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Simultaneous Screening and Analysis of Anti-inflammatory and Antiproliferative Compounds from Euphorbia maculata Combining Bio-affinity Ultrafiltration with Multiple Drug Targets

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Journal of Analysis and Testing 2022年第2期6卷 98-110页

作者： Tojofaniry Fabien Rakotondrabe Min-Xia Fan Yong-Li Zhang ming-quan guo CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074China Innovation Academy for Drug Discovery and Development Chinese Academy of SciencesShanghai 201203China

Euphorbia maculata has long been used for managing different impairments in Asian ***,its antioxidant,anti-inflammatory and antiproliferative potentialities,along with its potential bioactive compounds remain *** this context,a bio-a ffinity ultrafiltration strategy was developed to fish out ligand candidates against Cycloxygenase-2(COX-2),Topoisomerase I(Topo I),and TopoisomeraseⅡ(TopoⅡ).Thereafter,lead compounds activities were assessed in silico and in vitro for ascertaining the screening results and forecasting its corresponding *** a result,the *** ethyl acetate(EMEA)fraction showed interesting COX-2 inhibition activity with an IC 50 value of 0.67±0.09μg/mL,as well as good growth inhibitions for three malignant cell *** chemical fingerprinting was also conducted to enable a tentative identification of 17 compounds,among which,11 were assessed as ligand candidates to COX-2,8 compounds to Topo I,and 10 compounds to TopoⅡ.Dihydromyricetin and quercetin-3-O-arabinoside were revealed to be multipotent compounds which exerted good a ffinity to the three targeted enzymes,and also supported with their molecular docking simulations and in vitro assay *** interrelationship between ***’s associated activities(antioxidant,anti-inflammatory and antiproliferative)was revealed with the corresponding multipotent phytochemical active components from this *** also provided a useful direction for its empirical traditional use and further explorations in the near future.

关键词： Euphorbia maculata Antioxidant Anti-infl ammatory Antiproliferative UF-UPLC-QTOF-MS/MS Multipotent compounds

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基于GA-Otsu法的图像阈值分割及定量识别

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吉林大学学报（工学版） 2017年第3期47卷 959-964页

作者：赵夫群周明全耿国华西北大学信息科学与技术学院西安710127 咸阳师范学院教育科学学院陕西咸阳712000 北京师范大学信息科学与技术学院北京100875

针对传统Otsu法在图像分割中存在的计算量大、效率低的问题,提出了一种基于GA-Otsu的热波图像分割方法。该方法充分发挥了遗传算法的全局寻优能力,快速地求解热波图像分割的最佳阈值,缩短了损伤的分割时间。通过与人工阈值法的分割结果... 详细信息

针对传统Otsu法在图像分割中存在的计算量大、效率低的问题,提出了一种基于GA-Otsu的热波图像分割方法。该方法充分发挥了遗传算法的全局寻优能力,快速地求解热波图像分割的最佳阈值,缩短了损伤的分割时间。通过与人工阈值法的分割结果进行对比,表明本文方法不仅保持了冲击损伤的基本形状,而且对冲击点位置的分割提取也较为准确。最后,通过对缺陷的定量识别验证了本文方法在热波检测图像分割中的有效性。

关键词：计算机应用热波检测热波图像图像分割定量识别

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： guo Guanlun HAN ming LU Shaomin YU Jing JU Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： quan Shi Yun-Hao Xu ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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高管团队内部薪酬差距对企业竞争力的影响——基于锦标赛视角下的实证研究

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云南财经大学学报 2017年第5期33卷 150-160页

作者：盛明泉郭倩梅张春强安徽财经大学会计学院安徽蚌埠233030

以2013~2015年间沪深A股全部上市公司作为研究样本,基于锦标赛视角对高管团队内部薪酬差距与企业竞争力之间的关系进行研究。结果表明,高管薪酬差距对企业竞争力提升有显著的正向影响。管理者权力削弱了高管薪酬差距与企业竞争力之间的... 详细信息

以2013~2015年间沪深A股全部上市公司作为研究样本,基于锦标赛视角对高管团队内部薪酬差距与企业竞争力之间的关系进行研究。结果表明,高管薪酬差距对企业竞争力提升有显著的正向影响。管理者权力削弱了高管薪酬差距与企业竞争力之间的正相关性。国有产权性质对短期薪酬差距与企业竞争力的正向关系起到负向调节影响,对长期薪酬差距与企业竞争力的关系无显著调节作用。这些结论有助于丰富高管薪酬差距、企业竞争力的相关文献。

关键词：高管薪酬差距企业竞争力锦标赛理论管理者权力

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基于有界旋转角的点云配准算法

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微电子学与计算机 2017年第3期34卷 46-49页

作者：赵夫群周明全耿国华西北大学信息科学与技术学院陕西西安710127 咸阳师范学院教育科学学院陕西咸阳712000 北京师范大学信息科学与技术学院北京100875

针对目前已有的三维点云配准算法不能很好地解决旋转角度变化较大的配准问题,提出一种基于有界旋转角的配准算法.首先根据刚体变换的低维性质将全局配准问题转化成区域配准问题,通过区域划分、区域配准、求解组合系数、求解刚体变换等... 详细信息

针对目前已有的三维点云配准算法不能很好地解决旋转角度变化较大的配准问题,提出一种基于有界旋转角的配准算法.首先根据刚体变换的低维性质将全局配准问题转化成区域配准问题,通过区域划分、区域配准、求解组合系数、求解刚体变换等四个基本步骤实现初始配准;然后在基本ICP算法的基础上通过设置旋转角度的边界来改进算法,以达到精确配准的目的.实验结果表明,该算法具有精确、快速、鲁棒的特点,并能避免噪声和外点的干扰,适用范围更加广泛.

关键词：点云配准有界旋转角区域划分刚体变换迭代最近点

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