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Lomatogonium rotatum extract alleviates diabetes mellitus induced by a high-fat,high-sugar diet and streptozotocin in rats

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World Journal of Diabetes 2023年第6期14卷 846-861页

作者： Li-Li Dai Sung-Bo Cho Hui-Fang Li Li-Sha A Xiao-Ping Ji Sirigunqiqige Pan ming-lan bao Laxinamujila Bai Gen-Na Ba ming-Hai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsHainan Medical UniversityHaikou 571199Hainan ProvinceChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND Lomatogonium rotatum(LR)is traditionally used in Mongolian folk medicine as a hypoglycemic agent,but its evidence-based pharmacological effects and mechanisms of action have not been fully *** To emphasize the hypoglycemic action mechanism of LR in a type 2 diabetic rat model and examine potential biomarkers to obtain mechanistic understanding regarding serum metabolite *** A high-fat,high-sugar diet and streptozotocin injection-induced type 2 diabetic rat model was *** chemical composition of the LR was identified by high performance liquid *** extract administrated as oral gavage at 0.5 g/kg,2.5 g/kg,and 5 g/kg for 4 ***-diabetic effects of LR extract were evaluated based on histopathological examination as well as the measurement of blood glucose,insulin,glucagon-like peptide 1(GLP-1),and lipid *** metabolites were analyzed using an untargeted metabolomics *** According to a chemical analysis,swertiamarin,sweroside,hesperetin,coumarin,1.7-dihydroxy-3,8-dimethoxyl xanthone,and 1-hydroxy-2,3,5 trimethoxanone are the principal active ingredients in *** anti-diabetic experiment revealed that the LR treatment significantly increased plasma insulin and GLP-1 levels while effectively lowering blood glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,and oral glucose tolerance test compared to the model ***,untargeted metabolomic analysis of serum samples detected 236 metabolites,among which 86 were differentially expressed between the model and the LR *** was also found that LR considerably altered the levels of metabolites such as vitamin B6,mevalonate-5P,Dproline,L-lysine,and taurine,which are involved in the regulation of the vitamin B6 metabolic pathway,selenium amino acid metabolic pathway,pyrimidine metabolic pathway,and arginine and proline metabolic *** These findings indicated that LR may have a hypoglycemic im

关键词： Mongolian medicine Lomatogonium rotatum Type 2 diabetes Metabolomics Swertiamarin Streptozotocin

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Linking of Chemical Reactions and Silica Nanoparticle Contact Using Synthetic Helical Molecules

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Chinese Journal of Chemistry 2024年第15期42卷 1781-1796页

作者： Sheng Zhang ming bao Mieko Arisawa Masahiko Yamaguchi state Key Laboratory of Fine Chemicals Dalian University of TechnologyDalianLiaoning 116024China Department of Bioscience and Biotechnology Graduate Schoolof Bioresource and Bioenvironmental SciencesKyushu UniversityFukuoka 819-0395Japan

Biological cells exhibit diverse phenomena induced through linking of chemical reactions of molecules and solid surface *** is then a significant topic in the field of chemistry to study phenomena induced through this linking using synthetic systems,which can promote our understanding of biological phenomena and can be applied to the development of novel *** nanoparticles(sNPs),which are synthetic inorganic materials,are attractive for such purposes,because of their following characteristics:they can adsorb large amounts of molecules on their surfaces,they can aggregate through contact between SNPs as well as contact between molecules and SNPs,and the molecules can be easily removed from solutions by *** contact of sNP surfaces with molecules then affects chemical reactions of molecules and also behaviors of *** article describes systems derived from synthetic helical molecules and sNPs,which exhibit notable phenomena including selective adsorption and molecular recognition,equilibrium shift,step kinetics with induction period,precipitation with flow and sweeping,and disaggregation and desorption by sonication,in which the high affinity of helical molecules with sNP surfaces plays important *** models that explain the phenomena are *** applications are also discussed,including the separation of molecules,capture of intermediates,the storage and release of molecules,equilibrium shift,clocking,and the translation of mechanical stimulations into chemical reactions.

关键词： Silica nanoparticles Chemical reactions Molecular recognition Linking Nanoparticles Adsorption Chirality Precipitation

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Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-ming Xie Ji-Huai Wu Zhang lan lan-Fang Que bao-Sheng Liu Hao Luo Zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

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Novel MIP gene mutation causes autosomal-dominant congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 454-465页

作者： Jing-lan Ni Hua-ming Wen Xiao-Sheng Huang Qian-Wen Li Jia-Min Cai bao-Jian Fan Jun Zhao The Second Clinical Medical College Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Ophthalmology Dongguan Chang’an HospitalDongguan 523843Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Oral&Maxillofacial Surgery Shenzhen Stomatology Hospital Affiliated to Shenzhen UniversityShenzhen 518040Guangdong ProvinceChina Department of Neurosurgery Massachusetts General Hospital and Harvard Medical SchoolBoston 02114MassachusettsUSA Department of Ophthalmology Shenzhen People’s Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina

