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Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation

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Nano Research 2025年第1期18卷 559-571页

作者： Chunting He Penghui He Xue tang Shuting Bai ming Qin Yunting Zhang Zhaofei Guo Guangsheng Du Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China

Being a Th2 stimulator,classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous *** a thirdgeneration bisphosphonate,zoledronate(ZOL)can enhance antigen crosspresentation by inhibiting key enzymes of the mevalonate ***,we developed the subunit antigen ovalbumin(OVA)and ZOL co-loaded aluminum hydroxide nanoparticles(APN-OVA-ZOL)and investigated their capacity for inducing cellular immune responses against the *** results showed that the developed nanovaccines could successfully encapsulate OVA and ZOL,and enabled efficient lymph node *** by the mevalonate pathway inhibition effect of ZOL,APN-OVA-ZOL significantly promoted *** a result,APN-OVA-ZOL induced robust cellular immunity,including the activation of T and B *** a EG7-OVA tumor-bearing murine model,APN-OVA-ZOL significantly inhibited the tumor growth and prolonged mice *** work provided a strong empirical foundation indicating that zoledronate-loaded aluminum salt nanovaccines had a strong potency for cancer immunotherapy.

关键词： zoledronate(ZOL) mevalonate pathway antigen cross-presentation cellular immune responses

Photoinhibitive and Recovery Properties of Hybrid Rice Ⅱ You 129 under Field Conditions

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Rice Science 2003年第Z1期 33-37页

作者： XU Xiao-ming~1, tang Yun-lai~2, WANG Ying~1, LU Wei~1, DAI Xin-bin~1, ZHANG Rong-xian~1, KUANG Ting-yun~2 (~1Agronomy Department, Nanjing Agricultural University, Nanjing 210095, China ~2 Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China)

Photoinhibitive properties of super-high-yielding hybrid rice Ⅱ you 129 and its adaptation mechanism to strong light stress were investigated by measuring the light-response curve, diurnal variations of net photosynthetic rate and chlorophyll fluorescence parameters of Ⅱ you 129 leaves and compared with Shanyou 63. Photoinhibition of rice flag leaves under field conditions mainly resulted from the increase of thermal dissipation, especially for thermal dissipation depended on the xanthophyll circle, but no destruction of photosynthetic apparatus occurred. Potentially super-high-yielding hybrid rice Ⅱ you 129 was more tolerant to photoinhibition than Shanyou 63, because it had higher light saturation intensity and maximum net photosynthetic rate; more active xanthophyll cycle, and more rapid recovery ability after photoinhibition.

关键词： rice photoinhibition chlorophyll fluorescence xanthophyll cycle

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian tang Yuan-ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480

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World Journal of Gastroenterology 2008年第26期14卷 4227-4233页

作者： ming-Yu lai Jie-An Huang Zhi-Hai Liang Hai-Xing Jiang Guo-Du tang Department of Gastroenterology First Affiliated Hospital Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous Region China

AIM： To investigate the effects of aspirin （acetylsalicylic acid） on proliferation and apoptosis of colorectal cancer cell line SW480 and its mechanism. METHODS： Cyclooxygenase （COX）-2 negative colorectal cancer cell line SW480 was treated with aspirin at concentrations of 2.5 mmol/L, 5.0 mmol/L, 10.0 mmol/L for different periods in v/tro. Anti-proliferation effect of aspirin on SW480 was detected by 3-（4,5-dimeth- ylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay. Cell cycle and apoptosis were observed by flow cytometry （FCM）. Transmission electron microscope （TEM） was used for morphological study. Apoptosis-associated genes were detected by immunohistochemical staining and Western blotting. RESULTS： Aspirin inhibited SW480 proliferation and induced apoptosis in a dose- and time-dependent manner. Treatment with different concentrations of aspirin significantly increased the proportions of cells at the G0/G1 phase and decreased the proportions of cells at the S- and G2/M phases in a concentration-dependent manner. Aspirin not only induced apoptosis but also caused cell necrosis at a high concentration as well. After treatment with aspirin, SW480 cells displayed typically morphological features of apoptosis and necrosis under TEM, and increased the Bcl-2 expression in cells, but the expression of Bax was down regulated. CONCLUSION： Aspirin inhibits proliferation and induces apoptosis of SW480 cells. Its anti-tumor mechanism may arrest cell cycle and shift Bax/Bcl-2 balance in cells.

关键词： Aspirin Colorectal cancer Proliferation Apoptosis

Abundance and Diversity of RuBisCO Genes Responsible for CO_2 Fixation in Arid Soils of Northwest China

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Pedosphere 2015年第1期25卷 150-159页

作者： tang Zhi-Xi FAN Fen-Liang WAN Yun-Fan WEI Wei lai Li-ming State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Ministry of Agriculture Key Laboratory of Crop Nutrition and Fertilization Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Ministry of Agriculture Key Laboratory of Agro-Environment and Climate Change Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences

