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Chinese Chemical Letters 1993年第9期4卷 759-762页

作者： Zai ming ZHU qun liu Zhi Yun YANG Department of Chemistry,Northeast Normal Univresity,Chang Chun,130024

Aliphatic α-oxo ketene cyclic dithioacetals 1 were reacted with allyl magne- sium bromide to afford the 1,2-addition products *** by boron trifluoride etherate,the adducts 2 were etherified by methanol to afford the corresponding methyl ethers *** process provides a new method for the protection of the acid sensitive hydroxyl group in 2 under mild condition.

关键词： OXOKETENE CYCLIC DITHIOACETAL CHEMISTRY THE ETHERIFYING REACTION ON THE ADDUCTS OF ALIPHATIC 加名

Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth

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Signal Transduction and Targeted Therapy 2020年第1期5卷 495-507页

作者： Nan Yao Chen-Ran Wang ming-qun liu Ying-Jie Li Wei-Min Chen Zheng-Qiu Li Qi Qi Jin-Jian Lu Chun-Lin Fan Min-Feng Chen ming Qi Xiao-Bo Li Jian Hong Dong-Mei Zhang Wen-Cai Ye College of Pharmacy Jinan UniversityGuangzhouChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhouChina School of Medicine Jinan UniversityGuangzhouChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

Epidermal growth factor receptor(EGFR)activation plays a pivotal role in EGFR-driven non-small cell lung cancer(NSCLC)and is considered as a key target of molecular targeted *** tyrosine kinase inhibitors(TKIs)have been canonically used in NSCLC ***,prevalent innate and acquired resistances and EGFR kinase-independent pro-survival properties limit the clinical efficacy of EGFR ***,the discovery of novel EGFR degraders is a promising approach towards improving therapeutic efficacy and overcoming drug ***,we identified a 23-hydroxybetulinic acid derivative,namely DPBA,as a novel EGFR small-molecule *** exerted potent in vitro and in vivo anticancer activity in both EGFR wild type and mutant NSCLC by degrading *** studies disclosed that DPBA binds to the EGFR extracellular domain at sites differing from those of EGF and *** did not induce EGFR dimerization,phosphorylation,and ubiquitination,but it significantly promoted EGFR degradation and repressed downstream survival *** analyses showed that DPBA induced clathrin-independent EGFR endocytosis mediated by flotillin-dependent lipid rafts and unaffected by EGFR *** of the early and late endosome markers rab5 and rab7 but not the recycling endosome marker rab11 was involved in DPBA-induced EGFR lysosomal *** present study offers a new EGFR ligand for EGFR pharmacological degradation and proposes it as a potential treatment for EGFR-positive NSCLC,particularly NSCLC with innate or acquired EGFR TKI *** can also serve as a chemical probe in the studies on EGFR trafficking and degradation.

关键词： NSCLC EGFR positive

Spatial differentiation of carbon emissions from energy consumption based on machine learning algorithm:A case study during 2015–2020 in Shaanxi,China

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Journal of Environmental Sciences 2025年第3期149卷 358-373页

作者： Hongye Cao Ling Han ming liu Liangzhi Li China Jikan Research Institute of Engineering Investigations and Design Co.Ltd.Xi’an 710043China College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710061China School of Land Engineering Chang’an UniversityXi’an 710064China Xi’an Key Laboratory of Territorial Spatial Information School of Land EngineeringChang’an UniversityXi’an 710064China Department of Geography and Environmental Management University of WaterlooWaterlooOntario N2L 3G1Canada

Carbon emissions resulting from energy consumption have become a pressing issue for governments *** estimation of carbon emissions using satellite remote sensing data has become a crucial research *** studies relied on statistical regression models that failed to capture the complex nonlinear relationships between carbon emissions and characteristic *** this study,we propose a machine learning algorithm for carbon emissions,a Bayesian optimized XGboost regression model,using multi-year energy carbon emission data and nighttime lights(NTL)remote sensing data from Shaanxi Province,*** results demonstrate that the XGboost algorithm outperforms linear regression and four other machine learning models,with an R^(2)of 0.906 and RMSE of *** observe an annual increase in carbon emissions,with high-emission counties primarily concentrated in northern and central Shaanxi Province,displaying a shift from discrete,sporadic points to contiguous,extended spatial *** autocorrelation clustering reveals predominantly high-high and low-low clustering patterns,with economically developed counties showing high-emission clustering and economically relatively backward counties displaying low-emission *** findings show that the use of NTL data and the XGboost algorithm can estimate and predict carbon emissionsmore accurately and provide a complementary reference for satellite remote sensing image data to serve carbon emission monitoring and *** research provides an important theoretical basis for formulating practical carbon emission reduction policies and contributes to the development of techniques for accurate carbon emission estimation using remote sensing data.

