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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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后交叉韧带胫骨附着点撕脱骨折:关节镜治疗中的材料、植入物及内固定技术

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中国组织工程研究 2025年第4期29卷 872-880页

作者：余铭王文贵州医科大学贵州省贵阳市550004 暨南大学附属广州市红十字会医院广东省广州市510220

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不... 详细信息

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不同关节镜治疗方法、手术入路、胫骨隧道设计、缝合材料选择以及内固定植入物选择等。方法:通过计算机对中国知网、PubMed、Web of Science及ScienceDirect等数据库中的相关文献进行检索,检索时间为2003年1月至2023年11月,中文检索词为“后交叉韧带,后十字韧带,撕脱骨折,关节镜”;英文检索词为“posterior cruciate ligament,avulsion,fracture,tibia,arthroscopic,operation,fixation,treatment”。共纳入97篇文献进行综述。结果与结论:关节镜技术提供了一种可靠的治疗方式来治疗后交叉韧带胫骨附着点撕脱骨折。根据入路、缝合材料类型以及用于缝合的入路和胫骨隧道数量等不同,关节镜技术可以分为关节镜下缝线固定结合自体移植物增强重建、关节镜下多交叉带缝合桥固定、关节镜下高强度缝线固定以及关节镜下直接前后缝合悬吊固定等几类。在各种研究中,常用的临床结果评估指标包括关节活动度、Lysholm评分、国际膝关节文献委员会评分及KT-2000关节测量仪差等,研究显示关节镜手术后末次随访时上述指标检测结果较术前显著改善,影像学随访结果显示关节镜手术都取得了令人满意的结果。在随访过程中,接受关节镜技术治疗后的各类交叉韧带胫骨附着点撕脱骨折患者都未出现严重并发症,例如创伤性关节炎、神经血管损伤、围手术期伤口感染、血栓形成以及骨折不愈合等。

关键词：后交叉韧带胫骨撕脱骨折关节镜手术缝合材料内固定治疗

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丹酚酸B调控脂质代谢改善非酒精性脂肪肝实验研究

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中国药理学通报 2025年第1期41卷 107-115页

作者：张佳健郭梦茹梅金玉陈明安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第二附属医院耳鼻喉科安徽合肥230601

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低... 详细信息

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低剂量为15 mg·kg^(-1)·d^(-1),高剂量为30 mg·kg^(-1)·d^(-1),对照组和模型组用等剂量生理盐水灌胃。肝脏转录组测序结果揭示模型组和SalB组的差异表达基因,HE染色、油红O染色观察肝组织的病理变化,试剂盒检测血清和肝组织的脂质、氧化应激和炎症指标,RT-qPCR检测Lcn2、SREBP-1C以及脂质合成相关酶的mRNA水平。体外实验,用棕榈酸(PA)诱导L02和LX-2细胞24 h建立NAFLD模型,用SalB(30μmol·L^(-1))和PA(0.2 mmol·L^(-1))共孵育检测SalB体外改善NAFLD的情况。试剂盒检测L02细胞TC、TG的含量,细胞油红O染色试剂盒检测L02细胞的脂质积累,RT-qPCR检测LX-2细胞Lcn2、SREBP-1C以及脂质合成相关酶基因的mRNA水平。结果模型组血清、肝脏的生化指标异常,肝组织脂质、炎症和氧化应激水平升高,出现大面积脂肪空泡和大量的脂质沉积,PA诱导的L02细胞也出现大量的脂质积累,在SalB干预后均有明显改善。转录组测序结果表明SalB可以调控肝脏脂质代谢和炎症。肝脏和LX-2细胞mRNA水平显示模型组Lcn2、SREBP-1C以及脂质合成相关酶基因表达明显上调,SalB干预后均能降低这些基因的表达。结论丹酚酸B可以明显改善非酒精性脂肪肝,其机制可能是通过下调Lcn2、SREBP-1C和脂质合成酶的表达。

关键词： SalB 非酒精性脂肪肝脂质代谢 Lcn2 SREBP-1C 脂质合成相关酶

内镜食道静脉瘤套扎器治疗直肠神经内分泌肿瘤的疗效分析

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中国内镜杂志 2018年第10期24卷 89-93页

作者：孟明明魏南赵书博王洋刘红吴静首都医科大学附属北京世纪坛医院消化内科北京100038

目的评估超声内镜结合内镜食道静脉瘤套扎器行内镜下圈套器法黏膜切除术(EMR-L)治疗直肠神经内分泌肿瘤(NENs)的临床有效性、安全性以及技术的可行性。方法回顾性分析北京世纪坛医院消化内科2015年11月-2017年11月收治的13例直肠NENs患... 详细信息

