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Conjugate Points on a Type of Kahler Manifolds

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Acta Mathematica Sinica,English Series 2013年第6期29卷 1175-1184页

作者： wei ming liu Fu Sheng DENG Department of Mathematics and Physics Beijing Institute of Petrochemical Technology School of Mathematical Sciences Graduate University of Chinese Academy of Sciences

We study conjugate points on a type of Khler manifolds, which are submanifolds of Grassmannian manifolds. And then we give the applications to the study of the index of geodesics and homotopy groups.

关键词： Conjugate points Jacobi equation Khler manifolds

Distribution of P2O5 between solid solution and liquid phase in dephosphorization slag of CaO-SiO2-FeO-P2O5-Na2O system

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Journal of Iron and Steel Research International 2019年第11期26卷 1162-1170页

作者： Chuan-ming Du Ning-ning Lv Chang Su wei-ming liu Jin-xing Yang Hai-chuan Wang Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendaiMiyagi 980-8577Japan School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Anhui University of Technology) Ministry of Education.Ma'anshan 243002Anhui.China

A multi-phase slag containing Na2O is potential to efficiently dephosphorize high-P hot *** dephosphorization,the generated slag with high P2O5 content is regarded as a P *** P2O5 was mainly concentrated in the 2CaO SiO2-3CaO P2O5 solid solution,the recovery of P from dephosphorization slag primarily depends on the separation of the solid solution from other *** distribution ratios of P2O5 between solid solution and liquid phase in the CaOSiO2-FeO-P2O5-Nslag system were *** results indicated that the addition of Na2O facilitated the enrichment of P2O5 in the solid solution because it increased not only the distribution ratio of P2O5 but also the mass fraction of the solid *** distribution ratio of P2O5 was independent of the P2O5 content in slag.A higher P2O5 content in slag resulted in higher P2O5 and Na2O contents in the solid *** distribution ratio of P2O5 increased with the total Fe content in the liquid phase,regardless of the valence of *** increase in the FeO content in slag brought a higher P2O5 content in the solid *** slag basicity increased,the distribution ratio of P2O5 increased,but the P2O5 content in the solid solution decreased.

关键词： Dephosphorization Steelmaking slag Distribution ratio P2O5 2CaO·SiO2-3CaO·P2O5 solid solution

Morin, a matrix metalloproteinase 9 inhibitor, attenuates endothelial-to-mesenchymal transition in atherosclerosis by downregulating Notch-1 signaling

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Journal of Integrative Medicine 2024年第6期22卷 683-695页

作者： Yuan He Xiao-xuan Qin ming-wei liu wei Sun Department of Cardiology Jiangsu Provincial People's Hospital Nanjing Medical University Department of Neurology Jiangsu Provincial People's Hospital Nanjing Medical University

Objective: Atherosclerotic cardiovascular disease poses a significant health challenge globally. Recent findings highlight the pivotal role of the endothelial-to-mesenchymal transition(End MT) in atherosclerosis. Morin is a bioflavonoid mainly extracted from white mulberry, a traditional Chinese herbal medicine with anti-inflammatory and antioxidant properties. This study examines whether morin can alleviate atherosclerosis by suppressing End MT and seeks to elucidate the underlying ***: We induced an in vitro End MT model in human umbilical vein endothelial cells(HUVECs) by stimulating the cells with transforming growth factor-β1(TGF-β1)(10 ng/m L) for 48 h. The in vivo experiments were performed in an atherosclerosis model using apolipoprotein E(Apo E)–/–mice fed with a high-fat diet(HFD). Mice in the intervention group were given morin(50 mg/kg) orally for 4 *** docking and microscale thermophoresis were assayed to understand the interactions between morin and matrix metalloproteinase-9(MMP-9).Results: Morin inhibited the expression of End MT markers in a dose-dependent manner in TGF-β1-treated HUVECs. Administering 50 μmol/L morin suppressed the upregulation of MMP-9 and Notch-1 signaling in TGF-β1-induced End MT. Moreover, the overexpression of MMP-9 activated Notch-1 signaling,thereby reversing morin's inhibitory effect on End MT. In the HFD-induced atherosclerotic Apo E–/–mice,morin notably reduced aortic intimal hyperplasia and plaque formation by suppressing End ***, morin demonstrated a strong binding affinity for ***: Morin acts as an MMP-9 inhibitor to disrupt End MT in atherosclerosis by limiting the activation of Notch-1 signaling. This study underscores morin's potential utility in the development of antiatherosclerotic medication.

