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Plasma Membrane Localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice

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Molecular Plant 2010年第5期3卷 917-926页

作者： Fang Chen ming-jun gao Yan-Song Miao Yue-Xing Yuan Mu-Yang Wang Qun Li Bi-Zeng Mao Li-Wen Jiang Zu-Hua He National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Present address: Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06511 USA Department of Biology and Molecular Biotechnology Program The Chinese University of Hong Kong Shatin New Territories Hong Kong China Present address: Department of Emergency Medicine Thomas Jefferson University Philadelphia PA 19107 USA Biotechnology Institute Zhejiang University Hanghzou 310029 China

The rice pattern recognition receptor （PRR） XA21 confers race-specific resistance in leaf infection by bacterial blight Xathornonas oryzae pv. oryzae （Xoo）, and was shown to be primarily localized to the endoplasmic reticulum （ER） when expressed with its native promoter or overexpressed in the protoplast. However, whether the protein is still ER- localization in the intact cell when overexpressed remains to be identified. Here, we showed that XA21, its kinase-dead mutant XA21PK736EP and the triple autophosphorylation mutant XA21PS686AJT688AJS699A GFP fusions were primarily localized to the plasma membrane （PM） when overexpressed in the intact transgenic rice cell, and also localized to the ER in the transgenic protoplast. The transgenic plants constitutively expressing the wild-type XA21 or its GFP fusion displayed racespecific resistance to Xoo at the adult and seedling stages. XA21 and XA21PK736EP could be internalized probably via the SCAMP-positive early endosomal compartment in the protoplast, suggesting that XA21 might be endocytosed to initiate resistance responses during pathogen infection. We also established a root infection system and demonstrated that XA21 also mediated race-specific resistance responses to Xoo in the root. Our current study provides an insight into the nature of the XA21-mediated resistance and a practical approach using the root cell system to further dissect the cellular signaling of the PRR during the rice-Xoo interaction.

关键词： Rice XA21 pattern recognition receptor bacterial bight cellular localization internalization root infection race-specific resistance.

Association between serum resistin level and cardiovascular events in postmenopausal women with acute coronary syndrome undergoing percutaneous coronary intervention

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Chinese Medical Journal 2013年第6期126卷 1058-1062页

作者： LI Lei HAN Jiang-li MAO Jie-ming GUO Li-jun gao Wei Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background As an adipocytokine, resistin has been proposed as a link between inflammation, metabolic disorder and atherosclerosis. The aim of the study is to evaluate whether serum resistin is associated with acute coronary syndrome （ACS） and major adverse cardiovascular events （MACEs） among postmenopausal women with ACS undergoing percutaneous coronary intervention （PCI）. Methods A total of 106 consecutive postmenopausal women who underwent coronary angiography for evaluation of suspected myocardial ischemia were enrolled. Pre-procedure serum resistin, inflammatory and metabolic biomarkers were measured. All participants were followed for seven years for MACEs, including cardiovascular death, recurrent nonfatal myocardial infarction, and re-PCl. Results Patients with ACS （n=69） had significantly higher resistin levels than those without coronary artery disease （CAD）（n=37）（4.61 （1.79-10.80） ng/ml vs. 2.36 （0.85-4.15） ng/ml, P=0.002）. Correlation analysis revealed positive correlations between resistin levels and inflammatory and metabolic factors （P 〈0.05）. A follow-up of a mean of 83.4 months showed that patients with ACS suffered more MACEs than those without （13.0% vs. 2.7%, P=0.05）. Adjusted for cardiovascular risks, inflammatory and metabolic factors, multiple Logistic regression analysis indicated that an elevated resistin level was an independent predictor of ACS onset （OR=1.139, 95% CI 1.024-1.268, P=0.017） and of MACEs after PCI （OR=1.099, 95% CI 1.015-1.189, P=-0.019）. To clarify the association between resistin levels and MACEs, ACS patients were divided into two subgroups on the basis of resistin levels. Compared with the low resistin subgroup （≤4.35 ng/ml, n=32）, patients in the high resistin subgroup （〉4.35 ng/ml, n=37） were more prone to suffer MACEs （21.6% vs. 3.1%, P=0.015）. Kaplan-Meier analysis showed a significantly lower event-free survival rate in ACS patients with high resistin levels than in the low resistin subgroup （78.4% vs. 96.9%, Log r

关键词： postmenopausal women resistin acute coronary syndrome major adverse cardiovascular events