关键词： Machine learning Energy carbon emissions Nighttime light Spatial distribution

Fabrication of flake-like NiCo_(2)O_(4)/reduced graphene oxide/melamine-derived carbon foam as an excellent microwave absorber

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 556-565页

作者： Konghu Tian Hang Yang Chao Zhang Ruiwen Shu qun Shao Xiaowei liu Kaipeng Gao The First Affiliated Hospital of Anhui University of Science and Technology(Huainan First People’s Hospital) Huainan 232001China Analysis and Test Center Anhui University of Science and TechnologyHuainan 232001China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Carbon-based foams with a three-dimensional structure can serve as a lightweight template for the rational design and control-lable preparation of metal oxide/carbon-based composite microwave absorption *** this study,a flake-like nickel cobaltate/re-duced graphene oxide/melamine-derived carbon foam(FNC/RGO/MDCF)was successfully fabricated through a combination of solvo-thermal treatment and high-temperature *** indicated that RGO was evenly distributed in the MDCF skeleton,providing ef-fective support for the load growth of FNC on its *** S3,the FNC/RGO/MDCF composite prepared by solvothermal method for 16 h,exhibited a minimum reflection loss(RL_(min))of-66.44 dB at a thickness of 2.29 *** the thickness was reduced to 1.50 mm,the optimal effective absorption bandwidth was 3.84 *** of the absorption mechanism of FNC/RGO/MDCF revealed that its excellent absorption performance was primarily attributed to the combined effects of conduction loss,multiple reflection,scattering,in-terface polarization,and dipole polarization.

关键词： carbon foam reduced graphene oxide flake-like nickel cobaltate microwave absorbing materials

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi qun Yi Yao liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationHubei Key Laboratory of Novel Reactor and Green Chemical TechnologySchool of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan 430205HubeiChina Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079HubeiChina College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianChina

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER ***,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic ***,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during *** hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)*** obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER *** work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Efficient implementation of quantum permutation algorithm using a polar SrO molecule in pendular states

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Communications in Theoretical Physics 2025年第2期77卷 41-53页

作者： Jie-Ru Hu Zuo-Yuan Zhang Jin-ming liu State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University School of Physical Science and Technology Yangzhou University Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal University

Quantum algorithms offer more enhanced computational efficiency in comparison to their classical counterparts when solving specific tasks. In this study, we implement the quantum permutation algorithm utilizing a polar molecule within an external electric field. The selection of the molecular qutrit involves the utilization of field-dressed states generated through the pendular modes of SrO. Through the application of multi-target optimal control theory, we strategically design microwave pulses to execute logical operations, including Fourier transform,oracle Ufoperation, and inverse Fourier transform within a three-level molecular qutrit *** observed high fidelity of our outcomes is intricately linked to the concept of the quantum speed limit, which quantifies the maximum speed of quantum state manipulation. Subsequently,we design the optimized pulse sequence to successfully simulate the quantum permutation algorithm on a single SrO molecule, achieving remarkable fidelity. Consequently, a quantum circuit comprising a single qutrit suffices to determine permutation parity with just a single function evaluation. Therefore, our results indicate that the optimal control theory can be well applied to the quantum computation of polar molecular systems.

关键词： polar molecule optimal control quantum permutation algorithm pendular states

Structuring MoO3-polyoxometalate hybrid superstructures to boost electrocatalytic hydrogen evolution reaction

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Chinese Chemical Letters 2025年第2期36卷 239-243页

作者： Bowen Li Ting Wang ming Xu Yuqi Wang Zhaoxing Li Mei liu Wenjing Zhang ming Feng Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal University

Improving the surface atoms utilization efficiency of catalysts is extremely important for large-scale H2production by electrochemical water splitting,but it remains a great ***,we reported two kinds of Mo O3-polyoxometalate hybrid nanobelt superstructures (MoO3-POM HNSs,POM=PW12O40and Si W12O40) using a simple hydrothermal *** superstructure with highly uniform nanoparticles as building blocks can expose more surface atoms and emanate increased specific surface *** incorporated POMs generated abundant oxygen vacancies,improved the electronic mobility,and modulated the surface electronic structure of MoO3,allowing to optimize the H*adsorption/desorption and dehydrogenation kinetics of ***,the as-prepared MoO3-PW12O40HNSs electrodes not only displayed the low overpotentials of 108 mV at 10 mA/cm2current density in 0.5 mol/L H2SO4electrolyte but also displayed excellent long-term *** hydrogen evolution reaction （HER） performance of MoO3-POM superstructures is significantly better than that of corresponding bulk materials MoO3@PW12O40and Mo O3@Si W12O40,and the overpotentials are about 8.3 and 4.9 times lower than that of single Mo *** work opens an avenue for designing highly surface-exposed catalysts for electrocatalytic H2production and other electrochemical applications.