关键词： Morin Endothelial-to-mesenchymal transition Atherosclerosis Traditional Chinese medicine Matrix metalloproteinase-9

Inhibition of viability of human retinal microvascular endothelial cells by vialinin A under high glucose condition

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1809-1815页

作者： Zhi-Gang Chen Gao-Qin liu wei-ming liu Pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Jiangsu Clinical Immunology Institute the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To investigate the effects of vialinin A on viability of human retinal endothelial cells(HRECs)under high glucose condition and its potential ***:The HRECs were divided into four groups:normal glucose control group(NG,5 mmol/L D-glucose),high glucose group(HG,30 mmol/L D-glucose),HG+1μmol/L vialinin A group,and HG+5μmol/L vialinin A *** cell viabilities were measured with cell counting kit-8(CCK-8)assay for proliferation,with scratch assay for migration,and tube formation,for evaluation of the impact of vialinin A on cellular ***-time PCR and Western blotting were used to determine the expression level of vascular endothelial growth factor(VEGF).RESULTS:The proliferative capacity and migration of HRECs was reduced by 5μmol/L vialinin A in high glucose environment(both P<0.05).Vialinin A also inhibited highglucose-induced tube formation of *** expression level of VEGF and PI3K in HRECs was also significantly decreased by vialinin A(P<0.05).CONCLUSION:Vialinin A inhibits the cell viability of *** may serve as a potential target for anti-angiogenic therapy.

关键词： vialinin A vascular endothelial growth factor human retinal endothelial cells cell viability

Effects of micro-alloying and production process on precipitation behaviors and mechanical properties of HRB600

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Journal of Iron and Steel Research International 2017年第5期24卷 536-543页

作者： Hong-bo Pan Meng-jiao Zhang wei-ming liu Jun Yan Hui-ting Wang Chang-sheng Xie Zhan Guo Key Laboratory of Metallurgical Emission Reduction & Resources Recycling of Ministry of Education Anhui University of Technology Ma'anshan 243002 Anhui China Anhui Province Key Laboratory of Metallurgy Engineering & Resources Recycling Anhui University of Technology Ma'anshan 243002 Anhui China School of Metallurgical Engineering Anhui University of Technology Ma'anshan 243002 Anhui China Technology Center Ma'anshan Iron & Steel Company Limited Ma'anshan 243000 Anhui China

Effects of micro-alloying elements and production process on microstructure, mechanical properties and precipitates of 600 MPa grade rebars were studied by using pilot test, metallographic observa- tion, tensile test, thermodynamic calculation and transmission electron microscopy. The results show that the tested steels are composed of ferrite and pearlite, in which the conterlt range of pearlite is 33%-45%. For vanadium micro-alloyed steel, interphase preeipitation Strengthening effect of V can be promoted and the yield strength of tested steels can be increased with increasing V content and de- creasing finishing rolling temperature. The temperature of terminated cooling should be more than 700 ℃ when the water cooling is used. When niobium is added to the steel, more coarse （Nb,V）C,N precipitates are generated at high temperature, so that the solid solubility of precipitated phases of vanadium is reduced and the precipitation strengthening effect of vanadium is weakened.

关键词： Micro-alloying High-strength steel rebar Thermo-mechanical controlling process Mechanical property Precipitation strengthening Thermodynamics

Silicate Adsorption in Paddy Soils of Guangdong Province, China

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Pedosphere 2006年第5期16卷 654-659页

作者： HUANG Li-Yuan LI Hua-Xing ZHANG Xin-ming LU wei-Sheng liu Yuan-Jin Department of Soil Science South China Agricultural University Guangzhou 510642 （China）

Silicate adsorption in eight paddy soils developed from four different parent materials in Guangdong Province, China was examined to obtain fundamental knowledge of silicate adsorption to improve the efficacy of silicate fertilizer use in these areas. A correlation analysis showed that silicate adsorption did not obey the Langmuir equation (r = -0.664-0.301) but did obey the Freundlich and Temkin equations (P Pearl River Delta sediment-derived > granite-derived > sand-shale-derived. Stepwise regression and path analysis showed that for the investigated paddy soils amorphous MnO and Al2O3 were the two most important materials that affected silicate adsorption. Moreover, as Ci increased, amorphous Al2O3 tended to play a more important role in silicate adsorption, while the effects of amorphous MnO on silicate adsorption tended to decrease.

关键词： Guangdong Province paddy soils parent materials silicate adsorption

Trimethylamine N-oxide aggravates vascular permeability and endothelial cell dysfunction under diabetic condition:in vitro and in vivo study

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 25-33页

作者： Jia-Yi Jiang wei-ming liu Qiu-Ping Zhang Hang Ren Qing-Ying Yao Gao-Qin liu Pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Suzhou Center for Disease Prevention and Control Suzhou 215004Jiangsu ProvinceChina

