour bundle management combined with psychological intervention on negative emotion and sleep quality in patients with sepsis

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World Journal of Psychiatry 2024年第2期14卷 266-275页

作者： ming Xia Guang-yan Dong Shi-Chao Zhu Huan-Min Xing Li-ming Li Department of Intensive Care Unit Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Nursing Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUND Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately *** usually experience depression and anxiety,which affect their sleep quality and post-traumatic growth *** To investigate the effects of sepsis,a one-hour bundle(H1B)management was combined with psychological intervention in patients with *** This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People’s Hospital between June 2022 and June *** to different intervention methods,the participants were divided into a simple group(SG,n=150)and combined group(CG,n=150).H1B management was used in the SG and H1B management combined with psychological intervention was used in the *** changes of negative emotion,sleep quality and post-traumatic growth and prognosis were compared between the two groups before(T0)and after(T1)*** After intervention(T1),the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG(P<0.001).Sleep time,sleep quality,sleep efficiency,daytime dysfunction,sleep disturbance dimension score,and the total score in the CG were significantly lower than those in the SG(P<0.001).The appreciation of life,mental changes,relationship with others,personal strength dimension score,and total score of the CG were significantly higher than those of the SG(P<0.001).The scores for mental health,general health status,physiological function,emotional function,physical pain,social function,energy,and physiological function in the CG were significantly higher than those in the SG(P<0.001).The mechanical ventilation time,intensive care unit stay time,and 28-d mortality of the CG were significantly lower than those of the SG(P<0.05).CONCLUSION H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and inc

关键词： Cluster management Psychological intervention Sepsis Negative emotions Sleep quality Post-traumatic growth

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-xiang Gu xian-Xia yan Hong-Wei Fan ming-ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8^(+)T Cell Immunity against Tumor

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Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu Zheng Yin Hui yan xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu xian C.Li Wenhao Chen Immunobiology and Transplant Science Center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of Radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor CD8^(+)T cells using the TRAMP-C1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that CD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor CD8^(+)T cells,we conducted 3 adoptive cell therapy(ACT)***,depleting ***^(+)CD8^(+)TILs derived from ACT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor CD8^(+)T cells used for ACT led to a reduction in the frequency and effector differentiation of CD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor CD8^(+)T cells during ACT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining CD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation

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Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： Xuan Liu Zi-Xia Lin Yin-Biao Shi Xiao-yan Wang ming-Ye Ding Xiao-Fei yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

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