Arid soils where water and nutrients are scarce occupy over 30% of the Earth's total surface. However, the microbial autotrophy in the harsh environments remains largely unexplored. In this study, the abundance and diversity of autotrophic bacteria were investigated, by quantifying and profiling the large subunit genes of ribulose-1,5-bisphosphate carboxylase/oxygenase(Ru Bis CO) form I(cbb L) responsible for CO2 fixation, in the arid soils under three typical plant types(Haloxylon ammodendron, Cleistogenes chinensis,and Reaumuria soongorica) in Northwest China. The bacterial communities in the soils were also characterized using the 16 S r RNA gene. Abundance of red-like autotrophic bacteria ranged from 3.94 × 105 to 1.51 × 106 copies g-1dry soil and those of green-like autotrophic bacteria ranged from 1.15 × 106 to 2.08 × 106 copies g-1dry soil. Abundance of both red- and green-like autotrophic bacteria did not significantly differ among the soils under different plant types. The autotrophic bacteria identified with the cbb L gene primer were mainly affiliated with Alphaproteobacteria, Betaproteobacteria and an uncultured bacterial group, which were not detected in the 16 S r RNA library. In addition, 25.9% and 8.1% of the 16 S r RNA genes were affiliated with Cyanobacteria in the soils under H. ammodendron and R. soongorica, respectively. However, no Cyanobacteria-affiliated cbb L genes were detected in the same soils. The results suggested that microbial autotrophic CO2 fixation might be significant in the carbon cycling of arid soils, which warrants further exploration.

关键词： autotrophic bacteria carbon cycling cbb L harsh environments real-time polymerase chain reaction

Chemical reductive technologies for the debromination of polybrominated diphenyl ethers: A review

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Journal of Environmental Sciences 2023年第5期127卷 42-59页

作者： ming Lei Yao tang Lihua Zhu Heqing tang College of Resources and Environmental Science South-Central Minzu UniversityWuhan 430074China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China

Polybrominated diphenyl ethers(PBDEs)are widely used as brominated flame retardants,which had attracted amounts of attention due to their harmful characteristics of high toxicity,environmental persistence and potential *** chemical reductive debromination technologies have been developed for the debromination of PBDEs,including photolysis,photocatalysis,electrocatalysis,zero-valent metal reduction,chemically catalytic reduction and mechanochemical *** review aims to provide information about the degradation thermodynamics and kinetics of PBDEs and summarize the degradation mechanisms in various *** to the comparative analysis,the rapid debromination to generate bromine-free products in an electron-transfer process,of which photocatalysis is a representative one,is found to be relatively difficult,because the degradation rate of PBDEs depended on the Br-rich phenyl ring with the lowest unoccupied molecular orbital(LUMO)*** the contrary,the complete debromination occurs easily in other systems with active hydrogen atoms as the main reactive species,such as chemically catalytic reduction *** review provides the knowledge on the chemical reductive technique of PBDEs,which would greatly help not only clarify the degradation mechanism but also design the more efficient system for the rapid and deep debromination of PBDEs in the future.

关键词： Polybrominated diphenyl ethers (PBDEs) Debromination Chemical reduction Electron transfer Hydrogenation

A New H^2 Regularity Condition of the Solution to Dirichlet Problem of the Poisson Equation and Its Applications

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Acta Mathematica Sinica,English Series 2020年第1期36卷 21-39页

作者： Fu Chang GAO ming Jun lai Department of Mathematics University of IdahoMoscowID 83844 Department of Mathematics University of GeorgiaAthensGA 30602

We study the regularity of the solution of Dirichlet problem of Poisson equations over a bounded domain.A new sufficient condition,uniformly positive reach is *** the assumption that the closure of the underlying domain of interest has a uniformly positive reach,the H^2 regularity of the solution of the Poisson equation is *** particular,this includes all star-shaped domains whose closures are of positive reach,regardless if they are Lipschitz domains or non-Lipschitz *** to the strong solution to the second order elliptic PDE in non-divergence form and the regularity of Helmholtz equations will be presented to demonstrate the usefulness of the new regularity condition.

关键词： Regularity Poisson equations uniformly positive reach non-divergence form

Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： Jun-Hao Zhou Li-ming tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot *** prepolymers were characterized fully by various ***,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and *** from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical ***,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their *** influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then *** composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT *** addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

Cronkhite-Canada syndrome with steroid dependency: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3466-3471页

作者： Dan Jiang Guo-Du tang ming-Yu lai Zhen-Ning Huang Zhi-Hai Liang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare nonhereditary disease characterized by chronic diarrhoea,diffuse gastrointestinal polyposis and ectodermal *** lethality of CCS can be up to 50%if it is untreated or if treatment is delayed or *** than 35%of the patients do not achieve long-term clinical remission after corticosteroid administration,with relapse occurring during or after the cessation of glucocorticoid *** optimal strategy of maintenance therapy of this disease is *** SUMMARY A 47-year-old man presented to the hospital with a 3-mo history of frequent watery diarrhoea,accompanied by macular skin pigmentation that included the palms and soles,and onychodystrophy of the fingernails and *** and colonoscopy revealed numerous polyps in the stomach and *** other possibilities were ruled out by a series of examinations,CCS was diagnosed and treated with *** patient took prednisone for more than 1 year before achieving complete resolution of his symptoms and endoscopic *** patient was then given prednisone 5 mg/d for 6 mo of maintenance *** clinical improvement and polyp regression,prednisone was *** mo after the discontinuation of prednisone,the diarrhoea and gastrointestinal polyps ***,the patient was given the same dose of prednisone,and complete remission was achieved *** It is necessary to extend the duration of prednisone maintenance therapy for *** is still effective when readministered after *** endoscopy at intervals of 1 year or less is recommended to assess mucosal disease activity.

关键词： Cronkhite-Canada syndrome Endoscopy Prednisone Relapse Maintenance therapy Case report