AIM:To provide the direct evidence for the crucial role of trimethylamine N-oxide(TMAO)in vascular permeability and endothelial cell dysfunction under diabetic ***:The role of TMAO on the in vitro biological effect of human retinal microvascular endothelial cells(HRMEC)under high glucose conditions was tested by a cell counting kit,wound healing,a transwell and a tube formation *** inflammation-related gene expression affected by TMAO was tested by real-time polymerase chain reaction(RT-PCR).The expression of the cell junction was measured by Western blotting(WB)and immunofluorescence *** addition,two groups of rat models,diabetic and non-diabetic,were fed with normal or 0.1%TMAO for 16wk,and their plasma levels of TMAO,vascular endothelial growth factor(VEGF),interleukin(IL)-6 and tumor necrosis factor(TNF)-αwere *** vascular permeability of rat retinas was measured using FITC-Dextran,and the expression of zonula occludens(ZO)-1 and claudin-5 in rat retinas was detected by WB or immunofluorescence ***:TMAO administration significantly increased the cell proliferation,migration,and tube formation of primary HRMEC either in normal or high-glucose ***-PCR showed elevated inflammation-related gene expression of HRMEC under TMAO stimulation,while WB or immunofluorescence staining indicated decreased cell junction ZO-1 and occludin expression after high-glucose and TMAO *** rats showed higher plasma levels of TMAO as well as retinal vascular leakage,which were even higher in TMAO-feeding diabetic ***,TMAO administration increased the rat plasma levels of VEGF,IL-6 and TNF-αwhile decreasing the retinal expression levels of ZO-1 and ***:TMAO enhances the proliferation,migration,and tube formation of HRMEC,as well as destroys their vascular integrity and tight *** also regulates the expression of VEGF,IL-6,and TNF-α.

关键词： diabetic model trimethylamine N-oxide inflammation endothelial dysfunction rats retinal microvascular endothelial cells

Time trends and gender disparities of Chinese cataract burden and their predictions

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1527-1534页

作者： Tian-Hong Wu Bo Jiang wei-ming liu Jian-Qing Li Zi-Yue Song Pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To evaluate the trends and changes in the number and rates of disability-adjusted life years(DALYs)and prevalence of cataract in China between 1990 and 2019,and to predict the trends of cataract burden from 2020 to ***:The Global Burden of Diseases(GBD)database was employed to collect the data on DALYs and the prevalence of cataract in China,which was distinguished by age and sex during the past three decades from 1990 to 2019,and then changes in the number and rates of cataract from 2020 to 2030 were *** data were analyzed by the R program(version 4.2.2)and GraphPad Prism 9.0 statistics ***:The number of DALYs of cataract increased from 449322.84 in 1990 to 1087987.61 in 2019,number of cataract cases increased from 5607600.94 in 1990 to 18142568.96 in *** age-standardized DALY rates(ASDR)generally increased slightly[estimated annual percentage change(EAPC=0.1;95%CI:-0.24 to 0.45)],age-standardized prevalence rates(ASPR)also increased(EAPC=0.88;95%CI:0.6 to 1.15).Cataract burden increased with age and female *** the causes of cataract,air pollution was the most important,followed by smoking,high fasting plasma glucose,and high body mass index(BMI).The burden of cataract is predicted to grow persistently from 2020 to 2030,the number of DALYs and prevalence for cataract will rise to 2336431 and 43698620 respectively by 2030,the ASDR is predicted to be 85/100000 and ASPR will be 1586/100000 in 2030,females will still be at greater risk of suffering from cataract than ***:The burden of cataract in China kept rising from 1990 to *** age and female gender are risk factors for *** pollution,smoking,high fasting plasma glucose,and high BMI are associated with *** burden of cataract in China will gradually increase from 2020 to 2030,the elderly women in particular need *** results may be of help for providing reference strategies to reduce cataract burden in the near future

关键词： cataract disease burden tendency prediction

Arterioles in cerebral amyloid angiopathy and vascular dementia

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Chinese Medical Journal 2009年第24期122卷 2985-2988页

作者： ZHU Guang-ming ZHANG wei-wei liu Ying LI Juan Department of Neurology Beijing Military General HospitalBeijing 100700 China

Background Small cerebrovascular lesions are one of the most important factors in cerebral amyloid angiopathy （CAA） and vascular dementia （VaD）. We analyzed the difference of arteriolar pathology between CAA patients （CAAs） and vascular dementia patients without CAA （VaDs）. Methods Ten deceased CAAs and twelve deceased VaDs were available for this study. Five deceased patients without known cerebrovascular diseases served as controls. These patients were all autopsy cases. All transversely cut arterioles in the gray matter and white matter with an external diameter equal to or larger than 30 um and with a maximum of 300 um were examined. The internal and external diameters of arterioles were measured. Results The external diameter of gray matter arterioles in the CAAs was significantly greater than in controls. In gray matter arterioles, the diameter of the lumen in VaDs was markedly smaller than in the CAAs, whereas there was no significant difference between CAAs and controls. CAAs and VaDs may cause remarkable thickening of the arteriolar walls in either white matter or gray matter. The sclerotic index of arterioles in VaDs was significantly greater than in CAAs and controls. Conclusions Stenosis of arterioles occurred in both CAA and VaD, but the tendency was greater in VaD. Arterioles of CAA were also expanded in gray matter, which may be related to lobar hemorrhage. The loss and/or degeneration of vascular smooth muscle cells was predominant in CAA, while the over-proliferation of vascular smooth muscle cells was areater in VaD.

关键词： arterioles cerebral amyloid angiopathy vascular dementia