目的评估超声内镜结合内镜食道静脉瘤套扎器行内镜下圈套器法黏膜切除术(EMR-L)治疗直肠神经内分泌肿瘤(NENs)的临床有效性、安全性以及技术的可行性。方法回顾性分析北京世纪坛医院消化内科2015年11月-2017年11月收治的13例直肠NENs患者临床资料,治疗前均行超声内镜检查,后进行EMR-L切除病变。观察患者内镜表现、EMR-L操作过程及其并发症、病理结果,术后定期结肠镜随访。结果 13例患者顺利完成EMR-L切除病变,耗时10 min 36 s^52 min 21 s,平均(21.9±10.6)min。1例患者发生急性出血,予药物喷洒及钛夹封闭创面治疗后出血停止。无急性或迟发性直肠出血、穿孔等并发症。结论应用内镜食道静脉瘤套扎器行EMR-L可有效、安全的切除小于1.0 cm的直肠NENs,同时治疗费用较食管静脉曲张连环套扎器少,有很好的临床应用价值。

关键词：直肠神经内分泌肿瘤内镜食道静脉瘤套扎器圈套器内镜下黏膜切除术

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

The Exceptional Set in the Two Prime Squares and a Prime Problem

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Acta Mathematica Sinica,English Series 2006年第5期22卷 1329-1342页

作者： ming Qiang WANG Xian meng meng Department of Mathematics Qufu Normal University Qufu 273165 P. R. China Department of Computer Science Shandong University Ji'nan 250100 P. R. China Department of Statistics and Mathematics Shandong Finance Institute Jinan 250014 P. R. China

In this paper we prove that, with at most O（N^5/12＋ε） exceptions, all positive odd integers n ≤ N with n ≡ 0 or 1（mod 3） can be written as a sum of a prime and two squares of primes.

关键词： circle method Cauchy's inequality Siegel zero Dirichlet character

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Gossip-Based Resource Location Strategy in Interest Community for P2P Networks

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Chinese Journal of Electronics 2015年第2期24卷 272-280页

作者： HE ming ZHANG Yujie meng Xiangwu School of Computer Science Beijing University of Posts and Telecommunications Beijing Key Laboratory of Intelligent Telecommunications Software and Multimedia

Resource location strategy has become very popular for mass data distribution in complex and dynamic network. Searching for the objects is a fundamental problem to unstructured Peer to peer(P2P) networks. In this paper, we propose a resource location strategy for user requirements, which employs the collaborative exchange of information between peers to construct interest communities. This strategy can gather similar peers and disseminate useful information among them. Furthermore, we design an algorithm in unstructured P2 P systems named Appropriate degree gossip search algorithm(ADGSA). Using this search algorithm, the performance including search success ratio, recall rate and search response time has been improved dramatically. An efficient resource location system with a fast organization of users cluster based on their requirements can be provided, preventing the creation of unliked communities. The simulation results show that our strategy has better search efficiency, short response time and high recall ratio.

关键词： Unstructured P2P network Resource location Interest community Gossip-based search Flooding

Sparse recovery: from vectors to tensors

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National Science Review 2018年第5期5卷 756-767页

作者： Yao Wang Deyu meng ming Yuan School of Mathematics and Statistics Xi'an Jiaotong University Shenyang Institute of Automation Chinese Academy of Sciences Ministry of Education Key Lab of Intelligent Networks and Network Security Xi'an Jiaotong University Department of Statistics Columbia University

Recent advances in various fields such as telecommunications, biomedicine and economics, among others, have created enormous amount of data that are often characterized by their huge size and high dimensionality. It has become evident, from research in the past couple of decades, that sparsity is a flexible and powerful notion when dealing with these data, both from empirical and theoretical viewpoints. In this survey, we review some of the most popular techniques to exploit sparsity, for analyzing high-dimensional vectors, matrices and higher-order tensors.

关键词： high-dimensional data sparsity compressive sensing low-rank matrix recovery tensors

Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang Qi meng Zhi-ming Ma Academy of Mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants