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Ultra-fast polymer optical fibre Bragg grating inscription for medical devices

Light(Science & Applications) 2017年第1期6卷 104-113页

作者： Julien Bonefacino Hwa-Yaw Tam Tom S Glen Xin Cheng Chi-Fung Jeff Pun Jian Wang Po-Heng Lee ming-leung vincent tse Steven T Boles Photonics Research Centre Department of Electrical EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Division of Urban Environment Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

We report the extraordinary result of rapid fibre Bragg grating inscription in doped polymer optical fibres based on polymethyl methacrylate in only 7 ms,which is two orders of magnitude faster than the inscription times previously reported.This was achieved using a new dopant material,diphenyl disulphide,which was found to enable a fast,positive refractive index change using a low ultraviolet dose.These changes were investigated and found to arise from photodissociation of the diphenyl disulphide molecule and subsequent molecular reorganization.We demonstrate that gratings inscribed in these fibres can exhibit at least a 15 times higher sensitivity than silica glass fibre,despite their quick inscription times.As a demonstration of the sensitivity,we selected a highly stringent situation,namely,the monitoring of a human heartbeat and respiratory functions.These findings could permit the inscription of fibre Bragg gratings during the fibre drawing process for mass production,allowing costeffective,single-use,in vivo sensors among other potential uses.

关键词： bio-sensing fibre Bragg grating photosensitive dopant polymer optical fibre

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Characterization of Spirooxazine and Spiropyran Hosted in Poly(Methyl Methacrylate) for Germicidal UV Source Indicator Application

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Optics and Photonics Journal 2013年第7期3卷 11-16页

作者： Julien Bonefacino ming-leung vincent tse Chi-Fung Jeff Pun Xin Cheng Wing Kin Edward Chan Arjen Boersma Hwa-Yaw Tam Department of Responsive Materials & Coating Netherlands Organisation for Applied Scientific Research (TNO) Eindhoven The Netherlands Photonics Research Center Electrical Engineering Department The Hong Kong Polytechnic University Hong Kong China

A characterization of photophysical properties of 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3’-[3H]naphtha[2,1-b] [1,4]oxazine] (spirooxazine) and1’,3’-dihydro-1’,3’,3’-trimethyl-6-nitrospiro[2H-1-benzopyran-2,2’-(2H)-indole] (spiropyran) compounds hosted in poly(methyl methacrylate) (PMMA) was carried out. The parameters which influenced the photochromic behavior of both compounds were investigated. After ultraviolet (UV) irradiation, it was demonstrated that the temperature was the dominant factor which influenced the deactivation of both materials. For spiropyran, it was demonstrated that the process could be photo-induced with a certain wavelength which we have specified in this manuscript. It was also found that X-Ray did not affect the photo physical properties of spirooxazine and spiropyran. Finally, both materials could be used as low-cost germicidal UV indicators.

关键词： UV Indicator Water Disinfection Photochromism Polymer

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Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area

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Chinese Medical Journal 2013年第23期126卷 4504-4509页

作者： CHENG vincent Chi-Chung CHAN Jasper Fuk-Woo WONG Sally Cheuk-Ying CHEN Jonathan Hon-Kwan TAI Josepha Wai-ming YAN Mei-Kum KWAN Grace See-Wai tse Herman TO Kelvin Kai-Wang HO Pak-leung YUEN Kwok-Yung Department of Microbiology Queen Mary Hospital Hong KongChina Infection Control Team Queen Mary Hospital Hong Kong China