●AIM:To identify disease-causative mutations in families with congenital cataract.●METHODS:Two Chinese families with autosomaldominant congenital cataract(ADCC)were recruited and underwent comprehensive eye *** panel next-generation sequencing of common pathogenic genes of congenital cataract was performed in the proband of each *** sequencing was used to valid the candidate gene mutations and sequence the other family members for co-segregation *** effect of sequence changes on protein structure and function was predicted through bioinformatics *** intrinsic protein(MIP)-wildtype and MIP-G29R plasmids were constructed and microinjected into zebrafish single-cell stage *** embryonic lens phenotypes were screened using confocal microscopy.●RESULTS:A novel heterozygous mutation(c.85G>A;p.G29R)in the MIP gene was identified in the proband of one family.A known heterozygous mutation(c.97C>T;p.R33C;rs864309693)in MIP was found in the proband of another ***-silico prediction indicated that the novel mutation might affect the MIP protein *** embryonic lens was uniformly transparent in both wild-type PCS2+MIP and mutant PCS2+MIP.●CONCLUSION:Two missense mutations in the MIP gene in Chinese cataract families are identified,and one of which is *** findings expand the genetic spectrum of MIP mutations associated with *** functional studies suggest that the novel MIP mutation might not be a gain-of-function but a loss-of-function mutation.

关键词： congenital cataract major intrinsic protein missense mutation zebrafish model

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Failure evaluation and control factor analysis of slope block instability along traffic corridor in Southeastern Tibet

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Journal of Mountain Science 2024年第6期21卷 1830-1848页

作者： LIU Changqing bao Han lan Hengxing YAN Changgen LI Changbo LIU Shijie School of Highway Chang'an UniversityXi'an 710064China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Geological Engineering and Geomatics Chang'an UniversityXi'an 710054China

The instability of slope blocks occurred frequently along traffic corridor in Southeastern Tibet(TCST),which was primarily controlled by the rock mass structures.A rapid method evaluating the control effects of rock mass structures was proposed through field statistics of the slopes and rock mass structures along TCST,which combined the stereographic projection method,modified M-JCS model,and limit equilibrium *** instabilities of slope blocks along TCST were then evaluated rapidly,and the different control factors of instability were *** showed that the probabilities of toppling(5.31%),planar(16.15%),and wedge(35.37%)failure of slope blocks along TCST increased *** instability modes were respectively controlled by the anti-dip joint,the joint parallel to slope surface with a dip angle smaller than the slope angle(singlejoint),and two groups of joints inclined out of the slope(double-joints).Regarding the control effects on slope block instability,the stabilization ability of doublejoints(72.7%),anti-dip joint(67.4%),and single-joint(57.6%)decreased sequentially,resulting in different probabilities of slope block ***,nearby regional faults significantly influenced the joints,leading to spatial heterogeneity and segmental clustering in the stabilization ability provided by joints to the slope ***,the stability of slope blocks gradually weakened as they approached the fault *** paper can provide guidance and assistance for investigating the development characteristics of rock mass structures and the stability of slope blocks.

关键词： Slope engineering Block instability Rapid evaluation method Rock mass structure Control factor

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Crafting host materials for narrowband blue OLEDs with low efficiency roll-off by the medium-ring strategy

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Science China Chemistry 2024年第10期67卷 3265-3270页

作者： Yuanyuan bao Anping Luo Jingbo lan Junjie Liu Zhengyang Bin Jingsong You Key Laboratory of Green Chemistry and Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China

The pursuit of high-performance narrowband blue organic light-emitting diodes(OLEDs)is of paramount importance in both academic research and industrial *** obvious strides have been made in the design of narrowband blue emitters,the development of appropriate host materials has evidently trailed ***,we introduce a medium-ring strategy for crafting host molecules based on the heptagonal tribenzo[b,d,f]azepine(TBA)*** twisted three-dimensional(3D)architecture of the TBA framework not only endows the host molecules with fast hole-transporting pathways but also effectively reduces exciton *** with two TBA units,DTBA,synthesized with ease,demonstrates a huge horizontal orientation factor(Θ//)of 93.5%and a broad emission spectrum for accelerating the energy transfer process in the emitting layer,which contributes to enhancing device *** have fabricated high-performance narrowband blue OLEDs using DTBA as the host,FIrpic as the phosphor sensitizer,and the widely used boron-nitrogen-containing multiple resonance emitter *** devices exhibit a maximum external quantum efficiency(EQEmax)as high as 31.0%with an impressively lowefficiency *** at a high luminance level of 10,000 cd m^(-2),the EQE value remains noteworthy at 20.3%,marking a significant advancement in BCz-BN-based devices.

关键词： host molecule blue organic light-emitting diode low-efficiency roll-off multiple resonance C–H activation

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Accumulated-state-error-based event-triggered sampling scheme and its application to H∞ control of sampled-data systems

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Science China(Information Sciences) 2024年第6期67卷 328-341页

作者： Xian-ming ZHANG Qing-Long HAN bao-Lin ZHANG Xiaohua GE Dawei ZHANG School of Science Computingand Engineering TechnologiesSwinburne University of Technology College of Automation and Electronic Engineering Qingdao University of Science & Technology School of Mathematics Shandong University

This paper is concerned with event-triggered H∞control of sampled-data systems. Its novelties lie in three aspects:（i） A novel accumulated-state-error-based event-triggered scheme is introduced by comparing the integral of the state error from tk to t with the system state sampled at tk. This condition works well due to the fact that the so-called Zeno behaviour does not occur.（ii） A novel Lyapunov functional is constructed to establish a criterion to ensure some certain H∞performance of the closed-loop system. This Lyapunov functional is dependent on the integral of the state error involved in the event-triggered scheme.（iii） Under the event-triggered sampling scheme, suitable state-feedback controllers can be designed rather than be given a priori. Moreover, a self-triggered implementation of the proposed event-triggered sampling scheme is presented as well. Finally, a batch reactor model and an inverted pendulum system are given to demonstrate the effectiveness of the proposed method.

关键词： event-triggered sampling self-triggered implementation $H_\infty$ control looped-functional

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Mechanical Behavior and Failure Mechanism of an As-Extruded Mg-11wt%Y Alloy at Elevated Temperature

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 969-981页

作者： lan Zhang Dao-Kui Xu bao-Jie Wang Cui-lan Lu Shuo Wang Xiang-Bo Xu Dong-Liang Wang Xin Lv En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangdong510070China

Through carrying out the high-temperature tensile experiments on an as-extruded Mg-11wt%Y alloy at 350℃,400℃,450℃,500℃and 550℃,the mechanical behavior and fracture mechanisms at elevated temperatures are investigated and *** results show that with the increase of temperature,the yield strength and ultimate tensile strength of the alloy increase at first and then decrease,while that the elongation ratio decreases firstly and then *** the sample being tested at 350℃,the values of yield strength,ultimate tensile strength and the elongation ratio are 188 MPa,266 MPa and 11%,*** 400℃,the yield strength and ultimate tensile strength reach the maximum values of,respectively,198 MPa and 277 MPa,but the elongation ratio is the lowest and its value is only 8%.When the applied temperature is increased to 550℃,the values of yield strength and ultimate tensile strength,respectively,decrease to 140 MPa and 192 MPa and the elongation ratio increases to 38%.Failure analysis demonstrates that the fracture surfaces of different samples are mainly composed of plastic dimples and exhibit the typical characteristic of ductile *** observation to the fracture side surfaces indicates that at the temperatures of 350℃and 400℃,microcracks mainly initiate in the interior of Mg_(24)Y_(5)*** the temperatures are 450℃,500℃and 550℃,the cracks preferentially initiate at the Mg_(24)Y_(5)/α-Mg interfaces.

关键词： Mg-Y alloy High-temperature tensile properties Fracture mechanism Failure analysis

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Electrochemical Cascade Annulation for the Synthesis of 3-Sulfanylquinoline Derivatives under Mild Conditions

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Chinese Journal of Chemistry 2024年第16期42卷 1833-1838页

作者： Ke Li ming-Zhong Guo Zhuo Chen Hao-Ran Li Weisi Guo ming Li Lin-bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdaoShandong 266042China

An efficient electrochemical approach has been developed for the construction of 3-sulfanylquinoline derivatives by treating phenylethynylbenzoxazinanones with disulfides in an undivided *** protocol provided a convenient route to functionalized quinolines with good functional group ***,it does not require any metal catalysts or additives,furnishing a series of biologicalquinolines inmoderatetogoodyields.

关键词： Electrocatalysis Electrooxidation Annulation 3-Sulfany quinoline C3-thioetherification

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On the Preparation of Low-Temperature-Rise and Low-Shrinkage Concrete Based on Phosphorus Slag

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Fluid Dynamics & Materials Processing 2024年第4期20卷 803-814页

作者： Jianlong Jin Jingjing Ding Long Xiong ming bao Peng Zeng China Construction Ready Mixed Concrete Co. Ltd.Wuhan430000China

The effects of different contents of a MgO expansive agent and phosphorus slag on the mechanical properties,shrinkage behavior,and the heat of hydration of concrete were *** slump flow,setting time,dry shrinkage,and hydration heat were used as sensitive parameters to assess the response of the considered *** shown by the results,in general,with an increase in the phosphorus slag content,the hydration heat of concrete decreases for all ages,but the early strength displays a downward trend and the dry shrinkage rate *** 90-d strength and dry shrinkage of concrete could be improved with a phosphorus residue content between 0%-20%,with the best performances in terms of mechanical properties and shrinkage characteristics being achieved for a content of 20 kg/m^(3).On the basis of these results,it can be concluded that appropriate amounts of phosphorus slag and MgO expansive agent can be used to improve the compressive strength of concrete in the later stage by reducing the hydration heat and dry shrinkage rate,respectively.

关键词： Phosphorus slag MgO expansion agent mass concrete hydration heat

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