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Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery

Chinese Medical Sciences Journal 2009年第1期24卷 55-59页

作者： Yue-Dina Fan Jian-chun Yu Wei-ming kang Qun zhang Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complicati

关键词： glutamine dipepfide glutathione total parenteral nutrition abdominal operation

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A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy

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CCS Chemistry 2021年第5期3卷 1187-1202页

作者： Bo-Ru Xie Chu-Xin Li Yun Yu Jin-Yue Zeng ming-kang zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng zhang Key Laboratory of Biomedical Polymers of Ministry of Education Department of ChemistryWuhan UniversityWuhan 430072

Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to form poly-mPYR loaded porphyrin-nMOF,which is designated as PLP and used as a reservoir of singlet oxygen(^(1)O_(2)).It was found that PLP could quickly capture^(1)O_(2)in vitro and slowly release^(1)O_(2)in vivo to induce cancer cell *** release of^(1)O_(2)was light and oxygen independent,and the entire process did not cause intracellular oxygen *** also displayed good therapeutic effect in the treatment of both solid tumor and lung metastasis *** strategy of oxygenand light-independent^(1)O_(2)treatment presents great potential for treating refractory ***,the form of^(1)O_(2)capturing polymer-loaded nMOF expands the biomedical applications of MOFs and polymers,which can be used as a platform for biomedical applications.

关键词： cancer endoperoxides pyridone derivative metal-organic framework photodynamictherapy

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激光选区熔化设备及生物医学金属材料的研究与应用进展（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第2期19卷 122-136页

作者： Yu-chao BAI Fan FU Ze-feng XIAO ming-kang zhang Di WANG Yong-qiang YANG Chang-hui SONG School of Mechanical and Automotive Engineering South China University of Technology

本文主要介绍了华南理工大学(SCUT)在激光选区熔化(SLM)成型设备以及医用金属材料SLM成型的基础研究与应用的最新成果。首先,采用DiMetal-100设备研究316L不锈钢、CoCrMo与Ti6Al4V三种医用金属粉末SLM成型的工艺参数、微观组织和力学性... 详细信息

本文主要介绍了华南理工大学(SCUT)在激光选区熔化(SLM)成型设备以及医用金属材料SLM成型的基础研究与应用的最新成果。首先,采用DiMetal-100设备研究316L不锈钢、CoCrMo与Ti6Al4V三种医用金属粉末SLM成型的工艺参数、微观组织和力学性能。其次,详细介绍了SLM成型316L不锈钢在个性化舌侧正畸托槽和手术导板的应用,SLM成型CoCrMo在膝关节假体和牙冠牙桥的应用,以及SLM成型Ti6Al4V在骨盆骨折接骨板和个性化颅骨修复体方面的研究成果。最后,介绍了SCUT在SLM技术方面的发展方向和研究计划,具体包括实现新型多孔结构的SLM直接成型、实现多种材料SLM一次成型、实现SLM与减材复合成型、增加SLM设备的负反馈系统以及开发陶瓷和新型金属的SLM成型工艺。总结:SCUT对SLM设备及其医学应用进行了长期深入的研究,研究了医用金属材料316L不锈钢、CoCrMo合金以及Ti6Al4V合金的SLM成型工艺和微观组织,获得了性能优异的零件。SCUT成功将SLM成型的316L不锈钢应用于舌侧正畸托槽和手术导板,将SLM成型的CoCrMo合金应用于膝关节假体和牙冠牙桥,以及将SLM成型的Ti6Al4V合金应用于个性化接骨板和颅骨多孔修复体。其中,舌侧正畸托槽和牙冠固定桥已经进入商业应用。目前,SCUT正在进一步开展面向植入体内部结构的设计和制造技术研究,同时开始对SLM多材料成型、SLM与切削复合成型进行研究,并逐步开展SLM设备负反馈系统的开发及陶瓷、锌合金、镍钛合金等SLM成型工艺的研究等。

关键词：激光选区熔化(SLM) 生物医学金属材料工艺参数:微观组织机械性能应用

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Prevalence of Abnormity of Blood Lipid and Associated Factors in Health Examination Population in Beijing

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Chinese Medical Sciences Journal 2009年第3期24卷 142-146页

作者： Wei-ming kang Jie-shi zhang Xin-xin Liu Min-shan Wang ming-li Zhao Jian-chun Yu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing. Methods Totally, 38 462 individuals who received health examination were enrolled in our study. We divided them into eight groups according to their ages. The levels of serum total cholesterol, triglyceride, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were tested, and the relationship of blood lipid abnormity with body mass index (BMI) and fasting blood glucose was analyzed. Results The incidences of hypercholesterolemia, hyperglyceridemia, low high-density lipoprotein cholesterolemia, and hyper low-density lipoprotein cholesterolemia presented increasing trend in this population. The incidence rate of abnormity of blood lipid in health examination population increased with BMI increase. The incidence of abnormity of blood lipid in overweight and obesity population was significantly higher than that in low weight and normal weight populations (P<0.05). Meanwhile, the trend of abnormal blood lipid incidence coincided with that of abnormal fasting blood glucose. Conclusions The prevalence of overweight, obesity, and abnormity of blood lipid in Beijing presents increasing trend. The incidence of abnormity of blood lipid increases with BMI increase, in coincidence with that of fasting blood glucose.

