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Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2106-2118页

作者： xiao Wang Zhao-Yi Lin You Zhou Qin Zhong Zong-Ren Li xi-xiang Lin ming-Gen Hu Kun-Lun He Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Hepatobiliary Surgery Chinese PLA 970th HospitalYantai 264001Shandong ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Post-hepatectomy liver failure(PHLF)is a common consequence of radical partial hepatectomy in hepatocellular carcinoma(HCC).AIMS To investigate the relationship between preoperative antiviral therapy and PHLF,as well as assess the potential efficacy of hepatitis B virus(HBV)DNA level in predicting *** A retrospective study was performed involving 1301 HCC patients with HBV who underwent radical *** operating characteristic(ROC)analysis was used to assess the capacity of HBV DNA to predict PHLF and establish the optimal cutoff value for subsequent *** regression analyses were performed to assess the independent risk factors of *** increase in the area under the ROC curve,categorical net reclassification improvement(NRI),and integrated discrimination improvement(IDI)were used to quantify the efficacy of HBV DNA level for predicting *** P<0.05 was considered statistically *** Logistic regression analyses showed that preoperative antiviral therapy was independently associated with a reduced risk of PHLF(P<0.05).HBV DNA level with an optimal cutoff value of 269 IU/mL(P<0.001)was an independent risk factor of *** the reference models by adding the variable of HBV DNA level had an improvement in area under the curve,categorical NRI,and IDI,particularly for the fibrosis-4 model,with values of 0.729(95%CI:0.705-0.754),1.382(95%CI:1.341-1.423),and 0.112(95%CI:0.110-0.114),*** the above findings were statistically *** In summary,preoperative antiviral treatment can reduce the incidence of PHLF,whereas an increased preoperative HBV DNA level has a correlative relationship with an increased susceptibility to PHLF.

关键词： Hepatocellular carcinoma Hepatitis B virus Preoperative antiviral treatment Liver resection Post-hepatectomy liver failure

Advances in Triboelectric Nanogenerators for Blue Energy Harvesting and Marine Environmental Monitoring

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Engineering 2024年第2期33卷 204-224页

作者： Yang Jiang xi Liang Tao Jiang Zhong Lin Wang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro–Nano Energy and SensorsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Georgia Institute of Technology AtlantaGA 30332USA

Blue energy,which includes rainfall,tidal current,wave,and water-flow energy,is a promising renewable resource,although its exploitation is limited by current technologies and thus remains *** form of energy is mainly harvested by electromagnetic generators(EMGs),which generate electricity via Lorenz force-driven electron *** nano genera tors(TENGs)and TENG networks exhibit superiority over EMGs in low-frequency and high-entropy energy harvesting as a new approach for blue energy harvesting.A TENG produces electrical outputs by adopting the mechanism of Maxwell’s displacement *** date,a series of research efforts have been made to optimize the structure and performance of TENGs for effective blue energy harvesting and marine environmental *** the great progress that has been achieved in the use of TENGs in this context so far,continuous exploration is required in energy conversion,device durability,power management,and environmental *** review reports on advances in TENGs for blue energy harvesting and marine environmental *** introduces the theoretical foundations of TENGs and discusses advanced TENG prototypes for blue energy harvesting,including TENG structures that function in freestanding and contact-separation *** enhancement strategies for TENGs intended for blue energy harvesting are also ***,marine environmental applications of TENGs based on blue energy harvesting are discussed.

关键词： Triboelectric nanogenerator TENG networks Blue energy Energy harvesting Ocean sensors

Corrosion evaluation and resistance study of alloys in chloride salts for concentrating solar power plants

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Rare Metals 2024年第3期43卷 1222-1233页

作者： Dong-Mei Han Yong Shuai Bachirou Guene Lougou Bo-xi Geng xi-Bo He Tian-Tian Yan Jia-Meng Song School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China

Thermal energy storage(TES)systems based on molten salt are widely used in concentrating solar power(CSP)*** investigation of the corrosion behavior of alloy materials in molten salt is crucial for the correct selection of alloy materials and the design of TES *** this study,the corrosion behavior of 304,310S,316,and In625 alloys in molten chloride salts(27 mol%NaCl-22 mol%KCl-51 mol%MgCl,)was *** evolution of mass loss of the alloy samples with corrosion time and temperature and the analysis of the experimental results by scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),and X-ray diffraction(XRD)revealed the corrosion mechanism of the alloy samples in molten chloride *** main factors affecting the corrosion of the alloy samples were further *** was found that the loose multi-layer corrosion was formed on the surface of the corroded alloy samples with the increase in corrosion ***,the experimental *** that Mo played a positive role in improving the corrosion resistance of the alloy samples because the presence of Mo could inhibit the outward diffusion of alloying element *** work enriches the molten salt corrosion database and provides a reference for the selection of alloy materials for TES systems with potential application in CSP plants.