Background Identification of hospitalized carbapenem-resistant Enterobacteriaceae （CRE）-positive patient is important in preventing nosocomial transmission.The objective of this study was to illustrate the implementation of proactive infection control measures in preventing nosocomial transmission of CRE in a healthcare region of over 3200 beds in Hong Kong between October 1,2010 and December 31,2011.Methods The program included active surveillance culture in patients with history of medical tourism with hospitalization and surgical operation outside Hong Kong within 12 months before admission,and ＂added test＂ as an opportunistic CRE screening in all fecal specimens submitted to the laboratory.Outbreak investigation and contact tracing were conducted for CRE-positive patients.Serial quantitative culture was performed on CRE-positive patients and the duration of fecal carriage of CRE was analyzed.Results During the study period,a total of 6533 patients were screened for CRE,of which 76 patients were positive （10 from active surveillance culture,65 from ＂added test＂,and 1 secondary case from contact tracing of 223 patients with no nosocomial outbreak）,resulting in an overall rate of CRE fecal carriage of 1.2％.The median time of fecal carriage of CRE was 43 days （range,13-119 days）.Beta-lactam-beta-lactamase-inhibitors,cephalosporins,and fluoroquinolones were associated significantly with high fecal bacterial load when used 90 days before CRE detection,while use of cephalosporins,carbapenems,and fiuoroquinolones after CRE detection are significantly associated with longer duration of carriage.The duration of fecal carriage of CRE also correlates significantly with the initial fecal bacterial load （Pearson correlation：0.53; P=0.02）.Conclusion Proactive infection control measures by enhanced surveillance program identify CRE-positive patients and data obtained are useful for the planning of and resource allocation for CRE control.

关键词： surveillance nosocomial transmission carbapenem-resistant Enterobacteriaceae

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Overview of methodologies and statistical strategies in observational studies and meta-analyses on the risk of hepatocellular carcinoma in patients with chronic hepatitis B on entecavir or tenofovir therapy

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Hepatoma Research 2022年第1期8卷 143-156页

作者： Terry Cheuk-Fung Yip vincent Wai-Sun Wong Mandy Sze-Man Lai Vicki Wing-Ki Hui Yee-Kittse Grace Lai-Hung Wong Medical Data Analytics Centre Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics 9/F Lui Che Woo Clinical Sciences BuildingPrince of Wales Hospital30-32 Ngan Shing StreetShatinHong KongChina Institute of Digestive Disease The Chinese University of Hong KongHong KongChina

Entecavir(ETV)and tenofovir disoproxil fumarate(TDF)are first-line antiviral therapies for patients with chronic hepatitis B(CHB)and reduce the risk of disease progression and liver-related complications,as well as improve survival by effectively suppressing viral replication.Nevertheless,since the first publication in 2019 on a lower risk of hepatocellular carcinoma(HCC)in Korean patients receiving TDF than those receiving ETV,the topic has remained a hot and unsettled debate.Multiple studies and meta-analyses have yielded conflicting results.As HCC takes time to develop,studies are mainly observational to benefit from a larger sample size and longer follow-up that provides a higher statistical power to compare the two treatments.However,TDF was available to CHB patients a few years later than ETV in most countries,thus leading to a difference in follow-up duration.Moreover,despite studying the same topic,the difference in data sources and available parameters,inclusion and exclusion criteria,and use of statistical methods complicated the interpretation and comparison of the findings and contributed to between-study heterogeneity in meta-analyses.This review describes some caveats in interpreting and comparing the results from these observational studies and meta-analyses.Future studies should explore better designed observational studies with high-quality data sources,and aggregation of patient data in metaanalysis to tackle between-study heterogeneity.

关键词： Bias confounding hepatitis B virus hepatocellular carcinoma liver cancer nucleos(t)ide analogues propensity score

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均匀载荷下固定边环形薄板的大挠度问题

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物理学报 1957年第4期 294-312页

作者：黄择言北京地质勘探学院力学教研室

一.引言自从Th.von Karman建立了著名的平板大挠度方程以来,人们会尝试以各种各样的方法去寻求这一组非线性微分方程的解答。可是有的过于简略,不足以瞭解应力的分布情况;有的又过于繁复,既不便计算又不能用来作为设计的依据。只有摄... 详细信息

一.引言自从Th.von Karman建立了著名的平板大挠度方程以来,人们会尝试以各种各样的方法去寻求这一组非线性微分方程的解答。可是有的过于简略,不足以瞭解应力的分布情况;有的又过于繁复,既不便计算又不能用来作为设计的依据。只有摄动法计算比较容易而又能得到可用的结果。J.J.vincent首先以均匀载荷作为摄

关键词：圆薄板方程大挠度问题

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