关键词： body mass index total cholesterol triglyceride high density lipoprotein cholesterol low density lipoprotein cholesterol fasting blood glucose

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前列腺肉瘤11例报告

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复旦学报（医学版） 2003年第1期30卷 84-86页

作者：许明张永康张立复旦大学附属中山医院泌尿科上海200032

目的　探讨前列腺肉瘤的诊断及有效的治疗。方法　本院 1991年 1月 - 2 0 0 1年 6月共诊治前列腺肉瘤 11例 ,对其临床症状、实验室检查、手术方式、病理类型及预后进行分析。结果　前列腺肉瘤占同期收治前列腺恶性肿瘤的 3 .2 1%。患者... 详细信息

目的　探讨前列腺肉瘤的诊断及有效的治疗。方法　本院 1991年 1月 - 2 0 0 1年 6月共诊治前列腺肉瘤 11例 ,对其临床症状、实验室检查、手术方式、病理类型及预后进行分析。结果　前列腺肉瘤占同期收治前列腺恶性肿瘤的 3 .2 1%。患者年龄 2 0～ 5 8岁 ,平均 3 8.5岁 ;10例首发症状进行性排尿因难 ,血尿 1例 ;所有患者直肠指检发现前列腺巨大质软。 9例PSA正常 ;10例盆腔CT检查 ,7例提示有恶性肿瘤。 7例术前活检 6例确诊。按病情接受不同的治疗 ,3例全膀胱、前列腺切除 +尿流改道 (Bricker手术 ) +放疗和 (或 )化疗 ,其中 1例随访 18个月存活 ,其余 2例平均术后 7月死亡 ;1例作前列腺根治性切除 +膀胱造瘘术 +放疗和化疗 ,术后 6月复发 ,随访 9月仍存活 ;1例作非根治性前列腺切除 +放疗和化疗 ,术后 5月死亡 ;2例手术探查 ,未作放疗或化疗 ,分别 4月和 7月死亡 ;4例仅放疗和 (或 )化疗 ,平均于初诊后 7月死亡。结论　直肠指检可以提示前列腺肉瘤 ,依靠前列腺穿刺病理学检查获得确诊。该病预后极差。

关键词：前列腺肿瘤肉瘤病例分析诊断手术治疗症状

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Primary pigmented nodular adrenocortical disease: report of 5 cases

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Chinese Medical Journal 2006年第9期119卷 782-785页

作者： ZHU Yu WU Yu-xuan RUI Wen-bin LIU Ding-yi ZHOU Wen-long zhang Rong-ming SUN Fu-kang zhang Chong-yu SHEN Zhou-jun Department of Urology Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China

Primary pigmented nodular adrenocortical disease （PPNAD）, found in the mid 1980s, is a rare type of ACTH-independent hypercortisolism, can be part of Carney complex （CNC）, an autosomal dominant multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac myxomas and endocrine tumors. One of the putative CNC genes, located on 17q22-24, has been identified as the regulatory subunit RIA of protein kinase A （PRKAR1A）. Patients with isolated PPNAD and no familial history of CNC can also present a germline de novo mutation of PRKAR1A. In China, five patients with PPNAD underwent surgical treatment in our department from 2001 to August 2004.

关键词： adrenal hyperplasia congenital diagnosis adrenalectomy

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A compact and closed-loop spin-exchange relaxation-free atomic magnetometer for wearable magnetoencephalography

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Chinese Physics B 2023年第4期32卷 277-282页

作者：郭清乾胡涛冯晓宇张明康陈春巧张欣姚泽坤徐佳玉王青付方跃张寅常严杨晓冬 Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Jihua Laboratory Foshan 528000China School of Electronic and Information Engineering Changchun University of Science and TechnologyChangchun 130022China

Atomic magnetometers operated in the spin-exchange relaxation-free(SERF)regime are the promising sensor to replace superconducting quantum interference devices(SQUIDs)in the biomagnetism *** SERF magnetometer with compact size and good performance is crucial to the new generation of wearable magnetoencephalography(MEG)*** this paper,we developed a compact and closed-loop SERF magnetometer with the dimensions of 15.0×22.0×30.0 mm^(3)based on a single-beam *** bandwidth of the magnetometer was extended to 675 Hz while the sensitivity was maintained at 22 f T/Hz^(1/2).A nearly 3-fold enhancement of the bandwidth was obtained in comparison with the open-loop *** implementation of the closed-loop control also greatly improved the dynamic range,enabling the magnetometer to be robust against the disturbance of the ambient ***,the magnetometer was successfully applied for the detection of humanα-rhythm and auditory evoked fields(AEFs),which demonstrated the potential to be extended to multi-channel MEG measurements for future neuroscience studies.

关键词： atomic magnetometer miniaturization closed-loop magnetoencephalography(MEG)

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青海藏羊膈肌住肉孢子虫形态学观察

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黑龙江畜牧兽医（下半月） 2017年第9期 89-91,293,294页

作者：褚荣鹏康明张洪波西宁市畜牧兽医站西宁810003 青海大学农牧学院西宁810016 青海畜牧兽医科学院西宁810016

为了有效防控青海藏羊住肉孢子虫病,采集泽库、共和、贵南、海晏、乌兰、祁连6县180份藏羊膈肌肉样进行了住肉孢子虫检查,并对检出虫体进行形态学观察。结果表明:检出虫体呈浅灰白色、长梭形,囊壁表面平滑,虫体较小,为300~400μm;经染... 详细信息

为了有效防控青海藏羊住肉孢子虫病,采集泽库、共和、贵南、海晏、乌兰、祁连6县180份藏羊膈肌肉样进行了住肉孢子虫检查,并对检出虫体进行形态学观察。结果表明:检出虫体呈浅灰白色、长梭形,囊壁表面平滑,虫体较小,为300~400μm;经染色切片观察,虫体呈蓝色,肌肉呈红色,大小平均为132 mm×14 mm;同时对虫体原生囊壁、次生囊壁等显微结构进行了初步观察。

关键词：藏羊膈肌住肉孢子虫 H.E.染色形态学观察

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu ming-Yu zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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