关键词： Thermal energy storage Molten chloride salt Alloy materials Corrosion mechanism Corrosion resistance

Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

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Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu Zhehao Liang Zemiao Niu Ning Chen Yuemin Li Zhenhua Liang Yanwei Huo Hao xi rong Wang Yonghuan Yan xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang mingming Gao Pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(IL)7R^(+)and granzyme B^(+)T cells in the tumor ***,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and IL-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

Simulation of Fracture Process of Lightweight Aggregate Concrete Based on Digital Image Processing Technology

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Computers, Materials & Continua 2024年第6期79卷 4169-4195页

作者： Safwan Al-sayed xi Wang Yijiang Peng Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing100124China

The mechanical properties and failure mechanism of lightweight aggregate concrete(LWAC)is a hot topic in the engineering field,and the relationship between its microstructure and macroscopic mechanical properties is also a frontier research topic in the academic *** this study,the image processing technology is used to establish a micro-structure model of lightweight aggregate *** the information extraction and processing of the section image of actual light aggregate concrete specimens,the mesostructural model of light aggregate concrete with real aggregate characteristics is *** numerical simulation of uniaxial tensile test,uniaxial compression test and three-point bending test of lightweight aggregate concrete are carried out using a new finite element method-the base force element method ***,the image processing technology is used to produce beam specimens,uniaxial compression specimens and uniaxial tensile specimens of light aggregate concrete,which can better simulate the aggregate shape and random distribution of real light aggregate ***,the three-point bending test is numerically ***,the uniaxial compression specimen generated by image processing technology is numerically ***,the uniaxial tensile specimen generated by image processing technology is numerically *** mechanical behavior and damage mode of the specimen during loading were *** results of numerical simulation are compared and analyzed with those of relevant *** feasibility and correctness of the micromodel established in this study for analyzing the micromechanics of lightweight aggregate concrete materials are *** processing technology has a broad application prospect in the field of concrete mesoscopic damage analysis.

关键词： Digital image processing lightweight aggregate concrete mesoscopic model numerical simulation fracture analysis bending beams

Sex Disparities in the Association of Blood Pressure Parameters and Arterial Sclerosis Risk

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Biomedical and Environmental Sciences 2024年第7期37卷 795-799页

作者： Dongdong Zhang Weiling Chen Minqi Gu xi Li Yuying Wu Xueru Fu Ping Tang Fulan Hu Jing Li xizhuo Sun Dongsheng Hu ming Zhang Department of General Practice The Affiliated Luohu Hospital of Shenzhen University Medical SchoolShenzhen 518060GuangdongChina Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120GuangdongChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Medical SchoolShenzhen 518060GuangdongChina

Cardiovascular disease(CVD)is the leading cause of death worldwide[1].Arterial sclerosis(AS)and hypertension are the main risk factors and pathological bases of *** pulse wave velocity(PWV)measurements could reflect early progression of *** on the structure-function properties of the vascular wall and hemodynamics,strong evidence suggests that any increase in blood pressure levels can mechanically impair the ability of the endothelium to maintain vascular homeostasis[2].High levels of blood pressure parameters,such as systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),and mean arterial pressure(MAP)have been identified as essential risk biomarkers for atherosclerosis.

关键词： Blood Arterial atherosclerosis

A theoretical model for impact protection of flexible polymer material

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 217-226页

作者： Huifeng xi Hui Pan Song Chen Heng xiao MOE Key Lab of Disaster Forecast and Control in Engineering School of Machanics and Construction EngineeringJinan UniversityGuangzhou 510632China Doctor Workstation of Xuwen County Guangdong Hydropower Energy Co. Ltd.Xuwen 524100China

The relationship between the protective performance of flexible polymer material and material parameters(elasticmodulus,viscosity coefficient)is explored,an impact collision motion equation between two bodies is establishedfrom the viscoelastic material constitutive,and the relationship between the kinematic response and the materialparameters is *** on the Kelvin constitutive model,a theoretical model for impact between the pro-tective body and the protected body is established,then the dynamic response is *** feasibility of themodel was verified by drop hammer experiment,and the material parameters(elastic modulus,viscosity coeffi-cient)were obtained by *** model is discretized and the relationship between local impact response andmaterial parameters is *** discussion results on the relationship between the impact response and theprotective material performance indicate that adjusting the elastic modulus,viscosity coefficient,and thicknessof the protective material can effectively improve protective effect.

关键词： Flexible polymer material Viscoelastic material Kelvin modelDynamic response Elastic modulus and viscosity coefficient

B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 27-34页

作者： LI xi LIN xiangquan CHEN Dongdong LIU Hui the Third Clinical Medical College Fujian Medical University Department of Orthopedics Fuzhou Second HospitalFuzhou 350007China

OBJECTIVE:To explore the relationship between autophagy and apoptosis regulated by puerarin during ***:In this study,the effects of puerarin on the autophagic activity and apoptosis level of osteoblast precursors(MC3T3-E1 cells)was ***,the roles of puerarin on B-cell lymphoma-2(Bcl-2)phosphorylation at different sites in osteoblast precursors were *** effect of puerarin on the interaction between Bcl-2 and autophagy regulatory molecule or pro-apoptotic molecule was also investigated using Co-immunoprecipitation *** addition,the effect of puerarin on mitochondrial membrane potential of osteoblast precursors was also identified by mitochondrial membrane potential fluorescence probe ***:Our results showed that puerarin can promote the autophagic activity and apoptosis level of *** addition,puerarin promoted Bcl-2phosphorylation at Ser70 site,and the dissociation of Bcl-2-Beclin1 ***,puerarin could enhance the binding of Bcl-2-Bcl-2-Associated X(Bax)complex in MC3T3-E1 ***,puerarin increased the mitochondrial membrane potential of MC3T3-E1 ***:Therefore,puerarin promotes Beclin1into autophagy flux through Bcl-2 phosphorylation at Ser70,thereby enhancing autophagy of osteoblast precursors,which mediates its anti-apoptotic role during ***,the dissociation of Bcl-2-Beclin1 complex is conducive to the binding of Bcl-2-Bax complex,which resists the apoptosis of osteoblast precursors via the increased mitochondrial membrane potential.

关键词： puerarin osteoblasts autophagy apoptosis lymphoma B-cell

Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-Yao Huang Ya-Ru Wang Jun Li Shi-Long Han Hao xi Wen-Xue Gao Ying-Yu Cui ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report