关键词： Electrocatalysis Hydrogen production Metal oxide Polyoxometalate Superstructure

Characteristics of Energy Fluxes and Cold Frontal Effects on Energy Exchange over a Boreal Lake

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第2期42卷 357-372页

作者： Xu, Lujun liu, Huizhi Mammarella, Ivan Vaha, Aki Ala-Konni, Joonatan Li, Xuefei Du, qun liu, Yang Vesala, Timo Chinese Acad Sci Inst Atmospher Phys State Key Lab Atmospher Boundary Layer Phys & Atmo Beijing 100029 Peoples R China Univ Chinese Acad Sci Beijing 100864 Peoples R China Yunnan Univ Dept Atmospher Sci Kunming 650091 Peoples R China Univ Helsinki Inst Atmospher & Earth Syst Res Phys Fac Sci Helsinki 00014 Finland

Understanding the characteristics and variations of heat exchange and evaporation of lakes is important for regional water resource management and sustainable development. Based on eddy covariance measurements over Lake Vanajavesi in southern Finland, characteristics of energy fluxes and cold frontal effects on energy exchange were investigated. The lake acted as a heat sink in spring and summer and a heat source in winter. The latent heat flux reached its minimum value in the morning and peaked in the afternoon. The diurnal variation of sensible heat flux was opposite to that of latent heat flux. Impact factors for the sensible heat flux were mainly the lake-air temperature difference and the product of lake-air temperature difference and wind speed. The latent heat flux was mainly affected by the vapor pressure deficit and the product of vapor pressure deficit and wind speed. The annual mean values of bulk transfer coefficients for momentum, heat, and water vapor were 1.98 x 10-3, 1.62 x 10-3, and 1.31 x 10-3, respectively. Bulk transfer coefficients for heat and water vapor were not equal, indicating that the parameterization of energy exchange in numerical models, where the assumption that the heat coefficient equals the water vapor coefficient needs improvement. During the ice-free season, cold fronts resulted in 28 sensible heat pulses and 17 latent heat pulses, contributing to 50.59% and 34.89% of sensible and latent heat exchange in Lake Vanajavesi. These results indicate that cold fronts significantly impact the surface energy budget and evaporation over lakes. (sic)(sic)(sic)(sic)(sic)-(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)Vanajavesi(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)-(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)

关键词： sensible heat flux latent heat flux roughness length bulk transfer coefficient cold front (sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic) (sic)(sic)

Optimizing cooling approach of spiral coil for an electromagnetic steel teeming system of ladle in continuous casting production

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Journal of Iron and Steel Research International 2025年第1期32卷 85-94页

作者： ming He Qing-wei Wang Li-jia Zhao Wang-zhong Mu Xing-an liu Qiang Wang College of Horticulture Shenyang Agricultural UniversityShenyang110866LiaoningChina Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina Key Laboratory of Protected Horticulture(Ministry of Education) Shenyang Agricultural UniversityShenyang110866LiaoningChina Department of Materials Science and Engineering KTH Royal Institute of TechnologyStockholm10044Sweden

To address the current issues with the conventional slide gate system utilized in the steel teeming process,a unique electromagnetic induction controlled automated steel teeming(EICAST)technology has been *** means of spiral coil in this technology is directly related to its service ***,heat transfer processes of air cooling and spray cooling were compared and ***,the impacts of water temperature,water flow rate and air flow rate were examined in order to maximize the spray cooling *** maintain coil temperature at a low value consistently throughout the entire thermal cycle process of the ladle,a combined cooling mode was finally *** simulation was applied to examine the coil temperature variation with different cooling systems and *** coil operation,spray cooling is said to be more *** controlling the water flow rate and air flow rate,the spray cooling effect is ***,water temperature has little or no impact when using spray *** cooling during the secondary refining process and spray cooling prior to coil operation are combined to further lower coil *** the direction of the spray cooling is from bottom to top,the coil temperature is lowered below 165℃.A practical induction coil cooling plan was provided for the EICAST technology’s production process.

关键词： Electromagnetic induction controlled automated steel teeming technology Spiral coil Spray cooling Heat transfer Continuous casting