基于协作表示Boosting的辐射源多传感器融合识别

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控制与决策 2017年第8期32卷 1481-1485页

作者：周志文黄高明高俊海军工程大学电子工程学院武汉430033

由于单传感器辐射源识别的局限性,在低信噪比条件下仅提高单侦测平台的识别能力无法满足实际需求,为此提出基于协作表示Boosting的辐射源多传感器融合识别算法.利用多传感器数据信息的冗余性和互补性,对多处理支路采用时频分析提取特征... 详细信息

由于单传感器辐射源识别的局限性,在低信噪比条件下仅提高单侦测平台的识别能力无法满足实际需求,为此提出基于协作表示Boosting的辐射源多传感器融合识别算法.利用多传感器数据信息的冗余性和互补性,对多处理支路采用时频分析提取特征,并由协作表示分类器求得残差.根据Boosting在训练阶段的权重组合得到最小分类残差,实现多传感器决策域的融合识别.仿真实验结果验证了所提出方法有效性,并且在低信噪比情况下噪声鲁棒性更优异,易于实现.

关键词：辐射源识别协作表示多传感器数据融合时频分析 Boosting

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian gao Lin Tang jun Zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao gao Xingzhao Zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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含有患病鸟类迁入的禽流感动力学模型

数学的实践与认识 2017年第18期47卷 310-320页

作者：任明高俊莲徐向阳中国矿业大学(北京)管理学院北京100083 中国矿业大学(北京)资源与环境政策研究中心北京100083 中国矿业大学(北京)地球科学与测绘工程学院北京100083

禽流感是一种能够感染人畜的传染性疾病,野生鸟类在禽流感的传播与流行中起到不可忽视的作用.建立常微分方程模型来刻画禽流感在人类及禽类中的动态传播规律.模型包含患病鸟类的迁入,并且禽类和人类数量是可变的.通过构造适当的Liapuno... 详细信息

禽流感是一种能够感染人畜的传染性疾病,野生鸟类在禽流感的传播与流行中起到不可忽视的作用.建立常微分方程模型来刻画禽流感在人类及禽类中的动态传播规律.模型包含患病鸟类的迁入,并且禽类和人类数量是可变的.通过构造适当的Liapunov函数及LaSalle不变性原理证明了平衡点的局部及全局稳定性.在病鸟类迁入率不为零时,利用Poincare-Bendixson定理证明了地方病平衡点的全局渐进稳定性.还对模型进行了仿真及敏感性分析,讨论了含患病鸟类的迁入对禽流感流行的影响以及控制禽流感应采取的措施,为控制禽流感疫情提供理论基础.

关键词：禽流感迁徙全局稳定

三层复合自润滑材料的研制及其在转向架摩擦套上的应用

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铁道车辆 1996年第9期34卷 38-41页

作者：楼鸣高军唐山机车车辆厂工艺处

针对目前采用聚四氟乙烯乳液喷涂工艺生产的客车摩擦套易产生涂层龟裂等问题，提出采用改性聚四氟乙烯糊料轧制工艺研制的三层复合自润滑材料，再卷制成摩擦套。经检测表明。

关键词：客车转向架铁路润滑材料聚四氟四烯摩擦套

我国体育硕士专业学位研究生学位论文文献计量学统计分析——以运动训练方向学位论文为例

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体育研究与教育 2017年第1期32卷 41-46页

作者：龚明俊王健高玉英天津体育学院天津300381

采用词频分析法、共词分析法和社会网络分析法,对我国体育硕士运动训练方向学位论文授予年度、培养单位、论文被引、高频关键词、关键词共词等展开研究。结果显示:(1)学位授予单位以专业体育院校、师范类院校为主,专业体育院校学位论文... 详细信息

采用词频分析法、共词分析法和社会网络分析法,对我国体育硕士运动训练方向学位论文授予年度、培养单位、论文被引、高频关键词、关键词共词等展开研究。结果显示:(1)学位授予单位以专业体育院校、师范类院校为主,专业体育院校学位论文质量优于师范院校的论文;(2)运动训练方向学位论文选题以高校、现状、对策为核心词,田径、游泳、体操等基础大项的研究明显不足;(3)对运动项目的技战术分析、身体素质、体能训练等运动训练领域核心内容的关注度较低。建议从规范论文写作规程、加强论文选题与运动训练结合、强化和完善论文过程管理三方面提高学位论文质量。

关键词：体育硕士运动训练领域学位论文关键词选题